23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: American Journal of Cancer Research These pubmed results were generated on 2020/10/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Oct 14, 2020 06:31
[New drug approval: Encorafenib-metastatic colorectal cancers with BRAF V600E mutation after systemic chemotherapy]. Bull Cancer. 2020 Oct 09;: Authors: Boilève A, Samalin E PMID: 33046237 [PubMed - as supplied by publisher]
03:18
Anti-Cancer Drug Discovery: Structure, Function and Novel Strategy - Part-4. Curr Top Med Chem. 2020;20(22):1967 Authors: Thakur SS PMID: 33040731 [PubMed - in process]
Wed Oct 14, 2020 00:56
Cancer Estimates in Brazil Reveal Progress for the Most Lethal Malignancies. Curr Top Med Chem. 2020;20(22):1962-1966 Authors: Ferreira LLG, Andricopulo AD PMID: 33040730 [PubMed - in process]
Wed Oct 14, 2020 00:56
Importance of Environmental Factors on Production of Computationally- Defined Natural Molecules against COVID-19 Pandemic. Curr Top Med Chem. 2020;20(22):1958-1961 Authors: Abouleish M, El-Keblawy A, Mosa KA, Soliman SSM PMID: 33040729 [PubMed - in process]
Wed Oct 14, 2020 00:56
Fungal Infections in COVID-19-Positive Patients: A Lack of Optimal Treatment Options. Curr Top Med Chem. 2020;20(22):1951-1957 Authors: Silva LN, de Mello TP, de Souza Ramos L, Branquinha MH, Roudbary M, Dos Santos ALS PMID: 33040728 [PubMed - in process]
Wed Oct 14, 2020 00:56
[De-escalation concepts for chemoradiotherapy of HPV-positive oropharyngeal carcinomas: pros and cons]. HNO. 2020 Oct 13;: Authors: Rühle A, Nicolay NH Abstract BACKGROUND: In contrast to alcohol- and nicotine-induced head and neck tumors, human papillomavirus (HPV)-positive oropharyngeal carcinoma rather affects younger patients, and the incidence of this entity is continuously increasing. Due to the significantly better prognosis of...
Wed Oct 14, 2020 22:01
[Mutation signatures in head and neck squamous cell carcinoma : Pathogenesis and therapeutic potential]. HNO. 2020 Oct 12;: Authors: Plath M, Hess J, Zaoui K Abstract BACKGROUND: The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is a complex and multistage process which results from the interaction of exogenous and endogenous cellular processes. Each of these processes leaves a characteristic pattern of mutations on the...
Tue Oct 13, 2020 22:04
Management of transmodiolar and transmacular cochleovestibular schwannomas with and without cochlear implantation. HNO. 2020 Oct 12;: Authors: Plontke SK, Caye-Thomasen P, Strauss C, Kösling S, Götze G, Siebolts U, Vordermark D, Wagner L, Fröhlich L, Rahne T Abstract INTRODUCTION: Hearing rehabilitation with cochlear implants has attracted increasing interest also for patients with cochleovestibular schwannoma. The authors report their...
Tue Oct 13, 2020 22:04
Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway. Cancer Biol Ther. 2020 Oct 13;:1-11 Authors: Huang XB, Song KJ, Chen GB, Liu R, Jiang ZF, He YL Abstract Cervical cancer (CC) is the second most common malignancy in women worldwide. The mechanism underlying CC development remains unclear. Recently, Circular RNAs (circRNAs)have attracted attention because of its role...
03:47
Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 Oct 12;:1-8 Authors: Perez RE, Calhoun S, Shim D, Levenson VV, Duan L, Maki CG Abstract Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), is an enzyme that cleaves short peptides (<30 amino acids in length) on the C-terminal side of proline....
Tue Oct 13, 2020 21:45
Expression of STAT1 is positively correlated with PD-L1 in human ovarian cancer. Cancer Biol Ther. 2020 Oct 12;:1-9 Authors: Liu F, Liu J, Zhang J, Shi J, Gui L, Xu G Abstract Signal transducer and activator of transcription 1 (STAT1) is related to the immune microenvironment of tumorigenesis. The programmed cell death 1 (PD-1) and its ligand (PD-L1) have been reported to be important in immunotherapy by mediating tumor immune evasion. Blocking...
Tue Oct 13, 2020 21:45
Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway. Immunopharmacol Immunotoxicol. 2020 Oct 13;:1-29 Authors: Li XS, Tang XY, Su W, Li X Abstract Introduction: Vitiligo is the most common type of depigmented skin disease. Cellular oxidative stress caused by reactive oxygen species (ROS) has been implicated in the pathogenesis of vitiligo. Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element...
Wed Oct 14, 2020 20:49
Expression of concern. Immunopharmacol Immunotoxicol. 2020 Oct 12;:1 Authors: PMID: 33043738 [PubMed - as supplied by publisher]
Wed Oct 14, 2020 04:57
32 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[jour] These pubmed results were generated on 2020/10/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Oct 13, 2020 22:30
32 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[jour] These pubmed results were generated on 2020/10/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Oct 14, 2020 01:59
32 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[jour] These pubmed results were generated on 2020/10/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Oct 14, 2020 01:21
Eosinophilic esophagitis with and without airway involvement in children - A comparative analysis. Int J Pediatr Otorhinolaryngol. 2020 Oct 08;139:110422 Authors: Bora V, Olive A, Chiou E, Raj P, Mehta D Abstract BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic disease characterized by marked eosinophilic infiltration and inflammation of the esophagus eventually leading to esophageal dysfunction. This condition at times may involve...
