Related Articles Trial watch: IDO inhibitors in cancer therapy. Oncoimmunology. 2020 Jun 14;9(1):1777625 Authors: Le Naour J, Galluzzi L, Zitvogel L, Kroemer G, Vacchelli E Abstract Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first, rate-limiting step of the so-called "kynurenine pathway", which converts the essential amino acid L-tryptophan (Trp) into the immunosuppressive metabolite L-kynurenine (Kyn). While expressed constitutively...
Thu Sep 17, 2020 18:37
Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy.
Related Articles Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy. Oncoimmunology. 2020 Jun 16;9(1):1779991 Authors: Naseri M, Bozorgmehr M, Zöller M, Ranaei Pirmardan E, Madjd Z Abstract Identification of immunogenic tumor antigens that are efficiently processed and delivered by dendritic cells to prime the immune system and to induce an appropriate immune response is a research hotspot...
Thu Sep 17, 2020 18:37
Related Articles The role of trogocytosis in immune surveillance of Hodgkin lymphoma. Oncoimmunology. 2020 Jun 17;9(1):1781334 Authors: Zeng Q, Schwarz H Abstract Hodgkin lymphoma (HL) is a unique type of hematopoietic cancer that has few tumor cells but a massive infiltration of immune cells. Findings on how the cancerous Hodgkin and Reed-Sternberg (HRS) cells survive and evade immune surveillance have facilitated the development of novel...
Thu Sep 17, 2020 18:37
Related Articles The consensus immunoscore: toward a new classification of colorectal cancer. Oncoimmunology. 2020 Jul 11;9(1):1789032 Authors: Lanzi A, Pagès F, Lagorce-Pagès C, Galon J Abstract In its latest edition, the WHO classification of the Digestive System Tumors introduced for the first time the immune response as essential and desirable diagnostic criteria for colorectal cancer. The immune response within the tumor microenvironment...
Thu Sep 17, 2020 18:37
Related Articles IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connection. Oncoimmunology. 2020 Jul 09;9(1):1790716 Authors: Pilones KA, Charpentier M, Garcia-Martinez E, Demaria S Abstract IL15 is a key cytokine for the activation and survival of anti-tumor effectors CD8+ T and NK cells. Recently published preclinical studies demonstrate that the therapeutic activity of IL15 requires...
Thu Sep 17, 2020 18:37
Related Articles SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4. Oncoimmunology. 2020 Jul 12;9(1):1794163 Authors: Carmona-Rodríguez L, Martínez-Rey D, Mira E, Mañes S Abstract The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that the extracellular superoxide dismutase...
Thu Sep 17, 2020 18:37
Related Articles Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors. Oncoimmunology. 2020 Jul 20;9(1):1794423 Authors: Daillère R, Routy B, Goubet AG, Cogdill A, Ferrere G, Alves-Costa Silva C, Fluckiger A, Ly P, Haddad Y, Pizzato E, Thelemaque C, Fidelle M, Mazzenga M, Roberti MP, Melenotte C, Liu P, Terrisse S, Kepp O, Kroemer G, Zitvogel L, Derosa L ...
Thu Sep 17, 2020 18:37
Related Articles Trial Watch: experimental TLR7/TLR8 agonists for oncological indications. Oncoimmunology. 2020 Jul 21;9(1):1796002 Authors: Frega G, Wu Q, Le Naour J, Vacchelli E, Galluzzi L, Kroemer G, Kepp O Abstract Resiquimod (R848) and motolimod (VTX-2337) are second-generation experimental derivatives of imiquimod, an imidazoquinoline with immunostimulatory properties originally approved by the US Food and Drug Administration for...
Thu Sep 17, 2020 18:37
Related Articles The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisions. Oncoimmunology. 2020 Jul 20;9(1):1796003 Authors: Lanzi A, Sinicrope FA, Benson AB, Galon J Abstract The consensus Immunoscore is a routine assay quantifying the adaptive immune response within the tumor microenvironment. It has a prognostic value that has been confirmed in a phase 3 clinical trial (NCCTG N0147) in stage...
Thu Sep 17, 2020 18:37
Related Articles Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteria. Oncoimmunology. 2020 Jul 29;9(1):1800957 Authors: Livyatan I, Nejman D, Shental N, Straussman R Abstract Many characteristics of cancer such as proliferation, survival, progression, immunogenicity, sensitivity, and resistance to therapy are not just endogenously driven by the tumor cells themselves, but are greatly affected...
