The data herein represents multiple gauge sets and multiple radar sites of like-type Doppler data sets combined to produce populations of ordered pairs. Publications spanning decades yet specific to Doppler ra...
Wed Oct 14, 2020 03:00
Abstract Studies of early adversity such as trauma, abuse, and neglect highlight the critical importance of quality caregiving in brain development and mental health. However, the impact of normative range variability in caregiving on such biobehavioral processes remains poorly understood. Thus, we lack an essential foundation for understanding broader, population‐representative developmental mechanisms of risk and resilience. Here, we conduct a scoping review of the extant literature centered on...
Wed Oct 14, 2020 13:27
Abstract Genetic mediation of cortical plasticity and the role genetic variants play in previously observed response variability to transcranial direct current stimulation (tDCS) have become important issues in the tDCS literature in recent years. This study investigated whether inter‐individual variability to tDCS was in‐part genetically mediated. In sixty‐one healthy males, anodal‐tDCS (a‐tDCS) and sham‐tDCS were administered to the primary motor cortex at 1mA for 10‐minutes via 6x4cm active and...
Tue Oct 13, 2020 18:40
Abstract A variety of perceptual phenomena suggest that, contrary to our everyday experience, our perception may be discrete rather than continuous. The possibility of such discrete sampling processes inevitably prompts the question how such discretization is implemented in the brain. Evidence from neurophysiological measurements suggest that neural oscillations, particularly in the lower frequencies, may provide a mechanism by which such discretization can be implemented. It is hypothesized that...
Tue Oct 13, 2020 16:47
Abstract Behavioral findings suggest that aging alters the involvement of cortical sensorimotor mechanisms in postural control. However, corresponding accounts of the underlying neural mechanisms remain sparse, especially the extent to which these mechanisms are affected during more demanding tasks. Here, we set out to elucidate cortical correlates of altered postural stability in younger and older adults. 3D body motion tracking and high‐density electroencephalography (EEG) were measured while...
Mon Oct 12, 2020 17:31
We have conducted a systematic review of case reports of fistulae involving the appendix and identified 301 unique case reports, with a range of different sites and aetiologies. Abstract Background The appendix has a unique place in surgical history. Although the first ever appendicectomy involved a fistula to the skin, fistulae involving the appendix remain uncommon and can lead to unique surgical considerations. Methods A systematic review of the literature was performed for...
Tue Oct 13, 2020 14:13
Tue Oct 13, 2020 14:13
Tue Oct 13, 2020 14:13
This study examines the impact that social distancing measures introduced to combat coronavirus disease 2019 (COVID‐19) have had on the orthopaedic trauma load at a level 1 trauma hospital in Sydney. Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic has affected communities worldwide. This study examines the impact that public health measures to control viral spread have had on orthopaedic trauma presenting to an Australian level 1 trauma centre. We hypothesized that...
Tue Oct 13, 2020 11:56
Abstract Circulating cell‐free nuclear DNA (nDNA) has been implicated in individual cancer types with a diagnostic value; however, the role of cell‐free mitochondrial DNA (mtDNA) in cancers is controversial. We aimed to investigate and compare the diagnostic potential of both nDNA and mtDNA for multiple cancers and to investigate their ability to distinguish multiple cancers from healthy controls and from nonmalignant diseases. We also investigated the prognostic value of both nDNA and mtDNA. The...
