Oral squamous cell carcinoma associated with oral submucous fibrosis have better oncologic outcome than those without

Publication date: Available online 4 May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Pankaj Chaturvedi, Akshat Malik, Deepa Nair, Sudhir Nair, Aseem Mishra, Apurva Garg, Sagar Vaishampayan
ObjectivesOral submucous fibrosis (OSMF) is a potentially malignant disorder associated with the use of areca nut and is mainly seen in the parts of South-East Asia and Indian sub-continent. We hypothesized that Oral cancers occurring in presence of OSMF are clinico-pathologically a distinct entity.Study designWe analyzed 289 treatment naïve patients of oral cancer. They were followed up for a median of 44 months. Association of presence of OSMF with other histopathological factors was done using Chi square test. Kaplan Meier analysis was used for survival analysis.ResultsOral squamous cell carcinoma along with OSMF was seen more often in younger patients (p<0.001), males (p<0.007) and had a lower T (p<0.002), N stage (p<0.000). These were thinner (p<0.002), less infiltrative (p<0.04) tumors and required adjuvant therapy less frequently (p<0.017). The mean disease specific survival, overall for those with and without OSMF was 58.8 and 48.6 months (p<0.002) and specifically for stages III, IV was 49.4 and 38.5 months respectively (p<0.053).ConclusionOral squamous cell carcinomas associated with OSMF are associated with good clinico-pathological profile and have better prognosis and oncological outcomes.



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