Thu Sep 17, 2020 18:37
A man in his 40s presented with mobility of the anterior mandibular dentition; clinical examination revealed fullness on the mentolabial fold, but no gross facial asymmetry or mental nerve paresthesia. What is your diagnosis?
Thu Sep 17, 2020 03:00
A female smoker in her 50s was referred for hyperparathyroidism and a multinodular goiter. What is your diagnosis?
Thu Sep 17, 2020 03:00
This randomized clinical trial uses data from existing patients at a tertiary care facility to assess the efficacy of intranasal thermosensitive timolol gel in treating moderate-to-severe recurrent hereditary hemorrhagic telangiectasia–associated epistaxis.
Thu Sep 17, 2020 03:00
This case report describes man in his 60s who presented with a maxillary sinus squamous cell carcinoma and experienced hyperprogression following treatment with pembrolizumab.
Thu Sep 17, 2020 03:00
This cross-sectional study assesses the efficacy of nasal povidone-iodine against in vitro transmission of severe acute respiratory syndrome coronavirus 2.
Thu Sep 17, 2020 03:00
This case report describes a young African American girl who presented with a 2-month history of left cheek swelling and pain associated with an enlarging jaw mass that was determined to be a mature teratoma.
Thu Sep 17, 2020 03:00
This Viewpoint describes how a commonly held false presumption of nasal and nasopharyngeal anatomy may contribute to false-negative results in severe acute respiratory syndrome coronavirus 2 testing.
Thu Sep 17, 2020 03:00
Publication date: Available online 17 September 2020Source: World NeurosurgeryAuthor(s): Peh Hueh Low, Manvinder Singh Mangat, Donald Ngian San Liew, Albert Sii Hieng Wong
Thu Sep 17, 2020 18:49
Publication date: Available online 17 September 2020Source: World NeurosurgeryAuthor(s): Tianming Qiu, Apisara Chanchotisatien, Zhiyong Qin, Jinsong Wu, Shuguang Chu
Thu Sep 17, 2020 18:49
Publication date: Available online 17 September 2020Source: World NeurosurgeryAuthor(s): Ali Akhaddar
Thu Sep 17, 2020 18:49
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Takafumi Ogura, Makoto Sakamoto, Hiroki Yoshioka, Koichi Torihashi, Atsushi Kambe, Masamichi Kurosaki
Thu Sep 17, 2020 18:49
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Rei Enatsu, Mayumi Kitagawa, Takashi Morishita, Ayaka Sasagawa, Tomoyoshi Kuribara, Tsukasa Hirano, Masayasu Arihara, Takeshi Mikami, Nobuhiro Mikuni
Thu Sep 17, 2020 18:49
The data provided herein represent the whole-genome resequencing data related to three wolves and three Iranian local dogs. The understanding of genome evolution during animal domestication is an interesting s...
Wed Sep 16, 2020 03:00
Nuclear Factor One X (NFIX) is a transcription factor expressed by neural stem cells within the developing mouse brain and spinal cord. In order to characterise the pathways by which NFIX may regulate neural s...
Wed Sep 16, 2020 03:00
GLUT2 is a major facilitative glucose transporter, expressed from the SLC2A2 gene, with essential roles in the liver. Recent work in mice has shown that preventing Glut2 production in specific neuronal population...