01:43
Pediatric head and neck rhabdomyosarcoma: An analysis of treatment and survival in the United States (1975-2016). Int J Pediatr Otorhinolaryngol. 2020 Sep 25;139:110403 Authors: Darwish C, Shim T, Sparks AD, Chillakuru Y, Strum D, Benito DA, Monfared A Abstract INTRODUCTION: Rhabdomyosarcoma (RMS) is the most common soft tissue head and neck sarcoma in children. Stringent analysis of survival data is imperative to optimize treatment. ...
01:43
Patterns of pediatric cervical spine fractures in association with mandibular and facial fractures. Int J Pediatr Otorhinolaryngol. 2020 Oct 07;139:110428 Authors: Harounian JA, Ni G, Carr MM Abstract OBJECTIVES: To determine the incidence, demographics, and outcomes of concurrent cervical spine (C-spine) fractures in pediatric facial trauma. METHODS: The Kids' Inpatient Database (KID) from the 2016 Healthcare Cost Utilization Project...
01:43
Use of an intraocular handpiece for the removal of magnets from the oropharynx of a pediatric patient. Int J Pediatr Otorhinolaryngol. 2020 Oct 07;139:110429 Authors: Thirkateh P, Walner SM, Walner DL Abstract With the increasing availability of magnets within household objects and toys, otolaryngologists must be aware of the propensity of ingestions or impaction of magnets within the upper aerodigestive tract of pediatric patients. We describe...
01:43
Spatial-temporal aspects of continuous EEG-based neurorobotic control. J Neural Eng. 2020 Oct 13;: Authors: Suma D, Meng J, Edelman B, He B Abstract OBJECTIVE: The goal of this work is to identify the spatio-temporal facets of state-of-the-art electroencephalography (EEG)-based continuous neurorobotics that need to be addressed, prior to deployment in practical applications at home and in the clinic. APPROACH: Nine healthy human subjects...
Wed Oct 14, 2020 20:58
Comparison of signal decomposition techniques for analysis of human cortical signals. J Neural Eng. 2020 Oct 13;17(5):056014 Authors: Duraivel S, Rao AT, Lu CW, Bentley JN, Stacey WC, Chestek CA, Patil PG Abstract OBJECTIVE: Conventional neural signal analysis methods assume that features of interest are linear, time-invariant signals confined to well-delineated spectral bands. However, new evidence suggests that neural signals exhibit important...
Wed Oct 14, 2020 20:58
Long-term performance of Utah Slanted Electrode Arrays and intramuscular electromyographic leads implanted chronically in human arm nerves and muscles. J Neural Eng. 2020 Oct 12;: Authors: George JA, Page DM, Davis TS, Duncan CC, Hutchinson DT, Rieth L, Clark GA Abstract We explore the long-term performance and stability of seven percutaneous Utah Slanted Electrode Arrays (USEAs) and intramuscular recording leads (iEMGs) implanted chronically...
Wed Oct 14, 2020 01:10
Three-dimensionality shapes the dynamics of cortical interconnected to hippocampal networks. J Neural Eng. 2020 Oct 12;: Authors: Brofiga M, Pisano M, Tedesco M, Raiteri R, Massobrio P Abstract OBJECTIVE: The goal of this work is to develop and characterize an innovative experimental framework to design interconnected (i.e., modular) heterogeneous (cortical-hippocampal) neuronal cultures with a three-dimensional (3D) connectivity and to record...
Wed Oct 14, 2020 01:10
Decoding of voluntary and involuntary upper limb motor imagery based on graph Fourier transform and cross frequency coupling coefficients. J Neural Eng. 2020 Oct 12;: Authors: Feng N, Hu F, Wang H, Amin Gouda M Abstract OBJECTIVE: Brain-computer interface (BCI) technology based on motor imagery control has become a research hotspot but continues to encounter numerous challenges. BCI can assist in the recovery of stroke patients and serve as...
Wed Oct 14, 2020 01:10
Adaptive virtual referencing for the extraction of extracellularly recorded action potentials in noisy environments. J Neural Eng. 2020 Oct 10;17(5):056011 Authors: Cruttenden CE, Zhu W, Zhang Y, Soon SH, Zhu XH, Chen W, Rajamani R Abstract OBJECTIVE: Removal of common mode noise and artifacts from extracellularly measured action potentials, herein referred to as spikes, recorded with multi-electrode arrays (MEAs) which included severe noise...
Wed Oct 14, 2020 01:10
SECONIC: Towards multi-compartmental models for ultrasonic brain stimulation by intramembrane cavitation. J Neural Eng. 2020 Oct 10;17(5):056010 Authors: Tarnaud T, Joseph W, Schoeters R, Martens L, Tanghe E Abstract OBJECTIVE: To design a computationally efficient model for ultrasonic neuromodulation (UNMOD) of morphologically realistic multi-compartmental neurons based on intramembrane cavitation. APPROACH: A Spatially Extended Neuronal...
Wed Oct 14, 2020 01:10
Jaw Clonus: A Rhythmic Oscillatory Movement, but Not Tremor. Tremor Other Hyperkinet Mov (N Y). 2020 Sep 29;10:34 Authors: Williams L, Ryan M, Kilbride R, Llamas-Osorio Y Abstract Background: Jaw clonus is rhythmic, oscillatory contraction of jaw muscles induced by stretch and is caused by lesions of the descending motor neurons in the corticopontine tracts. Phenomenology shown: We illustrate jaw clonus elicited with jaw activation...
