Background To the authors' knowledge, there are no approved therapies for recurrent, metastatic (R/M) salivary gland carcinoma (SGC), but molecularly targeted therapies warrant ongoing investigation. In the current study, the authors have reported on the efficacy of tipifarnib in patients with aggressive HRAS ‐mutant, R/M SGC. Methods The current prospective, nonrandomized, multicenter, international cohort study involved 8 centers and was conducted from May 2015 to June 2019. The median follow‐up...
Thu Jun 18, 2020 16:37
Background Li‐Fraumeni syndrome (LFS) is a high‐risk cancer predisposition syndrome caused by pathogenic germline variants of TP53 . Cancer surveillance has noted a significant survival advantage in individuals with LFS; however, little is known about the feasibility, acceptance, and psychosocial effects of such a program. Methods Pathogenic TP53 germline variant carriers completed a 7‐part questionnaire evaluating sociodemographics, cancer history, surveillance participation, reasons for...
Thu Jun 18, 2020 16:37
Abstract Adult T cell leukemia‐lymphoma (ATL) is a peripheral T cell malignancy caused by human T cell leukemia virus–type 1 (HTLV‐1).1 Frequent structural variations that disrupt the 3' untranslated region of the programmed cell death–ligand 1 (PD‐L1) gene have been found to result in overexpression of PD‐L1 in ATL patients.2 The programmed cell death–1 (PD‐1)–PD‐L1 axis has thus attracted attention as a potential therapeutic target for ATL. However, in a phase 2 trial of the PD‐1 inhibitor nivolumab...
Thu Jun 18, 2020 18:04
Abstract Targeting the extracellular vesicle (EV) secretion can have potential clinical implications for cancer therapy; however, the precise regulatory mechanisms of EV secretion are not fully understood. Recently, we have shown a novel pathway of EV biogenesis in PCa cell lines, PC3 and PC3M. However, since the characteristics of EVs were divergent even among PCa cell lines, we hypothesized that other pathways or common regulatory pathways of EV biogenesis still exist. Here, we performed quantitative...
Thu Jun 18, 2020 18:04
Purpose: This phase 2 study (NCT03469557) assessed safety/tolerability and antitumor activity of first line tislelizumab, a monoclonal antibody against PD-1, plus chemotherapy in patients with locally advanced/metastatic esophageal squamous cell carcinoma (ESCC) or gastric cancer/gastroesophageal junction (G/GEJ) adenocarcinoma. Experimental Design: Patients with ESCC received tislelizumab (200mg IV every 3 weeks [Q3W]) plus cisplatin (80mg/m² IV Q3W for ≤6 cycles) and fluorouracil (800mg/m²/d,...
Fri Jun 19, 2020 16:31
Purpose: To evaluate the relationship between exposure of apalutamide and its active metabolite, N-desmethyl-apalutamide, and selected clinical efficacy and safety parameters in men with high risk non-metastatic castration-resistant prostate cancer. Patients and Methods: An exploratory exposure-response analysis was undertaken using data from the 1207 patients (806 apalutamide and 401 placebo) enrolled in the SPARTAN study, including those who had undergone dose reductions and dose interruptions....
Fri Jun 19, 2020 16:31
Purpose: Invasive lobular carcinoma (ILC) accounts for approximately 5-15% of all invasive breast cancer cases. Most of the correlations between multigene assays and patient outcome were derived from studies based on patients with invasive ductal carcinoma (IDC) or without distinction between the subtypes. Here, we investigate the prognostic value of EndoPredict in a large cohort of ILCs pooled from three phase III randomized trials (ABCSG-6, ABCSG-8, TransATAC). Experimental Design: The primary...
Fri Jun 19, 2020 16:31
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): Henry G. Smith, Jessica Glen, Nancy Turnbull, Howard Peach, Ruth Board, Miranda Payne, Martin Gore, Karen Nugent, Myles J.F. Smith
Fri Jun 19, 2020 16:41
Publication date: August 2020Source: European Journal of Cancer, Volume 135Author(s): Yihui Du, Grigory Sidorenkov, Marjolein A. Heuvelmans, Harry J.M. Groen, Karin M. Vermeulen, Marcel J.W. Greuter, Geertruida H. de Bock
Fri Jun 19, 2020 16:41
Trichinellosis is a rare parasitic zoonosis in the European Union. Meat from backyard pigs was the common source for a trichinellosis outbreak caused by Trichinella spiralis, which occurred in France and Serbia in the beginning of 2017. An epidemiological study was conducted in France and Serbia to determine the extent of the outbreak, to identify its source and to implement control measures. Three cases were exposed in Serbia and brought back to France pork delicatessen which they shared with relatives...
