The variant of pri-mir-26a-1 polymorphism is associated with the decreased risk of betel quid-related oral premalignant lesions and oral squamous cell carcinoma

Publication date: Available online 8 June 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Cheng-Mei Yang, Chien-Chou Chen, Yu-Kai Tseng, Sin-Jhih Huang, Huei-Han Liou, Yi-Cheng Lee, Jang-Hwa Lee, Jyh-Seng Wang, Hung-Chih Chen, Chao-Chuan Chi, Bor-Hwang Kang, Yun-Chung Lin, Kuo-Wang Tsai, Luo-ping Ger
ObjectivesThis case-control study evaluated the association of the single nucleotide polymorphism rs7372209 (T>C) in pri-mir-26a-1 with the risk and progression of betel quid (BQ)-related oral premalignant lesions (OPLs) and oral squamous cell carcinoma (OSCC).Study DesignIn total, 597 BQ chewers were recruited: 196 healthy controls, 241 OPL patients, and 160 OSCC patients. The genotypes were determined using the TaqMan real-time assay.ResultsThe C/T + T/T genotypes and T allele in pri-mir-26a-1 were correlated with a decreased risk of BQ-related OPLs (p=0.038 and 0.005, respectively), oral leukoplakia (OL; p=0.01 and 0.001, respectively), and advanced-stage OSCC (p=0.021 and 0.004, respectively). The effects of the C/T + T/T genotypes and T allele on the decreased risk of OPLs were potent in the old age group (both Pinteraction <0.001), heavy smokers (Pinteraction ≤0.003 and 0.006, respectively), and alcohol drinkers (Pinteraction ≤ 0.004 and 0.001, respectively). Furthermore, among OSCC patients, the C/T + T/T genotypes and T allele were associated with a decreased risk of advanced pathological stage (p=0.032) and lymph node involvement (p = 0.017).ConclusionBQ chewers carrying the T allele or C/T + T/T genotypes in pri-mir-26a-1 may have a decreased risk of OL, OPLs, and advanced-stage OSCC.



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