Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 14 Οκτωβρίου 2020

 


Long rDNA amplicon sequencing of insect-infecting nephridiophagids reveals their affiliation to the Chytridiomycota (Fungi) and a potential to switch between hosts [NEW RESULTS]
Nephridiophagids are unicellular eukaryotes that parasitize the Malpighian tubules of numerous insects. Their life cycle comprises multinucleate vegetative plasmodia that divide into oligonucleate and uninucleate cells, and sporogonial plasmodia that form uninucleate spores. Nephridiophagids are poor in morphological characteristics, and although they have been tentatively identified as early-branching fungi based on the SSU rRNA gene sequences of three species, their exact position within the fungal...
bioRxiv Subject Collection: Evolutionary Biology
Wed Oct 14, 2020 03:00
Ecological specialisation and evolutionary reticulation in extant Hyaenidae [NEW RESULTS]
During the Miocene, Hyaenidae was a highly diverse family of Carnivora that has since been severely reduced to four extant genera, each of which contains only a single species. These species include the bone-cracking spotted, striped, and brown hyenas, and the specialised insectivorous aardwolf. Previous genome studies have analysed the evolutionary histories of the spotted and brown hyenas, but little is known about the remaining two species. Moreover, the genomic underpinnings of scavenging and...
bioRxiv Subject Collection: Evolutionary Biology
Wed Oct 14, 2020 03:00
Multivariate distributions of behavioural, morphological, and ontogenetic traits in hybrids bring new insights into the divergence of sympatric Arctic charr morphs. [NEW RESULTS]
Studying the development of fitness related traits in hybrids from populations diverging in sympatry is a fundamental approach to understand the processes of speciation. However, such traits are often affected by covariance structures that complicate the comprehension of these processes, especially because the interactive relationships between traits of different nature (e.g. morphology, behaviour, life-history) remain largely unknown in this context. In a common garden setup, we conducted an extensive...
bioRxiv Subject Collection: Evolutionary Biology
Wed Oct 14, 2020 03:00
Dynamic visualisation of million-tip trees: the OneZoom project [NEW RESULTS]
The complete tree of life is now available, but methods to visualise it are still needed to meet needs in research, teaching and science communication. Dynamic visualisation of million-tip trees requires many challenges in data synthesis, data handling and computer graphics to be overcome. Our approach is to automate data processing, synthesise data from a wide range of available sources, then to feed these data to a client-side visualisation engine in parts. We develop a way to store the whole tree...
bioRxiv Subject Collection: Evolutionary Biology
Wed Oct 14, 2020 03:00
Drainage-structuring of ancestral variation and a common functional pathway shape limited genomic convergence in natural high- and low-predation guppies [NEW RESULTS]
Studies of convergence in wild populations have been instrumental in understanding adaptation by providing strong evidence for natural selection. At the genetic level, we are beginning to appreciate that the re-use of the same genes in adaptation occurs through different mechanisms and can be constrained by underlying trait architectures and demographic characteristics of natural populations. Here, we explore these processes in naturally adapted high- (HP) and low-predation (LP) populations of the...
bioRxiv Subject Collection: Evolutionary Biology
Wed Oct 14, 2020 03:00
Phylogenetic Permulations: a statistically rigorous approach to measure confidence in associations between phenotypes and genetic elements in a phylogenetic context [NEW RESULTS]
The wealth of high-quality genomes for numerous species has motivated many investigations into the genetic underpinnings of phenotypes. Comparative genomics methods approach this task by identifying convergent shifts at the genetic level that are associated with traits evolving convergently across independent lineages. However, these methods have complex statistical behaviors that are influenced by non-trivial and oftentimes unknown confounding factors. Consequently, using standard statistical analyses...
bioRxiv Subject Collection: Evolutionary Biology
Wed Oct 14, 2020 03:00
Higher temperatures worsen the effects of mutations on protein stability [NEW RESULTS]
Understanding whether and how temperature increases alter the effects of mutations on protein stability is crucial for understanding the limits to thermal adaptation by organisms. Currently, it is generally assumed that the stability effects of mutations are independent of temperature. Yet, mutations should become increasingly destabilizing as temperature rises due to the increase in the energy of atoms. Here, by performing an extensive computational analysis on the essential enzyme adenylate kinase...
