Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Lin Li, Xiangyang Chen, Congping Su, Qing Wang, Rui Li, Wenchao Jiao, Hui Luo, Yimiao Tian, Jiayang Tang, Xiaoxuan Li, Bin Liu, Wei Wang, Dongwei Zhang, Shuzhen Guo
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Zhou-Shan Tao, Wan-Shu Zhou, Hong-Guang Xu, Min Yang
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Zhenxing Ding, Xu Wu, Yueguo Wang, Shuang Ji, Wenying Zhang, Jiaying Kang, Jiajia Li, Guanghe Fei
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Yun Wang, Man Jiang, Jingjuan Zhu, Jialin Qu, Kang Qin, Deze Zhao, Li Wang, Lina Dong, Xiaochun Zhang
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Xiaopeng Ai, Peiling Yu, Ya Hou, Xinchen Song, Jie Luo, Ning Li, Xianrong Lai, Xiaobo Wang, Xianli Meng
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Wenxiu Qi, Xiuci Yan, Xiaohao Xu, Bailin Song, Liping Sun, Daqing Zhao, Liwei Sun
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Isaiah P.L. Abad, Ray L. Fam, Dan-Thanh Nguyen, Cameron J. Nowell, Phuc N.H. Trinh, David T. Manallack, Lubna A. Freihat, Jay Chakrabarti, Aamani Jamil, Betty Exintaris, Nor S. Yaakob, Helen R. Irving
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Rahaba Marima, Rodney Hull, Zodwa Dlamini, Clement Penny
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Long Huang, Can Yang, Yaodong Wang, Ge Li, Jingjing Pan, Huatian Luo, Zhangwei Wu, Yifeng Tian, Shi Chen, Jiangzhi Chen, Zhixiang Jian
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Shasha Fan, Zepeng Zhang, Hang Su, Peng Xu, Hongyu Qi, Daqing Zhao, Xiangyan Li
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Vahid Niazi, Benyamin Parseh, Milad Ahani, Farshid Karami, Samira Gilanchi, Kamran Atarodi, Mina Soufi, Masoud Soleimani, Soudeh Ghafouri-Fard, Mohammad Taheri, Hakimeh Zali
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Xiaobo Wang, Ya Hou, Xiaopeng Ai, Jiayi Sun, Binjie Xu, Xianli Meng, Yi Zhang, Sanyin Zhang
Publication date: December 2020Source: Biomedicine & Pharmacotherapy, Volume 132Author(s): Lan Bu, Ou Dai, Fei Zhou, Fei Liu, Jin-Feng Chen, Cheng Peng, Liang Xiong
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Abstract The rapidly advancing field of digital health technologies provides a great opportunity to radically transform the way clinical trials are conducted and to shift the clinical trial paradigm from a site‐centric to a patient‐centric model. Merck & Co., Inc.’s (Kenilworth, NJ, USA) digitally‐enabled clinical trial initiative is focused on introduction of digital technologies into the clinical trial paradigm to reduce patient burden, improve drug adherence, provide a means of more closely...
Abstract Bile holds biomarkers of malignant biliary strictures (MBS) but is unsuited for automated analyzers used in routine diagnostic laboratories. Selected Reaction Monitoring (SRM) is a flexible high‐throughput analytical approach based on targeted mass spectrometry (MS) already implemented in clinical settings. We tested the hypothesis that SRM could be used to quantify cancer biomarkers in human bile. An SRM‐based assay was developed to simultaneously quantify up to 37 peptides from 13 bile...
Abstract Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are involved in the disposition of a variety of commonly prescribed drugs. The evaluation of OATP1B1/1B3 inhibition potential by investigational drugs is of interest during clinical drug development due to various adverse events associated with increased exposures of their substrates. Regulatory guidance documents on the in vitro assessment of OATP1B1/1B3 inhibition potential are conservative with up to a third of predictions...