Wed Oct 14, 2020 01:06
Emerging Systemic Therapies for Atopic Dermatitis: Biologics. J Dermatolog Treat. 2020 Oct 12;:1-17 Authors: Nusbaum KB, Nguyen CM, Fleischer AB Abstract Background: The mainstay of atopic dermatitis treatment has been largely unchanged over the last few decades. With improved understanding of the immunologic pathways underlying atopic dermatitis in recent years, targeted biologic therapies are being developed.Objective: Discuss efficacy and...
00:50
Who Sees you Matters: A Population Study Examining Topical Corticosteroid Prescribing Patterns between Primary Care Providers and Dermatologists for Atopic Dermatitis. J Dermatolog Treat. 2020 Oct 12;:1-14 Authors: Singh I, Chat VS, Uy A, Borba A, Chen AY, Armstrong AW Abstract Background: Many patients with atopic dermatitis seek care from both primary care physicians and dermatologists. However, little is known regarding topical corticosteroid...
Wed Oct 14, 2020 00:43
Rituximab monotherapy in mild pemphigus. J Dermatolog Treat. 2020 Oct 12;:1-7 Authors: Nili A, Mahmoudi H, Heidari N, Tavakolpour S, Salehi Farid A, Balighi K, Daneshpazhooh M PMID: 33040641 [PubMed - as supplied by publisher]
Wed Oct 14, 2020 00:43
Beneficial Effect of Lactobacillus plantarum IS-10506 Supplementation in Adults with Atopic Dermatitis: A Randomized Controlled Trial. J Dermatolog Treat. 2020 Oct 12;:1-21 Authors: Prakoeswa C, Bonita L, Karim A, Herwanto N, Umborowati MA, Setyaningrum T, Hidayati AN, Surono IS Abstract Introduction: Although the therapeutic effects of probiotic in atopic dermatitis (AD) are known, the limited findings in adults are inconsistent. Lactobacillus...
Wed Oct 14, 2020 00:43
Combination treatment algorithm for pigmentary disorders of the face: A prospective observational study in Asian patients. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Takekawa C, Fukumoto T, Haraoka G, Terashi H Abstract BACKGROUND: Most patients with facial pigmentary disorders have multiple disorders. However, there is no definitive treatment algorithm improving various pigmentary disorders simultaneously. OBJECTIVES: To...
Wed Oct 14, 2020 21:15
Type of maxillary segment mobilization affects three-dimensional nasal morphology. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Denadai R, Chou PY, Lin YY, Yao CF, Chen YA, Huang CS, Lo LJ, Chen YR Abstract BACKGROUND: Surgical mobilization of the maxillary segment affects nasal morphology. This study assessed the impact of the type of maxillary mobilization on the three-dimensional (3D) nasal morphometry. METHODS: Pre- and...
Wed Oct 14, 2020 01:07
Overview of tools for the measurement of the orbital volume and their applications to orbital surgery. J Plast Reconstr Aesthet Surg. 2020 Sep 20;: Authors: Sentucq C, Schlund M, Bouet B, Garms M, Ferri J, Jacques T, Nicot R Abstract There are numerous applications in craniofacial surgery with orbital volume (OV) modification. The careful management of the OV is fundamental to obtain good esthetic and functional results in orbital surgery....
Wed Oct 14, 2020 01:07
Are gain values significantly altered by manual data selection when performing the video Head Impulse Test (v-HIT) on all six semicircular canals with two different v-HIT systems. J Vestib Res. 2020 Oct 05;: Authors: Abrahamsen ER, Skals RK, Hougaard DD Abstract BACKGROUND: It has not yet been tested whether averaged gain values and the presence of pathological saccades are significantly altered by manual data selection or if data selection...
Wed Oct 14, 2020 01:23
Menière's disease caused by CGRP - A new hypothesis explaining etiology and pathophysiology. Redirecting Menière's syndrome to Menière's disease. J Vestib Res. 2020 Oct 05;: Authors: Hegemann SCA Abstract This paper provides a new hypothetical explanation for the etiopathology and pathophysiology of Menière's Disease (MD), which to date remain unexplained, or incompletely understood. The suggested hypothesis will explain the close connection...
Wed Oct 14, 2020 01:23
Why the cerebellar shutdown/clampdown hypothesis of vestibular compensation is inconsistent with neurophysiological evidence. J Vestib Res. 2020 Oct 05;: Authors: Smith PF Abstract BACKGROUND: Vestibular compensation is the process by which the central nervous system (CNS) attempts to adapt to the loss of vestibular sensory inputs. As such, the compensation process is critically involved in the vestibular rehabilitation programs that are implemented...
Wed Oct 14, 2020 01:23
Erraum: Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain. J Vis Exp. 2019 Oct 12;(152): Authors: Abstract An erratum was issued for: Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain. An author name was updated. The name was corrected from:...
Tue Oct 13, 2020 22:58
Culturing Rat Sympathetic Neurons from Embryonic Superior Cervical Ganglia for Morphological and Proteomic Analysis. J Vis Exp. 2020 Sep 27;(163): Authors: Holt M, Adams B, Chandrasekaran V Abstract Sympathetic neurons from the embryonic rat superior cervical ganglia (SCG) have been used as an in vitro model system for peripheral neurons to study axonal growth, axonal trafficking, synaptogenesis, dendritic growth, dendritic plasticity...
Tue Oct 13, 2020 22:58
Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans. J Vis Exp. 2020 Sep 27;(163): Authors: Kot BCW, Chan DKP, Chung TYT, Tsui HCL Abstract With 6 years of experience in implementing virtopsy routinely into the Hong Kong cetacean stranding response program, standardized virtopsy procedures, postmortem computed tomography (PMCT) acquisition, postprocessing, and...
