Bryne’s grading system predicts poor disease-specific survival of oral squamous cell carcinoma: a comparative study among different histological grading systems

Publication date: Available online 28 February 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Vivian Petersen Wagner, Liana Preto Webber, Marina Curra, Isadora Peres Klein, Luise Meurer, Vinicius Coelho Carrad, Manoela Domingues Martins
ObjectivesTo access the prognostic value of four histopathological grading systems of oral squamous cell carcinoma (OSCC): the World Health Organization (WHO), Anneroth , Bryne (1989) and Bryne (1992).Study DesignEighty-five cases of OSCC diagnosed between 1996 and 2010 at the Clinics Hospital of Porto Alegre (Porto Alegre, Brasil) were included. Slides stained with hematoxylin-eosin (H&E) were obtained, and a histological grade was assigned based on the consensus of three expert oral pathologists who were blinded to the clinicopathological factors. Each system was correlated with proliferative labeling index (PLI), accessed through Ki67 immunostaining, clinicopathological factors, patient outcome (alive or deceased) and survival time.ResultsThe increase in Bryne (1992) histological grades was accompanied by an increase in PLI. Moreover, this system was the only one associated with patients' outcome (p=0.01) and survival. Grade III tumors of Bryne 1992 grading system were associated with poor disease-specific survival according to univariate and multivariate cox regression and log-rank test (p<0.05). The others systems evaluated presented no association with patients' outcome or survival.ConclusionBryne (1992) grading system is more effective in predicting OSCC survival than the systems proposed by the WHO, Anneroth or Bryne (1989).



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