At the moment, international guidelines for rectal cancer suggest to consider 18F-FDG PET/CT scan in a few conditions: (1) at disease presentation in case of suspected or proven metastatic synchronous adenocarcinoma with potentially curable M1 disease; (2) in the recurrence workup for serial carcinoembryonic antigen level elevation; (3) in the recurrence workup with metachronous metastases documented by CT, MRI, or biopsy; (4) in case of strong contraindication to IV contrast agent administration;...
Wed Jun 17, 2020 03:00
We present a 48-year-old woman with an olfactory neuroblastoma who was referred for accurate staging using PET/CT. The 68Ga-DOTATATE PET/CT showed a 51 × 32-mm mass with an SUVmax of 7.59 in the sphenoidal sinuses, whereas radiotracer uptake on 18F-FDG PET/CT was similar to that of brain tissue. 68Ga-DOTATATE PET/CT might be especially useful in regions with difficult tumor visualization resulting from high background, such as brain tissue. The results of this case may suggest that somatostatin receptor...
Wed Jun 17, 2020 03:00
We present the case of a 39-year-old woman with vaginal bleeding and abdominal pain. An 18F-FDG PET/CT showed high 18F-FDG uptake in a tumor in the pouch of Douglas, in 3 lymph nodes in the pelvis, and in the left tuber ischiadicum. Biopsies revealed a mesonephric carcinoma with metastases. Six series of empiric chemotherapy with carboplatin, paclitaxel, and bevacizumab were not sufficient to treat the cancer, and checkpoint immunotherapy with nivolumab and ipilimumab was initialized. Received...
Wed Jun 17, 2020 03:00
A 32-year-old woman with a FIGO (International Federation of Gynecology and Obstetrics) stage IIA invasive squamous cell carcinoma of the uterine cervix underwent a clinical FDG PET/CT scan, which revealed intense uptake in the primary. On research 18F-fluciclovine PET/MRI, the primary showed elevated fluciclovine uptake at 5 and 40 minutes after radiotracer injection, with no evidence of regional or distant metastasis. Fluciclovine PET may have diagnostic value for cervical cancer imaging with a...
Wed Jun 17, 2020 03:00
A 72-year-old man with a history of prostate adenocarcinoma initially managed by radical prostatectomy and salvage radiation therapy underwent resection of a left vas deferens recurrence identified on PSMA PET. Despite an initial response, PSA failed to fall below 3.5 ng/L, prompting re-evaluation with PSMA PET/CT: a left distal hydroureter with presumed physiologic urine activity remains despite diuretic administration. Upon scrutiny of the prior PSMA PET/CT and diagnostic CTs, the distal ureteral...
Wed Jun 17, 2020 03:00
A 37-year-old man, treated case of left temporal glioblastoma presented with headache, seizures, and progressive right-sided weakness with MRI evidence of recurrence. Exploratory 68Ga-PSMA PET/CT demonstrated PSMA expression in the recurrent lesion; it was decided to treat this patient with 177Lu-PSMA-617. After 3 cycles of 177Lu-PSMA-617, 68Ga-PSMA PET/CT showed significant reduction in PSMA uptake and regression in size of lesion on MRI with improvement in patient’s symptoms and performance status....
Wed Jun 17, 2020 03:00
We report the case of an asymptomatic (no fever, no cough, no dyspnea) 80-year-old woman who had an 18F-FDG PET/CT scan for initial staging of Lieberkühnian adenocarcinoma located on anal canal. Chest analysis incidentally revealed bilateral diffuse patchy ground-glass opacity with mild increasing 18F-FDG uptake, consistent with incidental COVID-19 infection finding during the March 2020 pandemic. The infection was confirmed by reverse transcription–polymerase chain reaction. It led us to improve...