Tue Oct 13, 2020 22:58
PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase. J Vis Exp. 2020 Sep 26;(163): Authors: Hilario E, Fan L, Mueller LJ, Dunn MF Abstract Structural studies with tryptophan synthase (TS) bienzyme complex (α2β2 TS) from Salmonella typhimurium have been performed to better understand its catalytic mechanism, allosteric behavior, and details...
Tue Oct 13, 2020 22:58
Localized Bathless Metal-Composite Plating via Electrostamping. J Vis Exp. 2020 Sep 22;(163): Authors: Townsend TK, Hancock J, Russell C, Shaw JP Abstract Composite plating with particles embedded into the metal matrix can enhance the properties of the metal coating to make it more or less conductive, hard, durable, lubricated or fluorescent. However, it can be more challenging than metal plating, because the composite particles are either...
Tue Oct 13, 2020 22:58
Generating a Fractal Microstructure of Laminin-111 to Signal to Cells. J Vis Exp. 2020 Sep 28;(163): Authors: Hochman-Mendez C, Coelho-Sampaio T, Kent AJ, Inman JL, Bissell MJ, Robertson C Abstract Laminin-111 (Ln1) is an essential part of the extracellular matrix in epithelia, muscle and neural systems. We have previously demonstrated that the microstructure of Ln1 alters the way that it signals to cells, possibly because Ln1 assembly...
Tue Oct 13, 2020 22:58
Use of Fimbrial Rod for F18ab Fimbriae+ STEC Colonization to Host Cells. J Vis Exp. 2020 Sep 24;(163): Authors: Zhou M, Duan Q, Yang Y, Zhu G Abstract Type 1 fimbriae are important virulence determinants of some Gram-negative pathogens, which promote bacterial colonization. The fimbrial rod is primarily composed of multiple copies of the major fimbrial subunit FimA. FimH adhesin, however, is present as a fibrillar tip structure that drive...
Tue Oct 13, 2020 22:58
Real-Time fMRI Brain Mapping in Animals. J Vis Exp. 2020 Sep 24;(163): Authors: Choi S, Takahashi K, Jiang Y, Köhler S, Zeng H, Wang Q, Ma Y, Yu X Abstract Dynamic fMRI responses vary largely according to the physiological conditions of animals either under anesthesia or in awake states. We developed a real-time fMRI platform to guide experimenters to monitor fMRI responses instantaneously during acquisition, which can be used to modify...
Tue Oct 13, 2020 22:58
An Orthotopic Resectional Mouse Model of Pancreatic Cancer. J Vis Exp. 2020 Sep 24;(163): Authors: Pang TCY, Xu Z, Mekapogu AR, Pothula S, Becker TM, Goldstein D, Pirola RC, Wilson JS, Apte MV Abstract There is a lack of satisfactory animal models to study adjuvant and/or neoadjuvant therapy in patients being considered for surgery of pancreatic cancer (PC). To address this deficiency, we describe a mouse model involving orthotopic implantation...
Tue Oct 13, 2020 22:58
Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation. J Vis Exp. 2020 Sep 27;(163): Authors: Hessel AL, Hahn D, de Marées M Abstract The mechanical properties of contracting skeletal fibers are crucial indicators of overall muscle health, function, and performance. Human skeletal muscle biopsies are often collected for these endeavors. However, relatively few...
Tue Oct 13, 2020 22:58
Cell-Free Production of Proteoliposomes for Functional Analysis and Antibody Development Targeting Membrane Proteins. J Vis Exp. 2020 Sep 22;(163): Authors: Zhou W, Takeda H Abstract Membrane proteins play essential roles in a variety of cellular processes and perform vital functions. Membrane proteins are medically important in drug discovery because they are the targets of more than half of all drugs. An obstacle to conducting biochemical,...
Tue Oct 13, 2020 22:58
Demonstration of Spin-Multiplexed and Direction-Multiplexed All-Dielectric Visible Metaholograms. J Vis Exp. 2020 Sep 25;(163): Authors: Kim I, Lee D, Rho J Abstract The optical holography technique realized by metasurfaces has emerged as a novel approach to projective volumetric display and information encryption display in the form of ultrathin and almost flat optical devices. Compared to the conventional holographic technique with spatial...
Tue Oct 13, 2020 22:58
Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties. J Vis Exp. 2020 Sep 27;(163): Authors: Cerezo R, Fernández E, Gómez C, Sánchez-Santillán M, Taub M, Azevedo R Abstract Learning disabilities (LDs) encompass disorders of those who have difficulty learning and using academic skills, exhibiting performance below expectations for their chronological age in the areas of reading, writing,...
Tue Oct 13, 2020 22:58
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice. J Vis Exp. 2020 Sep 22;(163): Authors: Xie Y, Deng SY, Chen SM, Chen XJ, Lai WW, Huang LF, Ba L, Wang W, Ding FF Abstract Sleep disturbance is generally common in populations as a chronic disease or a complained event. Chronic sleep disturbance is proposed to be closely linked to the pathogenesis...
Tue Oct 13, 2020 22:58
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia. J Vis Exp. 2020 Sep 22;(163): Authors: Suárez-Cuenca JA, Vera-Gómez E, Hernández-Patricio A, Ruíz-Hernández AS, Gutiérrez-Buendía JA, Zamora-Alemán CR, Melchor-López A, Rizo-García YA, Lomán-Zúñiga OA, Escotto-Sánchez I, Rodríguez-Trejo JM, Pérez-Cabeza de Vaca R, Téllez-González MA, Mondragón-Terán P Abstract ...
