Importance of tumor extent in adenosquamous carcinoma of the head and neck: a retrospective cohort study

Publication date: Available online 10 March 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Robert J. Lee, Thomas Lin, Serena A. Lee, Kevin K. Lee, Russell E. Christensen
PurposeTo determine the correlates of survival for patients diagnosed with adenosquamous carcinoma of the head and neck.Materials and MethodsPatients diagnosed with adenosquamous carcinoma of the head and neck between 1973 and 2012 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier and Cox proportional hazard regression models were conducted to investigate the prognostic factors and treatment modalities that determine overall survival (OS) and disease-specific survival (DSS).Results235 patients diagnosed with adenosquamous of the head and neck were analyzed. 66.8% were male and 33.2% were female with a median age at diagnosis of 64 years. Kaplan-Meier analysis determined 5-year survival rates of 30% for OS and 50% for DSS. Univariate and multivariate analysis found that age at diagnosis, tumor size, tumor extent of disease, surgical resection, and radiation therapy were independent predictors of OS and DSS.ConclusionThis study, to our knowledge, is the largest study to date determining the correlates of survival for adenosquamous carcinoma of the head and neck. Older age at diagnosis, larger tumor size, and further extent of disease were correlated with decreased survival. Surgical resection improves survival in patients with localized or regional disease while radiation therapy confers survival benefit in patients with distant extent.



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