Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Παρασκευή 24 Φεβρουαρίου 2017

Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Publication date: Available online 24 February 2017
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Flavio de Alcântara Camejo, Marina Azevedo, Viviane Ambros, Karina São Thiago Caporal, Andrea Duarte Doetzer, Luis Eduardo Almeida, Marcia Olandoski, Lucia Noronha, Paula Cristina Trevilatto
The inflammatory process is a coordinated response that protects host after infection or trauma, involving several molecular reactions. Once the inflammation is closely linked to the process of destruction of the temporomandibular joint, this study aims to examine, by immunohistochemistry, the expression of interleukin-6 (IL-6), an important inflammatory marker, in temporomandibular articular discs of patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR) and its association with osteoarthrosis (OA). Thirty-eight (n=38) articular discs were divided into two cutoffs: 1) analysis 1: 4 control (acute pathology), 17 ADDwR, 17 ADDwoR; and 2) analysis 2: without OA (n=21) and with OA (n=17). The area of immunostaining was compared statistically between groups (p<0.05). In the disc samples, no significant differences were observed between the groups ADDwR and ADDwoR, and with and without OA, in respect to the expression of IL-6 by immunohistochemical examination. Future studies should be conducted with a larger sample size, which could clarify the association of the inflammatory mediator IL-6 with temporomandibular joint dysfunction.



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