IL-10 Overexpression Predisposes to Invasive Aspergillosis by Suppressing Antifungal Immunity

Publication date: Available online 4 April 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Cristina Cunha, Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B. Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G. Castro, Ricardo Silvestre, Juan Sainz, Johan A. Maertens, Egídio Torrado, Ilse D. Jacobsen, João F. Lacerda, António Campos, Agostinho Carvalho

Teaser

We show that the genetically-determined overexpression of IL-10 is a risk factor for invasive aspergillosis after stem-cell transplantation. Our results identify an IL-10-mediated mechanism that regulates the balance between anti- and proinflammatory antifungal immunity.


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