A rare mutation in the F12 gene in a patient with ACE inhibitor-induced angioedema

Angioedema without wheals is a rare condition characterized by localized subcutaneous angioedema episodes that affect the extremities (hand, feet, limbs) and face and often are accompanied by painful bowel edemas and potentially life-threatening upper airway obstruction.1 According to Cicardi et al,1 when the family history is negative, angioedema without wheals can be classified into 4 subtypes representing acquired cases: idiopathic histaminergic angioedema, idiopathic non-histaminergic angioedema, angioedema with an acquired C1 inhibitor (C1-INH) deficiency, and acquired angioedema related to angiotensin-converting enzyme (ACE) inhibitors (or ACE-induced angioedema).

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