Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Κυριακή 21 Ιουνίου 2020


A Validated T Cell Radiomics Score is Associated with Clinical Outcomes Following Multi-site SBRT and Pembrolizumab
Publication date: Available online 20 June 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Mark C. Korpics, Mei-Yin Polley, Sandeep R. Bhave, Gage Redler, Sean P. Pitroda, Jason J. Luke, Steven J. Chmura
Radiation Molecular Biology.
Sun Jun 21, 2020 14:33
Efficacy of dose-escalated chemoradiation on complete tumour response in patients with locally advanced rectal cancer (RECTAL-BOOST); a phase 2 randomised controlled trial
Publication date: Available online 19 June 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Alice M. Couwenberg, Johannes P.M. Burbach, Maaike Berbee, Miangela M. Lacle, René Arensman, Mihaela G. Raicu, Frank J. Wessels, Joanne Verdult, Jeanine Roodhart, Onne Reerink, Sieske Hoendervangers, Jeroen Buijsen, Heike Grabsch, Apollo Pronk, Esther CJ. Consten, Anke B. Smits, Joost T. Heikens, Ane L. Appelt, Wilhelmina M.U. van Grevenstein, Helena M. Verkooijen
Radiation Molecular Biology.
Fri Jun 19, 2020 14:43
Evaluation of scar outcome post alar base reduction using different surgical approaches
Publication date: Available online 20 June 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Jibril Hudise, Saud Aldhabaan, Raad Nassar, Ahmed Alarfaj
Oral and Maxillofacial Surgery
Sun Jun 21, 2020 14:23
DIAGNOSIS AND TREATMENT OF LIP INFECTIONS
Publication date: Available online 20 June 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Dina Amin, Sruthi Satishchandran, Stephanie Drew, Shelly Abramowicz
Oral and Maxillofacial Surgery
Sun Jun 21, 2020 14:23
The higher temperature and ultraviolet, the lower COVID-19 prevalence – Meta-regression of data from large U.S. cities
Publication date: Available online 20 June 2020Source: American Journal of Infection ControlAuthor(s): Hisato Takagi, Toshiki Kuno, Yujiro Yokoyama, Hiroki Ueyama, Takuya Matsushiro, Yosuke Hari, Tomo Ando
ScienceDirect Publication: American Journal of Infection Control
Sun Jun 21, 2020 14:22
A Review of Wipes Used to Disinfect Hard Surfaces in Healthcare Facilities
Publication date: Available online 19 June 2020Source: American Journal of Infection ControlAuthor(s): John M. Boyce
ScienceDirect Publication: American Journal of Infection Control
Fri Jun 19, 2020 14:52
Hand Sanitizers: A Review of Ingredients, Mechanisms of Action, Modes of Delivery, and Efficacy Against Coronaviruses
Publication date: Available online 18 June 2020Source: American Journal of Infection ControlAuthor(s): Andrew P. Golin, Dexter Choi, Aziz Ghahary
ScienceDirect Publication: American Journal of Infection Control
Fri Jun 19, 2020 14:52
Assessing weaning stress – relations between enamel hypoplasia, δ<sup>18</sup>O and δ<sup>13</sup>C values in human teeth obtained from early modern cemeteries in Wroclaw, Poland
Publication date: Available online 20 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Paweł Dąbrowski, Michał Kulus, Joanna Grzelak, Magdalena Radzikowska, Maciej Oziembłowski, Zygmunt Domagała, Maciej T. Krajcarz
ScienceDirect Publication: Annals of Anatomy - Anatomischer Anzeiger
Sun Jun 21, 2020 13:57
Distribution and chemical coding of phoenixin-immunoreactive nerve structures in the spinal cord of the pig
Publication date: Available online 20 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Ewa Lepiarczyk, Agnieszka Bossowska, Marta Majewska, Agnieszka Skowrońska, Jerzy Kaleczyc, Mariusz Majewski
ScienceDirect Publication: Annals of Anatomy - Anatomischer Anzeiger
Sun Jun 21, 2020 13:57
Endoscopic projection of the gastroduodenal artery: Anatomical implications for bleeding management
Publication date: Available online 18 June 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): P. Wilhelm, D. Stierle, J. Rolinger, C. Falch, U. Drews, A. Kirschniak
ScienceDirect Publication: Annals of Anatomy - Anatomischer Anzeiger
Fri Jun 19, 2020 15:12
Sleep Problems And Their Association With Weight And Waist Gain - The Brazilian Longitudinal Study Of Adult Health (Elsa-Brasil)
Publication date: Available online 21 June 2020Source: Sleep MedicineAuthor(s): Tássia R. Camargo, Vivian C. Luft, Bruce B. Duncan, Maria Angélica A. Nunes, Dora Chor, Rosane H. Griep, Maria de Jesus M. da Fonseca, Sandhi M. Barreto, Sheila Maria A. de Matos, Maria I. Schmidt
Sleep Medicine
Sun Jun 21, 2020 13:48
Sleep bruxism and its associations with insomnia and OSA in the general population of Sao Paulo
Publication date: Available online 20 June 2020Source: Sleep MedicineAuthor(s): M. Maluly, C. Dal Fabbro, M.L. Andersen, A. Herrero Babiloni, G. Lavigne, S. Tufik
Sleep Medicine
Sun Jun 21, 2020 13:48
Protective effect of REM sleep during atrial bigeminy arrhythmia
Publication date: Available online 20 June 2020Source: Sleep MedicineAuthor(s): Gita Gupta, Peter M. Farrehi, Ronald D. Chervin
Sleep Medicine
Sun Jun 21, 2020 13:48
