Autosomal dominant familial generalized pustular psoriasis caused by a CARD14 mutation

Abstract

In 2012, gain-of-function mutations in CARD14, which encodes caspase recruitment domain family member 14, were identified as the cause of familial psoriasis vulgaris (PV) and familial pityriasis rubra pilaris (PRP).^1,2 We and another group reported that CARD14 variants are associated with generalized pustular psoriasis (GPP) and palmoplantar pustular psoriasis (PPP).^3-5 The other reports mentioned that CARD14 mutations in individuals with GPP and erythrodermic PRP. ^4,6 Very recently, we described PRP type V as an autoinflammatory disease caused by CARD14 mutations. ⁷

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