Wed Sep 16, 2020 03:00
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Nicolas Kluger, Mahtab Samimi
Thu Sep 17, 2020 18:50
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Pallab Bhattacharya, Anand Kumar Pandey, Sudip Paul, Ranjana Patnaik
Thu Sep 17, 2020 18:50
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Aziz Rodan Sarohan
Thu Sep 17, 2020 18:50
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Niels Lynøe, Anders Eriksson
Thu Sep 17, 2020 18:50
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Ashutosh Kumar, Muneeb A. Faiq, Vikas Pareek, Khursheed Raza, Ravi K. Narayan, Pranav Prasoon, Pavan Kumar, Maheswari Kulandhasamy, Chiman Kumari, Kamla Kant, Himanshu N. Singh, Rizwana Qadri, Sada N. Pandey, Santosh Kumar
Thu Sep 17, 2020 18:50
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Gasem Mohammad Abu-Taweel, Mohamed F. Attia, Jihan Hussein, Enas Mahmoud Mekawi, Heba M. Galal, Eman Ibrahim Ahmed, Ahmed A. Allam, Mehrez E. El-Naggar
Thu Sep 17, 2020 18:52
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Mohamed E. Shaker, Hesham A.M. Gomaa, Khalid S. Alharbi, Mohammad M. Al-Sanea, Mohamed E. El-Mesery, Sara H. Hazem
Thu Sep 17, 2020 18:52
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Thuy Trang Nguyen, Thi Thuy Dung Nguyen, Qui Thanh Hoai Ta, Van Giau Vo
Thu Sep 17, 2020 18:52
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Wei Liu, Yixuan Li, Xingjiang Xiong, Yuyi Chen, Lumin Qiao, Jie Wang, Xing Su, Fuyong Chu, Hongxu Liu
Thu Sep 17, 2020 18:52
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Meng Bian, Juan Wang, Yu Wang, Anzheng Nie, Chunsheng Zhu, Zongxi Sun, Zheng Zhou, Bing Zhang
Thu Sep 17, 2020 18:52
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Exp Ther Med"[jour] These pubmed results were generated on 2020/09/17PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 17, 2020 18:55
Fort- und Weiterbildung in Zeiten der Covid-19-Pandemie. Allergo J. 2020;29(6):3 Authors: Klimek L, Jakob T PMID: 32934440 [PubMed]
Thu Sep 17, 2020 19:00
Abstract Profound hearing loss requiring cochlear implantation and arachnoid cyst requiring placement of Cysto-Peritoneal Shunt (CPS) are two commonly seen entities. However, there are very few published cases of patients requiring both of them. The present report describes the importance of multidisciplinary surgical planning in one such patient.
Thu Sep 17, 2020 03:00
Abstract Extrapleural solitary fibrous tumor (ESFT) is a rare neoplasm with a variable biological behavior that may occur almost everywhere in the body, as it has been reported in head and neck, back, retroperitoneum, inguinal region and more. The diagnosis of ESFT may be challenging, especially in case of its morphological rare variants such as giant cell‐rich ESFT. Fine‐needle aspiration cytology (FNAC) is a rapid, poorly invasive, safe diagnostic technique, which is recently proving useful for...
Thu Sep 17, 2020 17:31
Publication date: Available online 16 September 2020Source: Radiotherapy and OncologyAuthor(s): D. Winkel, A.M. Werensteijn-Honingh, W.S.C. Eppinga, M.P.W. Intven, J. Hes, L.M.W. Snoeren, S.A. Visser, G.H. Bol, B.W. Raaymakers, I.M. Jürgenliemk-Schulz, P.S. Kroon
Thu Sep 17, 2020 19:05
This case report describes man in his 70s who presented with symptoms consistent with chronic rhinosinusitis despite treatment with azelastine, fluticasone propionate, levocetirizine, montelukast, and saline rinses and was diagnosed with a persistent foramen cecum.
Tue Sep 01, 2020 03:00
This case report describes man in his 60s who presented with recurrent squamous cell carcinoma of the right parotid gland with mild right lower lip and platysmal weakness and subsequently underwent reconstructive surgery using a pectoralis major myocutaneous flap.
Tue Sep 01, 2020 03:00
This case report describes a woman in her 30s who presented with headaches and sudden-onset diplopia, characterized by left abducens nerve palsy and was diagnosed with Cushing disease.
Tue Sep 01, 2020 03:00
In Reply Casale et al highlight our findings, which demonstrate that a transcanal totally endoscopic approach to middle ear and attic cholesteatoma is an effective alternative to postauricular surgery in children. We agree that the endoscope is one of many adjuncts that can facilitate successful removal of cholesteatoma. These adjuncts can be categorized as those that facilitate visualization, improve access, or eliminate invisible or inaccessible disease.
Tue Sep 01, 2020 03:00
This meta-analysis of randomized clinical trials evaluates the association between different central noninvasive brain stimulation therapies and efficacy and acceptability for treatment of patients with tinnitus.
Tue Sep 01, 2020 03:00
This cross-sectional study uses Medicare Physician/Supplier Procedure Summary data to characterize recent trends in the use of telemedicine by otolaryngologists to deliver care to Medicare beneficiaries.
Tue Sep 01, 2020 03:00
This Viewpoint details how COVID-19 surgical precautions taken in medical centers might be reflected in resident education.
