Relationship between Dental Status and Development of Osteoradionecrosis of the Jaw: A Multicenter Retrospective Study

Publication date: Available online 4 May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Yuka Kojima, Souichi Yanamoto, Masahiro Umeda, Yumiko Kawashita, Izumi Saito, Takumi Hasegawa, Takahide Komori, Nobuhiro Ueda, Tadaaki Kirita, Shin-ichi Yamada, Hiroshi Kurita, Yasuko Senga, Yasuyuki Shibuya, Hiroshi Iwai
ObjectiveOsteoradionecrosis of the jaws is a serious late adverse event in patients with head and neck cancer undergoing radiotherapy. The aim of this study is to investigate the relationship between dental status and development of osteoradionecrosis.Study DesignMulticenter, retrospective observational study. A total of 392 patients with head and neck cancer who underwent radiotherapy were investigated for correlations between osteoradionecrosis development and various factors. The cumulative occurrence rate of osteoradionecrosis was calculated by the Kaplan-Meier method, and analyzed by Cox regression and log-rank test.ResultsOsteoradionecrosis developed in 30 of 392 patients. In 23 patients, osteoradionecrosis occurred in the mandibular molar region. A univariate analysis showed that oral or oropharyngeal cancer, jaw radiotherapy dose exceeding 50 Gy, periapical periodontitis, and tooth extraction after radiotherapy were significantly correlated with the occurrence of osteoradionecrosis. Among these, oral and oropharyngeal cancer, periapical periodontitis, and tooth extraction after radiotherapy were significant independent risk factors by a multivariate analysis. Further, caries which occurred after RT and progressed rapidly, resulting periapical periodontitis, carious stump, or extraction was a major cause of osteoradionecrosis.ConclusionExtraction of mandibular molars with periapical periodontitis before radiotherapy and strict dental management after radiotherapy may reduce the risk of osteoradionecrosis.



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