Wed Jun 17, 2020 03:00
Ectopic parathyroid adenomas are a common cause of postsurgical persistent primary hyperparathyroidism. Our case highlights a patient with a negative bilateral 4-gland exploration with follow-up parathyroid 4-dimensional CT and 99mTc-MIBI SPECT/CT, yielding focal uptake in the right piriform sinus. Subsequent direct laryngoscopy revealed a mass in the piriform sinus, which was resected with surgical pathology yielding parathyroid adenoma. Received for publication April 5, 2019; revision accepted...
Wed Jun 17, 2020 03:00
Ectopic thyroid gland can be detected at any age. It is a developmental defect that results from abnormal migration of the primitive thyroid bud. Dual ectopia is very rare, and only a few cases have been reported in literature. Patients with thyroid ectopia may be either euthyroid or hypothyroid. Concept of thyroid autotransplantation is based on restoring euthyroidism and is an attempt to preserve the autoregulatory mechanism of hormone production. This is a case of dual ectopia who underwent heterotopic...
Wed Jun 17, 2020 03:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1162-8196 Background Human glucagon-like peptide-1 analogue, Liraglutide, has shown cardioprotective effects in animal and clinical studies of type 2 diabetes mellitus. This study was conducted to assess the effect of Liraglutide on diabetes-induced myocardial electrical remodeling. Materials and Methods A rat model of type 2...
Fri Jun 19, 2020 02:00
Abstract The risk of nest depredation is influenced by numerous factors, including predator density, environmental conditions of the nesting landscape, and nesting behaviors of mothers. Many reptiles choose nest microhabitats that facilitate embryonic development, but little is known about how the risk of nest depredation in different habitats influences egg survival and nesting behavior. To address this knowledge gap, we quantified predator–prey relationships between square-back...
Fri Jun 19, 2020 03:00
Abstract Patterns and processes of species diversification in the oceans are still not fully understood. Traditionally, studies have been using the pelagic larval duration (PLD) to explain the genetic structure and phylogeographic history of marine taxa. However, this trait has given inconsistent results, especially when there is a physiological barrier. Phylogeographic studies comparing species that have similar PLD but differ in other important traits can indicate which ones...
Fri Jun 19, 2020 03:00
After the widespread adoption of prostate-specific antigen (PSA) screening in the early 1990s, prostate cancer diagnoses increased rapidly while death rates halved over the course of the next quarter century. Initial results from randomized trials and recommendations against screening from…
Thu Jun 18, 2020 03:00
HOARDING TOILET PAPER From “The Stall” Season 5, Episode 12 Air date: January 6, 1994 After realizing her bathroom stall does not have toilet paper, Elaine asks the woman in the adjacent stall to share, thus prompting the iconic response “I can’t spare a square.” See every meme depicting toilet paper stockpiling and anxiety this past spring. Image description: Two pairs of feet can be seen under two separate public restroom stalls. One occupant, represented by yellow socks and brown shoes, is...
Sat Jun 20, 2020 00:53
Ted Gideonse is a medical anthropologist who studies the effects of public health discourses about HIV and drugs. As people with more than a passing understanding of biology and medicine know, movies about pandemic disasters tend to be wildly inaccurate. No virus is going to turn us into frenzied zombies in five minutes à la World War Z, and no cure is going to be found in a weekend, certainly not following a helicopter chase through a canyon, as in Outbreak. But films, even ones about things that...
Sat Jun 20, 2020 00:51
Political myth-making about America’s rural “heartland” is doubly pernicious, increasing rural vulnerability to COVID-19 and ignoring the disintegration of rural health services. In March 2020, Fairmont Regional Medical Center, the only hospital in Fairmont County, West Virginia, closed its doors amid increasing financial strains. Later that month, an ambulance was called to take an 88-year-old woman infected with COVID-19 to the hospital. Instead of making the usual two-minute drive to Fairmont...
Sat Jun 20, 2020 00:49
I came to meditation because my brain is always running. The part of an academic’s job that requires me to think and theorize sometimes grows much larger than the part that breathes and feels my way through. Can you relate? In this global pandemic, meditation is one of the tools that helps me stay grounded and calm enough to feel my feelings without always being overwhelmed by them. Below, I offer tips and affirmations to support anyone who wants to start or sustain a meditation practice. You don’t...
