Mutually Exclusive Expression Pattern of Keratin Markers for Differentiation and Proliferation in Circumscribed Palmar Hypokeratosis

Abstract

Circumscribed palmar or plantar hypokeratosis (CPH), has been regarded as a benign clonal epidermal differentiation or a keratinization disorder. CPH is characterized by a well-demarcated annular depressed erythematous lesion on the thenar or hypothenar eminences of the palms and sole, and its distinctive histopathological features are an abrupt decrease in the thickness of the corneal layer and hypogranulosis in the affected lesion. Herein, we present a case of CPH and also demonstrate mutually exclusive expression pattern of keratin markers for differentiation and proliferation between the affected and unaffected epidermis.

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