Abstract Previous computational model‐based approaches for understanding the dynamic changes related to Parkinson’s disease made particular assumptions about Parkinson’s disease related activity changes or specified dopamine‐dependent activation or learning rules. Inspired by recent model‐based analysis of resting‐state fMRI, we have taken a data‐driven approach. We fit the free parameters of a spiking neuro‐computational model to match correlations of blood‐oxygen‐level‐dependent signals between...
Fri Jun 19, 2020 17:30
Abstract Modification of ongoing walking movement to fit changes in external environments requires accurate voluntary control. In cats, the motor and posterior parietal cortices have crucial roles for precisely adjusting limb trajectory during walking. In human walking, however, it remains unclear which cortical information contributes to voluntary gait modification. In this study, we investigated cortical activity changes associated with visually guided precision stepping using EEG source analysis....
Thu Jun 18, 2020 20:27
Abstract We present a new strategy for needle insertion simulations without the necessity of meshing. A diffuse domain approach on a regular grid is applied to overcome the need for an explicit representation of organ boundaries. A phase field function captures the transition of tissue parameters and boundary conditions are imposed implicitly. Uncertainties of a volume segmentation are translated in the width of the phase field, an approach that is novel and overcomes the problem of defining an...
Fri Jun 19, 2020 18:14
Abstract Atypical teratoid rhabdoid tumor (ATRT) is a fatal pediatric malignancy of the central neural system lacking effective treatment options. It belongs to rhabdoid tumor family usually caused by biallelic inactivation of SMARCB1, encoding a key subunit of SWI/SNF chromatin remodeling complexes. Previous studies proposed that SMARCB1 loss drives rhabdoid tumor by promoting cell cycle through activating transcription of cyclin D1 while suppressing p16. However, low cyclin D1 protein expression...
Fri Jun 19, 2020 18:44
Abstract Hepatocellular carcinoma (HCC) is a biologically aggressive cancer. Targeted therapy is in need to tackle challenges in the treatment perspective. A growing body of evidence suggests a promising role of pharmacological inhibition of PIM (proviral integration site for Moloney murine leukaemia virus) kinase in some human haematological and solid cancers. Yet to date the potential application of PIM inhibitors in HCC is still largely unexplored. In the present study we investigated the pre‐clinical...
Fri Jun 19, 2020 18:24
Abstract Some 2,500 years ago Hippocrates developed the “Temperament Theory” of the four humors (fluids) he identified as blood, phlegm, yellow bile, and black bile which then led to the ancient medical concept known as ‘humorism.” In Greco‐Roman medicine, these humors were believed to be the influencers of an individual's relative wellness or ill‐health, served as a means to classify illnesses, and subsequently guided medical diagnosis and treatment. Centuries later modifications to Hippocrates’...
Fri Jun 19, 2020 15:53
Abstract Purpose The image registration of optical scans to radiographic images is essential for performing computer‐guided implant surgery. This study aimed to evaluate the effect of different image matching conditions on the accuracy of image registration for computer‐guided implant surgery in completely edentulous jaws. Materials and methods The optical scan image of a completely edentulous study model was registered to the respective cone‐beam computed tomography data using three different...
Fri Jun 19, 2020 13:31
In December 2019, a conference entitled “Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health” was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the F...
Fri Jun 19, 2020 03:00
Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...
Thu Jun 18, 2020 03:00
Abstract Background Vitamin A deficiency (VAD) has been hypothesized to play a role in the pathophysiology of atopic dermatitis (AD). Objective We sought to verify whether VAD can exacerbate AD development, and explore the possible pathophysiologic mechanism. Methods We detected serum vitamin A (VA) concentration in different phenotypes of AD infants (intrinsic AD, iAD and extrinsic AD, eAD), and established ovalbumin (OVA) percutaneous sensitized AD model and passive cutaneous anaphylaxis...
Fri Jun 19, 2020 19:49
Abstract Purpose of Review To provide an update on the current landscape of pediatric brain tumors and the impact of novel molecular insights on classification, diagnostics, and therapeutics. Recent Findings Scientific understanding of the genetic basis of central nervous system tumors has expanded rapidly over the last several years....
Sat Jun 20, 2020 03:00
Lipids contained in milk are an essential source of energy and structural materials for a growing neonate. Furthermore, lipids’ long-chain unsaturated fatty acid residues can directly participate in neonatal t...
Fri Jun 19, 2020 03:00
We investigated a central antihypertensive effect of acupuncture in rostral ventrolateral medulla (RVLM) in spontaneously hypertensive rats (SHRs). In total, 56 rats were randomly divided into seven groups as follows: the SHR group, SHR+acupuncture (SHR+Acu) group, SHR+nonacupuncture (SHR+Non-acu) group, GW9662+acupuncture (GW9662+Acu) group, GW9662+GW1929 group, GW9662 group, and 2% DMSO group (n = 8 per group). The whole eight Wistar–Kyoto rats were assigned to the WKY group. The acupuncture treatment...
