Antibiotics, Vol. 9, Pages 352: Isolation and Characterization of Pectobacterium Phage vB_PatM_CB7: New Insights into the Genus Certrevirus Antibiotics doi: 10.3390/antibiotics9060352 Authors: Colin Buttimer Caoimhe Lynch Hanne Hendrix Horst Neve Jean-Paul Noben Rob Lavigne Aidan Coffey To date, Certrevirus is one of two genera of bacteriophage (phage), with phages infecting Pectobacterium atrosepticum, an economically important phytopathogen that causes potato blackleg...
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Biomedicines, Vol. 8, Pages 169: From Orai to E-Cadherin: Subversion of Calcium Trafficking in Cancer to Drive Proliferation, Anoikis-Resistance, and Metastasis Biomedicines doi: 10.3390/biomedicines8060169 Authors: Aarushi Sharma Randolph C. Elble The common currency of epithelial differentiation and homeostasis is calcium, stored primarily in the endoplasmic reticulum, rationed according to need, and replenished from the extracellular milieu via store-operated calcium entry (SOCE)....
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Biomolecules, Vol. 10, Pages 936: Phytochemical Omics in Medicinal Plants Biomolecules doi: 10.3390/biom10060936 Authors: Jen-Tsung Chen Medicinal plants are used to treat diseases and provide health benefits, and their applications are increasing around the world [...]
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Cancers, Vol. 12, Pages 1645: Drugs Targeting Tumor-Initiating Cells Prolong Survival in a Post-Surgery, Post-Chemotherapy Ovarian Cancer Relapse Model Cancers doi: 10.3390/cancers12061645 Authors: Harrington Ozaki Caminear Hernandez Jordan Kalinowski Goldlust Guha Ferrer Thomas Shetty Tran Wong House Annunziata Disease recurrence is the major cause of morbidity and mortality of ovarian cancer (OC). In terms of maintenance therapies...
Cancers, Vol. 12, Pages 1644: Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach Cancers doi: 10.3390/cancers12061644 Authors: Jesús M. Urman José M. Herranz Iker Uriarte María Rullán Daniel Oyón Belén González Ignacio Fernandez-Urién Juan Carrascosa Federico Bolado Lucía Zabalza María Arechederra Gloria Alvarez-Sola Leticia Colyn María U. Latasa Leonor Puchades-Carrasco Antonio Pineda-Lucena...
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Cells, Vol. 9, Pages 1513: Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice Cells doi: 10.3390/cells9061513 Authors: Kang Xu Yannan Guo Lu Ping Ying Qiu Qingfei Liu Zhongchi Li Zhao Wang Sirtuin 6 (SIRT6), as a NAD + -dependent deacetylase, plays an indispensable role in the regulation of health and physiology. Loss of SIRT6 causes spontaneous colitis in mice and makes intestinal epithelial cells prone to stress. However, whether SIRT6...
Cells, Vol. 9, Pages 1512: Desialylation of Sonic-Hedgehog by Neu2 Inhibits Its Association with Patched1 Reducing Stemness-Like Properties in Pancreatic Cancer Sphere-forming Cells Cells doi: 10.3390/cells9061512 Authors: Shalini Nath Susmita Mondal Ramesh Butti Vinoth Prasanna Gunasekaran Uttara Chatterjee Aniket Halder Gopal C. Kundu Chitra Mandal Cancer stem cells (CSCs) are crucial regulators of tumor recurrence/progression. The maintenance of CSCs is dependent...
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Chemosensors, Vol. 8, Pages 43: Chemical and Temperature Sensors Based on Functionalized Reduced Graphene Oxide Chemosensors doi: 10.3390/chemosensors8020043 Authors: Esteban Araya-Hermosilla Matteo Minichino Virgilio Mattoli Andrea Pucci In this work, we investigated the functionalization of reduced graphene oxide (rGO) with 2-(dodecen-1-yl) succinic anhydride (TPSA) to increase the rGO effective interactions with organic solvents both in liquid and vapor phases. Thermogravimetric...
