Twist and E-Cadherin deregulation might predict poor prognosis in lower lip squamous cell carcinoma

Publication date: Available online 16 November 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Everton Freitas de Morais, Hellen Bandeira de Pontes Santos, Israel Leal Cavalcante, Silvia Helena Barem Rabenhorst, Jean Nunes dos Santos, Hébel Cavalcanti Galvão, Roseana de Almeida Freitas

ABSTRACT

Objective

To evaluate the expression of Twist and E-cadherin in Lower Lip Squamous Cell Carcinoma (LLSCC) and their association to clinical-pathological parameters.

Study Design

Fifty-nine LLSCC cases were analyzed applying immunohistochemistry techniques in a semi-quantitative manner. The systems proposed by Bryne et al. (1992), Brandwein-Gensler et al. (2005) and Almangush et al. (2015) were applied for the histopathological malignancy grading system analysis.

Results

Higher E-cadherin expression (general and membrane) was observed in cases presenting disease-free survival after 5 years of follow-up (p < 0 .05). Higher Twist expression was observed in lesions classified as in advanced stages, displaying recurrence and a high degree of malignancy. A significant negative correlation was detected between cytoplasmic Twist expression and membrane E-cadherin expression (p = 0.028). A statistically significant relationship between high total Twist expression in tumors classified as high risk by Brandwein-Gensler et al. (2005) was detected, and no significant difference was observed between total, membrane and cytoplasmic E-cadherin expression in LLSCC cases and the three applied grading systems (p>0.05).

Conclusions

The results of the present study suggest the potential involvement of Twist and E-cadherin in the modulation of events related to worse LLSCC prognoses.

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