Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Παρασκευή 24 Φεβρουαρίου 2017

Influence of surface roughness on silicone rubber voice prostheses on in vitro biofilm formation and clinical lifetime in laryngectomized patients

Abstract

Objectives

Evaluation of the influence of a smooth surface moulding technique of silicone rubber indwelling voice prostheses on in vitro biofilm formation and analysis of the clinical in situ lifetime.

Design

Biofilm formation on smooth and Groningen ultra-low resistance (URL) prostheses was studied in an artificial throat model. The clinical lifetime of smooth voice prostheses were compared to the previous lifetime of URL by counting the number of replacements in a consecutive 6 months period in the same patient. Participants: Eleven laryngectomized patients in follow up who required frequent replacement of their voice prostheses.

Settings

Tertiary University Medical Center.

Results

Use of a smoother mould and less viscous silicone rubber yielded a decrease in surface roughness from 46 nm to 8 nm, and was accompanied by a 40% reduction in the prevalence of bacteria and yeast in in vitro formed biofilms. Clinically, the lifetime was significantly (p < 0.005) increased by a factor of 2.1.

Conclusions

This combined in vitro and clinical study suggests that the choice of material and in particular its surface finishing, may be determining factors with respect to the clinical lifetime of silicone rubber implants and devices failing due to biofilm formation.

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