Mucosal Immunology, Published online: 19 June 2020; doi:10.1038/s41385-020-0316-4Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo
Fri Jun 19, 2020 03:00
Fri Jun 19, 2020 03:00
Tuberculosis is the 10th leading cause of death worldwide and the main cause of death from a single infectious agent. In 2019, the World Health Organization (WHO) estimated that 251,000 annual deaths due to tuberculosis occurred in persons with human immunodeficiency virus (HIV) infection.…
Thu Jun 18, 2020 03:00
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was discovered in Wuhan, China, in late 2019, and coronavirus disease 2019 (Covid-19), the disease caused by SARS-CoV-2, rapidly evolved into a global pandemic. As of June 15, 2020, there were more than 8.03 million confirmed cases…
Wed Jun 17, 2020 03:00
Publication date: Available online 19 June 2020Source: Radiotherapy and OncologyAuthor(s): Javed Mahmood, Ravina Pandita, Angel Zhang, Shriya Kamlapurkar, Ali Saeed, Minjie Chen, Paul N. Staats, Hem D Shukla, Akbar Anvari, Amit Sawant, Zeljko Vujaskovic
Fri Jun 19, 2020 21:35
Surgery has a reputation as being an intellectual profession, but a lot of the actual practice of surgery involves simple, routine tasks that are performed on nearly every patient. Suturing is one of those and a team of researchers from University of California Berkley and Intel thinks that it is possible to teach a robot to suture by having it learn from videos of suturing performed by real surgeons. This may one day allow human surgeons to focus on their core tasks while letting robots do the monotonous...
Fri Jun 19, 2020 21:29
Publication date: Available online 19 June 2020Source: Hearing ResearchAuthor(s): Björn Herrmann, Ingrid S. Johnsrude
Fri Jun 19, 2020 20:55
Publication date: Available online 18 June 2020Source: Hearing ResearchAuthor(s): Jeffrey R. Holt, Yehoash Raphael
Fri Jun 19, 2020 20:55
Fishbone ingestion is a common occurrence in the Middle East countries. We present a patient with a unique complication of fishbone ingestion. A 65-year-old woman presented with left-sided neck pain and swelling since 5 days before admission. A linear foreign body with horizontal orientation was seen in CT scan at the superior part of the pharynx along with a collection around it which caused a laceration on the medial aspect of internal jugular vein and thrombosis inside the internal jugular vein.
Fri Jun 19, 2020 19:35
The continuing spread of SARS-CoV-2 remains a Public Health Emergency of International Concern. What physicians need to know about transmission, diagnosis, and treatment of Covid-19 is the subject of ongoing updates from infectious disease experts at the Journal. In this audio interview conducted…
Thu Jun 18, 2020 03:00
In the early 1990s, direct injection of nucleic acids (RNA or DNA) into the muscles of mice led to in vivo expression of proteins encoded by the injected nucleic acid. This finding, together with studies showing the elicitation of immune responses and protection against infection by means of the…
Thu Jun 18, 2020 03:00
Despite the extraordinary advances in treating human immunodeficiency virus (HIV) infection during the past two decades, mortality, especially in resource-limited areas, remains unacceptably high. The leading killer of persons with HIV infection in these areas is tuberculosis, which accounted for…
Thu Jun 18, 2020 03:00
To the Editor: Carriers of balanced chromosomal rearrangements (BCRs) are at risk for infertility, recurrent miscarriages, and abnormal offspring because of unbalanced rearrangements. A small subgroup of carriers is at risk for neurodevelopmental or neuropsychiatric conditions. Preimplantation…
Thu Jun 18, 2020 03:00
Publication date: Available online 18 June 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Xiumei Li, Li Li, Yong Li, Shibao Fang, Cheng Zhao, Yongchun Zhang, Zongli Yang
Fri Jun 19, 2020 19:05
A 29-year-old man who had recently immigrated to the United States presented to the cardiology clinic with worsening exertional dyspnea, visual blurring, and headaches. These symptoms had been present since childhood, but he had not received regular medical care and the condition had not been…
Thu Jun 18, 2020 03:00
Publication date: Available online 18 June 2020Source: Brain Research BulletinAuthor(s): Xu Luo, Lina Li, Wen Zheng, Lingui Gu, Xiaolin Zhang, Yuanyou Li, Zongyi Xie, Yuan Cheng
Fri Jun 19, 2020 18:06
Publication date: July 2020Source: World Neurosurgery, Volume 139Author(s): Zhang Tao, Liu Hua, Yang Chengwei, Fan Bo, Qu Tao, Li Songkai
Fri Jun 19, 2020 18:02
Abstract Purpose To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain injury and the immunohistochemical analysis of IBA-1 and GFAP expressions. Methods Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. And then IBA-1 and GFAP expressions...