Abstract The aim of this study was to determine the expression of IL‐35 and the lymphatic vessel density (LVD) and microvessel density (MVD) in the pathological tissues from patients with non‐small cell lung cancer (NSCLC) and to analyze their correlation with other common clinical prognostic factors, as well as patients’ overall survival (OS) and progression‐free survival (PFS). We analyzed the pathological characteristics of 130 patients with NSCLC and determined the IL‐35 expression, MVD, and...
Abstract There is limited evidence to support pharmacogenetic testing (PGx) in children. We conducted a retrospective review of PGx among 452 patients at an academic children’s hospital to determine the potential utility of PGx in diseases of childhood and to identify targets for future pediatric pharmacogenetic research. An actionable gene‐drug pair associated with the 28 genes tested (Clinical Pharmacogenetics Implementation Consortium level A or B, Pharmacogenomics Knowledge Base (PharmGKB) level...
Abstract Recurrent and acute bleeding from intestinal tract angioectasia (AEC) presents a major challenge for clinical intervention. Current treatments are empiric, with frequent poor clinical outcomes. Improvements in understanding the pathophysiology of these lesions will help guide treatment. Using data from FDA’s Adverse Event Reporting System (FAERS) we analyzed 12 million patient reports to identify drugs inversely correlated with GI‐bleeding and potentially limiting AEC severity. FAERS analysis...
Abstract For drugs that are intended to fill unmet medical needs, such as the treatment of rare diseases or a subtype of cancer, it can take a long time to conduct confirmatory clinical trials due to limited patient availability. Delayed access to these drugs increases the risk of mortality of patients with these diseases. To address this issue, the Ministry of Health, Labour and Welfare of Japan has decided to implement the Conditional Early Approval System with issuing the Ministry Notification...
Abstract Lisinopril, a highly hydrophilic long‐acting ACE inhibitor, is frequently prescribed for the treatment of hypertension and congestive heart failure. Green tea consumption may reduce the risk of cardiovascular outcomes and total mortality, whereas green tea or its catechin components has been reported to decrease plasma concentrations of a hydrophilic β blocker, nadolol, in humans. The aim of this study was to evaluate possible effects of green tea extract (GTE) on the lisinopril pharmacokinetics....
Abstract Many targeted therapies are administered at or near the maximum tolerated dose (MTD). With the advent of precision medicine, a larger therapeutic window is expected. Therefore, dose optimization will require a new approach to early clinical trial design. We analyzed publicly available data for 21 therapies targeting six kinases, and four poly (ADP‐ribose) polymerase inhibitors, focusing on potency and exposure to gain insight into dose selection. The free average steady‐state concentration...
Abstract Forced expiratory volume in one second (FEV1) is a critical parameter for the assessment of lung function for both clinical care and research in patients with asthma. While asthma is defined by variable airflow obstruction, FEV1 is typically assessed during clinic visits. Mobile spirometry (mSpirometry) allows more frequent measurements of FEV1, resulting in a more continuous assessment of lung function over time and its variability. Twelve patients with moderate asthma were recruited...
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Summary Background The MYC oncogene is one of the most frequently altered driver genes in cancer. MYC is thus a potential target for cancer treatment as well as a biomarker for the disease. However, as a target for treatment, MYC has traditionally been regarded as “undruggable” or difficult to target. We set out to evaluate the efficacy of a novel MYC inhibitor known as MYCMI-6, which acts by preventing MYC from interacting with its cognate partner MAX. Methods MYCMI-6 response...
Summary Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are recommended first-line treatments in EGFR-mutated (EGFRm) non-small-cell lung cancer (NSCLC). However, acquired resistance (e.g. MET amplification) is frequently observed. Savolitinib (volitinib, HMPL-504, AZD6094) is an oral, potent, and highly selective MET-TKI. In this phase Ib, open-label, multicenter study, we enrolled Chinese patients with EGFRm advanced NSCLC, whose disease progressed following...