Tue Oct 13, 2020 22:58
Lipidico Injection Protocol for Serial Crystallography Measurements at the Australian Synchrotron. J Vis Exp. 2020 Sep 23;(163): Authors: Berntsen P, Sharma R, Kusel M, Abbey B, Darmanin C Abstract A facility for performing serial crystallography measurements has been developed at the Australian synchrotron. This facility incorporates a purpose built high viscous injector, Lipidico, as part of the macromolecular crystallography (MX2) beamline...
Tue Oct 13, 2020 22:58
Ultra-High-Speed Western Blot using Immunoreaction Enhancing Technology. J Vis Exp. 2020 Sep 26;(163): Authors: Higashi SL, Yagyu K, Nagase H, Pearson CS, Geller HM, Katagiri Y Abstract A western blot (also known as an immunoblot) is a canonical method for biomedical research. It is commonly used to determine the relative size and abundance of specific proteins as well as post-translational protein modifications. This technique has a rich...
Tue Oct 13, 2020 22:58
Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry. J Vis Exp. 2020 Sep 27;(163): Authors: Wang W, Zhang Y, Anzivino MJ, Bertram EH, Woznak J, Klibanov A, Dumont E, Wintermark M, Lee KS Abstract Surgical intervention can be quite effective for treating certain types of medically intractable neurological diseases. This approach is particularly useful for disorders in which identifiable neuronal circuitry plays...
Tue Oct 13, 2020 22:58
Horizontal Hippocampal Slices of the Mouse Brain. J Vis Exp. 2020 Sep 22;(163): Authors: Van Hoeymissen E, Philippaert K, Vennekens R, Vriens J, Held K Abstract The hippocampus is a highly organized structure in the brain that is a part of the limbic system and is involved in memory formation and consolidation as well as the manifestation of severe brain disorders, including Alzheimer's disease and epilepsy. The hippocampus receives a...
Tue Oct 13, 2020 22:58
In Vitro Evaluation of Oncogenic Transformation in Human Mammary Epithelial Cells. J Vis Exp. 2020 Sep 24;(163): Authors: Repullés J, Terradas M, Fuster G, Genescà A, Anglada T Abstract Tumorigenesis is a multi-step process in which cells acquire capabilities that allow their growth, survival, and dissemination under hostile conditions. Different tests seek to identify and quantify these hallmarks of cancerous cells; however, they often...
Tue Oct 13, 2020 22:58
Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model. J Vis Exp. 2020 Sep 22;(163): Authors: Deng Y, Zhou M, Lu Y, Chen J, Pu Z, Yu D, Dai Y, Zhan Y, Mou L Abstract Xenotransplantation is a feasible method to treat organ failure. However, how to effectively monitor the immune rejection of xenotransplantation is a problem for physicians and researchers. This manuscript describes a simple and effective...
Tue Oct 13, 2020 22:58
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device. J Vis Exp. 2020 Sep 24;(163): Authors: Blondonnet R, Paquette B, Audard J, Guler R, Roman FX, Zhai R, Belville C, Blanchon L, Godet T, Futier E, Bazin JE, Constantin JM, Sapin V, Jabaudon M Abstract Acute respiratory distress syndrome (ARDS) is a common cause of hypoxemic respiratory failure and death in critically...
Tue Oct 13, 2020 22:58
Laser-Induced Brain Injury in the Motor Cortex of Rats. J Vis Exp. 2020 Sep 26;(163): Authors: Kuts R, Melamed I, Shiyntum HN, Gruenbaum BF, Frank D, Knyazer B, Natanel D, Severynovska O, Vinokur M, Boyko M Abstract A common technique for inducing stroke in experimental rodent models involves the transient (often denoted as MCAO-t) or permanent (designated as MCAO-p) occlusion of the middle cerebral artery (MCA) using a catheter. This...
Tue Oct 13, 2020 22:58
Versatile Dual-Inlet Sample Introduction System for Multi-Mode Single Particle Inductively Coupled Plasma Mass Spectrometry Analysis and Validation. J Vis Exp. 2020 Sep 24;(163): Authors: Rosenkranz D, Kriegel FL, Mavrakis E, Pergantis SA, Reichardt P, Tentschert J, Jakubowski N, Laux P, Panne U, Luch A Abstract Metal-containing nanoparticles (NP) can be characterized with inductively coupled plasma mass spectrometers (ICP-MS) in terms...
Tue Oct 13, 2020 22:58
Three-Dimensional Motor Nerve Organoid Generation. J Vis Exp. 2020 Sep 24;(163): Authors: Osaki T, Chow SYA, Nakanishi Y, Hernández J, Kawada J, Fujii T, Ikeuchi Y Abstract A fascicle of axons is one of the major structural motifs observed in the nervous system. Disruption of axon fascicles could cause developmental and neurodegenerative diseases. Although numerous studies of axons have been conducted, our understanding of formation and...
Tue Oct 13, 2020 22:58
Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction. J Vis Exp. 2020 Sep 26;(163): Authors: Roche CD, Gentile C Abstract Testing regenerative properties of 3D bioprinted cardiac patches in vivo using murine models of heart failure via permanent left anterior descending (LAD) ligation is a challenging procedure and has a high mortality rate due to its nature. We developed a method to consistently transplant...
Tue Oct 13, 2020 22:58
Oral Intubation Attempts in Patients With a Laryngectomy: A Significant Safety Threat. Otolaryngol Head Neck Surg. 2020 Oct 13;:194599820960728 Authors: Brenner MJ, Cramer JD, McGrath BA, Balakrishnan K, Stepan KO, Pandian V, Roberson DW, Shah RK, Chen AY, Brook I, Nussenbaum B Abstract It is impossible to secure the airway of a patient with "neck-only" breathing transorally or transnasally. Surgical removal of the larynx (laryngectomy) or...