Fri Jun 19, 2020 18:02
Abstract Purpose To investigate the effects of bradykinin on reperfusion injury in an experimental intestinal ischemia reperfusion model. Methods We used 32 Wistar-Albino rats. We composed 4 groups each containing 8 rats. Rats in sham group were sacrified at 100 minutes observation after laparotomy. Thirty minutes reperfusion was performed following 50 minutes ischaemia in control group after observing 20 minutes. Ischaemic preconditioning was performed in one group of the study. We performed...
Fri Jun 19, 2020 18:02
Abstract Purpose To collect data capable of pointing out the effects of the ultracavitation treatment on the liver of rabbits after adipose tissue application, by means of histological analyses of the liver and hematological and biochemical exams. Methods This is an experimental study with 12 albino rabbits as sample, which were divided into 3 groups and submitted to a hypercaloric diet for one month. Subsequently, subjects underwent UCV treatment: 3 minutes, 30 W, continuous mode at 100%, every...
Fri Jun 19, 2020 18:02
The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.
Fri Jun 19, 2020 03:00
Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithel...
Thu Jun 18, 2020 03:00
Omalizumab is approved for treating severe allergic asthma from age 6, but the definition of severe asthma including a systematic assessment to rule out difficult-to-treat asthma has changed since the drug was...
Thu Jun 18, 2020 03:00
Publication date: August 2020Source: Brain and Language, Volume 207Author(s): Allison Whitten, Alexandra P. Key, Antje S. Mefferd, James W. Bodfish
Fri Jun 19, 2020 17:21
Publication date: Available online 18 June 2020Source: Medical Mycology Case ReportsAuthor(s): Avinash Sharma, Ann Hofmeyr, Anup Bansal, Devesh Thakkar, Leon Lam, Zinta Harrington, Deepak Bhonagiri
Fri Jun 19, 2020 16:49
After the widespread adoption of prostate-specific antigen (PSA) screening in the early 1990s, prostate cancer diagnoses increased rapidly while death rates halved over the course of the next quarter century. Initial results from randomized trials and recommendations against screening from…
Thu Jun 18, 2020 03:00
Physicians still lack consensus on the meaning of race. When the Journal took up the topic in 2003 with a debate about the role of race in medicine, one side argued that racial and ethnic categories reflected underlying population genetics and could be clinically useful. Others held that any small…
Wed Jun 17, 2020 03:00
Publication date: June 2020Source: Revue des Maladies Respiratoires, Volume 37, Issue 6Author(s): C. Raherison
Fri Jun 19, 2020 15:30
Publication date: June 2020Source: Revue des Maladies Respiratoires, Volume 37, Issue 6Author(s):
Fri Jun 19, 2020 15:30
New England Journal of Medicine, Ahead of Print.
Thu Jun 18, 2020 07:00
Abstract Background As patient-reported outcome, the Child Oral Impacts on Daily Performances (C-OIDP) has been commonly used for assessing children’s oral health needs in order to facilitate oral health service planning. It was translated and cross-culturally adapted into Turkish in 2008. Since then, there is no study to assess its psychometric properties in Turkish child population. This cross–sectional study aimed to investigate...
Fri Jun 19, 2020 03:00
Publication date: Available online 18 June 2020Source: Human PathologyAuthor(s): Esther Yoon, Parker Wilson, Tao Zuo, Marguerite Pinto, Kimberly Cole, Malini Harigopal
Fri Jun 19, 2020 14:50
Abstract Purpose of Review To critically review the evidence in favor or against the use of house dust mite (HDM) allergen avoidance measures in patients with asthma. Recent Findings Systematic reviews and meta-analyses suggested no positive effect of mite allergen avoidance strategies on asthma outcomes, resulting in a lack of consensus...