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Children, Vol. 7, Pages 65: Current Status and Challenges of Safety Education for Children, Including Those Requiring Medical Care, in Japanese General Schools: Focusing on Disasters Children doi: 10.3390/children7060065 Authors: Tomoko Yamamoto This paper discusses school safety mainly in relation to safety education and examines measures for the comprehensive development of systems to ensure the safety of children at school, including those requiring medical care. The number of children...
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Climate, Vol. 8, Pages 80: Discontinuities in Wintertime Warming in Northern Europe during 1951–2016
Climate, Vol. 8, Pages 80: Discontinuities in Wintertime Warming in Northern Europe during 1951–2016 Climate doi: 10.3390/cli8060080 Authors: Mikhail M. Latonin Vladimir A. Lobanov Igor L. Bashmachnikov Although there is a general consensus about the trends of current climate change, the North Atlantic region deserves special attention, as it is the key region for many climate processes. The aim of this study is to assess the climatic changes in this region for the period 1951–2016,...
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Diversity, Vol. 12, Pages 253: Fungal Diversity in the Mediterranean Area Diversity doi: 10.3390/d12060253 Authors: Giuseppe Venturella The Special Issue entitled “Fungal Diversity in the Mediterranean Area” aimed at highlighting the role of various organisms in the Mediterranean habitat. The role of fungi at the root and phyllosphere level; the biodiversity in small island territories and the sea; rare forms of fungi never previously found; the commercial, food,...
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Foods, Vol. 9, Pages 818: β-Cyclodextrin-Mediated Beany Flavor Masking and Textural Modification of an Isolated Soy Protein-Based Yuba Film Foods doi: 10.3390/foods9060818 Authors: Eun-Jung Lee Honggyun Kim Jong Yeop Lee Karna Ramachandraiah Geun-Pyo Hong The application of β-cyclodextrin (CD) to remove unattractive volatile compounds has been applied in various food products. This study investigated the effect of CD concentration (1–4%) on the beany flavor...
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Humanities, Vol. 9, Pages 53: Time Humanities doi: 10.3390/h9020053 Authors: Yousif M. Qasmiyeh This time sequence opens with a soliloquy, or more precisely, a submission to time, in the form of personal lamentations, and is followed by irregular stanzas spanning unidentified episodes of journeying, the intention to do so, or total stasis. Throughout, time is continuously prodded by the intimate journey within one’s own time, by its linguistic and haptic promise, through the...
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IJERPH, Vol. 17, Pages 4465: Gamification in Physical Education: Evaluation of Impact on Motivation and Academic Performance within Higher Education International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17124465 Authors: Alberto Ferriz-Valero Ove Østerlie Salvador García Martínez Miguel García-Jaén Gamification is an innovative pedagogical approach to addressing problems related to social behaviour, student motivation and academic performance at...
IJERPH, Vol. 17, Pages 4466: Challenges Affecting Access to Health and Social Care Resources and Time Management among Parents of Children with Rett Syndrome: A Qualitative Case Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17124466 Authors: Javier Güeita-Rodriguez Pilar Famoso-Pérez Jaime Salom-Moreno Pilar Carrasco-Garrido Jorge Pérez-Corrales Domingo Palacios-Ceña Rare diseases face serious sustainability challenges regarding...
IJERPH, Vol. 17, Pages 4463: Children Witnessing Domestic Violence in the Voice of Health and Social Professionals Dealing with Contrasting Gender Violence International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17124463 Authors: Stefania Carnevale Immacolata Di Napoli Ciro Esposito Caterina Arcidiacono Fortuna Procentese Witnessing domestic violence (WDV) is recognized by the Istanbul Convention as psychological abuse that has dramatic consequences...
