Primary pulmonary myxoid sarcoma (PPMS) is a recently reported, exceedingly rare low-grade lung neoplasm characterized by reticular/lace-like growth of spindle to epithelioid cells embedded in an abundant myxoid matrix. Morphologically, it overlaps with a myxoid variant of angiomatoid fibrous histiocytoma (AFH) of the soft tissue. Genetically, they were both reported to harbor EWSR1-CREB1 fusion, while EWSR1-ATF1 has only been reported in AFH thus far. We report a case of primary pulmonary low-grade...
Wed Oct 14, 2020 03:57
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant tumors of the central nervous system that predominantly occur in infants, and are characterized by the presence of rhabdoid cells and inactivation of INI1 or (rarely) BRG1. Most AT/RT are identified as primary tumors; however, rare AT/RT or INI1-deficient RTs arising from other primary tumors have been reported. Here, we report 3 cases of hitherto unclassifiable low-grade tumors with loss of INI1 nuclear expression, for which we propose...
Wed Oct 14, 2020 03:57
ESR1 and GREB1 fusions have recently been described in uterine tumor resembling ovarian sex cord tumor (UTROSCT). Thus far, recurrences have been documented in a subset of those harboring GREB1 fusions, but not in those with ESR1 rearrangements. Here we describe the clinicopathologic features of 3 recurrent UTROSCTs with striking rhabdoid morphology (an unusual feature of these tumors overall) and ESR1-NCOA2 fusions. The patients were 32, 37, and 54 years at initial diagnosis and first recurrence...
Wed Oct 14, 2020 03:57
The spectrum of benign superficial fibroblastic/myofibroblastic tumors continues to expand and includes entities such as plexiform fibrohistiocytic tumor, dermatomyofibroma and fibroblastic connective tissue nevus. Here, we describe a seemingly distinctive group of lesions which we have labeled “plexiform myofibroblastoma” (PM). PM is a rare superficial mesenchymal tumor of fibroblastic/myofibroblastic lineage that predominantly occurs in children and young adults. Thirty-six cases from the consultation...
Wed Oct 14, 2020 03:57
Intravascular lobular capillary hemangioma (ILCH), or intravascular pyogenic granuloma, is relatively rare and likely underrecognized. We reviewed all ILCH cases from our institution confirmed pathologically from 2006 to 2019. Immunostains for smooth muscle actin and Wilms tumor 1 were performed on all cases and prior immunohistochemical stains were reviewed. Forty cases were identified (22 females; 18 males) with a median age of 53 years (range: 13 to 85 y). Clinically, all were well-circumscribed,...
Wed Oct 14, 2020 03:57
Individuals with acquired cystic kidney disease (ACKD) in the setting of end-stage renal disease (ESRD) have a high risk of developing renal cell carcinoma (RCC). ACKD-RCC is considered a distinct renal neoplasm in the International Society of Urologic Pathologists (ISUP)-World Health Organization (WHO) classification of kidney tumors which may behave aggressively. Since its original description, there have been multiple case reports and series published; however, the pathogenesis of this neoplasm...
Wed Oct 14, 2020 03:57
Helicobacter pylori infection is present in two thirds of the world’s population and induces a myriad of human diseases, ranging from gastritis to gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Detection is critical for treatment and may require immunohistochemical (IHC) staining when organisms are not visible on hematoxylin and eosin. We have encountered cases in which IHC for Helicobacter pylori failed to demonstrate curvilinear or coccoid organisms, but did show a reticular...
Wed Oct 14, 2020 03:57
Synovial sarcoma most commonly occurs in the extremities but has rarely been described in the female genital tract. In this series, we describe the clinical, morphologic, immunohistochemical, and molecular features of 7 cases of vulvovaginal synovial sarcoma (vulva, n=6; vagina, n=1). We emphasize their wide morphologic spectrum, which can overlap significantly with other more common tumors at these sites, as highlighted by 2 cases initially diagnosed as other entities (endometrioid carcinoma and...
Wed Oct 14, 2020 03:57
High-grade neuroendocrine carcinomas (NEC) of the endometrium are rare and account for
Wed Oct 14, 2020 03:57
Although rectal neuroendocrine tumors (NETs) with an L-cell phenotype and small size are generally less clinically serious, the new 2019 World Health Organization (WHO) classification system has categorized all of these lesions as malignant. Identifying biomarkers of rectal NETs is thus important for stratifying their clinical behavior. Chromogranin A protein expression was assessed in 538 endoscopically or surgically resected rectal NETs and compared with clinicopathologic factors to identify its...
