Examination of the early wound healing process under different wound dressing conditions

Publication date: Available online 11 November 2016
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Toshiro Kibe, Takashi Koga, Kazuhide Nishihara, Takao Fuchigami, Takuya Yoshimura, Tetsushi Taguchi, Norifumi Nakamura
ObjectiveVarious types of wound-healing dressings have been used to assist recovery healing of surgical wounds. We analyzed the wound-healing process in an animal model using different existing wound dressings.Study designFull-thickness defects were created using a biopsy punch on the backs of seven-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid (PGA)) or TERUDERMIS (collagen sponge (CS)) affixed using a rat jacket. The wound area, neo-epithelium length, and α-SMA expression were evaluated and compared between the control, PGA and CS groups.ResultsThe wound areas in the control group on day four or seven were significantly smaller than those in PGA and CS groups. The expression of α-SMA in granulation tissue peaked on day four for all groups. The expression of α-SMA in the control group on day four or day seven after injury was greater than in PGA and CS groups. However, there was no significant difference in the expression of α-SMA between the PGA versus CS groups.ConclusionsIn this study, PGA and CS suppressed wound contracture and lowered expression of α-SMA in wound areas. However, PGA and CS did not affect the neo-epithelium length at the wound site.



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