IJERPH, Vol. 17, Pages 4464: Urgent Need for Adolescent Physical Activity Policies and Promotion: Lessons from “Jeeluna” International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17124464 Authors: Omar J. Baqal Hassan Saleheen Fadia S. AlBuhairan Physical inactivity is a growing concern in Kingdom of Saudi Arabia (KSA) and globally. Data on physical activity (PA) trends, barriers, and facilitators among adolescents in KSA are scarce. This study aims to...
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IJMS, Vol. 21, Pages 4418: EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases International Journal of Molecular Sciences doi: 10.3390/ijms21124418 Authors: Alaleh Zati Zehni Udo Jeschke Anna Hester Thomas Kolben Nina Ditsch Sven-Niclas Jacob Jan-Niclas Mumm Helene Hildegard Heidegger Sven Mahner Theresa Vilsmaier The aim of this study was to evaluate the prognostic impact of prostaglandin E2 receptor 3 (EP3) receptor expression might...
IJMS, Vol. 21, Pages 4416: OMV Vaccines and the Role of TLR Agonists in Immune Response International Journal of Molecular Sciences doi: 10.3390/ijms21124416 Authors: Mancini Rossi Necchi Micoli Outer Membrane Vesicles (OMVs) are bacterial nanoparticles that are spontaneously released during growth both in vitro and in vivo by Gram-negative bacteria. They are spherical, bilayered membrane nanostructures that contain many components found within the external surface of the...
IJMS, Vol. 21, Pages 4417: Computational Insights on the Mechanism of the Chemiluminescence Reaction of New Group of Chemiluminogens—10-Methyl-9-thiophenoxycarbonylacridinium Cations International Journal of Molecular Sciences doi: 10.3390/ijms21124417 Authors: Pieńkos Zadykowicz Immunodiagnostics, in which one of the promising procedures is the chemiluminescent labelling, is essential to facilitate the detection of infections in a human organism. One of the standards commonly used...
IJMS, Vol. 21, Pages 4415: A New Selective PPARγ Modulator Inhibits Triglycerides Accumulation during Murine Adipocytes’ and Human Adipose-Derived Mesenchymal Stem Cells Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms21124415 Authors: Ghina Al Haj Federica Rey Toniella Giallongo Mattia Colli Barbara Marzani Giammaria Giuliani Alfredo Gorio Gian Vicenzo Zuccotti Anna Maria Di Giulio Stephana Carelli Understanding the molecular basis...
IJMS, Vol. 21, Pages 4413: Assessing Advantages and Drawbacks of Rapidly Generated Ultra-Large 3D Breast Cancer Spheroids: Studies with Chemotherapeutics and Nanoparticles International Journal of Molecular Sciences doi: 10.3390/ijms21124413 Authors: Austin R. Holub Anderson Huo Kavil Patel Vishal Thakore Pranav Chhibber Folarin Erogbogbo Traditionally, two-dimensional (2D) monolayer cell culture models have been used to study in vitro conditions for their ease of use,...
IJMS, Vol. 21, Pages 4414: Immuno-Metabolism and Microenvironment in Cancer: Key Players for Immunotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21124414 Authors: Gaia Giannone Eleonora Ghisoni Sofia Genta Giulia Scotto Valentina Tuninetti Margherita Turinetto Giorgio Valabrega Immune checkpoint inhibitors (ICIs) have changed therapeutic algorithms in several malignancies, although intrinsic and secondary resistance is still an issue. In this...
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JCM, Vol. 9, Pages 1941: Glia-Derived Extracellular Vesicles in Parkinson’s Disease Journal of Clinical Medicine doi: 10.3390/jcm9061941 Authors: Bianca Marchetti Loredana Leggio Francesca L’Episcopo Silvia Vivarelli Cataldo Tirolo Greta Paternò Carmela Giachino Salvatore Caniglia Maria Francesca Serapide Nunzio Iraci Glial cells are fundamental players in the central nervous system (CNS) development and homeostasis, both in health and disease states. In Parkinson’s...