Wed Oct 14, 2020 03:57
Glomus tumors (GTs), together with myofibroma (MF), myopericytoma (MP), and angioleiomyoma (AL) are classified as members of the perivascular myoid family of tumors. The reported genetic abnormalities across these neoplasms is dissimilar, arguing against a pathogenetically unified family; half of the GT showing NOTCH-gene fusions and a smaller subset BRAFV600E mutations, while PDGFRB mutations are noted in a subset of MF and MP. This study aimed to investigate the prevalence and specificity of NOTCH-gene...
Wed Oct 14, 2020 03:57
HPV-independent Precursors Mimicking High-grade Squamous Intraepithelial Lesions (HSIL) of the Vulva
Two etiopathogenic types of vulvar squamous cell carcinoma (VSCC) have been described: human papillomavirus (HPV)-associated and HPV-independent. Precursor lesions, frequently identified in the adjacent skin, are also distinct in the 2 types of VSCC: high-grade squamous intraepithelial lesions (HSILs) in HPV-associated VSCC and differentiated vulvar intraepithelial neoplasia (dVIN) or vulvar acanthosis with altered differentiation in HPV-independent VSCC. Although HPV-independent precursors mimicking...
Wed Oct 14, 2020 03:57
Uterine carcinosarcomas (UCSs) are aggressive neoplasms composed of high-grade malignant epithelial and mesenchymal elements with most (∼90%) showing TP53 abnormalities. A subset, however, shows mismatch repair deficiency (MMR-D). We sought to describe their clinical, morphologic, and molecular features. Clinicopathologic data of MMR-D UCSs were recorded including age, stage, follow-up, mismatch repair and p53 immunohistochemistry (IHC), MLH1 promoter methylation status, and germline alterations,...
Wed Oct 14, 2020 03:57
Horm Metab Res 2020; 52: 732-741DOI: 10.1055/a-1240-5850Association between vitamin D and uric acid is complex and might be bidirectional. Our study aimed to determine the bidirectional association between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus, we systematically searched for observational or interventional studies in adults, which assessed the association between serum vitamin...
Tue Oct 13, 2020 02:00
Cochlear implantation under local anesthesia and conscious sedation: an Italian experience. Eur Arch Otorhinolaryngol. 2020 Oct 12;: Authors: Vincenti V, Plantone F, Ciavarro G, Lusetti F, Bartoli R, Di Lella F, Negri M, Fiorella ML, Quaranta N Abstract PURPOSE: To report our experience in performing cochlear implantation under local anesthesia in a group of patients who were deemed unfit for general anesthesia. METHODS: A retrospective...
Wed Oct 14, 2020 00:51
Pearls on resecting the TMJ chondrosarcoma: how i do it. Eur Arch Otorhinolaryngol. 2020 Oct 12;: Authors: Chia ZJ, Gan YJ, Lim MY Abstract BACKGROUND: Chondrosarcoma of the head and neck is uncommon and Chondrosarcoma of the Temporomandibular Joint is exceedingly rare. We present a 67-year-old male with a large right TMJ Chondrosarcoma. METHODS: Patient underwent right segmental mandibulectomy with excision of TMJ tumor, lateral temporal bone...
Wed Oct 14, 2020 00:51
Evaluation of HPV-related oral cancer using DNA microarray technology according to the 8th edition of the AJCC staging system. Eur Arch Otorhinolaryngol. 2020 Oct 12;: Authors: Kwon IJ, Lee JH, Kim SM PMID: 33044594 [PubMed - as supplied by publisher]
Wed Oct 14, 2020 00:51
Publication date: Available online 12 October 2020Source: Human PathologyAuthor(s): Cynthia Magro, J. Justin Mulvey, Jeffrey Laurence, Surya Seshan, A. Neil Crowson, Andrew J. Dannenberg, Steven Salvatore, Joanna Harp, Gerard J. Nuovo
Tue Oct 13, 2020 23:53
Publication date: Available online 12 October 2020Source: Human PathologyAuthor(s): Thomas J. Giordano, Daniel Berney, Ronald R. de Krijger, Lori Erickson, Martin Fassnacht, Ozgur Mete, Thomas Papathomas, Mauro Papotti, Hironobu Sasano, Lester D.R. Thompson, Marco Volante, Anthony J. Gill
Tue Oct 13, 2020 23:53
The role of computed tomography and magnetic resonance imaging for preoperative pediatric cochlear implantation work-up in academic institutions. Cochlear Implants Int. 2020 Oct 11;:1-7 Authors: Ambrosio AA, Loundon N, Vinocur D, Kruk P, Le Pointe HD, Chalard F, Zapala M, Carvalho D Abstract OBJECTIVE: The goal of the study is to investigate the association of pertinent preoperative temporal bone computed tomography (CT) and brain magnetic...
