Use of Biomarkers to Identify Phenotypes and Endotypes of Severe Asthma

Severe asthma is a complex, heterogeneous set of diseases. The European Respiratory Society and American Thoracic Society Task Force define severe asthma as asthma that requires or remains uncontrolled despite treatment with systemic corticosteroids or high dose inhaled corticosteroids plus another controller such as a long acting beta agonist1. Lack of control can be determined by symptoms, lung function, or exacerbations, accounting for inter-individual variability in disease state and outcomes.

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