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Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): Peter S.N. van Rossum, Paul M. Jeene, Tom Rozema, Pètra M. Braam, Irene M. Lips, Karin Muller, Daphne van Kampen, Bram D. Vermeulen, Marjolein Y.V. Homs, Vera Oppedijk, Maaike Berbée, Maarten C.C.M. Hulshof, Peter D. Siersema, Sherif Y. El Sharouni
Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): Barbara Alicja Jereczek-Fossa, Matteo Pepa, Mattia Zaffaroni, Giulia Marvaso, Alessio Bruni, Michela Buglione di Monale e Bastia, Gianpiero Catalano, Andrea Riccardo Filippi, Pierfrancesco Franco, Maria Antonietta Gambacorta, Domenico Genovesi, Giuseppe Iatì, Alessandro Magli, Luigi Marafioti, Icro Meattini, Anna Merlotti, Marcello Mignogna, Daniela Musio, Roberto Pacelli, Stefano Pergolizzi
Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): Meifeng Li, Haifeng Chen, Jun He, Jiajing Xie, Jie Xia, Hui Liu, Yidan Shi, Zheng Guo, Haidan Yan
Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): J. Van der Veen, S. Willems, H. Bollen, F. Maes, S. Nuyts
Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): Sofia Spampinato, Lars U. Fokdal, Richard Pötter, Christine Haie-Meder, Jacob C. Lindegaard, Maximilian P. Schmid, Alina Sturdza, Ina M. Jürgenliemk-Schulz, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hoskin, Bhavana Rai, Fleur Huang, Rachel Cooper, Elzbieta van der Steen-Banasik, Erik Van Limbergen, Marit Sundset, Henrike Westerveld, Remi A. Nout
Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): Joshua L. Rodríguez-López, Diane C. Ling, Andrew Keller, Hayeon Kim, Adrianna E. Mojica-Márquez, Scott M. Glaser, Sushil Beriwal
Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): Trinitat García-Hernández, Maite Romero-Expósito, Beatriz Sánchez Nieto
Publication date: Available online 14 October 2020Source: Radiotherapy and OncologyAuthor(s): Sweet Ping Ng, Julie Chu, Sarat Chander, Mathias Bressel, Joseph McKendrick, Rachel Wong, Malcolm Steel, William K Murray, Trevor Leong, Alexander Heriot, Michael Michael, Samuel Y Ngan
Publication date: Available online 13 October 2020Source: Radiotherapy and OncologyAuthor(s): Joanna Kazmierska, Andrew Hope, Emiliano Spezi, Sam Beddar, William H. Nailon, Biche Osong, Anshu Ankolekar, Ananya Choudhury, Andre Dekker, Kathrine Røe Redalen, Alberto Traverso
Publication date: Available online 13 October 2020Source: Radiotherapy and OncologyAuthor(s): Ivica Ratosa, Monica Emilia Chirilă, Mateja Steinacher, Elvisa Kozma, Radovan Vojtíšek, Pierfrancesco Franco, P. Philip Poortmans
Publication date: Available online 12 October 2020Source: Radiotherapy and OncologyAuthor(s): Bum-Sup Jang, Myung-Jin Cha, Hak Jae Kim, Seil Oh, Hong-Gyun Wu, Eunji Kim, Byoung Hyuck Kim, Jae Sik Kim, Ji Hyun Chang
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Gastric cancer (GC) is a malignant tumor [1] with a five-year survival rate of only 20-35% for patients treated with surgery alone [2, 3]. Previous studies have reported that local recurrence and distant metastasis are main causes of poor survival outcomes [4, 5], and 5-fluorouracil (5-FU)-based adjuvant chemoradiotherapy (ACRT) can reduce recurrence rates and improve clinical outcomes [6-10].
Radiotherapy (RT) is one of the cornerstones in the treatment of head and neck cancer (HNC), either alone, after surgery or concomitantly with chemotherapy. Delineation of organs at risk (OARs) and clinical target volumes (CTV) is an important step in the treatment process and is necessary before the treatment plan can be created. This step is typically done manually and is a time-consuming activity. It requires intensive training before it can be done correctly and is susceptible to intra-observer...
Cervical cancer is the fourth most common cancer in women worldwide and the primary cause of cancer-related deaths among women in low- and middle-income countries [1]. Chemoradiation followed by brachytherapy (BT) boost is the standard of care for patients with node-positive and/or locally advanced cervical cancer [2-5]. In the last few decades, there has been an evolution of BT planning from 2-dimensional (2D) point-based prescribing to 3-dimensional (3D)-computed tomography (CT) and most recently,...