Tue Oct 13, 2020 21:03
Coprevalence of Presbycusis and Its Effect on Outcome of Voice Therapy in Patients With Presbyphonia
Publication date: Available online 14 October 2020Source: Journal of VoiceAuthor(s): Ji Hye Park, Minsuk Chae, Yong-Hwi An, Hyun Joon Shim, Minsu Kwon
Wed Oct 14, 2020 13:01
Publication date: Available online 13 October 2020Source: Journal of VoiceAuthor(s): Hengxin Liu, ShengHwa Chen, Liqun Gao, Jinrang Li, Boquan Liu, Hayley Raj, Qingqing Xie, Haifeng Duan, Zhen Jiang, Yang Liu, Bangqi Chen, Yan Liu, Jack Jiang
Wed Oct 14, 2020 13:01
Publication date: Available online 13 October 2020Source: Journal of VoiceAuthor(s): Kristen MURDAUGH, Josipa BAINAC HAUSKNECHT, Christian T. HERBST
Wed Oct 14, 2020 13:01
Publication date: Available online 13 October 2020Source: Journal of VoiceAuthor(s): Seyed Abolfazl Tohidast, Banafshe Mansuri, Payman Dabirmoghadam, Mehran Choubineh, Rasool Bagheri, Abbas Ebadi, Hadi Azimi
Tue Oct 13, 2020 17:55
Publication date: Available online 12 October 2020Source: Journal of VoiceAuthor(s): Teresa Procter, Ashwini Joshi
Tue Oct 13, 2020 17:55
Publication date: Available online 12 October 2020Source: Journal of VoiceAuthor(s): Andrea Nacci, Alberto Macerata, Luca Bastiani, Gaetano Paludetti, Jacopo Galli, Maria Raffaella Marchese, Maria Rosaria Barillari, Umberto Barillari, Cecilia Laschi, Matteo Cianchetti, Mariangela Manti, Stefano Berrettini, Bruno Fattori, Francesco Ursino
Tue Oct 13, 2020 17:55
The estimated worldwide incidence of perioperative anaphylaxis (PA) is between 1 in 1,250 and 1 in 20,000 in procedures.
Wed Oct 14, 2020 03:00
Local activation of B cells and antibody production is important for protective and pathogenic immune responses. There is also evidence that local activation of B cells and antibody production is important for pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), and a severe subset of CRSwNP, aspirin-exacerbated respiratory disease (AERD). This review summarizes these findings and the potential role of B cells and antibodies in disease pathogenesis.
Tue Oct 13, 2020 03:00
Abstract Background The etiology of temporomandibular disorders (TMD) has been widely discussed in literature, but little is known about patients’ self‐belief of their TMD etiology. Objective For six categories of self‐believed etiology of the TMD complaint (viz., occlusal factors, physical trauma, emotional stress, deep pain input, parafunctions, and unknown), associations with physical, psychological, and socio‐demographic predictors were assessed. Methods In this retrospective...
Tue Oct 13, 2020 21:24
Abstract The use of oral implants as a form of replacing missing teeth in partial or total edentulous patients has been labeled the gold standard in oral rehabilitation1. It has been considered a history of success in modern dentistry since the reports of the well succeed osseointegration process early in 1980’s2,3.
Mon Oct 12, 2020 17:06
Sepsis is characterized by a life-threatening organ dysfunction caused by an unbalanced host response to microbe infection that can lead to death. Besides being currently the leading cause of death in intensive care units worldwide, sepsis can also induce long-term consequences among survivors, such as cognitive impairment. Statins (lipid-lowering drugs widely used to treat dyslipidemia) have been shown to possess pleiotropic anti-inflammatory and antimicrobial effects. These drugs act inhibiting...
Wed Oct 14, 2020 08:50
The intestinal barrier plays a crucial role in the absorption of nutrients and in preventing the entry of pathogenic microorganisms and toxic molecules. Several studies have shown a compromised intestinal barrier associated with low-grade inflammation in the small intestinal mucosa in celiac disease, inflammatory bowel disease, and irritable bowel syndrome (IBS), particularly in IBS with diarrhea (IBS-D). In light of these new data, IBS is no longer considered a functional disease but rather a heterogeneous...
Wed Oct 14, 2020 10:05
Background. With an enormous amount of research concerning kidney cancer being conducted, various treatments have been applied to its cure. However, high recurrence and metastasis rates continue to pose a threat to the survival of patients with kidney renal clear cell carcinoma (KIRC). Methods. Data from The Cancer Genome Atlas were downloaded, and a series of analyses were performed, including differential analysis, Cox analysis, weighted gene coexpression network analysis, least absolute shrinkage...
Tue Oct 13, 2020 19:35
Objectives. We investigated the influence of pain decrease after lumbar microdiscectomy on the interferon gamma (IFN-γ) serum level in patients with lumbar disc herniations. The study challenges the mechanism of sciatica pain and the role of IFN-γ in radicular pain development. Material and Methods. We performed clinical and immunoenzymatic assessment in a group of 27 patients with lumbar radicular pain due to disc herniations before and 3 months after surgery. Clinical status was assessed with the...
Tue Oct 13, 2020 15:05
ABSTRACT This second installment of The Effects of Obesity on the Human Body considers the nervous, respiratory, and lymphatic systems. Those with obesity face countless psychological hurdles in addition to the respiratory burden and widespread inflammation that can suppress the immune system, resulting in the accumulation of excess fluid in body tissues.