Fri Jun 19, 2020 03:00
Abstract Purpose of Review The purpose of this review was to explore mechanisms, causes, and therapies of itchy conditions involving organs beyond the skin including the eyes, ears, nose, and genital region. Recent Findings Conditions which cause itch in these locations vary from skin diseases that extend to these areas (i.e., atopic...
Fri Jun 19, 2020 03:00
Publication date: October 2020Source: Current Opinion in Neurobiology, Volume 64Author(s): Sang Soo Lee, Mark N Wu
Fri Jun 19, 2020 14:18
Abstract COCH is the most abundantly expressed gene in the cochlea. Unsurprisingly, mutations in COCH underly hearing loss in mice and humans. Two forms of hearing loss are linked to mutations in COCH, the well-established autosomal dominant nonsyndromic hearing loss, with or without vestibular dysfunction (DFNA9) via a gain-of-function/dominant-negative mechanism, and more recently autosomal recessive nonsyndromic hearing loss (DFNB110) via nonsense variants. Using a combination...
Fri Jun 19, 2020 03:00
Publication date: Available online 18 June 2020Source: Atlas of the Oral and Maxillofacial Surgery ClinicsAuthor(s): George R. Deeb, Dan Q. Tran, Janina Golob Deeb
Fri Jun 19, 2020 13:54
Background Diabetic nephropathy (DN) is among the most common microvascular complications of diabetes resulting in end-stage renal disease and therefore search for candidates which can ameliorate the kidney function is needed simultaneously with standard diabetic pharmacotherapy. The current study was aimed to investigate the effect of long term sacubitril/valsartan therapy (LCZ696) in diabetic rats to assess its ameliorative impact against various pathological parameters such as...
Fri Jun 19, 2020 03:00
Backgroud and Purpose Hyperphosphatemia, which is a high inorganic phosphate (Pi) level in the serum, promotes endothelial cells dysfunction and is associated with cardiovascular diseases in patients with chronic kidney diseases (CKD). However, the underlying mechanism of high Pi-induced endothelia cell apoptosis remains unclear. Methods Human umbilical vein endothelial cells (HUVECs) were treated with normal Pi (1.0...
Fri Jun 19, 2020 03:00
The New World sparrows (Passerellidae) are a large, diverse group of songbirds that vary in morphology, behavior, and ecology. Thus, they are excellent for studying trait evolution in a phylogenetic framework. We examined lability versus conservatism in morphological and behavioral traits in two related clades of sparrows (Aimophila, Peucaea), and assessed whether habitat has played an important role in trait evolution. We first inferred a multi-locus phylogeny which we used to reconstruct ancestral...
Fri Jun 19, 2020 03:00
Purpose To explore whether unilateral relapse of Bechet’s disease-associated uveitis (BDU) causes differences in the tear proteome between the diseased and the contralateral quiescent eye and potential tear biomarkers for uveitis recurrence and disease monitoring. Method To minimize interindividual variations, bilateral tear samples were collected from the same patient (n = 15) with unilateral relapse of BDU. A data-independent acquisition (DIA) strategy was used to identify proteins...
Fri Jun 19, 2020 03:00
Background and aims Fish by-products are generally used to produce fishmeal or fertilizers, with fish oil as a by-product. Despite their importance, fish wastes are still poorly explored and characterized and more studies are needed to reveal their potentiality. The goal of the present study was to qualitatively characterize and investigate the antimicrobial effects of the fish oil extracted from Salmo salar waste samples and to evaluate the potential use of these compounds for treating...
Fri Jun 19, 2020 03:00
Heterotrophic plants—plants that have lost the ability to photosynthesize—are characterized by a number of changes at all levels of organization. Heterotrophic plants are divided into two large categories—parasitic and mycoheterotrophic (MHT). The question of to what extent such changes are similar in these two categories is still open. The plastid genomes of nonphotosynthetic plants are well characterized, and they exhibit similar patterns of reduction in the two groups. In contrast, little is known...
Fri Jun 19, 2020 03:00
Eragrostis tef is an important cereal crop in Ethiopia with excellent storage properties, high–quality food, and the unique ability to thrive in extreme environmental conditions. However, the application of advanced molecular tools for breeding and conservation of these species is extremely limited. Therefore, developing chloroplast genome resources and high-resolution molecular markers are valuable to E. tef population and biogeographic studies. In the current study, we assembled and compared the...