Thu Jun 18, 2020 03:00
We evaluated SARS-CoV-2 RNA and neutralising antibodies in blood donors (BD) residing in the Lodi Red Zone, Italy. Of 390 BDs recruited after 20 February 2020 − when the first COVID-19 case in Lombardy was identified, 91 (23%) aged 19–70 years were antibody positive. Viral RNA was detected in an additional 17 (4.3%) BDs, yielding ca 28% (108/390) with evidence of virus exposure. Five stored samples collected as early as 12 February were seropositive.
Thu Jun 18, 2020 03:00
Containment strategies and clinical management of coronavirus disease (COVID-19) patients during the current pandemic depend on reliable diagnostic PCR assays for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we compare 11 different RT-PCR test systems used in seven diagnostic laboratories in Germany in March 2020. While most assays performed well, we identified detection problems in a commonly used assay that may have resulted in false-negative test results during the first...
Thu Jun 18, 2020 03:00
Abstract No specific translocation is associated with myeloproliferative neoplasms (MPNs). However, an interstitial deletion involving sub‐band 17q11.2 which includes the NF1 gene, although rare, is a recurrent aberration in several myeloid disorders including MPNs. For the first time, we report an acquired novel translocation involving 10p13 and 17q11.2 in a 62‐year‐old Caucasian female which was referred for investigation of chronic and persistent unexplained thrombocytosis. The patient had no...
Fri Jun 19, 2020 14:49
Abstract The aim was to provide evidence on systemically treated patients with advanced melanoma not represented in phase III trials to support clinical decision‐making. Analysis were performed on advanced melanoma patients diagnosed between 2014 and 2017 in the Netherlands, treated with immune‐ or targeted therapy, who met ≥1 trial exclusion criteria. These criteria were derived from the KEYNOTE‐006 and CHECKMATE‐067/−066 phase III trials. Prognostic importance of factors associated with overall...
Fri Jun 19, 2020 13:20
Abstract Kaposi's Sarcoma‐associated Herpesvirus (KSHV) is the causative agent of KS, an aggressive neoplasm that mainly occurs in immune‐compromised patients. Spindle cells represent the main feature of this aggressive malignancy and arise from KSHV‐infected endothelial cells undergoing endothelial to mesenchymal transition (EndMT), which changes their cytoskeletal composition and organization. As in epithelial to mesenchymal transition (EMT), EndMT is driven by transcription factors such as SNAI1...
Fri Jun 19, 2020 13:19
Abstract The purpose of this prospective phase II clinical trial was to investigate the efficacy and safety of anlotinib in patients with relapsed small cell lung cancer (SCLC). Forty‐five patients with relapsed SCLC were enrolled and treated with anlotinib (one cycle of 12 mg daily for 14 days, discontinued for 7 days, and repeated every 21 days) until disease progression or intolerance of treatment. The primary end point was progression‐free survival (PFS). Secondary end points were overall survival...
Thu Jun 18, 2020 22:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Thu Jun 18, 2020 10:00
Abstract The aim of this study was to determine the knowledge level of kindergarten teachers regarding skin cancer, the sun protection behaviors they exhibit for themselves/their students, and the affecting factors. This descriptive study was carried out in the Mediterranean region in a province located by the sea. The universe of the study consisted of 181 teachers working in kindergartens, and data were collected from the 81% who agreed to participate in the study. The mean...
Sun Jun 21, 2020 03:00
Abstract This systematic review provided synthesized evidence regarding the effectiveness of the interventions promoting the human papillomavirus (HPV) vaccination in college-aged population. The HPV infection is the most prevailing sexually transmitted disease. Despite the availability and effectiveness of the 9-Valent HPV vaccine, the vaccine coverage among young adults remained low. In witness to the increasing burden of HPV-related infections and cancers, research focused...
Sun Jun 21, 2020 03:00
Abstract There are several treatment options for localized prostate cancer with very similar outcome but vary in terms of technique and side effect profiles and risks. Considering the potential difficulty in choosing the best treatment, a patient decision aid (PDA) is used to help patients in their decision-making process. However, the use and applicability of PDA in a country in Asia Pacific region like Malaysia is still unknown. This study aims to evaluate the effectiveness...
Sat Jun 20, 2020 03:00
Abstract The purpose of this study was to evaluate the impact of implementing community-based prostate health education programs in rural communities. Prostate cancer (PrCA) remains one of the most common cancers among men, and a growing body of literature demonstrates that large interracial differences in PrCA incidence and mortality rates consistently disfavor African Americans in comparison to European Americans. It also is evident, despite the overall decrease in cancer death...