Fri Jun 19, 2020 03:00
Neuroinflammation has been implicated in neurodegenerative diseases and acute brain injuries such as stroke. Monocyte chemotactic protein-1-induced protein-1 (Mcpip1) is a multifunction protein known to have pro-apoptotic or anti-apoptotic actions depending on the nature of experimental settings. However, its role in brain damage after asphyxia in the developing brain has not been studied. We, therefore, explored the role of Mcpip1 in brain injury after hypoxic-ischemia in neonatal mice. At postnatal...
Fri Jun 19, 2020 03:00
Purpose When threatened, fear is one of the most important responses that an organism exhibits. The mechanisms involved in forming fear memories include specific neurological structures, neural circuits and detailed molecular interactions. Methods MicroRNAs (miRNAs, small non-coding RNAs) act as endogenous functional small molecules that participate in or interfere with the formation of new fear memory by inhibiting the expression of mRNA targets. MicroRNA-187 (miR-187) is a newly reported...
Fri Jun 19, 2020 03:00
Background Diaphragm dysfunction could be induced by sepsis with subsequent ventilatory pump failure that is associated with local infiltration of inflammatory factors in the diaphragm. It has been shown that the administration of anticonvulsant agent, magnesium sulfate (MgSO4) could decrease systematic inflammatory response. We recently reported that MgSO4 could inhibit macrophages high mobility group box 1 (HMGB1) secretion that confirms its anti-inflammatory properties. Toll-like receptor...
Fri Jun 19, 2020 03:00
The phosphorylation and aggregation of alpha-synuclein (α-Syn) play a key role in methamphetamine (METH)-induced dopaminergic neurotoxicity. The exact mechanism underlying the interaction between METH-induced neurotoxicity and α-Syn was poorly clarified. We aimed to figure out the role of serine 129 phosphorylation (pS129) of α-Syn on its aggregation and neurotoxicity in vitro and in vivo. In this study, we examined pS129 α-Syn expression in vitro and in vivo at the protein phosphorylation and genetic...
Fri Jun 19, 2020 03:00
Rejuvenation Research, Ahead of Print.
Thu Jun 18, 2020 10:00
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Whether statins can reduce the incidence of cancers has been an interesting topic in recent years. This meta-analysis aimed to determine the relationship between statin treatment with the risk of hepatocellular carcinoma.Methods:Studies published up to July 2019 were screened from databases. The data from approved studies were pooled. Random-effects or fixed-effects model was used to calculate the relative...
Fri Jun 19, 2020 13:25
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. The current researches have reported that circular RNA is an important regulatory factor in the progression of various human disease. However, the function and mechanism of most circular RNAs remain unknown in cancers including multiple myeloma. Our study has confirmed that hsa_circ_0007841 is up regulated in U266 doxorubicin resistant cells (U266R) and 8226 doxorubicin resistant cells (8226R) compared to U266...
Fri Jun 19, 2020 13:22
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:To evaluate and quantify the planning performance of automatic planning (AP) with manual planning (MP) for nasopharyngeal carcinoma in the RayStation treatment planning system (TPS).Methods:A progressive and effective design method for AP of nasopharyngeal carcinoma was realized through automated scripts in this study. A total of 30 patients with nasopharyngeal carcinoma with initial treatment was enrolled....
Fri Jun 19, 2020 13:21
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri Jun 19, 2020 05:42
Stem Cells and Development, Ahead of Print.
Sat Jun 20, 2020 08:06
Abstract The objective of the present study was to investigate the relationship between hair essential trace element and mineral content and ADHD in preschool (4–6 years old) and primary school children (6–10 years old) in relation to age and gender. Hair essential trace element and mineral content in 90 Russian children with ADHD and 90 age- and gender-matched neurotypical controls were assessed using inductively coupled plasma mass-spectrometry after microwave digestion. The...
Sat Jun 20, 2020 08:03
Abstract To comprehensively evaluate the relationship between high iodine concentration and biomarker abnormalities related to autoimmune thyroiditis in a Chinese population. Medline, PubMed, and Embase electronic databases were searched for articles published domestically and internationally on the relationship between high iodine concentrations and thyroid hormone antibodies and thyroid-stimulating hormone in China before March 2019. Articles published in Chinese were searched...
Sat Jun 20, 2020 08:03
Abstract In order to investigate the effect of dietary Zn levels on laying performance, eggshell quality, and eggshell microstructure in Muscovy duck breeders under furnished cages. Firstly, the effects of age (35 weeks vs 40 weeks) and rearing system (littered floor vs furnished cage) on eggshell quality of laying duck breeders were studied (Exp. 1). Then, a total of 324 30-week-old Muscovy duck breeders were allotted into 3 dietary Zn groups with 6 replicates (18 ducks per...