Fri Jun 19, 2020 03:00
Spiders (Araneae) form abundant and diverse assemblages in agroecosystems such as fruit orchards, and thus might have an important role as natural enemies of orchard pests. Although spiders are polyphagous and opportunistic predators in general, limited information exists on their natural prey at both species and community levels. Thus, the aim of this study was to assess the natural prey (realized trophic niche) of arboreal hunting spiders, their role in trophic webs and their biological control...
Fri Jun 19, 2020 03:00
Early supplementary feeding of lambs before weaning is important to meet their nutritional needs, promote the development of rumen and improve performance. To study the effect of early supplementary feeding on rumen development and the microbiota of lambs, 22 Hu lambs were randomly divided into two groups: one group was fed with milk replacer (group C), and the other group was fed with milk replacer and starter (group S). At 28 days, six lambs in each group were slaughtered, and the rumen content...
Fri Jun 19, 2020 03:00
Reef-building corals can harbour high abundances of diverse invertebrate epifauna. Coral characteristics and environmental conditions are important drivers of community structure of coral-associated invertebrates; however, our current understanding of drivers of epifaunal distributions is still unclear. This study tests the relative importance of the physical environment (current flow speed) and host quality (e.g., colony height, surface area, distance between branches, penetration depth among branches,...
Fri Jun 19, 2020 03:00
Grazing as one of the most important disturbances affects the abundance, diversity and community composition of arbuscular mycorrhizal (AM) fungi in ecosystems, but the AM fungi in response to grazing in wetland ecosystems remain poorly documented. Here, we examined AM fungi in roots and soil in grazing and non-grazing plots in Zoige wetland on the Qinghai-Tibet plateau. Grazing significantly increased AM fungal spore density and glomalin-related soil proteins, but had no significant effect on the...
Fri Jun 19, 2020 03:00
Color is an essential clue for intra- and interspecies communication, playing a role in selection and speciation. Coloration can be based on nanostructures and pigments; carotenoids and carotenoproteins are among the most widespread pigments in animals. Over 350 species and subspecies of amphipods (Crustacea: Amphipoda) endemic to Lake Baikal exhibit an impressive variability of colors and coloration patterns, including intraspecific color morphs. However, the mechanisms forming this diversity are...
Fri Jun 19, 2020 03:00
Background Predicting the effects of climate warming on the dynamics of ecological systems requires understanding how temperature influences birth rates, death rates and the strength of species interactions. The temperature dependance of these processes—which are the underlying mechanisms of ecological dynamics—is often thought to be exponential or unimodal, generally supported by short-term experiments. However, ecological dynamics unfold over many generations. Our goal was to empirically document...
Fri Jun 19, 2020 03:00
Alveolar soft-part sarcoma (ASPS) is an extremely rare malignancy characterized by the unbalanced translocation der(17)t(X;17)(p11;q25). This translocation generates a fusion protein, ASPL-TFE3, that drives pathogenesis through aberrant transcriptional activity. Although considerable progress has been made in identifying ASPS therapeutic vulnerabilities (e.g., MET inhibitors), basic research efforts are hampered by the lack of appropriate in vitro reagents with which to study the disease. In this...
Fri Jun 19, 2020 03:00
Background To reduce bird fatalities from millions of window collisions each year in North America, it is important to understand how design and landscape elements relate to collision risk. The current study extends prior research that found that buildings near ornamental pear trees (Prunus calleryana) and buildings with mirrored windows significantly increased odds of collisions among eight buildings on the University of Utah campus in winter. The previous study found bird-friendly...
Fri Jun 19, 2020 03:00
Background The novel coronavirus diseases 2019 (COVID-19) caused over 1.7 million confirmed cases and cumulative mortality up to over 110,000 deaths worldwide as of 14 April 2020. A total of 57 Macao citizens were obligated to stay in Hubei province, China, where the highest COVID-19 prevalence was noted in the country and a “lockdown” policy was implemented for outbreak control for more than one month. They were escorted from Wuhan City to Macao via a chartered airplane organized by Macao SAR...
