18F-Fluoromisonidazole positron emission tomography (FMISO-PET) may reflect hypoxia and cell proliferation activity in oral squamous cell carcinoma

Publication date: Available online 8 June 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Jun Sato, Yoshimasa Kitagawa, Shiro Watanabe, Takuya Asaka, Noritaka Ohga, Kenji Hirata, Shozo Okamoto, Tohru Shiga, Masanobu Shindoh, Yuji Kuge, Nagara Tamaki
BackgroundHypoxia is a common feature and prognostic factor in cancer. ¹⁸F-fluoromisonidazole (FMISO) - positron emission tomography (PET) can detect tumor hypoxia noninvasively. The aim of this study is to assess the correlations between FMISO- and ¹⁸F-fluorodexyglucose (FDG) -PET parameters with cell proliferation and hypoxia in patients with oral squamous cell carcinoma (OSCC).MethodsTwenty-three preoperative patients with OSCC were included. The tumor-muscle ratio (TMR) of FMISO-PET, the maximum standardized uptake values (SUVmax) of FDG-PET, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured. Ki-67 and hypoxia-inducible factor-1α (HIF-1α) expression was immunohistochemically evaluated.ResultsFMISO TMR (P = 0.003) and FDG SUVmax (P = 0.04) were significantly higher in patients with high than low expression of Ki-67. FMISO TMR (P = 0.006) and FDG SUV max (P = 0.01) were also significantly higher in patients with than without HIF-1α expression. MTV was not significantly related to either Ki-67 or HIF-1α expression. Multivariate analysis showed that FMISO TMR was independently predictive of Ki-67 (P = 0.002; odds ratios, 31.1) and HIF-1α (P = 0.049; odds ratio, 10.5) expression.ConclusionFMISO-PET showed significant relationships with Ki-67 and HIF-1α expression, which are key features of cell proliferation and hypoxia in OSCC.



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