Tue Sep 01, 2020 03:00
This narrative review discusses the concepts and development of tools to improve shared decision-making among patients who are undergoing head and neck surgery and surgeons.
Tue Sep 01, 2020 03:00
To the Editor Eliezer and colleagues reported a case where the main symptom expressed by the patient infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the sudden and complete loss of the olfactory function without nasal obstruction. Computed tomographic and magnetic resonance imaging of the nasal cavity showed bilateral inflammatory obstruction of the patient’s olfactory clefts. We recognize that this approach should reveal important aspects about the possible association...
Tue Sep 01, 2020 03:00
This Viewpoint discusses the overall safety and benefits of using nasal saline irrigations on viral upper respiratory infections during a pandemic, such as coronavirus disease 2019 (COVID-19).
Tue Sep 01, 2020 03:00
An 85-year-old woman presents with a history of frontal pain and pressure and progressive nontender facial edema; endoscopy findings reveal a mucosal soft tissue mass, and biopsy results show epithelioid shaped cells in whorled lobulated pattern. What is your diagnosis?
Tue Sep 01, 2020 03:00
In Reply We read with great interest the recent letters by Lechner et al, Malnic and Glezer, and Kheok and Yang in JAMA Otolaryngology–Head and Neck Surgery regarding our recent study. There is now strong evidence that patients with proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection might develop loss of smell and taste, and in some cases this might constitute the main symptom.
Tue Sep 01, 2020 03:00
A 71-year-old man previously treated for p16-positive (human papillomavirus-related) oropharyngeal squamous cell carcinoma presented with concern for regional recurrence. Fine needle aspiration of the thyroid gland was performed with immunohistochemical staining positive for p16, CK5, and p40 and negative for thyroid transcription factor 1. What is your diagnosis?
Tue Sep 01, 2020 03:00
This Viewpoint highlights some techniques to overcome barriers to care that people with hearing loss encounter during the COVID-19 pandemic.
Tue Sep 01, 2020 03:00
This cohort study analyzes data from the Public Health Information System database to evaluate the prevalence of cholesteatoma in children with Down syndrome.
Tue Sep 01, 2020 03:00
Mission Statement: JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies,...
Tue Sep 01, 2020 03:00
This cross-sectional study evaluates whether diversity of practice, clinical productivity, and Medicare payment differ between male and female otolaryngologists and whether any identified variation is influenced by practice setting.
Tue Sep 01, 2020 03:00
This cohort study examines the characteristics of the horizontal and vertical semicircular canals and the change in endolymphatic hydrops volume during medical treatment, including treatment with diuretic therapy, among patients with Ménière disease over a 2-year period.
Tue Sep 01, 2020 03:00
This narrative review discusses how we should interpret negative and positive results from commercial molecular tests of thyroid nodules and whether available data support the routine use of these assays for all cytologically indeterminate thyroid nodules.
Tue Sep 01, 2020 03:00
This review evaluates the reporting and definition of minimal clinically important differences in randomized clinical trials.
Tue Sep 01, 2020 03:00
This systematic review examines evidence on the risks of aerosolization and transmission of severe acute respiratory syndrome coronavirus 2 from patients to health care personnel during endoscopy of the upper aerodigestive tract.
Tue Sep 01, 2020 03:00
This case report describes a woman in her 30s who presented with sinonasal metastasis secondary to radioiodine-refractory vesicular thyroid carcinoma.
Tue Sep 01, 2020 03:00
This diagnostic study describes the use of a microvascular clamp to identify adenomas in patients with hyperparathyroidism.
Tue Sep 01, 2020 03:00
To the Editor We praise the article by Dixon and James, who confirmed the pivotal role of using endoscope alone or in adjunct to a microscope for the completeness of cholesteatomas resection in selected cases, resulting in reduced surgical invasiveness, morbidity, and costs. The main challenge of cholesteatoma surgery is to minimize the risk of residual disease needed to obtain a safe, dry, waterproof, and hearing ear. Over the years, various technological innovations have been proposed to reduce...
Tue Sep 01, 2020 03:00
In the Original Investigation titled “Assessment of the Progression of Vertical Semicircular Canal Dysfunction and Increased Vestibular Endolymphatic Hydrops in Patients With Early-Stage Ménière Disease,” published online July 9, 2020, there was an error in the Author Contributions end matter. The listing given as “Drafting of the manuscript: Fukushima, Kitayama.” should have read “Drafting of the manuscript: Fukushima.” This article has been corrected online.