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Life, Vol. 10, Pages 90: Validating the Use of Corifollitropin Alfa in Progestin-Primed Ovarian Stimulation Protocol on Normal and High Responders by Comparing with Conventional Antagonist Protocol: A Retrospective Study Life doi: 10.3390/life10060090 Authors: Chen-Yu Huang Guan-Yeu Chen Miawh-Lirng Shieh Hsin-Yang Li Our previous study showed a satisfactory reproductive outcome resulting from the patient-friendly ovarian stimulation protocol using long-acting follicle stimulation...
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Microorganisms, Vol. 8, Pages 935: Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii Microorganisms doi: 10.3390/microorganisms8060935 Authors: Corneliu Ovidiu Vrancianu Irina Gheorghe Ilda Barbu Czobor Mariana Carmen Chifiriuc Antibiotic resistance is one of the biggest challenges for the clinical sector and industry, environment and societal development. One of the most important pathogens responsible for severe...
Microorganisms, Vol. 8, Pages 934: Rapid Microscopic Detection of Bacillus anthracis by Fluorescent Receptor Binding Proteins of Bacteriophages Microorganisms doi: 10.3390/microorganisms8060934 Authors: Peter Braun Immanuel Wolfschläger Leonie Reetz Lilia Bachstein Ana Clara Jacinto Carolina Tocantins Johannes Poppe Gregor Grass Bacillus anthracis, the etiological agent of anthrax disease, is typically diagnosed by immunological and molecular methods such as polymerase...
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Molecules, Vol. 25, Pages 2863: Polyhalonitrobutadienes as Versatile Building Blocks for the Biotargeted Synthesis of Substituted N-Heterocyclic Compounds Molecules doi: 10.3390/molecules25122863 Authors: Viktor A. Zapol’skii Ursula Bilitewski Sören R. Kupiec Isabell Ramming Dieter E. Kaufmann Substituted nitrogen heterocycles are structural key units in many important pharmaceuticals. A new synthetic approach towards heterocyclic compounds displaying antibacterial activity...
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Nanomaterials, Vol. 10, Pages 1212: Solid Plasmonic Substrates for Breast Cancer Detection by Means of SERS Analysis of Blood Plasma Nanomaterials doi: 10.3390/nano10061212 Authors: Gabriela Fabiola Știufiuc Valentin Toma Mihail Buse Radu Mărginean Gabriela Morar-Bolba Bogdan Culic Romulus Tetean Nicolae Leopold Ioana Pavel Constantin Mihai Lucaciu Rareș Ionuț Știufiuc Surface enhanced Raman spectroscopy (SERS) represents a promising technique in providing...
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Nutrients, Vol. 12, Pages 1853: Development of the Home Cooking EnviRonment and Equipment Inventory Observation form (Home-CookERITM): An Assessment of Content Validity, Face Validity, and Inter-Rater Agreement Nutrients doi: 10.3390/nu12061853 Authors: Sonja Schönberg Roberta Asher Samantha Stewart Matthew J. Fenwick Lee Ashton Tamara Bucher Klazine Van der Horst Christopher Oldmeadow Clare E. Collins Vanessa A. Shrewsbury Introduction: Quantifying Home Cooking...
Nutrients, Vol. 12, Pages 1852: Vitamin K2 Needs an RDI Separate from Vitamin K1 Nutrients doi: 10.3390/nu12061852 Authors: Asim Cengiz Akbulut Angelina Pavlic Ploingarm Petsophonsakul Maurice Halder Katarzyna Maresz Rafael Kramann Leon Schurgers Vitamin K and its essential role in coagulation (vitamin K [Koagulation]) have been well established and accepted the world over. Many countries have a Recommended Daily Intake (RDI) for vitamin K based on early research, and...
