Nasal Compliance Measurement for Diagnosis of Idiopathic Non-Allergic Rhinitis: a Prospective Case-Controlled Study of 63 Patients

Abstract

• Idiopathic non allergic rhinitis (i-NAR) is a frequent cause of non-allergic rhinitis and associates nonspecific symptoms. There is no simple direct procedure to establish i-NAR diagnosis.

• Diagnosis of i-NAR is currently based on an absence of a definite causal factor and a lack of evidence for IgE-mediated allergy by skin prick tests and allergen-specific serum IgE

• Measurement of nasal compliance with acoustic rhinometry evaluates the vasomotricity-related deformability of the nasal mucosa. It has been already suggested that nasal compliance could be abnormal in i-NAR.

• In this prospective case-controlled study of 42 patients with chronic rhinitis and 21 control patients, after topical decongestion, compliances in i-NAR group were significantly increased compared to allergic rhinitis (AR) and Control group (n=21) (p<0.01).

• Measurement of nasal compliance after topical decongestion allows to objectively and non-invasively discriminating i-NAR from AR.

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