Tue Oct 13, 2020 17:23
Zusammenfassung Maschinelles Lernen (ML) hält gegenwärtig Einzug in viele Bereiche der Gesellschaft, so auch in die Medizin. Diese Transformation birgt das Potenzial, den ärztlichen Berufsalltag drastisch zu verändern. In der Interaktion zwischen den Disziplinen und Modalitäten der onkologischen Patientenversorgung wird dies besonders deutlich. Computer erbringen in mehreren Forschungsarbeiten in Kollaboration mit Menschen oder allein bereits bessere Ergebnisse in der Tumoridentifikation,...
Wed Oct 14, 2020 03:00
Abstract Trastuzumab deruxtecan (T‐DXd: DS‐8201a) is an anti‐HER2 antibody drug conjugated with deruxtecan (DXd), a derivative of exatecan. The objective of this study was to characterize T‐DXd‐induced lung toxicity in cynomolgus monkeys. T‐DXd was administered intravenously to monkeys once every 3 weeks for 6 weeks (10, 30, and 78.8 mg/kg) or for 3 months (3, 10, and 30 mg/kg). To evaluate the involvement of DXd alone in T‐DXd‐induced toxicity, DXd monohydrate was administered intravenously to...
Wed Oct 14, 2020 10:57
Abstract Regulation of genome wide DNA methylation is fundamental for a variety of biological processes such as mammalian development, stem cell function, cellular proliferation/ differentiation and oncogenesis. Among the regulators of DNA methylation, Ten‐Eleven Translocation 2 (TET2) is one of the most frequently mutated genes in clonal hematopoiesis of indeterminate potential and in various hematological malignancies, underscoring a pivotal role for TET2 in blood homeostasis and hematopoietic...
Tue Oct 13, 2020 17:43
Summary Tislelizumab, an anti‐programmed death protein‐1 (PD‐1) monoclonal antibody, was engineered to minimize binding to FcγR on macrophages to abrogate antibody‐dependent phagocytosis, a mechanism of T‐cell clearance and potential resistance to anti‐PD‐1 therapy. This single‐arm phase 2 trial (NCT04004221/CTR20170071) assessed the safety, tolerability, and efficacy of tislelizumab in patients with PD‐L1 positive urothelial carcinoma who progressed during/following platinum‐containing therapy...
Mon Oct 12, 2020 17:05
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveThis study was performed to introduce posterior laminectomy and pedicle screw fixation for the treatment of upper cervical spinal cord tumors and investigate the curative effects.MethodsEighteen patients (11 men, 7 women) who underwent surgical treatment of an upper cervical intraspinal tumor from January 2008 to June 2013 were reviewed. Clinical parameters including age, sex, affected spinal levels, lesion location,...
Wed Oct 14, 2020 07:58
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveWe aimed to explore the relationship between neutrophil-to-lymphocyte ratio (NLR) at three timepoints and prognosis of patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing elective percutaneous coronary intervention (PCI) within 1 year of PCI.MethodsThis retrospective study enrolled 231 patients with NSTE-ACS who received PCI and were followed for 1 year after PCI. The study population...
Wed Oct 14, 2020 07:56
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Although customized three-dimensional tantalum implants have been used to treat a large variety of diseases, few reports have described the application of such implants to reconstruct large pelvic bone defects after the removal of massive tumors. We herein describe a 30-year-old woman with a 9-year history of a massive low-grade chondrosarcoma in the pelvic bone. After removal of a solid 12- × 8- × 6-cm tumor with clear...
Wed Oct 14, 2020 07:53
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Postpancreatectomy haemorrhage (PPH) is a rare and life-threatening complication that can occur after pancreaticoduodenectomy (PD). Recently, radiological intervention has become a first-line approach for the diagnosis and treatment of late PPH in haemodynamically stable patients. Surgical intervention should be performed in haemodynamically unstable patients. We report the case of a 54-year-old man who underwent PD for...
Wed Oct 14, 2020 07:49
Journal of International Medical Research, Volume 48, Issue 10, October 2020. The occurrence of early esophageal cancer located within an area of leiomyoma is extremely rare, and its clinical features and treatment methods have not been well described. We herein report the clinical characteristics, diagnosis, and treatment methods of early esophageal cancer that developed on top of a leiomyoma in the upper third of the esophagus in a 78-year-old woman. All tumor marker concentrations were normal....