Tue Oct 13, 2020 23:36
Background. Bilious vomiting in the newborn is common and requires urgent attention to exclude malrotation. The proportion of neonates with surgical abnormalities, however, is small, and there are other causes. Study Objectives. We reviewed our experience of infants with bilious vomiting to demonstrate the importance of input from the tertiary surgical and medical team to arrive at the correct diagnosis. Design. Admissions with bilious vomiting/aspirates of term born infants over a three-year period...
Tue Oct 13, 2020 10:50
Publication date: Available online 12 October 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): S. Vergez, N. Fakhry, C. Cartier, T. Kennel, M. Courtade-Saidi, E. Uro-Coste, A. Varoquaux, C.-A. Righini, O. Malard, P. Mogultay, J. Thariat, S. Tronche, R. Garrel, D. Chevalier
Tue Oct 13, 2020 21:40
Publication date: November 2020Source: Neoplasia, Volume 22, Issue 11Author(s): Xiaoxiao Fan, Yirun Li, Xin Yi, Guoqiao Chen, Shengxi Jin, Yili Dai, Bin Cui, Binghua Dai, Hui Lin, Daizhan Zhou
Tue Oct 13, 2020 21:38
Abstract Introduction We present here a literature review focusing on the repercussions of osteoporosis on the oral and maxillofacial complex. Osteoporosis is a silent metabolic disorder characterized by reduced bone mineral density (BMD), which can lead to bone fractures, particularly affecting elderly women. The prevalence of this disease has increased significantly worldwide, and since it accelerates bone resorption also in the jaw...
Tue Oct 13, 2020 03:00
This is the first reported case of follicular T‐cell lymphoma (FTCL) that primarily developed in the extranodal site of the right submandibular gland. An 86‐year‐old man was detected with a right cervical mass suspected to be malignant lymphoma during his physical examination. Imaging studies revealed that the mass was a submandibular gland tumor. The tumor was excised for diagnosis and treatment. Pathologically, the tumor was composed of densely aggregated lymphocytes with a follicular growth pattern....
Tue Oct 13, 2020 18:18
Abstract We aimed to detect the causative gene in five unrelated families with recessive inheritance pattern neurological disorders involving the central nervous system, and the potential function of the NEMF gene in the central nervous system. Exome sequencing (ES) was applied to all families and linkage analysis was performed on family 1. A minigene assay was used to validate the splicing effect of the relevant discovered variants. Immunofluorescence (IF) experiment was performed...
Tue Oct 13, 2020 03:00
Abstract Background Using the rat sciatic nerve model, the difference in outcome using a nerve segment either sliced open or minced with a blade incorporated into a nerve conduit were compared and the relative effects upon the rate and completeness of the nerve regeneration was determined. Materials and Methods A 10‐mm gap was created in the rat sciatic nerve and bridged with a biodegradable nerve conduit. Segments of the resected nerve (2‐mm lengths) were prepared by either slicing the...
Tue Oct 13, 2020 18:33
Publication date: Available online 12 October 2020Source: Revista de Logopedia, Foniatría y AudiologíaAuthor(s): Henriette W. Langdon
Tue Oct 13, 2020 19:20
Publication date: Available online 12 October 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Safa Manav, M. Sühan Ayhan, Erkan Deniz, Esra Özkoçer, Çiğdem Elmas, Meltem Yalinay, Erdem Şahin
Tue Oct 13, 2020 18:49
Publication date: Available online 12 October 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Assalmi Mustapha, Diaf El Yamani, Mansour Najim
Tue Oct 13, 2020 18:45
Abstract Following infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of ‘gut-homing’ integrin β7 on peripheral blood αβT cells. This subset of patients with intestinal symptoms also displayed a striking and persistent expansion of putative Vδ2+ γδT cells in the circulation which declined over a 2-year period following drug infusion,...
Tue Oct 13, 2020 03:00
Publication date: Available online 13 October 2020Source: Academic RadiologyAuthor(s): Zhaonan Li, Dexun Hao, Dechao Jiao, Wenguang Zhang, Xinwei Han
Tue Oct 13, 2020 18:40
We present a novel all‐fiber probe with 710‐μm outside diameter for combined optical coherence tomography and pH detection. In cancer surgery, a significant challenge is how to completely remove the malignant tumor without cutting too much normal tissue. The difference between cancer tissue and normal tissue not only lies in morphology and structure but also in tissue pH, where malignant tissue has a lower pH. This dual‐modality probe combined optical coherence tomography and pH detection of biological...