02:53
[Clinical value of upper airway MSCT measurement in adult male patients with moderate to severe OSA]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Sep;34(9):814-819 Authors: Guo C, Long P, Ye J, Li H Abstract Objective:To investigate the pathogenesis of OSA-related through 128-slice spiral CT measurements of adult male patients with moderate to severe OSA at different respiratory phases, and to optimize treatment options for patients...
02:53
[Guidance of laser therapy for early laryngeal carcinoma by mucosal wave changes]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Sep;34(9):769-772 Authors: Ding S, Huang J, Guo W, Zhang Y, Zhong Q, Huang Z Abstract Objective:Analyze the relationship between the change of mucosal wave and the infiltrating level of early laryngeal carcinoma so as to guide the cordectomy. Method:Retrospective research on patients of 1a stage without anterior...
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[Surgical landmarks of the inferior laryngeal nerve : do they differ by ethnicity ?] Rev Med Suisse. 2020 Oct 07;16(709):1849-1852 Authors: Ngo-Nyeki AR, Triponez F, Guyot JP Abstract For safe procedures, the surgeon performing thyroid gland surgeries must know precisely the anatomical relationships of the inferior laryngeal nerve with other cervical structures, in particular the inferior laryngeal artery and its branches. Classic descriptions...
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[Laryngeal reinnervation]. Rev Med Suisse. 2020 Oct 07;16(709):1845-1848 Authors: Salati V, Beharry A, Fries S, Sandu K, Gorostidi F Abstract The surgical management of unilateral and bilateral vocal cord paralysis depends on the severity of the condition, the potential for spontaneous recovery, the patient's age and vocal expectations. Standardized re-innervation surgeries, unilateral non-selective and bilateral selective, are viable alternatives...
02:53
Related Articles Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-induced Goblet Cell Metaplasia in the Adult Murine Lung. Am J Respir Cell Mol Biol. 2020 07;63(1):46-56 Authors: Carrer M, Crosby JR, Sun G, Zhao C, Damle SS, Kuntz SG, Monia BP, Hart CE, Grossman TR Abstract Goblet cell metaplasia, excessive mucus production, and inadequate mucus clearance accompany and exacerbate multiple chronic respiratory disorders, such...
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Related Articles Transcutaneous laryngeal ultrasonography: a reliable, non-invasive and inexpensive preoperative method in the evaluation of vocal cords motility-a prospective multicentric analysis on a large series and a literature review. Updates Surg. 2020 Sep;72(3):885-892 Authors: Gambardella C, Offi C, Romano RM, De Palma M, Ruggiero R, Candela G, Puziello A, Docimo L, Grasso M, Docimo G Abstract Thyroidectomy is a largely performed intervention...
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Related Articles The Protective Effect of Echinochrome A on Extracellular Matrix of Vocal Folds in Ovariectomized Rats. Mar Drugs. 2020 Jan 24;18(2): Authors: Kim JM, Kim JH, Shin SC, Park GC, Kim HS, Kim K, Kim HK, Han J, Mishchenko NP, Vasileva EA, Fedoreyev SA, Stonik VA, Lee BJ Abstract Here, we investigated the effects of sex hormones on extracellular matrix (ECM)-related gene expression in the vocal fold lamina propria of ovariectomized...
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Related Articles Coaxial projective imaging system for surgical navigation and telementoring. J Biomed Opt. 2019 10;24(10):1-9 Authors: Zhang F, Zhu X, Gao J, Wu B, Liu P, Shao P, Xu M, Pawlik TM, Martin EW, Xu RX Abstract A coaxial projective imaging (CPI) module acquires surgical scene images from the local site of surgery, transfers them wirelessly to the remote site, and projects instructive annotations to the surgical field. At the remote...
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Pilocarpine for Radiotherapy-Induced Dry Mouth and Dry Eyes: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines Book. 2020 01 08Authors: Marchand DK, McCormack S Abstract The jaw, larynx, nasopharynx, mouth, ears, and salivary glands are some of the most common areas affected when referring to head and neck cancers.1 The yearly incidence of head and neck cancer in Canada is over 4,300.2 A common side-effect of radiation therapy for head and...
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[Effect of extraction on condylar process position and upper airway in 12-14 years old females with skeletal Class Ⅱ high angle]. Shanghai Kou Qiang Yi Xue. 2020 Jun;29(3):281-286 Authors: Lei J, Xiao Y, Luo MX, Xu XM Abstract PURPOSE: To investigate the effect of extraction on condylar process position and upper airway in 12-14 years old females with skeletal ClassⅡhigh angle. METHODS: Twenty seven 12-14 years old females with skeletal...
Tue Oct 13, 2020 23:18
Pleomorphic adenoma of the nasal septum - A rare entity. Natl J Maxillofac Surg. 2020 Jan-Jun;11(1):136-139 Authors: Bose S, Agarwal M, Nawale K Abstract Pleomorphic adenoma (PA) is the most common benign tumor of major salivary glands, and it rarely arises in minor salivary glands. PA has been reported at various sites where minor salivary glands are found and include nasal cavity, nasopharynx, pharynx, larynx, hypopharynx, and even lacrimal...