Tue Sep 01, 2020 03:00
This narrative review describes the ongoing definition of chronic rhinosinusitis into phenotypes and endotypes as well as the proposed classification of primary chronic rhinosinusitis by anatomical distribution and endotype dominance.
Tue Sep 01, 2020 03:00
In the review titled “Contemporary Classification of Chronic Rhinosinusitis Beyond Polyps vs No Polyps: A Review” that was published online July 9, 2020, the “Mechanical (mucociliary)” box in Figure 5 should be coming from the “Diffuse (bilateral)” box to the left, not the “Localized (unilateral)” box. There should be 3 arrows coming from the “Diffuse (bilateral)” box, and 1 of them should point to the “Mechanical (mucociliary)” box. The article has been corrected online.
Tue Sep 01, 2020 03:00
This cross-sectional study assesses the prevalence of specific ingredients in over-the-counter sinonasal products found in US pharmacies.
Tue Sep 01, 2020 03:00
In the Letter to the Editor titled “Olfactory Loss of Function as a Possible Symptom of COVID-19,” published online July 16, 2020, there was an error in the second author’s name in the byline. This article was corrected online.
Tue Sep 01, 2020 03:00
This Viewpoint discusses how surgical global health programs are affected by the coronavirus disease 2019 pandemic and why global surgical outreach models may need to be rehashed.
Tue Sep 01, 2020 03:00
Publication date: Available online 16 September 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): J. Zhu, S. Zhang, X. Yuan, T. He, H. Liu, J. Wang, B. Xu
Thu Sep 17, 2020 19:10
Abstract The Dutch ophthalmologist, Jan van der Hoeve, first introduced the terms phakoma/phakomata (from the old Greek word “ϕαχοσ” = lentil, spot, lens-shaped) to define similar retinal lesions recorded in tuberous sclerosis (1920) and in neurofibromatosis (1923). He later applied this concept: (a) to similar lesions in other organs (e.g. brain, heart and kidneys) (1932) and (b) to other disorders (i.e. von Hippel–Lindau disease and Sturge–Weber syndrome) (1933), and coined...
Thu Sep 17, 2020 03:00
Publication date: Available online 17 September 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Gaurav Vishal, Ramakant Dandriyal, Niranjanaprasad Indra B, Himanshu Pratap Singh, Archana Chaurasia
Thu Sep 17, 2020 19:20
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02438
Thu Sep 17, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03476
Thu Sep 17, 2020 07:00
Publication date: Available online 16 September 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Thomas Tschernig, Reinhard Pabst
Thu Sep 17, 2020 19:49
Publication date: Available online 16 September 2020Source: Academic RadiologyAuthor(s): Heang-Ping Chan, Mark A. Helvie, Katherine A. Klein, Carol McLaughlin, Colleen H. Neal, Rebecca Oudsema, W. Tania Rahman, Marilyn A. Roubidoux, Lubomir M. Hadjiiski, Chuan Zhou, Ravi K. Samala
Thu Sep 17, 2020 19:54
Publication date: Available online 16 September 2020Source: Academic RadiologyAuthor(s): Chinmay Bhimaji Kulkarni, Sreekumar Karumathil Pullara, Nirmal Kumar Prabhu, Sunil Patel, Aarathi Suresh, Srikanth Moorthy
Thu Sep 17, 2020 19:54
Current Anthropology, Ahead of Print.
Thu Sep 17, 2020 08:03
Publication date: Available online 16 September 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Dimitrios Chytas, Michael-Alexander Malahias, Maria-Kyriaki Kaseta
Thu Sep 17, 2020 20:17
Publication date: Available online 16 September 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Mark L. Jewell
Thu Sep 17, 2020 20:17
Publication date: Available online 16 September 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Sammy Al-Benna, Andrew Bruce-Chwatt, Andreas Gohritz
Thu Sep 17, 2020 20:17
Malignant tumors presented in hernia sac are very rare and the clinicopathological features are not well studied. We retrospectively reviewed 21 patients with cancers identified in surgically resected hernia sac specimens at our institution, including 14 males and 7 females, with a median age of 65 years (range 35–93). Fourteen patients (66.7%) carried a synchronous or metachronous cancer diagnosis elsewhere and the tumors in hernia sac were proven to be metastasis. Of the remaining seven (33.3%)...