Tue Oct 13, 2020 16:07
Abstract Selectin ligands are present on the surface of tumour cells, for this reason lowering the L‐selectin level in the blood and lymph can indicate presence of the tumour. Therefore the selectin level in the plasma are potential targets for anti‐cancer therapy. We demonstrate the surface enhanced Raman spectroscopy (SERS)‐based sensor for the determination of L‐selectin level in biological samples that can be used in medical diagnosis. The combination of SERS with the method of multivariate...
Tue Oct 13, 2020 15:46
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance quinmerac. To assess the occurrence of quinmerac residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EC) No 33/2008, the European authorisations reported by Member States (including the supporting residues...
Tue Oct 13, 2020 12:02
Abstract Stress Recovery Theory (SRT) suggests that time spent in nature reduces stress. While many studies have examined changes in stress physiology after exposure to nature imagery, nature virtual reality, or nature walks, this study is the first to examine changes in heart rate (HR) and vagally mediated HR variability, as assessed by Respiratory Sinus Arrythmia (RSA), after a longer duration of nature exposure. Consistent with SRT, we hypothesized that immersion in nature would promote stress...
Tue Oct 13, 2020 16:10
Abstract Infant autonomic reactivity to stress is a potential predictor of later life health complications, but research has not sufficiently examined sympathetic activity, controlled for effects of physical activity and respiration, or studied associations among autonomic adjustments, cardiac activity, and affect in infants. We studied 278 infants during the repeated Still‐Face Paradigm, a standardized stressor, while monitoring cardiac activity (ECG) and respiratory pattern (respiratory inductance...
Tue Oct 13, 2020 16:09
Abstract In healthy, young individuals, a reduction in cardiovascular output and a shift from sympathetic to parasympathetic (vagal) dominance is observed from wake into stages of nocturnal and daytime sleep. This cardiac autonomic profile, measured by heart rate variability (HRV), has been associated with significant benefits for cardiovascular health. Aging is associated with decreased nighttime sleep quality and lower parasympathetic activity during both sleep and resting. However, it is not...
Tue Oct 13, 2020 16:08
Abstract Background Children and adolescents with juvenile idiopathic arthritis (JIA) may suffer pain from temporomandibular disorder (TMD). Still, routines for the assessment of temporomandibular joint (TMJ) pain in health and dental care are lacking. The aims of this study were to examine the prevalence of TMD in children and adolescents with JIA compared to their healthy peers and to investigate potential associations between...
Tue Oct 13, 2020 03:00
Abstract Background Coronavirus Disease (COVID-19) epidemic is a public health emergency of international concern. Dentists are exposed to the enormous risk of COVID-19 infection during this epidemic. This study aims to assess the knowledge and practice of dentists toward the COVID-19 epidemic in Lebanon. Methods We conducted an online...
Tue Oct 13, 2020 03:00
Summary Diverse inherited and acquired abnormalities in epidermal structural and enzymatic proteins compromise permeability, barrier function and antimicrobial defense in atopic dermatitis (AD). Though several mutations in filaggrin (FLG) predominate, alterations in other S‐100, cornified envelope precursor proteins (hornerin [HRNR], filaggrin 2 [FLG2], SPRR3, mattrin) which regulate lamellar body formation; SPINK5, which encodes the serine protease inhibitor, LEKTI1, and a fatty acid transporter,...
Tue Oct 13, 2020 17:27
Diagnosis of maxillary sinus pathology must include the clinical radiological study (CRS) and histopathological analysis. The aim of this study is 1) to describe the clinicopathological features of maxillary s...
Tue Oct 13, 2020 03:00
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Immune checkpoint inhibitors are rapidly becoming popular therapeutic options for patients suffering from a number of malignancies. Atezolizumab is a programmed cell death ligand-1 inhibitor, and binding to this ligand decreases the ability of tumor cells to evade the immune system, resulting in self-tolerance. While inhibition of these molecules leads to increased T-cell destruction of tumor cells,...
Tue Oct 13, 2020 13:03
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Merkel cell carcinoma (MCC) is a rare malignant neuroendocrine tumor more common in immunosuppressed old patients. It is characterized by a high frequency of local recurrence, regional nodal metastasis, distant metastasis, and low survival rate. The diagnosis of MCC is challenging due to its rarity and can be clinically mistaken for other skin cancer. We report a case of locally advanced MCC of the...