Nutrients, Vol. 12, Pages 1851: Mori Cortex Radicis Attenuates High Fat Diet-Induced Cognitive Impairment via an IRS/Akt Signaling Pathway Nutrients doi: 10.3390/nu12061851 Authors: SoHyeon You Miran Jang Gun-Hee Kim Present study was conducted to investigate ameliorating effects of Mori Cortex radicis on cognitive impair and neuronal defects in HFD-induced (High Fat Diet-Induced) obese mice. To induce obesity, C57BL/6 mice were fed an HFD for 8 weeks, and then mice were fed the...
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Pharmaceuticals, Vol. 13, Pages 126: Ocular co-Delivery of Timolol and Brimonidine from a Self-Assembling Peptide Hydrogel for the Treatment of Glaucoma: In Vitro and Ex Vivo Evaluation Pharmaceuticals doi: 10.3390/ph13060126 Authors: Elissavet Taka Christina Karavasili Nikolaos Bouropoulos Thomas Moschakis Dimitrios D. Andreadis Constantinos K. Zacharis Dimitrios G. Fatouros Effective pharmacotherapy during glaucoma treatment depends on interventions that reduce intraocular...
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Pharmaceutics, Vol. 12, Pages 575: RGD-PEG-PLA Delivers MiR-133 to Infarct Lesions of Acute Myocardial Infarction Model Rats for Cardiac Protection Pharmaceutics doi: 10.3390/pharmaceutics12060575 Authors: Bixi Sun Shuwen Liu Rubin Hao Xinyue Dong Lanbo Fu Bing Han Studies have shown that microRNA-133 (miR-133) plays a positive role in the growth of cardiac myocytes, the maintenance of cardiac homeostasis, and the recovery of cardiac function, which is of great significance...
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Pharmacy, Vol. 8, Pages 106: Implementation and Effectiveness of an Interprofessional Support Program for Patients with Type 2 Diabetes in Swiss Primary Care: A Study Protocol Pharmacy doi: 10.3390/pharmacy8020106 Authors: Bawab Moullin Perraudin Bugnon This research protocol illustrates the use of implementation science to support the development, dissemination and integration in primary care of effective and sustainable collaborative pharmacy services for chronic care...
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Psych, Vol. 2, Pages 114-127: Self-Body Recognition through a Mirror: Easing Spatial-Consistency Requirements for Rubber Hand Illusion Psych doi: 10.3390/psych2020011 Authors: Hikaru Hasegawa Shogo Okamoto Ken Itoh Masayuki Hara Noriaki Kanayama Yoji Yamada Considering that humans recognize mirror images as copies of the real world despite misinterpreting optical reflections, spatial disagreement may be accepted in rubber hand illusion (RHI) settings when a mirror is used...
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Religions, Vol. 11, Pages 302: Meaning Agnosticism and Pragmatism Religions doi: 10.3390/rel11060302 Authors: Sami Pihlström This paper proposes to reconsider agnosticism by taking a step onto a meta-level, investigating agnosticism not as an epistemic stance regarding the choice between theism and atheism, but as a stance toward the question concerning the cognitive meaningfulness and/or truth-aptness of religious discourse. It is argued that this “meta-level” meaning...
Religions, Vol. 11, Pages 288: The Dynamic Universal Profiles of Spiritual Awareness: A Latent Profile Analysis Religions doi: 10.3390/rel11060288 Authors: Simon Hanseung Choi Clayton Hoi-Yun McClintock Elsa Lau Lisa Miller The aim of the current investigation was to identify universal profiles of lived spirituality. A study on a large sample of participants (N = 5512) across three countries, India, China, and the United States, suggested there are at least five cross-cultural...
Religions, Vol. 11, Pages 301: Hostility toward Gender in Catholic and Political Right-Wing Movements Religions doi: 10.3390/rel11060301 Authors: Ute Leimgruber Starting with a speech by Theodor Adorno, the essay analyzes some thematic parallels between political and religious populism regarding the view on gender and feminism. In both certain traditional Catholic circles and right-wing political parties, an explicit hostility toward gender can be observed. In this article, this resentment...