Thu Sep 17, 2020 18:22
Synovial sarcoma is a high‐grade soft tissue sarcoma that occurs primarily in the deep soft tissue of extremities, and primary colorectal synovial sarcoma is extremely rare. In this report, we present a synovial sarcoma mostly located within the mucosa of the sigmoid colon. The patient was a man in his forties with a germline deletion in the MSH2 gene. He had experienced undifferentiated pleomorphic sarcoma of the left forearm 7 years before and adenocarcinoma of the transverse colon 6 years before,...
Thu Sep 17, 2020 18:22
We demonstrated the clinicopathological findings of 13 myoepitheliomas of soft tissue and bone (MESTBs) and two myoepithelioma‐like tumors of the vulvar region (MELTVRs), focusing on the association between nuclear atypia and clinical course, and the utility of immunohistochemistry (IHC) of pleomorphic adenoma gene 1 (PLAG1) for the pathological diagnosis of these tumors. Of the 13 MESTBs, eight, one and four cases exhibited mild, moderate and severe nuclear atypia, respectively. Two cases with venous...
Thu Sep 17, 2020 18:22
Publication date: Available online 17 September 2020Source: Magnetic Resonance ImagingAuthor(s): Oleg I. Gnezdilov, Oleg N. Antzutkin, Rustam Gimatdinov, Andrei Filippov
Thu Sep 17, 2020 20:32
Publication date: Available online 17 September 2020Source: International Journal of PsychophysiologyAuthor(s): Björn Wieland, Michael Behringer, Karen Zentgraf
Thu Sep 17, 2020 20:34
Publication date: Available online 16 September 2020Source: Behavioural Brain ResearchAuthor(s): Jonah D. Stickney, Michael M. Morgan
Thu Sep 17, 2020 20:42
Publication date: Available online 16 September 2020Source: Behavioural Brain ResearchAuthor(s): Jia-Yi Li, Terry B.J. Kuo, Chang-Tsen Hung, Cheryl C.H. Yang
Thu Sep 17, 2020 20:42
Publication date: Available online 16 September 2020Source: Behavioural Brain ResearchAuthor(s): Antoine Besnard, Amar Sahay
Thu Sep 17, 2020 20:42
Publication date: Available online 17 September 2020Source: Behavioural Brain ResearchAuthor(s): J. Francis-Oliveira, I.C Shieh, G.S. Vilar Higa, M.A. Barbosa, R. De Pasquale
Thu Sep 17, 2020 20:42
Publication date: Available online 17 September 2020Source: Behavioural Brain ResearchAuthor(s): Juhyun Lee, Kyungmin Lee
Thu Sep 17, 2020 20:42
Abstract Hypogonadism is a common comorbidity associated with HIV-1 that is more prevalent among infected individuals over the age of 45. The underlying mechanisms are unknown, but both combined antiretroviral therapeutics and HIV-1 proteins, such as trans-activator of transcription protein (Tat), dysregulate steroid-synthetic mechanisms including lipid storage/synthesis and mitochondrial function. Thus, Tat expression may accelerate age-related comorbidities partly by impairing...
Thu Sep 17, 2020 03:00
Here is a protocol to identify genetic interactions through an increased copy number suppressor screen in Saccharomyces cerevisiae. This method allows researchers to identify, clone, and test suppressors in short-lived yeast mutants. We test the effect of the copy number increase of SIR2 on lifespan in an autophagy null mutant.
Thu Sep 17, 2020 20:54
AbstractLung cancer (LC) is an aggressive malignancy with early metastatic spread and poor prognosis. Gastrointestinal metastases from primary LC are extremely rare with highly variable presentations. In this report, we review the case of a patient who presented with peritonitis secondary to perforated sigmoid mass as the first manifestation of metastatic squamous cell LC.
Mon Sep 14, 2020 03:00
AbstractSeptic knee arthritis is a common disease, mostly due to bacterial infections. We describe a rare case of Haemophilus haemolyticus causing unilateral septic arthritis of a native knee. The affected patient presented with persistent severe knee pain after repeated intra-articular injections. Patient history included knee arthroscopy and a known rheumatoid arthritis treated by steroids. Since conservative treatment was ineffective and infection could not be excluded, diagnostic arthroscopy...