Tue Oct 13, 2020 13:03
Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease
Abstract Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by recruitment of leukocytes into skin and release of damaging enzymes, resulting in epidermal detachment and blister formation. To better understand the role of leukotriene B4 (LTB4) and other inflammatory factors in BP pathophysiology, we conducted microscopic and immunohistochemical analyses of preserved skin biopsy sections and conducted flow cytometry and ELISA analyses of matched blood and blister fluid from...
Mon Oct 12, 2020 17:06
High Altitude Medicine &Biology, Ahead of Print.
Mon Oct 12, 2020 10:00
Publication date: Available online 13 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Farhan Zubair, Jeremy McMahon, Eva Carson, James McCaul, W. Stuart Hislop, Craig Wales, Mark Ansell, Ewen Thomson, Shiva Subramaniam, Kevin Fitzpatrick
Tue Oct 13, 2020 16:52
Risk factors for post-extraction bleeding in patients with haemophilia: a retrospective cohort study
Publication date: Available online 12 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Takahiro Yagyuu, Sachiko Yata, Mitsuhiko Imada, Naoki Funayama, Yuichiro Imai, Koji Yada, Keiji Nogami, Tadaaki Kirita
Tue Oct 13, 2020 16:52
Publication date: Available online 12 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Zhengzhong Shen, Can Lu, Long Huang, Ning Li, Weiming Wang, Canhua Jiang
Tue Oct 13, 2020 16:52
Publication date: Available online 12 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Khaled Borghol, Ahmed Abdelrahman, Nicolaos Pigadas
Tue Oct 13, 2020 16:52
Background The European Randomized Study of Screening for Prostate Cancer has shown a 20% reduction in prostate cancer (PC) mortality by prostate‐specific antigen–based screening. In addition, screening has been shown to reduce the risk of advanced PC. The objective of the current study was to analyze the impact of screening participation on the incidence of PC by risk group. Methods The participants in the screening arm of the Finnish trial (31,867 men) were classified according to screening...
Tue Oct 13, 2020 15:49
Background Evidence suggests that early‐onset gastric cancers are distinct from traditional gastric cancers; however, detailed genomic and morphologic characterization of these cancers has not been performed. Methods Genomic analysis was performed for 81 patients with gastric cancer who were 50 years old or younger; pathology slides were available for 53 of these patients, and they were re‐reviewed to perform a morphologic‐molecular correlation analysis. The results were compared with corresponding...
Tue Oct 13, 2020 15:41
Background Treatment characteristics such as cranial radiation therapy (CRT) do not fully explain adiposity risk in childhood acute lymphoblastic leukemia (ALL) survivors. This study was aimed at characterizing genetic variation related to adult body mass index (BMI) among survivors of childhood ALL. Methods Genetic associations of BMI among 1458 adult survivors of childhood ALL (median time from diagnosis, 20 years) were analyzed by multiple approaches. A 2‐stage genome‐wide association study...
Tue Oct 13, 2020 15:40
Abstract Background To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods We followed 5743 OSCCs between 2004 and 2009 from a population‐based screening program and ascertained death until the end of 2012. Results The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30‐1.65) and 1.18 (1.04‐1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks....
Tue Oct 13, 2020 16:35
Abstract Background Data supporting linear accelerator (linac) stereotactic radiosurgery (SRS) for jugulotympanic paragangliomas (JTPs) come from small series with minimal follow‐up. Herein, we report a large series of JTPs with extended follow‐up after frameless linac‐based SRS. Methods JTPs treated with linac‐based SRS from 2002 to 2019 with 1+ follow‐up image were reviewed for treatment failure (radiographic or clinical progression, or persistent symptoms after SRS requiring intervention)...
Tue Oct 13, 2020 11:49
Tue Oct 13, 2020 11:56
Abstract Objectives The current COVID‐19 outbreak in conjunction with the need to provide safe dental treatments, and the limited knowledge on the efficacy of protective measures has posed dentists into a challenging situation. Therefore, the present article aimed at collecting experiences and recommendations of front‐line clinical experts on critical aspects of dental treatment provision during pandemic. Material & Methods From a total of 32 European countries, one leading academic...
