Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas.

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Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas.

Acta Otorhinolaryngol Ital. 2017 Feb;37(1):17-24

Authors: Mesolella M, Iorio B, Landi M, Cimmino M, Ilardi G, Iengo M, Mascolo M

Abstract
This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

PMID: 28374866 [PubMed - in process]

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