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16962-7Bioproduction of hyaluronan needs increases in yield and greater diversity of the molecular weights. Here, the author increases hyaluronan production and diversifies the molecular weights through engineering the hyaluronan biosynthesis pathway and disruption of Corynebacterium glutamicum encapsulation caused by secreted hyaluronan.
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16922-1Force-dependent formation of the talin-vinculin complex reinforces actin anchoring to focal adhesions, but how different talin-binding proteins respond to force is unclear. Here authors use an in vitro microscopy assay and show that the actomyosin force triggers the dissociation of RIAM from several talin domains.
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16948-5Amides are versatile synthetic building blocks, however the general stability of the amide bond makes its selective transformation challenging. Here, the authors report a chemodivergent transformation of primary, secondary and tertiary amides by using 1,1-diborylalkanes as pro-nucleophiles.
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16929-8Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16637-3MicroRNA2118 induces the production of phased small interfering RNAs (phaisRNAs) in plants. Here the authors show that rice miR2118 is required for both male and female fertility and supports the production of atypical U-rich 21 nt phasiRNAs that are abundant in anther walls.
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16823-3The necroptotic cell death pathway involves signaling through pseudokinases. Here the authors define the structural determinants of species specificity in necroptosis signaling mediated by the essential necroptotic effector pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL).
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16887-1Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junctions promotes necroptosis.
Fri Jun 19, 2020 03:00
Nature Communications, Published online: 19 June 2020; doi:10.1038/s41467-020-16863-9In information processing applications, directional amplifiers are key components which can be realized in very different systems. Here, the authors present a theoretical framework based on the introduction of a topological invariant that helps to understand directional amplification in coupled cavity arrays.
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Sampling localities of Alouatta palliata mexicana individuals and principal component analysis plot based on 83 individuals genotyped for seven microsatellites. Colored circles represent individuals from Tabasco (gold), Uxpanapa (red), and Western Veracruz (blue). Source : Mantled howler monkey image by Stephen Nash. Abstract Genetic diversity provides populations with the possibility to persist in ever‐changing environments, where selective regimes change over time. Therefore, the long‐term...
Thu Jun 18, 2020 16:25
Intrahemispheric correlation spectra obtained from the rapid eye movement sleep in the spider monkey. Principal component analyses grouped the electroencephalographic activity only in three bands. Abstract The study of electroencephalographic (EEG) activity during sleep in the spider monkey has provided new insights into primitive arboreal sleep physiology and behavior in anthropoids. Nevertheless, studies conducted to date have maintained the frequency ranges of the EEG bands commonly used...
Thu Jun 18, 2020 16:25
Fri Jun 19, 2020 03:00
Abstract Racemic RS‐4‐(4‐hydroxyphenyl)‐2‐butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin‐lightening cosmetics, was unexpectedly reported in Japan to induce leukoderma or vitiligo called RD‐induced leukoderma (RIL) after repeated application. To our knowledge, no studies have investigated chemical‐induced vitiligo pathogenesis on a genome‐wide scale. Here, we conducted a genome‐wide association study (GWAS) for 147 cases and 112 controls. CDH13 , encoding a GPI‐anchored...
Thu Jun 18, 2020 17:33
Abstract Melanoma presents challenges for timely and accurate diagnosis. Expert panels have issued risk‐based screening guidelines, with recommended screening by visual inspection. To assess how recent technology can impact the risk/benefit considerations for melanoma screening, we comprehensively reviewed noninvasive visual‐based technologies. Dermoscopy increases lesional diagnostic accuracy for both dermatologists and primary care providers; total body photography and sequential digital dermoscopic...
Thu Jun 18, 2020 11:29
Abstract In the feline Donskoy breed, a phenotype that breeders call "pink‐eye", with associated light‐brown skin, yellow irises and red‐eye effect, has been described. Genealogical data indicated an autosomal recessive inheritance pattern. A single candidate region was identified by genome‐wide association study and SNP‐based homozygosity mapping. Within that region, we further identified HPS5 (HPS5 Biogenesis Of Lysosomal Organelles Complex 2 Subunit 2 ) as a strong candidate gene, since HPS5...