Mon Oct 12, 2020 17:30
Publication date: Available online 12 October 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Yolanda Escamilla Carpintero, María Teresa Sellares Fabres, Carmen Blázquez Maña, Mario Prenafeta Moreno
Tue Oct 13, 2020 16:19
Publication date: Available online 12 October 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Filipe Correia, Ana Beatriz Medeiros, Luís Castelhano, Pedro Cavilhas, Pedro Escada
Tue Oct 13, 2020 16:19
Publication date: November 2020Source: European Journal of Cancer, Volume 140Author(s): Ashley V. Geerlinks, Aaron Campigotto, Michelle Science, Sumit Gupta
Tue Oct 13, 2020 16:12
Publication date: November 2020Source: European Journal of Cancer, Volume 140Author(s): Marcel Wiesweg, Fabian Mairinger, Henning Reis, Moritz Goetz, Jens Kollmeier, Daniel Misch, Susann Stephan-Falkenau, Thomas Mairinger, Robert F.H. Walter, Thomas Hager, Martin Metzenmacher, Wilfried E.E. Eberhardt, Gregor Zaun, Johannes Köster, Martin Stuschke, Clemens Aigner, Kaid Darwiche, Kurt W. Schmid, Sven Rahmann, Martin Schuler
Tue Oct 13, 2020 16:12
Abstract Background Although MR elastography allows for quantitative evaluation of liver stiffness to assess chronic liver diseases, it has associated drawbacks related to additional scanning time, patient discomfort, and added costs. Objective To develop a machine learning model that can categorically classify the severity of liver stiffness using...
Tue Oct 13, 2020 03:00
Abstract We describe the heretofore unreported case of an HPV-related carcinoma of the palatine tonsil with distinct areas of squamous cell- and adenoid cystic carcinoma-like differentiation in a 54-year old patient. The morphological, immunophenotypic and molecular findings of the tumor are illustrated. We discuss the parallels between the tumor and HPV-related multiphenotypic sinonasal carcinoma (HMSC) which is well-known to exhibit adenoid cystic carcinoma-like features. A review...
Tue Oct 13, 2020 03:00
Abstract Laryngeal oncocytic cysts and cystadenomas are uncommon and observed in 0.1–1% of laryngeal biopsy specimens. A 66-year-old male was admitted to the hospital with a hoarse voice of 6 months duration. On laryngoscopic examination, a lesion of the left anterior vocal cord was present. It was excised by direct laryngoscopy and histopathologic examination revealed a cystic cavity with papillary projections into the lumen. The epithelial lining comprised bland oncocytic epithelium....
Tue Oct 13, 2020 03:00
Background Hürthle cell features are frequently observed on the fine‐needle aspiration (FNA) cytology of thyroid nodules and often pose a diagnostic challenge because of a significant overlap between cytomorphologic features seen in benign and malignant lesions. Molecular alterations (MAs) associated with these lesions are not well described. The objective of the current study was to evaluate the molecular profile of Hürthle cell lesions classified as Hürthle cell neoplasm (HCN) on cytologic evaluation....
Mon Oct 12, 2020 20:54
Mon Oct 12, 2020 20:50
Background The distinction between mesothelioma with epithelioid features and metastatic carcinoma may be challenging, particularly on cytology. A novel 2‐hit Claudin‐4 and BRCA‐associated protein 1 (BAP1) panel was investigated. Methods The objective of this study was to determine the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the panel on cytology from pleural effusions and matched biopsies, including 49 malignant mesotheliomas on cytology...
Mon Oct 12, 2020 20:49
Background: According to early reports, patients affected by coronavirus disease 2019 (COVID-19) are at an increased risk of developing cerebrovascular events, including acute ischemic stroke (AIS). The COVID-19 pandemic may also impose difficulties in managing AIS patients undergoing endovascular thrombectomy (EVT), as well as concerns for the safety of health care providers. This international global survey aims to gather and summarize information from tertiary care stroke centers on periprocedural...
Mon Oct 12, 2020 03:00
Introduction: The course of anosmia and ageusia in COVID-19 patients is not yet clearly known. We present short-term follow-up data concerning mild to moderate disease in home-quarantined COVID-19 patients in Greece. Methods: We provided a symptom questionnaire and instructions for a self-administered home smell-and-taste test to 79 positive COVID-19 patients from 2 tertiary hospitals in Greece. The patients recorded their subjective symptoms before and during infection as well as 4 weeks after the...