Wed Oct 14, 2020 07:46
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo evaluate the clinical efficacy of double-balloon endoscopy (DBE) for small bowel disease (SBD).MethodsThe clinical and endoscopic data of patients who underwent DBE in a Chinese tertiary hospital from January 2006 to December 2019 were retrospectively reviewed. The patients were divided into three groups by age: the young group (<45 years), middle-aged group (45–65 years), and older group (>65 years).ResultsIn...
Wed Oct 14, 2020 07:43
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectivesThis study presented the feasibility of oxycodone as the sole opioid for general anaesthesia in minor/moderate surgery.MethodsIn this prospective, observational, descriptive study, 62 patients were enrolled and received intravenous oxycodone as the sole opioid for the induction and maintenance of general anaesthesia. We observed all of these patients to determine whether oxycodone alone could provide sufficient...
Wed Oct 14, 2020 07:41
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo investigate whether the combination of D-dimer and simplified pulmonary embolism severity index (sPESI) could improve prediction of in-hospital death from pulmonary embolism (PE).MethodsPatients with PE (n = 272) were divided into a surviving group (n = 249) and an in-hospital death group (n = 23).ResultsCompared with surviving patients, patients who died in hospital had significantly higher rates of hypotension...
Wed Oct 14, 2020 07:39
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveThis study was performed to determine the maximum voluntary molar bite force (MVMBF) in relation to age, sex, lip competency, midline shifting, dental and skeletal malocclusion, overjet, overbite, and crowding.MethodsOne hundred Saudi patients with orthodontic malocclusion aged 14 to 25 years (51 male and 49 female patients) were investigated in this cross-sectional study. The baseline MVMBF on the right and left...
Wed Oct 14, 2020 07:36
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveThe present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury.MethodsA prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they were enrolled as research participants and randomly assigned to control and experimental groups (n = 44 per group) using a random...
Wed Oct 14, 2020 07:34
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo explore the usefulness of highly sensitive nucleic acid detection for assisting with the accurate antiviral treatment of patients with cirrhosis that was caused by hepatitis.MethodsThere were 377 patients with hepatitis B with cirrhosis and 119 patients with hepatitis C with cirrhosis, either as hospitalized patients and outpatients, who were enrolled into the study. Among them, 299 were men and 197 were women...
Wed Oct 14, 2020 07:30
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo determine if iodine-125 seed implantation improved the efficacy of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) (≤5 cm).MethodsWe retrospectively reviewed the medical records of 83 consecutive patients with HCC (≤5 cm) who underwent TACE or TACE–iodine-125 from January 2014 to July 2017. The primary endpoint was progression-free survival (PFS). The secondary endpoints...
Wed Oct 14, 2020 07:27
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Splenic infarction is rare, resulting from occlusion of the splenic artery or its branches. Its aetiology is complex and multifactorial involving various vascular and thrombotic diseases, thus, misdiagnosis or missed diagnosis is common. Here, the case of a 45-year old male patient diagnosed with splenic infarction caused by secondary erythrocytosis associated with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is...
Wed Oct 14, 2020 07:26
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Solitary fibrous tumors are rare mesenchymal tumors that typically arise from the pleura and rarely originate from the mesentery. We herein report a case involving a 66-year-old patient who presented with a mass on the left abdomen. This mass had been incidentally noticed 10 years earlier. The patient sometimes experienced abdominal pain. Physical examination revealed an irregular mass, which was resected. A biopsy of the...
Wed Oct 14, 2020 07:25
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectivesTo investigate the effects of sevoflurane and propofol anesthesia on inflammatory or anti-inflammatory responses in patients undergoing laparoscopic cholecystectomy (LC).MethodsPatients undergoing LC (n = 23) were divided into sevoflurane (S) (n = 11) and propofol (P) (n = 12) anesthesia groups. A blood sample was taken before induction (T0), after induction but before pneumoperitoneum (T1), 15 minutes after pneumoperitoneum...
Wed Oct 14, 2020 07:22
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveThis study was performed to compare two different shapes of stylets, 60° and J-shaped stylets, for intubation using the McGrath MAC® video laryngoscope (MVL).MethodsTwo hundred twenty-two patients undergoing surgery under general anesthesia were randomly allocated to Group J (n = 111) or Group 60° (n = 111) and intubated using the MVL with the stylet bent into the allocated shape. The time to intubation (TTI) and...