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Robotics, Vol. 9, Pages 46: Simulation of an Autonomous Mobile Robot for LiDAR-Based In-Field Phenotyping and Navigation Robotics doi: 10.3390/robotics9020046 Authors: Iqbal Xu Sun Li The agriculture industry is in need of substantially increasing crop yield to meet growingglobal demand. Selective breeding programs can accelerate crop improvement but collectingphenotyping data is time- and labor-intensive because of the size of the research fields andthe frequency of the...
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Safety, Vol. 6, Pages 31: Aquatic Competencies and Drowning Prevention in Children 2–4 Years: A Systematic Review Safety doi: 10.3390/safety6020031 Authors: Taylor Franklin Peden Aquatic competencies have been proposed as a prevention strategy for children aged 2–4 years who are over-represented in drowning statistics. For this recommendation to be made, exploration of the connection between aquatic competencies and drowning is required. This review critically analyzed...
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Toxins, Vol. 12, Pages 413: Toxicokinetics of Hydrolyzed Fumonisin B1 After Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet Toxins doi: 10.3390/toxins12060413 Authors: Antonissen Baere Novak Schatzmayr Hollander Devreese Croubels The toxicokinetics (TK) of hydrolyzed fumonisin B1 (HFB1) were evaluated in 16 broiler chickens after being fed either a control or a fumonisins-contaminated diet (10.8 mg fumonisin...
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Urban Science, Vol. 4, Pages 28: Multi-Domain Design Structure Matrix Approach Applied to Urban System Modeling Urban Science doi: 10.3390/urbansci4020028 Authors: Peter Hoffmann Yutaka Nomaguchi Keishiro Hara Kana Sawai Ingenuin Gasser Myriam Albrecht Benjamin Bechtel Jana Fischereit Kikuo Fujita Philine Gaffron Anne Caroline Krefis Markus Quante Jürgen Scheffran Katharina Heinke Schlünzen Malte von Szombathely Modeling the urban system for...
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Water, Vol. 12, Pages 1767: Evolution of the Materials and Methods Used for Subsurface Drainage of Agricultural Lands from Antiquity to the Present Water doi: 10.3390/w12061767 Authors: Yannopoulos Grismer Bali Angelakis Agricultural drainage plays an important role worldwide in food production and conservation of soil resources, while safeguarding investments in agricultural production and irrigation projects. It can improve crop yields and land productivity, especially...
Water, Vol. 12, Pages 1764: Bioremediation of Landoltia punctata to Microcystis aeruginosa Contaminated Waters Water doi: 10.3390/w12061764 Authors: Shi Li Sixiu Le Guolin Li Mei Luo Rui Wang Yun Zhao Microcystis aeruginosa is one of the dominant algae in the “phytoplankton bloom” phenomenon. A high density of microcystins (MCs) are produced when algae have explosive growth, which can damage the water environment and pose a great threat to aquatic animals,...
Water, Vol. 12, Pages 1765: Application of Geologically Constrained Machine Learning Method in Characterizing Paleokarst Reservoirs of Tarim Basin, China Water doi: 10.3390/w12061765 Authors: Wei Xin Fei Tian Xiaocai Shan Yongjian Zhou Huazhong Rong Changchun Yang As deep carbonate fracture-cavity paleokarst reservoirs are deeply buried and highly heterogeneous, and the responded seismic signals have weak amplitudes and low signal-to-noise ratios. Machine learning in seismic...
Water, Vol. 12, Pages 1766: Numerical and Experimental Study of Classical Hydraulic Jump Water doi: 10.3390/w12061766 Authors: Eugene Retsinis Panos Papanicolaou The present work is an effort to simulate numerically a classical hydraulic jump in a horizontal open channel with a rectangular cross-section, as far as the jump location and free surface elevation is concerned, and compare the results to experiments with Froude numbers in the range 2.44 to 5.38. The governing equations...
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