The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: A Randomized, Double-Blind, Crossover Study assessing different doses of oral rinse

Publication date: Available online 28 February 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Noam Yarom, Keren Zelig, Joel B. Epstein, Meir Gorsky
Objectiveto assess the efficacy of 2 different concentrations of minocycline mouthwashes on recurrent aphthous stomatitis (RAS) symptoms.Study DesignThe two year study was designed as a randomized, double-blind, crossover Study. Healthy subjects, with frequent RAS episodes received two sealed and computer randomized marked kits containing minocycline mouthwashes (0.2% and 0.5% solution). Subjects were asked to use one of the kits on the first episode of RAS started with the first onset of prodromal symptoms until the symptoms resolved or up to a maximum of 10 days (whichever came first). On the following episode the patients were asked to use their second kitResultsA total of 14 subjects (8 males, 6 females) completed the 2 arms of the study. The mean intensity of pain was significantly lower when the 0.5% solution was used compared to the 0.2% solution (p=0.027). The difference reached the level of statistical significance as soon as the end of the second day of use (p=0.032). Only minor and temporary adverse reactions were documentedConclusion0.5% minocycline mouth rinse was found to be more effective than the 0.2% concentration suggested by our group in previous studies for the management of RAS.



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