Intravenous Bisphosphonates Therapy does not Thicken Cementum or Change Periodontal Ligament of Cancer Patients

Publication date: Available online 21 February 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Mariana de Pauli Paglioni, Wagner Gomes da Silva, Juliana Pereira, César Augusto Migliorati, Marcio Ajudarte Lopes, Oslei Paes de Almeida, Mario Fernando Goes, Ana Carolina Prado Ribeiro, Thais Bianca Brandão, Alan Roger Santos-Silva
ObjectiveTo test the hypothesis that intravenous (IV) bisphosphonates (BPs) therapy thicken or alter the micromorphology of cementum and periodontal ligament (PL) in cancer patients.Study design32 teeth extracted from 24 cancer patients and separated in test (n=16; patients who have undergone IV BPs) and control (n=16; patients naive to BPs) groups were studied. Cementum thickness was measured in 3 different areas of the dental root through polarized light microscopy and micromorphology of cementum. PL was accessed by optical light microscopy and the immunohistochemical expression of periostin.ResultsNo significant difference was detected in cementum thickness (apical: p=0.06; medium: p=0.16; cervical: p=0.18) between groups. The numbers of fibroblasts (p=0.56), incremental lines of cementum (p=0.51) and the immunohistochemical patterns of periostin expression in PL (p=0.68) did no differ between groups.ConclusionIV BPs therapy does not thicken cementum or change the micromorphology of LP.



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