Extramammary paget’s disease of the oral mucosa and perioral skin

Publication date: Available online 11 May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Xiangjian Wang, Lanyan Wu, Xueke Shi, Xin He, Wei Li, Hongmei Zhou
Extramammary paget's disease (EMPD) is an unusual intraepidermal adenocarcinoma, with only two cases in the oral mucosa reported previously. Here, we first report a rare case of Paget's disease of the oral mucosa and perioral skin with extensive contiguous erythematous and erosive manifestations. Ultimately, the patient was treated with oral thalidomide for 8 weeks. We noticed an improvement with resolution of the symptoms. A 3-year follow-up showed no relapse. Thus, this case might provide new insight for clinicians in treating EMPD. More importantly, we advise that dentists should be vigilant for the possibility of some clinically significant conditions in patients with extensive non-specific clinical lesions mimicking inflammatory or infectious diseases in the oral and maxillofacial regions, especially those who are refractory to long-term treatment. Requesting consultations with relevant clinical departments promptly and obtaining histopathological confirmation at an early stage are crucial for early therapy and a better prognosis.



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