Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τρίτη 18 Απριλίου 2017

A Case Control, Multi-Site, Positive Controlled, Prospective Study of the Safety and Effectiveness of Immediate Inferior Alveolar Nerve Processed Nerve Allograft Reconstruction with Ablation of the Mandible for Benign Pathology

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Publication date: Available online 13 April 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): John R. Zuniga, Fayette Williams, Daniel Petrisor
PurposeThis study determined if the immediate reconstruction of the inferior alveolar nerve (IAN) with a long (>4.5cm) processed nerve allograft (PNA) in conjunction with the simultaneous ablation and reconstruction of the mandible was effective in restoring subjective sensation and reaching functional sensory recovery that was safe.Materials and MethodsPatients (age 5-70) requiring resection of the unilateral or bilateral mandible for benign pathology were included. The length of the graft had to be greater than 4.5 cm. Sensory nerve tests and three different surveys (Direct Path, Numerical rating scale, Word Choice) were collected before and at 3, 6 , and 12 months. Safety data were recorded.ResultsTwenty-six subjects were consented to this study. Three patients served as positive control (no nerve repair). Five in the repair and 1 in the positive control group were lost to follow up. Data over a 1 year time was collected on 18 patients. There were 7 males and 11 females, mean age were 26.4 years, range 10 to 64. The mean length of the PNA was 62.7mm, range 45 to 70mm. Seventeen of 18 had S4 sensory scores preoperatively and the postoperative score was S4 at 3 months in 3, in 10 at 6 months, and in 12 at 1 year. The positive control patients never exceeded S2. Numerical rating scales and word choices were not significantly different from presurgical scores at 6 and 12 months. There were no adverse events.ConclusionsPNA are safe and effective when immediately inserted with resection and reconstruction of the mandible: 90% of patients reach functional sensory recovery and report similar sensations to preoperative subjective values.



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