Sat Jun 20, 2020 08:03
Abstract Fluoride, as an environmental toxin, causes damage to intestinal mucosa. It may promote pathogen infection by increasing the intestinal mucosa permeability. In this study, the colonic fecal samples from the control group (C group, 0 mg/L NaF for 60 days) and the fluoride group (F group, 100 mg/L NaF for 60 days) were subjected to high-throughput 16S rRNA sequencing to verify the effects of fluoride on the colonic flora of animals. Results revealed a total of 253 operative...
Sat Jun 20, 2020 08:03
Abstract Consumption and trade in bushmeat are entrenched in sub-Saharan Africa amid growing land degradation and environmental pollution that raise safety concerns, yet sustainability of bushmeat extraction and zoonoses considerations have been the focus of bushmeat research. Here, we evaluated the health risk of trace metals in the skeletal muscle, bone, liver, and skin of the black duiker (Cephalophus niger), brush-tailed porcupine (Atherurus africanus), bushbuck (Tragelaphus...
Sat Jun 20, 2020 08:03
Abstract For the first time, bioavailability, pharmacokinetics, and biotransformation of selenium-enriched yeast (SeY) and sodium selenite (Na2SeO3) in rats were systemically compared by analyzing free selenomethionine (SeMet), total SeMet, and selenium (Se). After SeY and Na2SeO3 were orally administered to rats at a dose of 100 μg Se/kg, plasma free SeMet, total SeMet, and Se at various time points were determined by ultra-performance liquid chromatography-tandem mass spectrometry....
Sat Jun 20, 2020 08:03
Abstract We hypothesized that magnesium supplementation might help improve metabolic profiles and clinical symptoms of polycystic ovary syndrome (PCOS) through its role in insulin action. The present study aimed to investigate the effect of magnesium supplementation on metabolic profiles and levels of sex hormones in women with PCOS. In this parallel randomized, double-blind, placebo-controlled clinical trial, 60 women with PCOS aged 20–45 years were recruited. After stratification...
Sat Jun 20, 2020 08:03
Abstract Manganese (Mn) is an essential element for the body’s composition and is required for various functions, including nutrient metabolism, immune system function, and antioxidant ability. However, there are insufficient data on the nutritional status of Mn. In this study, we aimed to analyze the relationship between Mn intake and urinary excretion in Korean adults. A twice dietary intake survey using a 24-h recall method was conducted on 640 adults (320 men and 320 women),...
Sat Jun 20, 2020 08:03
Abstract The protective effect of caffeic acid on ferric-induced pancreatic injury was investigated using ex vivo and in silico models. Incubation of pancreatic tissues with Fe2+ led to significant depleted levels of glutathione (GSH) and SOD and catalase activities, with concomitant elevated levels of malondialdehyde (MDA) and nitric oxide (NO) and acetylcholinesterase and α-chymotrypsin activities. Treatment with caffeic acid led to significant reversion of these levels and...
Sat Jun 20, 2020 08:03
Abstract Zinc is an essential micronutrient for the organism and is critical for the functional and structural integrity of cells. Determination of the amount of trace element concentrations in tissues such as hair samples have been used for the evaluation of the metabolic status especially in children. Unlike serum zinc, concentrations of zinc in hair are more stable and indicative of variations over time. The purpose of this study is to assess the zinc status of healthy school-age...
Sat Jun 20, 2020 08:03
Abstract Abnormal hepatic iron metabolism is detrimental to health. The objective of this study was to detect repeated restraint stress on liver iron metabolism in rats. Twenty-four male rats aged 7 weeks were randomly divided into 2 groups: control group (Con) and repeated restraint stress group (RS). Rats were subjected to 6 h of daily restraint stress for 14 consecutive days in the repeated restraint stress group. The results showed that repeated restraint stress exposure...
Sat Jun 20, 2020 08:03
Abstract Polycystic ovary syndrome (PCOS) is characterized by various reproductive and cardiometabolic disorders. Asymmetric dimethylarginine (ADMA) is associated with cardiovascular, metabolic, and hormonal status. Selenium, a micronutrient with antioxidant properties, could affect multiple physiological pathways. This study aimed to investigate the effect of selenium supplementation on ADMA, cardiometabolic risk factors, and hormonal status in women with PCOS. In this randomized,...
Sat Jun 20, 2020 08:03
Abstract Vascular endothelial growth factor (VEGF) is the most important regulator of angiogenesis which serves to provide sufficient blood supply, and can trigger both physiological and pathological angiogenesis. Recent studies have shown that VEGF increases in gynecological diseases (such as endometriosis, ovarian, and endometrial cancers) and is a prognostic factor in these pathologies. Therefore, VEGF should be maintained at appropriate levels. Magnesium is used in many gynecological...
Sat Jun 20, 2020 08:03
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02570
Fri Jun 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01631
Fri Jun 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01641
Fri Jun 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01129
Fri Jun 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01421
Thu Jun 18, 2020 07:00
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