Tue Oct 13, 2020 23:18
Effect of 4% nebulized lignocaine versus 2% nebulized lignocaine for awake fibroscopic nasotracheal intubation in maxillofacial surgeries. Natl J Maxillofac Surg. 2020 Jan-Jun;11(1):40-45 Authors: Kumar L, Abbas H, Kothari N, Kohli M, Dhasmana S Abstract Introduction: Securing a difficult airway during maxillofacial surgeries is a great challenge for anesthetists, and the flexible fiber-optic bronchoscope is the gold standard while managing...
Tue Oct 13, 2020 23:18
Insulin-like growth factor 1 promotes the extension of Tracheal Epithelium in an in Vitro Tracheal organ culture model. Auris Nasus Larynx. 2020 Oct 08;: Authors: Kishimoto I, Ohnishi H, Yamahara K, Nakagawa T, Yamashita M, Omori K, Yamamoto N Abstract OBJECTIVE: Rapid epithelialization is crucial to maintain tracheal patency and prevent potential graft failure in tracheal reconstruction after tracheal resection for cancer with tracheal infiltration...
Tue Oct 13, 2020 23:18
Related Articles Clipping Technique for the Repair of the Intraoperative Cerebrospinal Fluid Leakage during Transsphenoidal Pituitary Tumor Surgery. Oper Neurosurg (Hagerstown). 2019 10 01;17(4):382-388 Authors: Kim EH, Moon JH, Kim SH Abstract BACKGROUND: During transsphenoidal surgery (TSS) for a pituitary adenoma with a large suprasellar extension, cerebrospinal fluid (CSF) leakage commonly develops from a defect in the arachnoid recess...
Wed Oct 14, 2020 21:39
Exploring metastatic breast cancer treatment changes during COVID-19 pandemic. J Chemother. 2020 Oct 13;:1-6 Authors: Fedele P, Ferro A, Sanna V, La Verde N, Paris I, Chiari R Abstract The emergency caused by COVID-19 pandemic has imposed a sudden reorganization of the healthcare structures and has created consequences in cancer patients management. General clinical recommendations for cancer patients were released, even if limited clinical...
Wed Oct 14, 2020 23:58
Real world experience on maintenance chemotherapy with gemcitabine in second line setting for advanced non-small cell lung carcinoma. J Chemother. 2020 Oct 12;:1-8 Authors: Kwok WC, Lam DCL, Chiang KY, Ho JCM, Ip MSM, Tam TCC Abstract Maintenance chemotherapy was studied in first line setting for advanced stage non-small cell lung carcinoma (NSCLC). There has not been any data on the role of continuation maintenance chemotherapy in second line...
Tue Oct 13, 2020 23:52
Liquid biopsy in lymphoma: Molecular methods and clinical applications. Cancer Treat Rev. 2020 Sep 22;91:102106 Authors: Cirillo M, Craig AFM, Borchmann S, Kurtz DM Abstract In this article, we broadly review the application of cfDNA analysis to the diagnosis and management of lymphoma. We introduce the advantages of cfDNA measurement over conventional tissue biopsy and describe how cfDNA may be utilized for both genotyping and detection of...
Wed Oct 14, 2020 23:09
Circulating microRNAs as biomarkers to assist the management of the malignant germ-cell-tumour subtype choriocarcinoma. Transl Oncol. 2020 Oct 10;14(1):100904 Authors: Murray MJ, Smith S, Ward D, Verduci L, Nicholson JC, Scarpini CG, Coleman N Abstract Germ-cell-tumours (GCTs) are heterogeneous and management is complex. The current conventional biomarkers, alpha-fetoprotein and human-chorionic-gonadotropin (HCG), have limited utility for diagnosis/follow-up...
Wed Oct 14, 2020 23:09
High preoperative levels of circulating SFRP5 predict better prognosis in colorectal cancer patients. Future Oncol. 2020 Oct 13;: Authors: Kirana C, Smith E, Ngo DT, Trochsler MI, Hewett PJ, Stubbs RS, Hardingham JE, Maddern GJ, Hauben E Abstract The purpose of this research was to investigate the diagnostic and prognostic value of circulating SFRP5 (cSFRP5) in colorectal cancer (CRC). We evaluated preoperative cSFRP5 levels in CRC patients...
Wed Oct 14, 2020 23:09
Targeting FGFR2 in advanced cholangiocarcinoma: an interview with Arndt Vogel. Future Oncol. 2020 Oct 13;: Authors: Vogel A Abstract Professor Arndt Vogel, a senior consultant and professor of gastrointestinal oncology in the Department of Gastroenterology, Hepatology and Endocrinology at Hannover Medical School, Germany, speaks with Rachel Jenkins (Senior Editor of Oncology Central) about cholangiocarcinoma, the challenges of the field and...
Wed Oct 14, 2020 23:09
Pharmacodynamic biomarkers in metronomic chemotherapy: multiplex cytokine measurements in gastrointestinal cancer patients. Clin Exp Med. 2020 Oct 13;: Authors: Valenzuela P, Oaxaca D, Di Desidero T, Parra K, Rodriguez G, Manciu M, Allegrini G, Falcone A, Bocci G, Kirken RA, Francia G Abstract Metronomic chemotherapy has shown promising antitumor activity in a number of malignancies. We previously reported a phase II clinical trial of metronomic...
Wed Oct 14, 2020 23:09
Impact of Vulvovaginal Symptoms in Women Diagnosed with Cancer: A Psychometric Evaluation of the Day-to-Day Impact of Vaginal Aging Questionnaire. J Womens Health (Larchmt). 2020 Oct 12;: Authors: Toivonen K, Santos-Iglesias P, Walker LM Abstract Background: Vulvovaginal symptoms (VVS), such as dyspareunia, dryness, and itching, are common following cancer treatment and can negatively impact sexual well-being, daily activities, mood, self-concept,...