bioRxiv Subject Collection: Evolutionary Biology
Wed Oct 14, 2020 03:00
Genetic variation in heat tolerance of the coral Platygyra daedalea offers the potential for adaptation to ocean warming [NEW RESULTS]
Reef-building corals are foundational species in coral reef ecosystems and are threatened by many stressors including rising ocean temperatures. In 2015/16 and 2016/17, corals around the world experienced consecutive bleaching events and most coral populations are projected to experience temperatures above their current bleaching thresholds annually by 2050. Adaptation to higher temperatures is therefore necessary if corals are to persist in a warming future. While many aspects of heat stress have...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Defects in plant immunity modulate the rates and patterns of RNA virus evolution [NEW RESULTS]
It is assumed that host genetic variability for susceptibility to infection will necessarily condition the evolution of viruses, either by driving them to diversification into strains that track the different host defense alleles (e.g., antigenic diversity), or by canalization to infect only the most susceptible genotypes. Associated to these processes, virulence may or may not increase. To tackle these questions, we performed evolution experiments with turnip mosaic virus (TuMV) in Arabidopsis thaliana...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Evolution of Honey Resistance in Experimental Populations of Bacteria Depends on the Type of Honey, and Has no Major Side Effects for Antibiotic Susceptibility [NEW RESULTS]
With rising antibiotic resistance, alternative treatments for communicable diseases are increasingly relevant. One possible alternative for some types of infections is honey, used in wound care since before 2000 BCE and more recently in licensed, medical-grade products. However, it is unclear whether medical application of honey results in the evolution of bacterial honey resistance, and whether this has collateral effects on other bacterial traits such as antibiotic resistance. Here, we used single-step...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Utilization of cobalamin is ubiquitous in early-branching fungal phyla [NEW RESULTS]
Cobalamin is a cofactor present in essential metabolic pathways in animals and one of the water-soluble vitamins. It is a complex compound synthesized solely by prokaryotes. Cobalamin dependence is scattered across the tree of life. In particular, fungi and plants were deemed devoid of cobalamin. We demonstrate that cobalamin is utilized by all fungal lineages, except for Dikarya. This observation is supported by the genomic presence of both B12 dependent enzymes and cobalamin modifying enzymes....
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Re-emergence and diversification of a specialised antennal lobe morphology in ithomiine butterflies [NEW RESULTS]
How an organisms sensory system functions is central to how it navigates its environment and meets the behavioural challenges associated with survival and reproduction. Comparing sensory systems across species can reveal how facets of behaviour and ecology promote adaptive shifts in the relative importance of certain environmental cues. The insect olfactory system is prominent model for investigating how ecological factors impact sensory reception and processing. Notably work in Lepidoptera led to...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Genetic variation in heat tolerance of the coral Platygyra daedalea offers the potential for adaptation to ocean warming [NEW RESULTS]
Reef-building corals are foundational species in coral reef ecosystems and are threatened by many stressors including rising ocean temperatures. In 2015/16 and 2016/17, corals around the world experienced consecutive bleaching events and most coral populations are projected to experience temperatures above their current bleaching thresholds annually by 2050. Adaptation to higher temperatures is therefore necessary if corals are to persist in a warming future. While many aspects of heat stress have...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Widespread lateral gene transfer among grasses [NEW RESULTS]
Lateral gene transfer (LGT) has been documented in a broad range of prokaryotes and eukaryotes, and it can promote adaptation. LGT of functional nuclear genes has been reported among some plants, but systematic studies are needed to assess the frequency and facilitators of LGT in the group. We scan the genomes of a diverse set of 17 grass species that span more than 50 million years of divergence and include major crops to identify grass-to-grass protein-coding LGT. We identify LGT in 13 species,...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
On the potential of Angiosperms353 for population genomics [NEW RESULTS]
Targeted sequencing using Angiosperms353 has emerged as a low-cost tool for phylogenetics, with early results spanning scales from all flowering plants to within genera. The use of universal markers at narrower scales--within populations-- would eliminate the need for specific marker development while retaining the benefits of full-gene sequences. However, it is unclear whether the Angiosperms353 markers provide sufficient variation within species to calculate demographic parameters. Using herbarium...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Statistics used to infer inter-breeding between humans and Neanderthals are strongly predicted by flanking sequence heterozygosity [NEW RESULTS]
A large and rapidly expanding literature has grown out of the observation that humans carry a genetic legacy reflecting ancient inter-breeding with archaic hominins such as Neanderthals and Denisovans. However, a recent study suggests that a commonly used statistic used to assess legacy size, D, is driven mainly by heterozygous sites in Africa acting to increase divergence from our common ancestor rather than introgressed fragments outside Africa reducing divergence. To test this new model, I analysed...