Cough Severity Index in Brazilian Portuguese: Translation and Cross-Cultural Adaptation
Publication date: Available online 21 June 2020Source: Journal of VoiceAuthor(s): Vanessa Veis Ribeiro, Leonardo Wanderley Lopes, Allan Carlos França da Silva, Agostinho Hermes de Medeiros Neto, Jackie Gartner-Schmidt, Mara Behlau
Voice
Sun Jun 21, 2020 12:58
A Comparative Study Utilizing the Voice Handicap Index-10 (VHI-10) in Teachers and the General Population of Kuwait
Publication date: Available online 21 June 2020Source: Journal of VoiceAuthor(s): Hamoud Alarouj, Jasem M. Althekerallah, Hussain AlAli, Mohammad A. Ebrahim, Mahmoud A.K. Ebrahim
Voice
Sun Jun 21, 2020 12:58
Transcultural Adaptation and Validation of the Korean Version of the Vocal Tract Discomfort Scale
Publication date: Available online 20 June 2020Source: Journal of VoiceAuthor(s): Ha Na Lee, Jae Yeon Yoo, Ji Hye Han, Yoon Sik Park, Do Yoon Jung, Jun Hee Park
Voice
Sun Jun 21, 2020 12:58
Differences on Voice Acoustic Parameters between Colombian College Professors with and without Vocal Fatigue
Publication date: Available online 19 June 2020Source: Journal of VoiceAuthor(s): Lady Catherine Cantor-Cutiva, Hédrick Yoseft Robles-Vega, Emilio Alejandro Sánchez, Diego Alejandro Morales
Voice
Fri Jun 19, 2020 17:31
The Challenge of Virtual Voice Therapy During the COVID-19 Pandemic
Publication date: Available online 18 June 2020Source: Journal of VoiceAuthor(s): Giovanna Cantarella, Maria Rosaria Barillari, Jerome R. Lechien, Lorenzo Pignataro
Voice
Fri Jun 19, 2020 17:31
Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models – A systematic review and meta‐analysis
Abstract Objectives To determine whether photofunctionalization influences dental implant osseointegration. Material and methods Data on osseointegration rates were extracted from 8 databases, based on bone‐to‐implant contact (BIC) and push‐out tests. Internal validity was accessed through the SYRCLE risk‐of‐bias tool for animal experimental studies. Meta‐analyses were performed for investigation of the influence of photofunctionalization on implant osseointegration, with a random effect...
Clinical Oral Implants Research
Sun Jun 21, 2020 12:18
The positive effect of tenting screws for primary horizontal guided bone regeneration: a retrospective study based on cone‐beam computed tomography data
Abstract Objectives to radiographically evaluate the effect of the adjunctive use of tenting screws (TS) for primary horizontal guided bone regeneration (GBR). Materials & Methods 28 patients in need of staged bone augmentation were consecutively treated in a private practice. A xenogenic particulate bone substitute material (DBBM) and a resorbable collagen membrane were used in all patients. Subjects were divided into two groups: control (conventional GBR; n = 22) and test (tenting...
Clinical Oral Implants Research
Fri Jun 19, 2020 18:25
Evaluation and Comparison of Histologic Changes and Implant Survival in Extraction Sites Immediately Grafted with Two Different Xenografts: A Randomized Clinical Pilot Study
Abstract Objectives The purpose of this prospective, single‐center randomized pilot study was to histologically evaluate and compare vital bone development in premolar and molar extraction sites grafted with 2 different bovine‐derived xenografts. The secondary outcome of interest was implant survival in the grafted sites. Materials and Methods Adult patients in need of at least 2 tooth extractions were enrolled. A paired design was used; each patient received at least one of each type of...
Clinical Oral Implants Research
Fri Jun 19, 2020 17:12
Prosthetic outcomes and clinical performance of CAD‐CAM monolithic zirconia versus porcelain‐fused‐to‐metal implant crowns in the molar region: 1‐year results of a RCT
Abstract Objective To investigate the clinical performance of monolithic zirconia implant crowns as compared to porcelain‐fused‐to‐metal (PFM) implant crowns. Materials and methods Seventy‐six healthy patients received reduced diameter implants in the molar region. Following random allocation, either a monolithic zirconia crown (Mono‐ZrO2) or a (PFM) was inserted. Crown and implant survival rates, modified USPHS criteria, clinical measurements and interproximal marginal bone level (MBL)...
Clinical Oral Implants Research
Fri Jun 19, 2020 16:40
Implant survival after surgical treatment of peri‐implantitis lesions by means of deproteinized bovine bone mineral with 10% collagen: 10‐year results from a prospective study
Abstract Objectives To evaluate the 10‐year outcomes of a regenerative surgical treatment of single peri‐implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC). Material and Methods The original population consisted of 26 patients with one crater‐like defect, around either SLA or TPS dental implants, with a probing depth ≥ 6 mm and no implant mobility. After debridement and surface decontamination, the defects were filled with DBBMC. Subsequently,...