Thu Jun 18, 2020 11:15
Position Paper for the State-of-the-Art Application of Respiratory Support in Patients with COVID-19
Against the background of the pandemic caused by infection with the SARS-CoV-2 virus, the German Respiratory Society has appointed experts to develop therapy strategies for COVID-19 patients with acute respiratory failure (ARF). Here we present key position statements including observations about the pathophysiology of (ARF). In terms of the pathophysiology of pulmonary infection with SARS-CoV-2, COVID-19 can be divided into 3 phases. Pulmonary damage in advanced COVID-19 often differs from the known...
Fri Jun 19, 2020 11:22
Background Inflammatory profiles for patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) vary between North American and Asian populations. An elevated ethmoid‐to‐maxillary (E/M) opacification ratio on preoperative imaging is associated with certain postoperative outcomes in Asian populations and populations that are non‒type 2 dominant. In this study we explore this factor in North American/type 2‒based populations. Methods Adult patients (n = 165) from a North American population...
Thu Jun 18, 2020 22:08
Background Aspirin‐exacerbated respiratory disease (AERD) represents a severe endotype of chronic rhinosinusitis with nasal polyposis. Although aspirin desensitization (AD) has emerged as an effective therapeutic option, the natural history of AERD without AD remains unclear. Methods A retrospective review was conducted of AERD patients who underwent endoscopic sinus surgery (ESS) without AD between 2010 and 2019. The primary outcomes were revision surgery rate and time to revision surgery....
Thu Jun 18, 2020 22:05
Background Aspirin‐exacerbated respiratory disease (AERD) is an aggressive respiratory tract inflammatory disorder manifesting as asthma, chronic rhinosinusitis with nasal polyposis, and a respiratory sensitivity to aspirin and nonsteroidal anti‐inflammatory drugs (NSAIDs). Corticosteroids, both systemic and topical/inhaled, are used to treat inflammation of the upper and lower airways. Our objective was to examine the potential impact of complete endoscopic sinus surgery (ESS) and aspirin desensitization...
Thu Jun 18, 2020 22:04
Background Olfactory neuroblastoma (ONB) is a rare skull‐base malignancy associated with delayed local recurrence. Treatment options in recurrent disease are few and unreliable. We undertook analysis of the ONB exome and immune environment in order to identify potential future immunotherapy treatment options. Methods Retrospective chart review and next‐generation targeted 595‐gene genomic profiling was performed on a cohort of 14 ONB cases utilizing Tempus proprietary DNA and RNA sequencing...
Thu Jun 18, 2020 21:58
Thu Jun 18, 2020 12:49
Abstract Objectives The aims of this research are to explore the diet, mobility, social organization, and environmental exploitation patterns of early Mediterranean farmers, particularly the role of marine and plant resources in these foodways. In addition, this work strives to document possible gendered patterns of behavior linked to the neolithization of this ecologically rich area. To achieve this, a set of multiproxy analyses (isotopic analyses, dental calculus, microremains analysis, ancient...
Thu Jun 18, 2020 21:24
Abstract Objectives Mandibular morphological variation is often used to examine various aspects of human palaeobiology. However, fossil and archeological skeletal remains are often fragmented/distorted and so are frequently excluded from studies. This leads to decreased sample sizes and, potentially, to biased results. Thus, it is of interest to restore the original anatomy of incomplete/distorted specimens. Thin plate splines (TPS), commonly used in Geometric Morphometrics (GM), offer the prospect...
Thu Jun 18, 2020 21:17
Summary Increased photosensitivity is a common cutaneous adverse effect associated with the BRAF inhibitor vemurafenib. Clinically, it presents as an immediate sensation of heat and edematous erythema during sun exposure, as well as a sunburn reaction in terms of a late reaction. Phototesting has shown that the UVA range (320 nm to 400 nm), for both the immediate and the late reaction. In terms of pathogenesis, photochemical studies have suggested that exposure of vemurafenib to UVA radiation produces...
Thu Jun 18, 2020 20:16
Abstract Objectives We assessed fibroblast growth factor (FGF) regenerative efficacy in an aged vocal fold rat model and confirmed it in a prospective clinical trial. Design, Setting, and Participants For animal experiments, 48 Sprague‐Dawley rats were divided into two groups: 24 six‐month‐olds (young group) and 24 twenty‐four‐month‐olds (old group). FGF was injected once a week thrice into the left vocal fold of the old group, dividing them into two sub‐groups (injected [left] and uninjected...
