Psoriasis and palmoplantar pustulosis: an endless debate?

Abstract

Since 2007, palmoplantar pustulosis (PPP) has been classified as a separate entity and not a clinical variant of psoriasis despite the presence of certain phenotypes common in both diseases.¹ We read with interest the review by Misiak-Galazka et al., and we found that even after the extensive work (inclusion of 65 articles), some relevant data are missing.^1-3

The clue question remains the following: Is palmoplantar pustulosis (PPP) closely related to psoriasis or is PPP a separate condition? Herein we will systematically review the literature searching for frequency of psoriasis in PPP patients and we will discuss new genetic insights that connect PPP and psoriasis vulgaris.

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