Clinical Oral Implants Research
Fri Jun 19, 2020 11:05
Gravity prior in human behaviour: a perceptual or semantic phenomenon?
Abstract Humans show a gravitational advantage in perception: we are more precise at judging the speed of downwards-moving than upwards-moving objects, indicating that gravitational acceleration is an internalised prior. However, it is unclear whether this gravity prior is based on purely perceptual cues or whether it can incorporate semantic knowledge. Previous research has used only objects which are known to comply with gravity, possibly confounding semantic and perceptual cues....
Experimental Brain Research
Sun Jun 21, 2020 03:00
Fear of movement is associated with corticomotor depression in response to acute experimental muscle pain
Abstract Acute musculoskeletal pain is associated with reductions in corticomotor output that persists even after pain resolves. Factors that contribute to corticomotor depression following acute pain are unknown. This study examined whether psychological factors, including pain catastrophising, kinesiophobia, and implicit theories of pain, were associated with corticomotor depression following acute experimental muscle pain. Forty-two healthy individuals participated. Participants...
Experimental Brain Research
Sat Jun 20, 2020 03:00
Association of hypnotizability and deep sleep: any role for interoceptive sensibility?
Abstract The aim of the study was to investigate the possible association of hypnotizability and deep sleep (N3) duration, and whether the interoceptive sensibility influences this association. This was motivated by the proneness of highly hypnotizable individuals to easily change their psychophysiological state, i.e., from wakefulness to hypnosis and sleep, and by the positive association observed between hypnotizability and interoceptive sensibility. Forty-seven healthy participants...
Experimental Brain Research
Fri Jun 19, 2020 03:00
Detection of synovial sarcoma with an atypical fusion transcript by using SS18‐SSX and SSX antibodies
Pathology International
Sat Jun 20, 2020 20:09
Telomerase reverse transcriptase (TERT) promoter mutation correlated with intratumoral heterogeneity in hepatocellular carcinoma
Telomerase reverse transcriptase (TERT ) promoter mutations are frequently observed in hepatocellular carcinoma (HCC); however, the impact of TERT promoter mutations (TPMs) on clinical features and morphological patterns in HCC remains unresolved. Using DNA extracted from 97 HCCs, correlations between TPM status and both the clinical features of HCC and the immunohistochemically‐based subgroups were evaluated. Morphological tumor patterns were semi‐quantitatively analyzed using hematoxylin and eosin‐stained...
Pathology International
Fri Jun 19, 2020 15:44
Author Reply to: “A case of HRAS Q61‐mutated metaplastic breast carcinoma associated with squamous metaplasia: Which came first, metaplasia or neoplasia?”
Pathology International
Fri Jun 19, 2020 15:44
Global research trends in complex oral sensitivity disorder: a systematic bibliometric analysis of the framework
Abstract Objectives A systematic bibliometric analysis was performed to investigate trends in Complex Oral Sensitivity Disorder (COSD) research worldwide and compare the contributions of different countries/institutions, scientific journals, authors, keywords, and citations. Methods Web of Science database from 1985 to 2018 was systematically searched to identify all relevant articles using the MeSH terms “complex oral sensitivity disorder” and all synonyms used in the literature. We included...
Oral Pathology & Medicine
Sat Jun 20, 2020 22:24
Common Factors in the Presentation and Management of Chronic Temporomandibular Disorders and Chronic Overlapping Pain Disorders.
Abstract The International Association for the Study of Pain has released a new classification scheme for chronic pain. This classification scheme describes chronic pain as either a symptom of a disease (chronic secondary pain) or as the disease itself (chronic primary pain). Chronic temporomandibular disorders have many similarities to other proposed chronic overlapping pain disorders, but are classified and managed by dental practitioners as a localized pain condition of the orofacial region....
Oral Pathology & Medicine
Fri Jun 19, 2020 17:58
Molecular Mechanisms of Painful Traumatic Trigeminal Neuropathy – Evidence from Animal Research and Clinical Correlates
Abstract Painful traumatic trigeminal neuropathy (PTTN) may occur following major craniofacial or oral trauma, or may be subsequent to relatively minor dental interventions. Following injury, pain may originate from a peripheral nerve, a ganglion, or from the central nervous system. In this review, we focus on molecular mechanisms of pain resulting from injury to the peripheral branch of the trigeminal nerve. This syndrome has been termed painful traumatic trigeminal neuropathy (PTTN) by the International...
Oral Pathology & Medicine
Thu Jun 18, 2020 11:25
Global research trends in complex oral sensitivity disorder: a systematic bibliometric analysis of the structures of knowledge
Abstract Objectives A systematic bibliometric analysis of the structure of knowledge was performed to investigate the co‐word analysis, the co‐citation analysis, and the social network analysis regarding Complex Oral Sensitivity Disorder (COSD). Methods Web of Science database from 1985 to 2018 was systematically searched to identify all relevant articles using the MeSH terms “complex oral sensitivity disorder” and all synonyms used in the literature. We included original articles, review...