Thu Jun 18, 2020 11:51
The water sorption and solubility of two polymer resin‐based dental composite materials were assessed in order to evaluate the effects of immediate post‐cure water exposure on the water sensitivity of the composites. Each material was tested with two different light curing setups. The radiant exposure of the two curing setups differed by a factor of 5. After exposure to water and subsequent drying, the Knoop surface hardness was measured. The change in the degree of conversion in both water and air...
Thu Jun 18, 2020 11:55
Abstract It has been proposed that sleep readies the brain for novel learning, and previous work has shown that sleep loss impairs the ability to encode new memories. In the present study, we examined if a daytime nap would increase mnemonic discrimination (MD) performance. MD is the ability to differentiate between memories that are similar but not identical. Participants performed the Mnemonic Similarity Task (MST) twice, once in the morning and once in the afternoon. The goal of this task is...
Thu Jun 18, 2020 20:30
Abstract Sleep apnea syndrome treatment relies primarily on continuous positive airway pressure, which requires a homecare follow‐up. Excessive daytime sleepiness is a key symptom to be measured during follow‐up, and there is a need for more easy‐to‐administer, ecological and engaging tools to assess it. Virtual agents have shown their effectiveness in performing clinical evaluation in a medical environment. A virtual agent assessing excessive daytime sleepiness via the Epworth Sleepiness Scale...
Thu Jun 18, 2020 16:19
Abstract Weight loss, continuous positive airway pressure (CPAP) and positional therapy (PT) are important treatments in obstructive sleep apnea (OSA). Although all of these reduce the apnea–hypopnea index (AHI) effectively, the benefits of these treatments have not been thoroughly investigated in a patient‐specific manner. Therefore, clinicians do not have objective means to choose an optimal treatment for each patient. We aim to provide clinicians the possibility for treatment optimization in...
Thu Jun 18, 2020 16:16
Abstract Insufficient sleep syndrome (ISS) is prevalent, but poorly studied. This descriptive study was performed to determine its diagnostic challenges and clinical characteristics in a large (n = 3,461) retrospective sample from a single sleep laboratory. Based on actigraphy, polysomnography and multiple sleep latency tests, we diagnosed “suspected insufficient sleep syndrome” in patients with chronic sleepiness, short time in bed, longer sleep duration during weekends or vacation, and without...
Thu Jun 18, 2020 15:20
Abstract It is commonly observed that plant species’ range margins are enriched for increased selfing rates and, in otherwise self‐incompatible species, for self‐compatibility (SC). This has often been attributed to a response to selection under mate and/or pollinator limitation. However, range expansion can also cause reduced inbreeding depression, and this could facilitate the evolution of selfing in the absence of mate or pollinator limitation. Here, we explore this idea using spatially explicit...
Thu Jun 18, 2020 18:47
Abstract Longitudinal morphological growth data of apes are incredibly difficult to obtain. Long life histories, combined with practical and ethical issues of obtaining such long‐term data have resulted in few longitudinal data sets in chimpanzees of known chronological ages. One classic, long‐term growth study of chimpanzees was that of Drs Nissen and Riesen initiated at the Yale Laboratories of Primate Biology in 1939. Through that study, whole‐body radiological images were taken on a regular...
Thu Jun 18, 2020 22:00
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. A 79-year-old man was admitted for a transcatheter aortic valve replacement due to severe aortic stenosis. A preoperative chest computed tomography with angiography revealed an apical variant hypertrophic cardiomyopathy with a prominent apical pouch. In addition, there was near-complete obliteration of the left ventricle in the mid to apical aspect during systole suggesting a midventricular gradient....
Thu Jun 18, 2020 13:48
Osteoporosis is an important skeletal disease characterized by bone weakness and high risk of fracture in postmenopausal women. Tea consumption is known to play an important role in the prevention or alleviation of osteoporosis. However, the therapeutic effects of aqueous extracts of white tea (WT) have not been evaluated in osteoporosis rat models. The aim of this study was to investigate the potential anti-osteoporotic role of WT in ovariectomized (OVX) rats. WT was given orally at 0.5% w/v doses...
Fri Jun 19, 2020 09:02
Journal of Neurotrauma, Ahead of Print.
Thu Jun 18, 2020 10:00
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