A polycaprolactone-β-tricalcium phosphate-heparan sulfate device for cranioplasty

Large bone defects in the skull following trauma or brain surgery, such as trepanation, must be treated promptly to restore the protective and cosmetic function of the skull. Such cranioplasty procedures date back thousands of years yet they still remain a challenge for clinicians, despite extensive research and advances in our understanding of the human body and bone biology (Donati et al. 2007, Feroze et al. 2015). The current reported complication rate ranges from 16% to 40% and general reoperation rate is about 25% (Feroze et al.

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