Oral Pathology & Medicine
Thu Jun 18, 2020 11:09
Liquid platelet‑rich fibrin promote the regenerative potential of human periodontal ligament cells
Abstract Objective To compare the biological effect of PRP and liquid‐PRF on human periodontal ligament cells (hPDLCs) in vitro . Methods The liquid‐PRF was processed with centrifugation at 700g for 3 minutes and PRP was processed according to Curasan’s protocol. Migration and proliferation assay were performed by a scratch/transwell assay and a CCK‐8 assay respectively. To investigate hPDLCs differentiation, alkaline phosphatase (ALP) assay, alizarin red S staining and gene expression...
Oral Diseases
Sun Jun 21, 2020 11:38
Altered Taste in Patients with COVID‐19: The Potential Role of Salivary Glands
Abstract The novel coronavirus disease (COVID‐19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) constitutes a public health emergency of international concern. Taste and smell disorders have been reported along with various other clinical problems. In some studies (Fitzgerald, 2020; Machado & Gutierrez, 2020; Parma et al., 2020; Yan, Faraji, Prajapati, Boone, & DeConde, 2020), smell and taste disturbances have been reported in COVID‐19‐positive subjects, suggesting...
Oral Diseases
Sat Jun 20, 2020 19:19
The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation
ABSTRACT Background The expression of XCR1 receptor and its metamorphic ligand lymphotactin (hLtn) has been shown in cancers but their precise role in tumorigenesis is poorly understood including the significance of the physiologically existing hLtn monomeric (CC3) and dimeric (W55D) confirmations where the latter thought to function as the receptor antagonist. The aim of this study was to explore the functional role of bioengineered hLtn variants and the role of fibroblasts in XCR1/hLtn expression...
Oral Diseases
Fri Jun 19, 2020 19:15
Oral mucosa lesions in COVID‐19
Abstract SARS‐CoV‐2 marks a new era in the medical field. The literature has outlined several signs and symptoms of COVID‐19 (Lake, 2020), but there are some manifestations not yet confirmed or not entirely described. There have been reported several dermatological conditions associated with COVID‐19: rash, urticaria and chickenpox‐like vesicles (Recalcati, 2020) and studies on cutaneous manifestations of COVID‐19 have been announced (Fernandez‐Nieto et al., 2020). The main path of COVID‐19 transmission...
Oral Diseases
Fri Jun 19, 2020 17:44
Sjögren’s syndrome in Systemic Sclerosis: impact on oral features
Abstract We read with great pleasure the interesting comments of Parat et al. on “Sjögren’s syndrome: an important confounder in evaluation of oral features in systemic sclerosis” (Parat et al., 2020). The authors highlight some aspects that we would like to address. The aim of our study (Gomes da Silva et al., 2019) was to evaluate the oral features of patients diagnosed with systemic sclerosis (SSc), and salivary gland function was one among several the aspects being assessed.
Oral Diseases
Fri Jun 19, 2020 17:34
The Alarming Burden of Non‐Communicable Diseases in COVID‐19 New Normal: Implications on Oral Health
Abstract The coronavirus disease (COVID‐19) outbreak has triggered massive debates within dental professional organizations about prioritization of offered services, served groups, and required protective measures.(Volgenant et al., 2020) While navigating through the post‐outbreak era, we aim to demonstrate the importance of continuous global focus on the burden of non‐communicable diseases (NCDs) such as oral diseases. Oral diseases are the most prevalent NCDs worldwide consuming one‐fifth of out‐of‐pocket...
Oral Diseases
Thu Jun 18, 2020 18:16
Benzo[a]pyrene promotes progression in tongue squamous cell carcinoma
Abstract Objectives Benzo[a]pyrene (B[a ]P) is a member of the polycyclic aromatic hydrocarbon (PAH) family. Although the potent carcinogenicity of high‐dose B[a ]P has been extensively reported, the effects of long‐term exposure to B[a ]P on the progression of tongue squamous cell carcinoma (TSCC) are poorly understood. Methods In the present study, TSCC cells were treated with 5 nM or 50 nM of B[a]P for three months. The proliferation and chemoresistance of B[a ]P‐treated cells to 5‐fluoruracil...
Oral Diseases
Thu Jun 18, 2020 17:30
A family‐based genome‐wide association study of recurrent aphthous stomatitis
Abstract Objectives The aetiology of recurrent aphthous stomatitis (RAS) remains unknown. Individuals may share features of genetic susceptibility and there may also be a hereditary component. The aim was to identify patterns of association and segregation for genetic variants and to identify the genes and signalling pathways that determine the risk of developing RAS, through a family‐based genome‐wide association study (GWAS). Subjects and methods DNA was extracted from buccal swabs of...
Oral Diseases
Thu Jun 18, 2020 17:25
FAK inhibition protects condylar cartilage under excessive mechanical stress
Abstract Objectives Excessive mechanical stress is assumed to be a major cause of temporomandibular joint (TMJ) osteoarthritis (OA). Focal adhesion kinase (FAK) is a cytoplasmic non‐receptor tyrosine kinase involved in a variety of signaling pathways. Little has been reported on the function of FAK in TMJ‐OA. In the present study, we investigated the effect of FAK inhibition on TMJ cartilage under excessive mechanical loading stress. Materials and Methods Articular cartilage explants were...