Thu Sep 17, 2020 03:00
AbstractA myxoma is one of the most common tumors in cardiac surgery, with most of them originating from the left or right atrial walls and causing embolic complications. An 84-year-old woman was referred to our institution after echocardiography showed an interatrial septum tumor that was presumed to be a thrombus; however, postoperative pathological examination revealed it to be a cardiac myxoma. This atypical myxoma was covered with a solid capsule containing connective tissue and substantial...
Thu Sep 17, 2020 03:00
AbstractGastrointestinal lipomas are a rare benign non-epithelial neoplasms derived from mature adipocytes. The colon is the commonest organ involved in the entire digestive tract and has an incidence rate ~4.4% in autopsy series. Most of the colonic lipomas are asymptomatic and incidentally detected. Lipomas need to be distinguished from true neoplasia, because in most cases they do not need to be resected unless when they cause a clear symptom or they are large in size. Surgical rather than endoscopic...
Thu Sep 17, 2020 03:00
AbstractMalignant paratesticular and spermatic cord tumors are rare and often misdiagnosed preoperatively due to clinical presentations similar to other benign scrotal mass etiologies. Only a few cases regarding giant, paratesticular liposarcomas (>10 cm) have been reported. We report a unique case of an aggressive giant dedifferentiated liposarcoma of the scrotum with osteosarcoma features in a 70-year-old patient who initially presented with indolent scrotal swelling. A CT scan showed a large,...
Thu Sep 17, 2020 03:00
Publication date: Available online 17 September 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Takuma Yanaoka, Akane Yoshimura, Risa Iwata, Momoko Fukuchi, Norikazu Hirose
Thu Sep 17, 2020 21:07
Publication date: Available online 17 September 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Somayeh Azarnia, Iraj Abdollahi, Maryam Minoo, Soofia Naghdi, Mahyar Salavati
Thu Sep 17, 2020 21:07
Publication date: Available online 17 September 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Sarvenaz Karimi Ghasem Abad, Behnam Akhbari, Mahyar Salavati, Saeed Talebian Moghaddam, Ahmad Saeedi, Mahsa Seydi, Mahnaz Ahangari, Hosein Negahban
Thu Sep 17, 2020 21:07
Decoherence limits the physical realization of qubits, and its mitigation is critical for the development of quantum science and technology. We construct a robust qubit embedded in a decoherence-protected subspace, obtained by applying microwave dressing to a clock transition of the ground-state electron spin of a silicon carbide divacancy defect. The qubit is universally protected from magnetic, electric, and temperature fluctuations, which account for nearly all relevant decoherence channels in...
Thu Sep 17, 2020 20:40
Several species of intestinal bacteria have been associated with enhanced efficacy of checkpoint blockade immunotherapy, but the underlying mechanisms by which the microbiome enhances antitumor immunity are unclear. In this study, we isolated three bacterial species—Bifidobacterium pseudolongum, Lactobacillus johnsonii, and Olsenella species—that significantly enhanced efficacy of immune checkpoint inhibitors in four mouse models of cancer. We found that intestinal B. pseudolongum modulated enhanced...
Thu Sep 17, 2020 20:40
Production of small ribosomal subunits initially requires the formation of a 90S precursor followed by an enigmatic process of restructuring into the primordial pre-40S subunit. We elucidate this process by biochemical and cryo–electron microscopy analysis of intermediates along this pathway in yeast. First, the remodeling RNA helicase Dhr1 engages the 90S pre-ribosome, followed by Utp24 endonuclease–driven RNA cleavage at site A1, thereby separating the 5'-external transcribed spacer (ETS) from...
Thu Sep 17, 2020 20:40
Adsorption involves molecules colliding at the surface of a solid and losing their incidence energy by traversing a dynamical pathway to equilibrium. The interactions responsible for energy loss generally include both chemical bond formation (chemisorption) and nonbonding interactions (physisorption). In this work, we present experiments that revealed a quantitative energy landscape and the microscopic pathways underlying a molecule’s equilibration with a surface in a prototypical system: CO adsorption...
Thu Sep 17, 2020 20:40
Although mechanisms of embryonic development are similar between mice and humans, the time scale is generally slower in humans. To investigate these interspecies differences in development, we recapitulate murine and human segmentation clocks that display 2- to 3-hour and 5- to 6-hour oscillation periods, respectively. Our interspecies genome-swapping analyses indicate that the period difference is not due to sequence differences in the HES7 locus, the core gene of the segmentation clock. Instead,...
Thu Sep 17, 2020 20:40
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