Sat Jun 20, 2020 00:47
Higher education is at a crossroads. Can we adapt to the ongoing challenges and create transformative educational courses for an uncertain future? As colleges and universities started shutting down classrooms and moving courses online, it became apparent to edtech professionals that this might be a “moment” for online learning, and given the rush with which things were thrown together, it might not be a shining one. A flurry of tweets and blog posts in the edtech world eventually swarmed around...
Sat Jun 20, 2020 00:45
Way back (what seems like a thousand years ago!) on March 4, my office closed and we were sent to work from home. Knowing that I would have a bit of extra time on my hands, I decided to have some fun on Twitter and Instagram, posting clips of songs from my record collection. I called it #quarantunes, and a hashtag was born. Here is a special mix for Anthropology News. Some tracks are old favourites of mine, while others are songs by artists that I’ve been introduced to more recently. All speak...
Sat Jun 20, 2020 00:43
Sign language interpreters have become social media celebrities of our coronavirus moment. But signing is not a form of light entertainment; it should be lifesaving information. Dutch health minister Hugo de Jonge paused in the middle of a somber press briefing on COVID-19. As he admonished Dutch citizens to not hoard, or hamsteren, which literally means stuffing one’s cheeks like a hamster, he swung his head back to the signing woman behind him (@EuropeansPod, March 31, 2020). His gaze, and the...
Sat Jun 20, 2020 00:41
In March 2020, a video of Italian mayors scolding citizens for failing to stay at home went viral. Only ostensibly insignificant, these clickable white men reveal new forms and affects of digital governance at the heart of twenty-first century politics. The camera tracks a man in a suit as he walks with determination toward an outdoor ping-pong table and shouts in Italian: “Ping-pong is not allowed! Go home to your PlayStation!” Cut to another man who sits at a desk, sighing: “Where are you going...
Sat Jun 20, 2020 00:39
Get creative with our coloring page produced in collaboration with March Mammal Madness. Image description: A gorilla stands in mid-stride. Charon Henning March Mammal Madness is a bracket-based tournament of empirically informed hypothetical encounters between animal “combatants” using social media, community events, and creative works to reach large and diverse audiences. Storytelling scientists craft accessible narratives from the scientific literature, citing over 1,250 scholarly works and...
Sat Jun 20, 2020 00:37
We should not expect COVID-19 to behave in the same way as historical pandemics of plague. But both show how inequalities exacerbate mortality outcomes. It’s a gorgeous, warm day in London, in the summer of 2003. I get off the London Underground at Tower Hill Station, and slowly inch forward through a crowd of people eager to make their way toward the many tourist destinations in the area. As I exit the station, directly across the street in front of me is the Tower of London—beautiful and imposing...
Sat Jun 20, 2020 00:35
In much of the Global North COVID-19 is wreaking existential havoc. For the war-seasoned Lebanese in the throes of an economic meltdown and ongoing protests, it is yet another in a long line of disasters to navigate and resist. “Pestilence is so common, there have been as many plagues in the world as there have been wars, yet plagues and wars always find people equally unprepared,” writes Albert Camus in The Plague (1991, 37). As the coronavirus spreads across the planet in a wave of disruption...
Sat Jun 20, 2020 00:33
For my family and neighbors here in Istria, polenta has become quite an occasion during the pandemic. Together we sowed a field with maize, the first for many years, and I learned how labor-intensive it is—the harvesting, drying, shelling, grinding, and sifting. While movement was restricted here due to COVID-19 the polenta flowed through the village in the form of gift exchanges of eggs, cabbages, olive oil, and cakes. And when restrictions eased our first communal meal was a feast featuring wild...
