Small airway function in children with mild-to-moderate asthmatic symptoms and healthy controls

Background: Clinical significance of small airway obstruction in mild pediatric asthma is unclear.Objective: To evaluate small airway properties in children with mild-tomoderate asthmatic symptoms, and the association of small airway function with asthma control and exercise-induced bronchoconstriction (EIB).Methods: Children (5-10 years) with either recurrent wheezing (n=42) or persistent troublesome cough (n=16), and healthy controls (n=19) performed impulse oscillometry (IOS), spirometry, and multiple-breath nitrogen washout (MBNW) test.

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