Sat Jun 20, 2020 03:00
Abstract Human papillomavirus (HPV) causes 99% of cervical cancers. In the USA, HPV testing has recently been recommended as a stand-alone option for cervical cancer screening in women over 30 years of age. Yet, studies have shown low awareness of HPV testing. This study examines awareness and knowledge that US women possess regarding HPV testing using the social determinants of health (SDOH) framework. Women aged 30 to 65 years, without hysterectomy, completed an online survey...
Sat Jun 20, 2020 03:00
Abstract Massage therapists are uniquely positioned to identify skin cancer. Seminal work in 2013 revealed that 40% of massage therapists do not receive any training in skin cancer identification (Campbell et al. J Cancer Educ 28:158–164, 2013). Limited work has been published assessing optimal training methodologies to close this educational gap. We present the results of a study in which students were given access to a 30-min self-driven web-based learning module designed to...
Sat Jun 20, 2020 03:00
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic interventio...
Sat Jun 20, 2020 03:00
Aberrant alternative splicing events play critical roles in carcinogenesis and progression of many cancers, while sparse studies regarding to alternative splicing are available for clear cell renal cell carcin...
Fri Jun 19, 2020 03:00
Abstract Melanoma is an aggressive, deadly skin cancer derived from melanocytes, a neural crest cell derivative. Melanoma cells mirror the developmental program of neural crest cells in that they exhibit the same gene expression patterns and utilize similar cellular mechanisms, including increased cell proliferation, epithelial‐mesenchymal transition, and migration. Here we studied the role of neural crest regulator PRDM1 in melanoma onset and progression. In development, Prdm1a functions to promote...
Sat Jun 20, 2020 14:09
Abstract Cancer‐associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. In the present study, we investigated the role for CAFs in breast cancer progression and underlying molecular mechanisms. Human breast cancer MDA‐MB‐231 cells treated with the CAF‐conditioned media manifested a more proliferative phenotype, as evidenced by enhanced messenger RNA (mRNA) expression of Cyclin D1, c‐Myc, and proliferating cell nuclear antigen. Analysis of data from The Cancer...
Thu Jun 18, 2020 20:21
Publication date: Available online 19 June 2020Source: Practical Radiation OncologyAuthor(s): Mark J. Stavas
Fri Jun 19, 2020 14:02
Publication date: Available online 19 June 2020Source: Practical Radiation OncologyAuthor(s): Viola De Luca, Elena Gallio, Sara Bartoncini, Francesca Romana Giglioli, Anna Sardo, Chiara Cavallin, Giuseppe Carlo Iorio, Erika Orlandi, Ramona Parise, Carmela Palladino, Alberto Buonavita, Christian Fiandra, Mario Levis, Umberto Ricardi
Fri Jun 19, 2020 14:02
The objectives of this study were to determine the objective effective response rate, survival, and safety of radiotherapy combined with gefitinib in patients with locally advanced non-small cell lung cancer (...
Sat Jun 20, 2020 03:00
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Hadrien Charvat, Taichi Shimazu, Manami Inoue, Motoki Iwasaki, Norie Sawada, Taiki Yamaji, Shoichiro Tsugane, for the JPHC Study Group
Sat Jun 20, 2020 15:03
Publication date: April–June 2020Source: Seminars in Oncology, Volume 47, Issues 2–3Author(s):
Sat Jun 20, 2020 15:38
Publication date: April–June 2020Source: Seminars in Oncology, Volume 47, Issues 2–3Author(s):
Sat Jun 20, 2020 15:38
Publication date: April–June 2020Source: Seminars in Oncology, Volume 47, Issues 2–3Author(s):
Sat Jun 20, 2020 15:38
Publication date: April–June 2020Source: Seminars in Oncology, Volume 47, Issues 2–3Author(s):
Sat Jun 20, 2020 15:38
Publication date: Available online 19 June 2020Source: Seminars in OncologyAuthor(s): Bahar Laderian, Mengxi Zhou, Tito Fojo
Fri Jun 19, 2020 15:23
Fri Jun 19, 2020 03:00
Fri Jun 19, 2020 03:00
Abstract Background and purpose High-dose 6‑MV radiotherapy may cause cardiac implantable electronic devices (CIEDs) to malfunction. To assess CIED malfunctions resulting from direct exposure up to 10 Gy, 100 pacemakers (PMs) and 40 implantable cardioverter-defibrillators (ICDs) were evaluated. Materials and methods CIEDs underwent baseline interrogation....
Fri Jun 19, 2020 03:00
Fri Jun 19, 2020 03:00
Fri Jun 19, 2020 03:00
Fri Jun 19, 2020 03:00
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