Fri Jun 19, 2020 20:26
How one medical anthropologist is boosting our capacity to understand and contend with COVID-19. In late February 2020, I traveled back to the United States from India and Indonesia where I had been conducting fieldwork. Having researched emerging and neglected diseases for years, I recognized the potential for COVID-19 to become the pandemic that my global health colleagues and I had long dreaded. During layovers in Thailand and Japan—countries on high alert for COVID-19 and experiencing a growing...
Fri Jun 19, 2020 18:20
Australian researchers have made significant advances in understanding the inflammatory cell death regulatory protein MLKL and its role in disease.
Fri Jun 19, 2020 16:05
Plant experts at UC Davis have defined the genetic basis of sex determination in grapevines, one of the oldest and most valuable crops worldwide. In new research biologists propose a novel model of sex evolution before and during grapevine domestication nearly 8,000 years ago. Their work could have broad application in breeding grapes and other plant species.
Thu Jun 18, 2020 22:03
Plants are some of nature's most extraordinary chemists. Unlike animals, they can't run from predators or pathogens. They can't uproot themselves to spread their seeds. So instead, they manufacture chemicals to make love and war. But how did plants obtain these capabilities? In a new study, scientists explore this question through the evolution of Gardenia jasminoides, sequencing the species' genome and learning how the plant evolved to make crocin, a useful chemical.
Thu Jun 18, 2020 14:35
A human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.
Thu Jun 18, 2020 22:03
Pediatric Allergy, Immunology, and Pulmonology, Volume 33, Issue 2, Page 63-68, June 2020.
Wed Jun 17, 2020 10:00
Pediatric Allergy, Immunology, and Pulmonology, Volume 33, Issue 2, Page 43-43, June 2020.
Wed Jun 17, 2020 10:00
Pediatric Allergy, Immunology, and Pulmonology, Volume 33, Issue 2, Page 85-91, June 2020.
Wed Jun 17, 2020 10:00
Pediatric Allergy, Immunology, and Pulmonology, Volume 33, Issue 2, Page 57-62, June 2020.
Wed Jun 17, 2020 10:00
On January 20, 2020, the first U.S. case of Covid-19 was reported in Washington State. Substantial challenges lay ahead. Covid-19 is highly contagious, it can cause severe illness, and no proven, effective treatments or vaccines are available. As leaders at the University of Washington (UW) and UW…
Thu Jun 18, 2020 03:00
Physicians still lack consensus on the meaning of race. When the Journal took up the topic in 2003 with a debate about the role of race in medicine, one side argued that racial and ethnic categories reflected underlying population genetics and could be clinically useful. Others held that any small…
Wed Jun 17, 2020 03:00
Multiple myeloma (MM) is a hematopoietic malignancy characterized by heterogeneity, which corresponds to alternative splicing (AS) profiles and disadjust gene expression. Bioinformatics analysis of AS factors possibly related to MM progression identified the polypyrimidine tract binding protein (PTBP1) as candidate. The purpose of this study was to confirm the incidence and prognostic value of PTBP1 in MM patients. Several cohorts of 2971 patients presenting newly diagnosed and relapsed MM were enrolled....
Fri Jun 19, 2020 17:35
Backgrounds. Fatty acid synthase (FASN) has been regarded as a prognostic marker in prostate cancer (PCa). In this study, we evaluated FASN expression at both mRNA and protein levels and assessed the association between FASN expression and prognosis in male Han Chinese with PCa treated with radical prostatectomy (RP). Methods. Expression profile and prognostic value of FASN were analyzed in tissue microarray (TMA) and data retrieved from databases including TCGA public database, GEO database, and...
Fri Jun 19, 2020 17:35
Red blood cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) have shown a prognostic value in various clinical settings. We aimed to investigate the association between RDW, NLR, and in-hospital mortality in patients with dyspnea. In this retrospective study with the Medical Information Mart for Intensive Care III database (version 1.4), adult patients who came to the emergency department with dyspnea were included. Patients’ comorbidities, hematological parameters within the...
Fri Jun 19, 2020 17:35
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