Tue Oct 13, 2020 15:09
The authors would like to correct the conflicts of interest statement for this article. Unfortunately, the original statement did not include the authors’ nonfinancial conflicts of interest, including grants and personal fees. The corrected conflict of interest statement is shown below: T. …
Tue Oct 13, 2020 03:00
Publication date: Available online 13 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Haruka Miki, Hong Pei, Donald Tom Gracias, Joel Linden, Michael Croft
Tue Oct 13, 2020 13:29
Publication date: Available online 13 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Paola Nicoletti, Daniel F. Carr, Sarah Barrett, Laurence McEvoy, Peter S. Friedmann, Neil H. Shear, Matthew R. Nelson, Anca M. Chiriac, Natalia Blanca-López, Jose A. Cornejo, Francesco Gaeta, Alla Nakonechna, Maria J. Torres, Cristiano Caruso, Rocco L. Valluzzi, Aris Floratos, Yufeng Shen, Rebecca K. Pavlos, Elizabeth J. Phillips, Pascal Demoly
Tue Oct 13, 2020 13:29
Abstract Purpose of Review To review the incidence, treatment and genetics of psychosis in people with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Recent Findings Psychosis in Alzheimer’s disease (AD) has an incidence of ~ 10% per year. There is limited evidence regarding psychological interventions. Pharmacological...
Tue Oct 13, 2020 03:00
Abstract High‐throughput sequencing analysis represented both a medical diagnosis and technological revolution. Gene panel analysis is now routinely performed in the exploration of hereditary predisposition to cancer, which is becoming increasingly heterogeneous, both clinically and molecularly. We present 1,530 patients with suspicion of hereditary predisposition to cancer, for which 2 types of analyses were performed: a) oriented according to the clinical presentation (n = 417), or b)...
Mon Oct 12, 2020 18:38
Abstract Several genetic disorders have variable degree of central nervous system white matter abnormalities. We retrieved and reviewed 422 genetic conditions with prominent and consistent involvement of white matter from the literature. We herein describe the current definitions, classification systems, clinical spectrum, neuroimaging findings, genomics and molecular mechanisms of these conditions. Though diagnosis for most of these disorders relies mainly on genomic tests, specifically...
Mon Oct 12, 2020 18:29
Abstract Early‐life conditions have been shown to have a profound effect on an animal’s body size and fecundity across diverse taxa. However, less is known about how early‐life effects on fecundity within each sex interact to determine reproductive success. We used experiments with burying beetles Nicrophorus vespilloides to analyse this problem. The nutritional conditions experienced by burying beetles in early life are a key determinant of adult body size in both sexes, and adult body size in...
Mon Oct 12, 2020 19:05
Abstract Age‐related changes in parental phenotypes or genotypes can impact offspring fitness, but separating germline from non‐germline transgenerational effects of ageing is difficult for wild populations. Further, in cooperatively‐breeding species, in addition to parental ages, the age of ‘helpers’ attending offspring may also affect juvenile performance. Using a 30‐year study of a cooperative breeder with very high rates of extra‐pair paternity, the superb fairy‐wren (Malurus cyaneus), we investigated...
Mon Oct 12, 2020 19:02
How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels
Abstract The Mytilus complex of marine mussel species forms a mosaic of hybrid zones, found across temperate regions of the globe. This allows us to study “replicated” instances of secondary contact between closely‐related species. Previous work on this complex has shown that local introgression is both widespread and highly heterogeneous, and has identified SNPs that are outliers of differentiation between lineages. Here, we developed an ancestry‐informative panel of such SNPs. We then compared...
Mon Oct 12, 2020 19:00
Abstract Parasitism is often invoked as a factor explaining the variation in diversification rates across the tree of life, while also representing up to half of Earth's diversity. Yet, patterns and processes of parasite diversification remain mostly unknown. In this study, we assess the patterns of parasite diversification, and specifically determine the role of life history traits (i.e. life cycle complexity and host range) and major coevolutionary events in driving diversification across eight...
Mon Oct 12, 2020 16:24
Abstract Despite the ubiquity and importance of mutualistic interactions, we know little about the evolutionary genetics underlying their long‐term persistence. As in antagonistic interactions, mutualistic symbioses are characterized by substantial levels of phenotypic and genetic diversity. In contrast to antagonistic interactions, however, we, by and large, do not understand how this variation arises, how it is maintained, nor its implications for future evolutionary change. Currently, we rely...
Mon Oct 12, 2020 16:22
Abstract Animals show a rich diversity of signals and displays. Among the many selective forces driving the evolution of communication signals, one widely recognized factor is the structure of the environment where animals communicate. In particular, animals communicating by sounds often emit acoustic signals from specific locations, such as high up in the air, from the ground or in the water. The properties of these different display sites may impose different constraints on sound production, and...
Mon Oct 12, 2020 16:20
Abstract Introduction Past research shows that stress during pregnancy predicts adverse birth outcomes. These patterns might differ based on immigration status. Our objective was to analyze differences in relationships between perceived stress during pregnancy and birth outcomes by immigration status. Methods We recruited 81 pregnant women in Canada...