Tue Oct 13, 2020 08:21
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Spinal subarachnoid hemorrhage is a life-threatening condition often associated with markedly high morbidity and mortality rates. However, diagnosis is difficult because of its atypical symptoms. We herein describe a 52-year-old Chinese man who had been receiving warfarin therapy since having undergone mechanical mitral valve replacement surgery 3 years previously. Two days before admission to our hospital, he suddenly...
Tue Oct 13, 2020 08:20
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Most cases of female genital tuberculosis (TB) are asymptomatic and are thus difficult to diagnose. Coexistence of genital TB and ovarian serous cystadenofibroma (OSCAF) is rare and easily ignored or misdiagnosed. We report a 26-year-old woman with coexistence of genital TB and OSCAF, and with an adnexal mass detected by B-ultrasound. Laparoscopic biopsy of diffuse miliary white nodules was performed on the surface of the...
Tue Oct 13, 2020 08:16
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveWe aimed to evaluate the effects of a clinical pharmacist-led-guidance-team (CPGT) on improving rational prophylactic injectable proton pump inhibitor use (PIPU) and to explore the application of the Plan–Do–Check–Act (PDCA) method in promoting rational PIPU.MethodsWe conducted a retrospective study among 814 patients at a Chinese tertiary teaching hospital from January 2017 to December 2018. We enrolled 98 patients...
Tue Oct 13, 2020 08:15
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo assess the diagnostic value of the Xpert® MTB/RIF (GeneXpert) assay for tracheobronchial tuberculosis (TBTB) using bronchial washing fluid (BWF).MethodsThis retrospective study enrolled patients suspected of having TBTB and patients with non-TB pulmonary disease as controls. BWF were used to undertake acid-fast bacillus (AFB) smears, the GeneXpert assay and the Lӧwenstein–Jensen (LJ) culture method. The sensitivity,...
Tue Oct 13, 2020 08:11
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo investigate the relationship between Helicobacter pylori (H. pylori) infection and gallstones or gallbladder polyps.MethodsThis retrospective analysis included 27,881 individuals who underwent health examinations that included a H. pylori test and an abdominal ultrasound scan. Patients were divided into four groups: gallbladder polyp (P group), gallstone (S group), gallstone and gallbladder polyp (SP group),...
Tue Oct 13, 2020 08:10
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Autoimmune polyglandular syndrome (APS) is a rare disease that is characterized by autoimmune reactions to multiple endocrine and non-endocrine organs, which can be divided into four main types. The principal manifestations of APS-3 are autoimmune thyroid disease and other autoimmune diseases, such as type 1 diabetes, atrophic gastritis, pernicious anemia, vitiligo, alopecia, and myasthenia gravis, but not Addison’s disease...
Tue Oct 13, 2020 08:08
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveStress urinary incontinence (SUI) is prevalent worldwide, particularly among elderly women. Although electroacupuncture (EA) has been accepted by many patients and physicians in Asia, its efficacy for SUI has not been evaluated scientifically and systematically. We aimed to conduct a systematic evaluation of the efficacy and safety of EA treatment for women with SUI.MethodsWe retrieved publications up to February...
Tue Oct 13, 2020 07:49
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo investigate the clinical manifestations of infectious mononucleosis in children of different ages.MethodsClinical data from pediatric patients with infectious mononucleosis admitted from May 2015 to April 2019 were retrospectively analyzed. Patients were stratified into three groups (age 1–3 years, 4–6 years, and 7–14 years) for analysis of clinical and laboratory results.ResultsData from 61 patients (male:female...
Tue Oct 13, 2020 07:35
Journal of International Medical Research, Volume 48, Issue 10, October 2020. A diaphragmatic tumor is usually caused by metastasis from lung cancer, malignant mesothelioma, and malignant thymoma. Endometrial cancer is rarely involved in metastasis to the diaphragm. A right anterior mediastinal tumor was found in a 60-year-old woman who was initially diagnosed with endometrial carcinoma. There was initially no relationship between the right anterior mediastinal tumor and endometrial carcinoma. Radical...
Mon Oct 12, 2020 07:41
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveThis study evaluated the anti-fibrotic effects of oxymatrine and the role of endoplasmic reticulum (ER) stress in hepatic fibrosis (HF) in animal models.MethodsThe HF rat model was established by exposure to NaAsO2, followed by treatment with oxymatrine. Biomarkers of HF and ER stress were measured. The difference in protein expression between groups was evaluated using isobaric tag for relative and absolute quantification...