Oral Diseases
Thu Jun 18, 2020 17:20
Issue Information
Oral Diseases
Tue Jun 16, 2020 12:20
Cover Image
The cover image is based on the Original Article Heterogeneity of fibroblasts from radicular cyst influenced osteoclastogenesis and bone destruction by Jingwen Yang et al., https://doi.org/10.1111/odi.13317.
Oral Diseases
Tue Jun 16, 2020 12:20
Mortality statistics in England and Wales: the SARS-CoV-2 paradox
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveTo analyse mortality statistics in the United Kingdom during the initial phases of the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic and to understand the impact of the pandemic on national mortality.MethodsRetrospective review of weekly national mortality statistics in the United Kingdom over the past 5 years, including subgroup analysis of respiratory mortality rates.ResultsDuring the early phases...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Sat Jun 20, 2020 07:48
Cardiac metastasis of neuroendocrine tumor of the thymus diagnosed by cardiac magnetic resonance T1 mapping: a case report
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Carcinoid heart disease is a late complication of carcinoid syndrome, and imaging can help in the diagnosis of diffuse cardiac metastasis. We herein report a case of diffuse cardiac metastasis of a neuroendocrine tumor of the thymus diagnosed using different imaging modalities. Cardiac magnetic resonance imaging played an important role in the diagnosis. The patient underwent conservative medical treatment and remained able...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Fri Jun 19, 2020 06:17
Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveWe aimed to describe the clinical characteristics and prognosis of 22 patients with Brucella-induced reproductive system injury.MethodsWe assessed 22 patients with reproductive system injury between 2010 and 2018 at The First Affiliated Hospital of Xinjiang Medical University.ResultsThe disease is predominant in men. Male patients had orchitis, erectile dysfunction, prostatitis, and urethral stricture, while female...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 15:41
Comparison of plasma exchange, double plasma molecular adsorption system, and their combination in treating acute-on-chronic liver failure
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveOur objective was to compare the effectiveness of nonbiological artificial liver (NBAL) support, particularly short-term (28-day) survival rates, in patients who underwent treatment using double plasma molecular adsorption system (DPMAS), plasma exchange (PE), or combined PE+DPMAS, in addition to comprehensive physical treatment for different stages of acute-on-chronic liver failure (ACLF).MethodsWe retrospectively...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 13:57
Insertion of a 1.9F central venous catheter via the internal jugular vein in neonates
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveThis study aimed to develop a technique for placing a 1.9 French (F) central venous catheter in the internal jugular vein of newborns.MethodsIn this retrospective study, punctures were performed with a modified ultrasound-guided Seldinger technique with 57 1.9F catheters in 48 newborns. Punctures were performed in the right internal jugular vein in 43 (75.4%) patients and in the left internal jugular vein in 14 (24.6%)...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 12:02
Association of urinary incontinence and depression or anxiety: a meta-analysis
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveWe explored the relationship between urinary incontinence (UI) and depression or anxiety.MethodsWe searched the Cochrane Library, Embase, and PubMed for articles on the association between depression, anxiety, and UI. We calculated pooled 95% confidence intervals (CIs) and odds ratios (ORs).ResultsTwelve articles (31,462 participants) were included. The UI group had significantly higher depression and anxiety levels...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 11:04
Perioperative nursing care of a patient with urogenital sinus malformation who underwent vaginal calculus removal and correction: a case report
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Cases of urogenital sinus malformation with a huge calculus are complex and rare. Improper nursing care of these cases can lead to a series of problems. We report here a 23-year-old married woman who was admitted to hospital because of primary amenorrhea and failed sexual intercourse for 5 years. Through combined diagnosis and treatment of radiology, ultrasound, urology, gynecology, and other disciplines, the patient was diagnosed...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 10:59
Multiple extracranial metastases from glioblastoma multiforme: a case report and literature review
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Extracranial metastasis from glioblastoma multiforme (GBM) is rare, especially multi-site metastases without intracranial recurrence. However, the metastatic mechanism of GBM remains unknown and there is currently no consensus regarding the best therapeutic regimen. We report the case of a 46-year-old man with primary GBM who developed scalp metastases and subsequent multiple pulmonary metastases. He was treated with the Stupp...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 05:48
Burden of vertigo at home: Risks for patients with vertigo
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveWe aimed to clarify the burden of vertigo in patients’ homes.MethodsThis was a questionnaire survey among patients with vestibular vertigo. Four main questions were prepared. Q1: Where did you first notice vertigo? Q2: Where have you had the most difficulty with vertigo in your home? Q3: Where do you have difficulty at present? Q4: What household equipment have you used as a countermeasure to prevent further problems...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 05:46
Enalapril inhibits inflammatory osteolysis induced by wear debris in a mouse model
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectiveAseptic loosening, the most frequent complication after total joint replacement, is probably caused by an inflammatory response to the shedding of wear debris from the implant. The only effective treatment is surgical revision. Using a mouse model, we investigated whether enalapril inhibits wear debris-induced inflammatory osteolysis.MethodsTitanium (Ti) alloy particles were introduced, and calvarial bone from syngeneic...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 05:44
The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Osteoarthritis (OA) is a chronic joint disorder that causes degeneration of cartilage, synovial inflammation, and formation of osteophytes. Aging, obesity, and sex are considered the main risk factors of OA. Recent studies have suggested that metabolic syndrome (MetS) disorders, such as hypertension, hyperlipidemia, diabetes mellitus, and obesity, may be involved in the pathogenesis and progression of OA. MetS disorders are...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 05:42
Natural compounds attenuate heavy metal-induced PC12 cell damage
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesTo investigate the neuroprotective effects of six natural compounds (caffeine, gallic acid, resveratrol, epigallocatechin gallate [EGCG], L-ascorbic acid and alpha tocopherol [Vitamin E] on heavy metal-induced cell damage in rat PC12 cells.MethodsIn this in vitro experiment, rat PC12 cells were exposed to four heavy metals (CdCl2, HgCl2, CoCl2 and PbCl2) at different concentrations and cell apoptosis, necrosis and...