Tue Oct 13, 2020 03:00
Background: Directional deep brain stimulation (DBS) enlarges the therapeutic window by increasing side-effect thresholds and improving clinical benefits. To determine the optimal stimulation settings and interpret clinical observations, knowledge of the lead orientation in relation to the patient’s anatomy is required. Objective: To determine if directional leads remain in a fixed orientation after implantation or whether orientation changes over time. Method: Clinical records of 187 patients with...
Tue Oct 13, 2020 08:08
Ethnobotanical and ethnopharmacological studies of many Centaurea species indicated their potential in folk medicine so far. However, investigations of different Centaurea calcitrapa L. extracts in terms of cytot...
Mon Oct 12, 2020 03:00
Abstract ObjectiveSpiritual Well‐Being (SpWb) is an important dimension of Health Related Quality of Life for many cancer patients. Accordingly, an increasing number of psychosocial intervention studies have included SpWb as a study endpoint, and may improve SpWb even if not designed explicitly to do so. This meta‐analysis of randomized controlled trials (RCTs) evaluated effects of psychosocial interventions on SpWb in adults with cancer and tested potential moderators of intervention effects.MethodsSix...
Mon Oct 12, 2020 20:22
ABSTRACT ObjectiveEmotional symptoms are frequently reported among patients with cancer. We evaluated the association between emotional symptoms and problem‐related distress in a sample of patients with cancer about to initiate chemotherapy within a private hospital in Brazil.MethodsPatients were assessed before initiating chemotherapy, treatment mid‐point and on the last day of treatment for anxiety and depression (Hospital Anxiety and Depression Scale (HADS)) and for problem‐related distress (Distress...
Mon Oct 12, 2020 18:01
Violence against women and girls (VAWG) has been significantly increased by the rise of conflict and insecurity in the territories under controlling so-called Islamic State of Iraq and Syria (ISIS). This revie...
Mon Oct 12, 2020 03:00
A systematic literature review of researchers and healthcare professionals’ attitudes towards the secondary use and sharing of health administrative and clinical trial data was conducted using electronic data ...
Mon Oct 12, 2020 03:00
Abstract Deletion of chromosome 5q is common in prostate cancer and is linked to aggressive disease. Most previous studies focused on 5q21 where CHD1 is located, but deletion mapping studies have identified a second deletion hotspot at 5q13. To clarify the prevalence and clinical relevance of 5q13 deletions and to determine the relative importance of 5q13 and 5q21 abnormalities, a tissue microarray containing samples from 12,427 prostate cancers was analyzed by fluorescence in situ hybridization....
Mon Oct 12, 2020 11:55
Abstract To report on the association of trial sponsors with intervention type, treatment intent, recruitment success and reasons to terminate cancer trials. The ClinicalTrials database was searched for interventional phase 3 cancer trials (01/2006‐05/2017). Non‐cancer studies and ongoing studies were excluded, permanently suspended studies were counted as terminated. Trials were stratified according to sponsors (industry/non‐industry), intervention type, setting (curative/palliative) and intent...
Mon Oct 12, 2020 11:54
ABSTRACT Mortality from non‐small cell lung cancer (NSCLC) exhibits substantial geographical disparities. However, there is little evidence on whether this variation could be attributed to patients’ clinical characteristics and/or socio‐economic inequalities. This study evaluated the independent and relative contribution of the individual‐ and area‐level risk factors on geographic variation in two‐year all‐cause mortality among NCLC patients. In the Hierarchical‐related regression approach, we...
Mon Oct 12, 2020 11:54
Introduction: Portal vein embolization (PVE) is an accepted technique to preoperatively increase the volume of the future remnant liver before major hepatectomy. A permanent material is usually preferred since its superiority to induce liver hypertrophy over absorbable material has been demonstrated. Nevertheless, the use of an absorbable material generates a reversible PVE (RPVE) capable of inducing significant liver hypertrophy. In small animal models, the possibility to proceed to a repeated RPVE...
Tue Oct 13, 2020 08:01
Abstract Neurocutaneous melanosis (NCM; MIM # 249400; ORPHA: 2481], first reported by the Bohemian pathologist Rokitansky in 1861, and now more precisely defined as neurocutaneous melanocytosis, is a rare, congenital syndrome characterised by the association of (1) congenital melanocytic nevi (CMN) of the skin with overlying hypertrichosis, presenting as (a) large (LCMN) or giant and/or multiple (MCMN) melanocytic lesions (or both; sometimes associated with smaller “satellite”...
Tue Oct 13, 2020 03:00
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