Mon Oct 12, 2020 07:39
Journal of International Medical Research, Volume 48, Issue 10, October 2020. Black hairy tongue (BHT) is characterized by a discolored, hairy tongue. We herein report two cases of BHT associated with antibacterial agents and review previous cases. In Case 1, a 17-year-old girl with a central neurocytoma was administered intravenous piperacillin–tazobactam for postoperative infection, and BHT developed 12 days later. Her symptoms resolved 8 days after she discontinued the piperacillin–tazobactam...
Mon Oct 12, 2020 07:31
Future Oncology, Ahead of Print.
Tue Oct 13, 2020 10:51
High preoperative levels of circulating SFRP5 predict better prognosis in colorectal cancer patients
Future Oncology, Ahead of Print.
Tue Oct 13, 2020 10:41
Abstract Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about 50% of the human population. Although most infections caused by H. pylori are asymptomatic, the microorganism is strongly associated with serious diseases of the upper gastrointestinal tract such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer, and it is classified as a group I carcinogen....
Wed Oct 14, 2020 03:00
Abstract N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels essential for glutamatergic transmission and plasticity. NMDARs are inhibited by acute ethanol and undergo brain region-specific adaptations after chronic alcohol exposure. In previous studies, we reported that knock-in mice expressing ethanol-insensitive GluN1 or GluN2A NMDAR subunits display altered behavioral responses to acute ethanol and genotype-dependent changes in drinking using protocols...
Wed Oct 14, 2020 03:00
Abstract Purpose We aimed to investigate whether 6% HES 130/0.4 was associated with postoperative reduction of estimated glomerular filtration rate (eGFR) in donor patients who underwent nephrectomy for living kidney transplantation. Methods This retrospective study included 213 living kidney transplant donors treated at Kyushu University Hospital...
Wed Oct 14, 2020 03:00
British Journal of Cancer, Published online: 14 October 2020; doi:10.1038/s41416-020-01106-xPrognostic significance of pre-treatment neutrophil-to-lymphocyte ratio (NLR) in patients with oropharyngeal cancer treated with radiotherapy
Wed Oct 14, 2020 03:00
The IRE-1 kinase/RNase splices the mRNA of the XBP-1 gene, resulting in the spliced XBP-1 (XBP-1s) mRNA that encodes the functional XBP-1s transcription factor that is critically important for the growth and survival of B-cell leukemia, lymphoma and multiple myeloma (MM). Several inhibitors targeting the expression of XBP-1s have been reported; however, the cytotoxicity exerted by each inhibitor against cancer cells is highly variable. To design better therapeutic strategies for B-cell cancer, we...
Tue Oct 13, 2020 16:56
Abstract BackgroundSutures are a set of standard actions which are accomplished by multi‐instruments, researchers studied the robot autonomy of suturing, which was based on movement planning completed by a single instrument, but did not consider the assignment of suturing tasks to instruments.MethodA method was proposed for the autonomous suturing task assignment to instruments, which built a comprehensive evaluation index under some constraint conditions to determine the optimal scheme of the suturing...
Tue Oct 13, 2020 21:19
Abstract BackgroundThis study evaluates image quality of a new flat‐panel 3D C‐arm to the current generation and to intraoperative and stationary CT in spinal surgery.Methods3D‐imaging of 44 posterior screws acquired with two generations of 3D C‐arms (Arcadis Orbic, AO and Cios Spin, CS, Siemens, Germany) and CT scans (mobile intraoperative CT Airo, iCT, Brainlab, Germany and stationary CT Aquilion 32, sCT, Toshiba, Japan) were performed. Evaluation regarded assessability and measurements of implant...
Tue Oct 13, 2020 15:45
Abstract BackgroundWe assessed pedicle screw accuracy utilizing a novel navigation‐based spine surgery robotic system by comparing planned pathways with placed pathways in a porcine model.MethodsWe placed three mini screws per vertebra for accuracy evaluation and used a reference frame for registration in four pigs (46 screws in 23 vertebrae). We planned screw paths and performed screw insertion under robot guidance. Using C‐arm and CT images, we evaluated accuracy by comparing the 3D distance of...