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents
Thu Jun 18, 2020 04:52
Diagnostic value of preoperative fine needle aspiration cytology in parotide gland tumors
Abstract Background Salivary gland masses constitute a broad spectrum of lesions ranging from non‐neoplastic to benign and malignant lesions. Parotid is the largest salivary gland and constitutes 75% to 80% of all salivary gland areas. 80% of parotid lesions are benign and 20% are malignant. Methods Two‐hundred and eight‐six patients who underwent aspiration cytology in the pathology laboratory between January 1995 and January 2019, evaluated with a sufficient sample and diagnosed, and...
Diagnostic Cytopathology
Sat Jun 20, 2020 17:18
Predictive value of MCM5 (ADXBLADDER) analysis in urine of men evaluated for the initial diagnosis of bladder cancer: A comparative prospective study
Abstract Background To compare predictive value of MCM5 to urinary cytology (UC) for the primary diagnosis of bladder cancer (BCa). Methods We prospectively enrolled 91 patients who presented macroscopic hematuria or persistent lower urinary tract symptoms at our institution. Single voided mid‐stream urine specimens were collected for UC and MCM5 (ADXBLADDER; Arquer Diagnostics Ltd, Sunderland, United Kingdom) assessment. Cystoscopy was used as confirmatory test, and positive cases underwent...
Diagnostic Cytopathology
Sat Jun 20, 2020 16:07
Adamantinoma‐like Ewing sarcoma of the thyroid
Abstract Adamantinoma‐like Ewing sarcoma (ALES) is a rare variant of Ewing sarcoma family of tumors (ESFTs). ALES is characterized by translocations of the EWSR 1 (Ewing sarcoma breakpoint region 1) gene on chromosome 22, morphologic features of small round blue cell tumors with focal squamous differentiation, and a unique immunoprofile. Herein, we report a 21‐year‐old patient who presented with severe, acute onset back pain. Imaging revealed a large, exophytic, heterogeneously enhancing mass in...
Diagnostic Cytopathology
Fri Jun 19, 2020 22:35
Fine‐needle aspiration findings of fibroadenoma with pseudolactational changes in the vulva: A case report
Abstract Fibroadenoma is a common benign neoplasm of the breast and ectopic breast tissue, associated with possible lactational changes in pregnant or lactating women. Uncommon pseudolactational changes are possible in this neoplasm among nulliparous women. Fibroadenoma and lactating adenoma are rarely seen in the vulvar region. Theoretically, pseudolactational changes can occur in fibroadenomas of the vulva in young nulliparous women although there have been no reports so far. In this case report,...
Diagnostic Cytopathology
Fri Jun 19, 2020 19:04
Cytomorphological spectrum of hand, wrist, and foot lesions at tertiary care center in central India
Abstract Background Fine‐needle aspiration cytology (FNAC) being a fast technique is used as a primary investigation to diagnose wide spectrum of hand, wrist, and foot lesions. These sites are prone to trauma, reparative, and infectious process, which forms mass lesions mimicking neoplasia. Our study highlighted the importance of FNAC with the chance of reduction in biopsy or excision. Aims and objectives To report the prevalence and cytomorphological spectrum of hand and foot lesions with...
Diagnostic Cytopathology
Fri Jun 19, 2020 18:49
Amelanotic melanoma recurrence diagnosed by fine‐needle aspiration cytology: A case report
Abstract Amelanotic melanoma is a variant of malignant melanoma. Amelanotic melanoma has similar morphology of a wide variety of epithelial and non‐epithelial malignant tumours, variable cytomorphology of melanoma has been described on exfoliative and fine‐needle aspiration cytology (FNAC). Aim of index study to describe FNAC of a rare case of recurrent amelanotic melanoma of right lateral knee swelling. Case: A 37‐year‐old male presented right lateral knee multi‐nodular swelling last for 1 month...
Diagnostic Cytopathology
Thu Jun 18, 2020 20:22
The predictive value of positive and suspicious urine cytology: Are they different?
Abstract Background Urine cytology evaluation is an effective test in the detection of high‐grade urothelial carcinoma (HGUC). While the guideline distinguishes the 2 categories: “positive for HGUC” (PHGUC) and “suspicious for HGUC” (SHGUC), the association between these categories with their subsequent follow‐up biopsies remains unclear. This study aims to determine and compare the positive predictive value (PPV) of the specimens in PHGUC and SHGUC categories with their respective histologic...
