GLOMUS TUMOR: A COMPREHENSIVE REVIEW OF THE CLINICAL AND HISTOPATHOLOGIC FEATURES WITH REPORT OF TWO INTRAORAL CASES

Publication date: Available online 17 August 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Molly Housley Smith, Indraneel Bhattacharyya, Donald M. Cohen, Steven R. Hinze, Mohammed N. Islam

Abstract

Background

Glomus tumors are benign neoplasms that most commonly present in the subungual region. Their occurrence in the oral cavity is exceedingly rare. We present two cases from the oral cavity and detail their clinical and histopathological features, as well as review the literature for solitary cases involving the oral regions.

Methods

The English-language literature was queried for cases of benign glomus tumors in/around the oral cavity. Additional citations were cross-referenced from the identified sources.

Results

Thirty-one cases of solitary glomus tumor in the oral and paraoral regions have been described, including the present cases. The ages ranged from 10 to 85 years, with an average age of 47 years. Twelve out of the 31 cases were from the lips, 5 from the palate, 4 from the tongue, 4 from the buccal mucosa, 3 from the gingiva, and one each from the parotid, pterygoid fossa, and oropharynx. Only 18 of these cases had accompanying immunohistochemical stains, with 14 expressing positivity for muscle cell markers.

Conclusion

Although glomus tumors have distinct histopathological features, diagnostic confusion may exist in extradigital locations. Detailed documentation and discussion of the clinical and histopathological features of rare tumors such as these are vital to their understanding.

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