Preoperative radiotherapy and total mesorectal excision (TME) have significantly reduced the risk of locoregional recurrence in rectal cancer. Local failure rate has been reduced to less than 10% with preoperative chemoradiotherapy. Distant metastatic disease is now the predominant site of recurrence following curative-intent therapy with 30% of patients with T3 primary tumour developing distant recurrence despite the use of adjuvant chemotherapy [1-3]. In the pursuit of improving overall survival...
A matched comparison of external beam radiotherapy (EBRT) versus brachytherapy recently demonstrated that EBRT appears at least as effective for palliating dysphagia in patients with incurable esophageal cancer. The aim of this analysis was to compare patient-reported outcomes (PROs) after EBRT versus brachytherapy.
Late morbidity after pelvic radiotherapy includes urinary side effects which may significantly impact patients quality of life (QoL) [1]. For locally advanced cervical cancer (LACC), the introduction of image-guided adaptive brachytherapy (IGABT) has led to a decrease in side effects compared to two-dimensional brachytherapy (BT) [2,3]. Disease control and overall survival are improved [4], but urinary morbidity still represents a burden for cancer survivors [5].
The objective of this work is to evaluate the risk of carcinogenesis of low dose ionizing radiation therapy (LDRT), for treatment of immune-related pneumonia following COVID-19 infection, through the estimation of effective dose and the lifetime attributable risk of cancer (LAR).
Italy was the first European country heavily involved in the COrona VIrus Disease 19 (COVID-19) pandemic 1, with 294,932 cases and more than 35,000 deaths as of 18th September 2020 2. Despite the severity of the pandemic in the so-called Italian phase (P) 1 (18th March - 3rd May 2020), radiation therapy (RT) facilities in the country managed to efficiently reorganized themselves to maintain a high standard of care while minimizing the risk of contagion for patients and staff 3. The safety measures...
Breast cancer (BC) is the most common cancer in women [1], and post-operative radiation therapy (RT) is a fundamental part of treatment after either conservative surgery or mastectomy [2–4]. BC ranks as the first amongst all cancer types with respect to the absolute numbers of RT indications needed in the forthcoming years in more than half of the European countries [5]. Furthermore, it has been estimated that the number of RT courses for BC patients in Europe will increase on average by 10.1% from...
Many large commercial enterprises are redirecting their business approaches to exploit the new knowledge they can gain from the data they collect daily. This strategy arose from the need to mine a large amount of diverse data, often unstructured and coming from multiple sources: so-called “big data.” Whereas initially big data seemed to present an obstacle, now it is becoming more evident that leveraging massive data collections using novel techniques can reveal previously undiscovered knowledge...
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Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Yuan Xin, Shuping Zhang, Zhili Deng, Dandan Zeng, Ji Li, Yiya Zhang
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Fatemeh Taheri, Shahram Nazarian, Tooba Sadat Ahmadi, Seyed Latif Mousavi Gargari
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Zi-Kuan Wang, Rui-Rui Chen, Jing-Hua Li, Jing-Yuan Chen, Wei Li, Xiao-Lin Niu, Fang-Fang Wang, Jing Wang, Jing-Xiao Yang
Publication date: Available online 13 October 2020Source: International ImmunopharmacologyAuthor(s): Reza Malekzadeh, Atefeh Abedini, Behzad Mohsenpour, Ehsan Sharifipour, Roya Ghasemian, Seyed Ali Javad-Mousavi, Rozita Khodashahi, Mahboobeh Darban, Saeed Kalantari, Nafiseh Abdollahi, Mohammad Reza Salehi, Abbas Rezaei Hosseinabadi, Farzin Khorvash, Melika Valizadeh, Farzaneh Dastan, Sahar Yousefian, Hamed Hosseini, Nassim Anjidani, Payam Tabarsi
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Hua Zhou, Min Yang, Li Cui, Jingting Jiang