Diagnostic Cytopathology
Thu Jun 18, 2020 20:22
High‐Activity Organocatalysts for Synthesis of Polyether via Intramolecular Ammonium Cation‐Assisted SN2 Ring‐Opening Polymerization
Current metal‐catalyzed ring‐opening polymerization (ROP) of epoxides for polyether production suffers from low catalytic efficiency and stubborn metal residue. Herein, we communicate a kind of bifunctional organocatalyst that has unprecedented reactivity for synthesis of polyether under mild conditions. Our bifunctional organoboron catalyst incorporates two 9‐borabicyclo[3.3.1]nonane  complexing boron centers on the both sides as Lewis‐acid sites for epoxides activation and a quaternary ammonium...
Angewandte Chemie International Edition
Sat Jun 20, 2020 13:03
Hypoxia‐instructed pro‐protein therapy assisted with self‐catalyzed nanozymogen
The success of intracellular protein therapy demands potent intracellular delivery efficiency and selective protein activity in diseased cells. To fulfil these requirements, a cascaded nanozymogen incorporating hypoxia‐instructed pro‐protein engineering and hypoxia‐strengthened intracellular protein delivery was developed. RPAB, a pro‐protein of RNase A reversibly caged with hypoxia‐cleavable azobenzene yet deprived of the enzymatic activity, was designed and co‐delivered with glucose oxidase (GOx)...
Angewandte Chemie International Edition
Sat Jun 20, 2020 12:37
Proving and Probing the Presence of the Elusive C‐H∙∙∙O Hydrogen Bond in Liquid Solutions at Room Temperature
Hydrogen bonds (H‐bonds) play a major role in defining the structure and properties of many substances, as well as phenomena and processes. Traditional H‐bonds are ubiquitous in nature and have received considerable attention, yet the demonstration of weak H‐bonds, as occur between a highly polarized C‐H group and an electron‐rich oxygen atom, have proven elusive. Herein, we detail linear and non‐linear IR spectroscopy experiments that reveal the presence of H‐bonds between the chloroform C‐H group...
Angewandte Chemie International Edition
Fri Jun 19, 2020 22:05
Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6‐Disubstituted Tetrazines from Carboxylic Ester Precursors
As tetrazines are important tools to the field of bioorthogonal chemistry, there is a need for new approaches to synthesize unsymmetrical and 3‐monosubstituted tetrazines. Described here is a general, one‐pot method for converting (3‐methyloxetan‐3‐yl)methyl carboxylic esters into 3‐thiomethyltetrazines. These versatile intermediates were applied as a platform for the synthesis of unsymmetrical tetrazines via Pd‐catalyzed cross‐coupling and in the first example of catalytic thioether reduction to...
Angewandte Chemie International Edition
Fri Jun 19, 2020 22:04
The mineral/water interface probed with nonlinear optical spectroscopy
The interaction between minerals and water is relevant for a wide range of geological, atmospheric, environmental, and electro(photo‐)chemical systems. This interaction is manifold and complex: the mineral surface can be (de‐)protonated by water, thereby changing its charge, and thus the interaction with water; mineral ions dissolved into the aqueous phase screen the surface charges, also modifying the water interaction. Intrinsically molecular‐level processes and interactions thus govern macroscopic...
Angewandte Chemie International Edition
Fri Jun 19, 2020 22:00
BIMP Catalyzed 1,3‐Prototropic Shift for the Highly Enantioselective Synthesis of Conjugated Cyclohexenones
A bifunctional iminophosphorane (BIMP) catalyzed enanti‐oselective synthesis of α,β‐unsaturated cyclohexenones via a facially selective 1,3‐prototropic shift of β,γ‐unsaturated prochiral isomers, under mild reaction conditions and in short reaction times, on a range of structurally diverse substrates, is reported. α,β‐Unsaturated cyclohexenone products primed for downstream derivatisation were obtained in high yields (up to 99%) and consistently high enantioselectivity (up to 99% ee). In‐depth studies...
Angewandte Chemie International Edition
Fri Jun 19, 2020 17:34
Highly Concentrated Electrolyte towards Enhanced Energy Density and Cycling Life of Dual‐Ion Battery
Dual‐ion batteries (DIBs) have attracted much attention owing to their low‐cost, high‐voltage, and environmental friendliness. As the source of active ions during the charging/discharging process, the electrolyte plays a critical role in the performance of DIBs, including capacity, energy density, and cycling life. However, most used electrolyte systems based on the LiPF 6 salt shows unsatisfied performance in DIBs. In this work, we successfully developed a 7.5 m lithium bis(fluorosulfonyl)imide...
Angewandte Chemie International Edition
Fri Jun 19, 2020 17:34
4‐Dimensional DNA‐gold nanoparticle assemblies
Although utilizing oligonucleotides to organize gold nanoobjects has resulted in many three dimensional colloidal assemblies that show a large diversity in size, shape and complexity, autonomous and temporal control of their formation is still a great challenge. In contrast, living systems temporally and spatially self‐regulate the formation of functional structures by internally orchestrating assembly and disassembly kinetics of dissipative biomacromolecular networks. Taking such systems from nature...