Wed Oct 14, 2020 23:09
Health-related quality of life in breast cancer patients: review of reviews from 2008 to 2018. Health Qual Life Outcomes. 2020 Oct 12;18(1):338 Authors: Mokhatri-Hesari P, Montazeri A Abstract BACKGROUND: Breast cancer still is a topic. This overview of the literature aimed to update the current knowledge on quality of life in breast cancer patients. METHODS: A review of literature in MEDLINE, Cochrane Database of Systematic Reviews...
Wed Oct 14, 2020 23:09
Related Articles Egg White as a Quality Control in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI). Anal Chem. 2019 12 03;91(23):14846-14853 Authors: Condina MR, Mittal P, Briggs MT, Oehler MK, Klingler-Hoffmann M, Hoffmann P Abstract The strength of MALDI-MSI is to analyze and visualize spatial intensities of molecular features from an intact tissue. The distribution of the intensities can then be visualized...
Wed Oct 14, 2020 23:09
Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem. 2020 Oct 07;209:112857 Authors: Granchi C, Bononi G, Ferrisi R, Gori E, Mantini G, Glasmacher S, Poli G, Palazzolo S, Caligiuri I, Rizzolio F, Canzonieri V, Perin T, Gertsch J, Sodi A, Giovannetti E, Macchia M, Minutolo F, Tuccinardi T, Chicca A Abstract An interesting enzyme...
Tue Oct 13, 2020 21:24
Prevalence and predictors of weight loss during induction therapy for childhood acute lymphoblastic leukemia. Nutrition. 2020 Jul 03;81:110937 Authors: Hill R, Hamby T, Johnson D, Boren C, Downs H, Ray A Abstract Children with acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma often experience significant weight gain during induction therapy. However, a subgroup of patients may experience weight loss, which can impact outcomes; thus,...
Tue Oct 13, 2020 21:24
Hematopoietic Cell Transplantation: Practice predictions for the Year 2023. Biol Blood Marrow Transplant. 2020 Oct 09;: Authors: Farhadfar N, Burns LJ, Mupfudze T, Shaw BE, Bollard CM, Devine SM, Horowitz MM, Jones RJ, Murthy HS, Wingard JR, Lee SJ Abstract BACKGROUND: Research priorities are best determined by the most pressing scientific questions, in the context of current knowledge. However, definitive research studies take time while real-world...
Tue Oct 13, 2020 21:24
Likelihood of Proceeding to Allogeneic Hematopoietic Cell Transplantation in the United States after Search Activation in the National Registry: Impact of Patient Age, Disease and Search Prognosis. Biol Blood Marrow Transplant. 2020 Oct 09;: Authors: Dehn J, Chitphakdithai P, Shaw BE, McDonald AA, Devine SM, Burns LJ, Spellman S Abstract The National Marrow Donor Program® (NMDP) operates the Be The Match Registry® to serve patients who require...
Tue Oct 13, 2020 21:24
The Cryo-immunologic effect: a therapeutic advance in the treatment of glioblastomas? Neurochirurgie. 2020 Oct 09;: Authors: Cebula H, Noel G, Garnon J, Todeschi J, Burckel H, DeMathelin M, Gangi A, Proust F Abstract The immunotherapy of cerebral glioblastoma has become a hot topic. Immune checkpoint blockade antibodies have progressively acquired a role in the management of malignant tumors. A multimodal approach using surgery, radiotherapy,...
Tue Oct 13, 2020 21:24
Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review. Cochrane Database Syst Rev. 2020 Oct 12;10:CD013600 Authors: Chai KL, Valk SJ, Piechotta V, Kimber C, Monsef I, Doree C, Wood EM, Lamikanra AA, Roberts DJ, McQuilten Z, So-Osman C, Estcourt LJ, Skoetz N Abstract BACKGROUND: Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with viral respiratory diseases,...
Tue Oct 13, 2020 21:24
Poly(ADP-Ribose) Polymerase Inhibitors in Prostate Cancer: Molecular Mechanisms, and Preclinical and Clinical Data. Target Oncol. 2020 Oct 12;: Authors: Sigorski D, Iżycka-Świeszewska E, Bodnar L Abstract Genomic instability is one of the hallmarks of cancer. The incidence of genetic alterations in homologous recombination repair genes increases during cancer progression, and 20% of prostate cancers (PCas) have defects in DNA repair genes....
Tue Oct 13, 2020 21:24
Colonic J-Pouch or Straight Colorectal Reconstruction After Low Anterior Resection For Rectal Cancer: Impact on Quality of Life and Bowel Function: A Multicenter Prospective Randomized Study. Dis Colon Rectum. 2020 Nov;63(11):1511-1523 Authors: Gavaruzzi T, Pace U, Giandomenico F, Pucciarelli S, Bianco F, Selvaggi F, Restivo A, Asteria CR, Morpurgo E, Cuicchi D, Jovine E, Coletta D, La Torre G, Amato A, Chiappa A, Marchegiani F, Rega D, De Franciscis S, Pellino...
Tue Oct 13, 2020 21:24
Non-invasive imaging techniques to assess myocardial perfusion. Expert Rev Med Devices. 2020 Oct 12;: Authors: Villemain O, Baranger J, Jalal Z, Lam C, Calais J, Pernot M, Cifra B, Friedberg MK, Mertens L Abstract INTRODUCTION: Coronary artery disease affecting myocardial perfusion continues to be the leading cause of cardiovascular morbidity and mortality worldwide. While invasive evaluation based on coronary angiography and flow measurements...
Tue Oct 13, 2020 21:24
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