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Hong-xia Ye, Lan Li, Ya-jun Dong, Peng-hao Li, Qin Su, Yan-hua Guo, Yan-rong Lu, Ying Zhong, Yan Jia, Jing-qiu Cheng
Publication date: Available online 12 October 2020Source: International ImmunopharmacologyAuthor(s): V. Kumar
Nucleic acid and antibody assay results in Chinese patients with coronavirus disease 2019 (COVID-19)
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Yong Lu, Yongyan Li, Yiping Wang, Jianping Luo, Wanjun Yu
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Publication date: Available online 14 October 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Nicole Rodriguez, Craig Liebenson D.C, Fred Duncan
Publication date: Available online 13 October 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Adriana Cristine Koch BUTTELLI, Rochelle Rocha COSTA, Juliano Boufleur FARINHA, Alex de Oliveira FAGUNDES, Alexandra Ferreira VIEIRA, Bruna Machado BARROSO, Cláudia Gomes BRACHT, Leandro COCONCELLI, Thaís REICHERT, Vitoria de Mello Bones da ROCHA, Luiz Fernando Martins KRUEL
Publication date: Available online 13 October 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Rodrigo Rodrigues, Emmanuel Souza da Rocha, Kelli Daiana Klein, Francesca Chaida Sonda, Klauber Dalcero Pompeo, Viviane Bortoluzzi Frasson, Marco Aurélio Vaz
Publication date: Available online 13 October 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Daniel M. Cushman, Linda Vernon Scholl, Monica Ludlow, Shellie Cunningham, Masaru Teramoto
Publication date: Available online 13 October 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Jaqueline Mello Porto, Renato Campos Freire Júnior, Luciana Mendes Cangussu-Oliveira, Erika Leitner, Lara Gonçalves Freitas, Bruna Garcia Medeiros de Oliveira, Patrícia Silva Tofani, Daniela Cristina Carvalho de Abreu
Publication date: Available online 13 October 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Thomas Rosenkilde Rasmussen, Karl Christian Meulengracht
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Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Nayane de Lanes Gonçalves, Vinícius Martins Borges, José Alcides Almeida de Arruda, Emerson Gomes dos Santos, Ivana Márcia Alves Diniz, Mila Fernandes Moreira Madeira, Amália Moreno
Publication date: Available online 13 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Wendong Jin, Xiafei Shi, Huijuan Yin, Haixia Zhang, Zhiyuan Wang, Qianqian Chen, Hongjun Wu, Yu Han, Yinxin Li
Publication date: Available online 13 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Hui Pan, Dongqing Wang, Fengqiu Zhang
Publication date: Available online 13 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Joo-Young Lee, Hyo-Jung Kim, Eun-Song Lee, Elbert de Josselin de Jong, Hoi-In Jung, Baek-Il Kim
Publication date: Available online 13 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Ozge Pinar Akarsu Acar, Ismail Umut Onur, Fatma Selin Kaya, Bengi Demirayak, Fadime Ulviye Yigit
Publication date: Available online 13 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Rose Mary Kiriyanthan, S. Aruna Sharmili, R. Balaji, S. Jayashree, Shahid Mahboob, Khalid A. Al-Ghanim, Fahad Al-Misned, Zubair Ahmed, Marimuthu Govindarajan, Baskaralingam Vaseeharan
Publication date: Available online 13 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Nawaf Labban, Mansour K. Assery, Reem Al-Kattan, Nouf Al-Shibani, Afnan F. Alfouzan, Sara Mohammad Al Taweel
Publication date: Available online 12 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Thaiany Wendy Silva Daltro, Suênia Andressa Gomes de Almeida, Marlon Ferreira Dias, Paulo Cardoso Lins-Filho, Claudio Heliomar Vicente da Silva, Renata Pedrosa Guimarães
Publication date: Available online 12 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Baoqu Zhang, Jun’an Xiao, Xiaohui Wang, Peiyuan Li, Wei Su
Publication date: Available online 12 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Xiaoxiao Shen, Liwen Dong, Xuan He, Chuanqi Zhao, Wanqi Zhang, Xinying Li, Yuangang Lu
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