Source:Journal of Oral and Maxillofacial Surgery
Author(s): Meltem Karsiyaka Hendek, Fatma Şenses, Üçler KISA, Nurkan AKSOY, Umut TEKİN
PurposeNitric oxide (NO) is an indicator of oxidative stress in several tissues. Its role in dental follicular (DF) tissues of impacted third molars with history of recurrent pericoronitis is not well elucidated. The present study aimed to compare NO levels between inflamed and noninflamed DF tissues of impacted third molars with history of recurrent pericoronitis.Materials and MethodsA cross-sectional study was designed. The study sample included inflamed DF tissues (test group) with certain local inflammatory symptoms such as pain, tenderness, swelling, erythema, and noninflamed DF tissues (control group) without local inflammatory symptoms of impacted mandibular third molars. Each subject contributed only one specimen to the samples. All tissues samples were biochemically investigated for NO levels as an indicator of oxidative stress. The primary predictor variable was inflammatory status; secondary predictor variables were age and gender. The primary outcome variable was NO level. Descriptive and comparative analyses were conducted.ResultsThe test group consisted of 57 patients (28 men, 29 women, mean age: 23.28 ± 5.16 years), and the control group consisted of 57 patients (30 men, 27 women, mean age: 23.02 ± 5.42 years). No significant intergroup differences were noted in terms of demographic findings such as age and gender. NO levels were significantly higher in inflamed DF tissues of impacted third molars than compared with noninflamed DF tissues (p < 0.05).ConclusionResults of this study showed that NO might be used as an indicator of oxidative stress and the necessity to remove impacted mandibular third molars with history of recurrent pericoronitis.
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