ATR gene mutations in HPV negative oropharyngeal cancer

Oropharyngeal cancer is increasing in incidence and has now become the commonest sub-site of cancer in the head and neck region [1]. It is unusual as these cancers tend to occur in younger patients, non-smokers and majority are associated with Human Papilloma Virus (HPV) infection. The prognosis of patients with HPV-associated oropharyngeal cancer tends to be significantly better in terms of survival outcome as compared to patients with HPV-negative oropharyngeal cancer [2]. However, the molecular mechanisms causing distinct treatment response are largely unknown.

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