Tue Oct 13, 2020 15:11
ABSTRACT BackgroundThis work presents user evaluation studies to assess the effect of information rendered by an interventional planning software on the operator's ability to plan transrectal MR‐guided prostate biopsies using actuated robotic manipulators.MethodsAn intervention planning software was developed based on the clinical workflow followed for MR‐guided transrectal prostate biopsies. The software was designed to interface with a generic virtual manipulator and simulate an intervention environment...
Tue Oct 13, 2020 13:47
Abstract This study examined the correlation between improvements in excessive daytime sleepiness in participants with obstructive sleep apnea or narcolepsy and changes in functional status, work productivity and health‐related quality of life. Data from two 12‐week randomized controlled trials of solriamfetol were analyzed. Participants completed the Epworth Sleepiness Scale, 10‐item Functional Outcomes of Sleep Questionnaire, Work Productivity and Activity Impairment questionnaire and 36‐Item...
Tue Oct 13, 2020 15:15
Summary Delirium may lead to poor outcomes in hospitalized older adults, and sleep deprivation may contribute to its pathogenesis. Thus, we sought to measure sleep duration and fragmentation using wrist‐worn actigraphy in older, hospitalized patients with and without delirium, and to determine if actigraphy‐based parameters could be used to predict delirium prior to clinical recognition. We conducted a secondary analysis of data from a recent, randomized clinical trial aimed at preventing inpatient...
Tue Oct 13, 2020 15:09
Abstract We studied the association between objectively measured smartphone usage and objectively measured sleep quality and physical activity for seven consecutive days among Hong Kong adolescents and young adults aged 11–25 years (n = 357, 67% female). We installed an app that tracked the subjects’ smartphone usage and had them wear an ActiGraph GT3X accelerometer on their wrist to measure their sleep quality and physical activity level. Smartphone usage data were successfully obtained from 187...
Tue Oct 13, 2020 13:44
Low-grade appendiceal mucinous neoplasm (LAMN) is an enigmatic tumor that lacks the capacity for classic invasion but can dissect through the appendiceal wall, causing pseudomyxoma peritonei (PMP). Most large studies of the histologic spectrum of LAMN and its rate of associated PMP include cases submitted from outside institutions, potentially skewing their findings. We identified 117 cases of LAMN at our institution. Hematoxylin and eosin-stained slides from each were reviewed, and clinical and...
Wed Oct 14, 2020 03:57
Breslow thickness (BT) is the cornerstone of malignant melanoma staging. However, to our knowledge no-one has ever assessed the horizontal width of invasion, measured microscopically, as a prognostic feature. This was investigated as a prognostic feature in this study. A retrospective cohort of 1329 melanoma cases was collected from patients presenting to a UK teaching hospital from January 1, 2004, to December 31, 2014. The main outcome was overall survival (OS). We found that width was associated...
Wed Oct 14, 2020 03:57
Inflammatory myofibroblastic tumors (IMT) of the uterus may be underrecognized as their morphology and immunophenotype may overlap with myxoid variants of uterine smooth muscle tumors and endometrial stromal tumors. Although ALK is a helpful biomarker, not all uterine IMTs are ALK-rearranged, and a small subset of myxoid leiomyosarcomas is ALK-positive. Herein, we evaluated a series of 23 IMTs for the novel endometrial stromal markers interferon-inducible transmembrane protein-1 (IFITM1) and BCOR,...
Wed Oct 14, 2020 03:57
The separation of benign from malignant mesothelial proliferations is an important clinical but often a difficult morphologic problem. Over the last roughly 10 years a variety of new markers that aid in this separation have been published and some older recommended markers reconsidered. Unlike previous, and largely unusable, empiric immunohistochemical (IHC) stains, these new markers, some using IHC and some using fluourescent in situ hybridization (FISH), are largely based on documented genomic...
Wed Oct 14, 2020 03:57
TFE3-fusion associated renal cell carcinoma (TFE3-RCC) accounts for up to 5% adults and 40% of childhood RCC. Their comprehensive immunohistochemical (IHC) profile in correlation to fluorescence in situ hybridization (FISH) testing and their role in the diagnostic approach are not well documented because of lacking published data. FISH confirmed TFE3-RCC between years 2010 and 2020 were identified from institutional electronic database and retrospectively reviewed. Eighty-five TFE3-RCC were identified....
Wed Oct 14, 2020 03:57
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου