Propionibacterium acnes phylotypes and acne severity: an observational prospective study

Although a number of facts on the physiopathological mechanisms of acne are now well established, it is still unclear what triggers the severity of this inflammatory disease of the sebaceous follicle. Thus, could the severity of the acne be somehow linked to different strains of its main bacterium, Propionibacterium acnes? We know that there are several types of P. acnes, and a study (1) has recently shown that different strains of P. acnes could up-regulate or down-regulate in vitro inflammatory keratinocyte response.

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