Local Application of Platelet-Rich Fibrin during Lower Third Molar Extraction Improves Treatment Outcomes

Publication date: Available online 8 June 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Yun He, Junliang Chen, Yue Huang, Qin Pan, Minhai Nie
PurposeApplication of platelet-rich fibrin (PRF) during tooth extraction is able to accelerate wound healing, stimulate osseous and soft tissue regeneration and reduce unwanted side effects. The aim of this meta-analysis was to investigate the effect of local application of PRF on controlling post-operative signs and symptoms following the extraction of an impacted lower third molar.MethodsA systematic search of Pubmed, Web of Science, EMBASE and Cochrane Library was performed to identify all studies published up to October 2016 that investigate the effect of PRF in lower third molar extraction. Pain, swelling, trismus, alveolar osteitis (AO) and osteoblastic activity were extracted to evaluate the effect of PRF. After quality assessment, meta-analysis was performed using RevMan 5.3 software.ResultsAfter the search and selection process, ten studies were selected in the present meta-analysis, including 468 cases of PRF application and 467 cases of non-PRF application. Nine of the studies were randomized controlled trials, including seven split-mouth studies and there was one retrospective case-control study. The results indicated that PRF significantly relieves pain (p = 0.01) and 3-day postoperative swelling (p = 0.03) and reduces the incidence of AO (p < 0.0001). However, there were no significant differences between PRF and non-PRF groups with respect to 1-day post-operative swelling and osteoblastic activity.ConclusionLocal application of PRF after lower third molar extraction is a valid method in relieving pain and 3-day postoperative swelling and reducing the incidence of AO. For patients undergoing complicated surgical extraction, PRF might be a recommendation for local application into the sockets.



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