Angewandte Chemie International Edition
Fri Jun 19, 2020 15:37
Two Pyrophosphates with Large Birefringences and Second‐Harmonic Responses as Ultraviolet Nonlinear Optical Materials
Two new pyrophosphates nonlinear optical (NLO) materials, Rb3PbBi(P2O7)2 (I) and Cs3PbBi(P2O7)2 (II), were successfully designed and synthesized. Both compounds exhibit large nonlinear optical (NLO) effects and birefringences. Especially, I presents the scarce case of possessing the coexistence of large birefringence (0.031 at 1064 nm and 0.037 at 532 nm) and second harmonic generation (SHG) response (2.8 × KDP) in ultraviolet (UV) NLO phosphates and breaks through the zero pyrophosphates with large...
Angewandte Chemie International Edition
Fri Jun 19, 2020 15:37
An Unusual Adduct of SO to a Frustrated Sn/P Lewis Pair
The geminal frustrated Lewis pair (F 5 C 2 ) 3 Sn­CH 2 ­P(tBu) 2  ( 1 ) reacted with N ‐ sulfinylaniline PhNSO to afford the first sulphur monoxide adduct of a main group metal (F 5 C 2 ) 3 Sn­CH 2 ­P(tBu) 2 ·SO ( 2 ). It contains a SnCPSO ring. The second product is a phenylnitrene adduct of 1 . The surprising stability of 2 was compared with the so far inaccessible O 2 and S 2 adducts of 1 . Attempts to prepare these from 1 and the elemen­tal chalcogens (O...
Angewandte Chemie International Edition
Thu Jun 18, 2020 22:00
An RCM‐Based Total Synthesis of the Antibiotic Disciformycin B
The total synthesis of the potent new antibiotic disciformycin B (2) is described, which shows significant activity against methicillin‐ and vancomycin‐resistant Staphylococcus aureus (MRSA/VRSA) strains. The synthetic route is based on macrocyclization of a tetraene substrate to the 12‐membered macrolactone core by ring‐closing olefin metathesis (RCM). Although macrocyclization was accompanied by concomitant cyclopentene formation by an alternative RCM pathway, conditions could eventually be established...
Angewandte Chemie International Edition
Thu Jun 18, 2020 20:36
Biocatalysis: Enzymatic Synthesis for Industrial Applications
Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are also used on large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using...
Angewandte Chemie International Edition
Thu Jun 18, 2020 20:01
Naphthalene Diimide‐Based Ionenes as Universal Interlayers for Efficient Organic Solar Cells
Self‐doping ionone polymers were efficiently synthesized by reacting functional naphthalene diimide (NDI) with 1,3‐dibromopropane ( NDI‐NI ) or trans‐1,4‐dibromo‐2‐butene ( NDI‐CI ) via quaternization polymerization. These NDI‐based ionene polymers are universal interlayers with random molecular orientation, boosting the efficiencies of fullerene‐based, non‐fullerene‐based, and ternary organic solar cells (OSCs) over a wide range of interlayer thicknesses, with maximum efficiency of 16.9%....
Angewandte Chemie International Edition
Thu Jun 18, 2020 18:59
Template‐directed copying of RNA by non‐enzymatic ligation
The non‐enzymatic replication of the primordial genetic material is thought to have enabled the evolution of early forms of RNA‐based life. However, the replication of oligonucleotides long enough to encode catalytic functions is problematic due to the low efficiency of template copying with mononucleotides. Here we show that template‐directed ligation can assemble long RNAs from shorter oligonucleotides, which would be easier to replicate. The rate of ligation can be greatly enhanced by employing...
Angewandte Chemie International Edition
Thu Jun 18, 2020 18:59
Ultrafast Exciton Self‐trapping and Delocalization in Cycloparaphenylenes: The Role of Excited‐state Symmetry in Electron‐vibrational Coupling
Upon photon absorption, π‐conjugated organics are apt to undergo ultrafast structural reorganization via electron‐vibrational coupling during non‐adiabatic transitions. Ultrafast nuclear motions modulate local planarity and quinoid/benzenoid characters within conjugated backbones which control primary events in the excited states such as localization, energy transfer, etc. In this study, fs ‐broadband fluorescence upconversion measurements were conducted to investigate exciton self‐trapping and...
Angewandte Chemie International Edition
Thu Jun 18, 2020 18:34
A Rhombicuboctahedral Ag100: Four‐Layered Octahedral Silver Nanocluster Adopting the Russian Nesting Doll Model
Precise atomic structure of metal nanoclusters (NCs) is fundamental to elucidate the structure‐property relationship and the inherent size‐evolution principles. Herein, we report the largest known FCC‐based (FCC denotes face‐centered‐cubic) silver nanocluster, [Ag 100 (SC 6 H 3 3,4 F 2 ) 48 (PPh 3 ) 8 ] ‐ : the first all‐octahedral symmetric nesting Ag nanocluster with four‐layered Ag 6 @Ag 38 @Ag 48 S 24 @Ag 8 S 24 P 8 structure, consistent symmetry elements, and a...
Angewandte Chemie International Edition
Thu Jun 18, 2020 17:09

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