bioRxiv Subject Collection: Evolutionary Biology
Tue Oct 13, 2020 03:00
Persistent swallowing disorders after extubation in mechanically ventilated patients in ICU: a two-center prospective study
Persistent swallowing disorders (SD) are non-pulmonary complications of mechanical ventilation (MV). However, there are few clinical studies on persistent SD in critically ill patients undergoing tracheal intu...
Annals of Intensive Care - Latest Articles
Wed Oct 14, 2020 03:00
Response to Damiani and colleagues
Annals of Intensive Care - Latest Articles
Wed Oct 14, 2020 03:00
Tigecycline pharmacokinetics in critically ill patients on renal replacement therapy: possible warnings and potential perspectives for the research agenda
Annals of Intensive Care - Latest Articles
Wed Oct 14, 2020 03:00
High doses of tigecycline are associated with satisfactory plasmatic and pulmonary concentrations for the treatment of severe infections due to fully susceptible bacteria: do we need even higher doses in patients under CRRT?
Annals of Intensive Care - Latest Articles
Wed Oct 14, 2020 03:00
pCLIF-SOFA is a reliable outcome prognostication score of critically ill children with cirrhosis: an ESPNIC multicentre study
Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensi...
Annals of Intensive Care - Latest Articles
Wed Oct 14, 2020 03:00
Treatment variables associated with outcome in emergency department patients with suspected sepsis
Early treatment is advocated in the management of patients with suspected sepsis in the emergency department (ED). We sought to understand the association between the ED treatments and outcome in patients admi...
Annals of Intensive Care - Latest Articles
Wed Oct 14, 2020 03:00
Limitations of Detecting Genetic Variants from the RNA Sequencing Data in Tissue and Fine-Needle Aspiration Samples
Thyroid, Ahead of Print.
liebertpub1
Tue Oct 13, 2020 10:00
Letter to the Editor: Hoermann Response to Fitzgerald et al. (DOI: 10.1089/thy.2019.0535)
Thyroid, Ahead of Print.
liebertpub1
Tue Oct 13, 2020 10:00
Hashimoto's Thyroiditis Induces Hippocampus-Dependent Cognitive Alterations by Impairing Astrocytes in Euthyroid Mice
Thyroid, Ahead of Print.
liebertpub1
Mon Oct 12, 2020 10:00
Loss of 5-Hydroxymethylcytosine is an Epigenetic Hallmark of Thyroid Carcinomas with TERT Promoter Mutations
Abstract Epigenetic dysregulation is a hallmark of cancer, and aberrant methylation of cytosine residues plays a crucial role in abnormal gene expression in cancer cells. Recent studies demonstrate that 5-hydroxymethylcytosine (5-hmC) generated through 5-methylcytosine (5-mC) oxidation is significantly depleted in various cancers. However, whether 5-hmC levels change during the stepwise progression of thyroid carcinoma and the mechanisms underlying this effect remain unknown....
Endocrine Pathology
03:00
The Influence of Printing Parameters and Cell Density on Bioink Printing Outcomes
Tissue Engineering Part A, Ahead of Print.
Tissue Engineering
Wed Oct 14, 2020 10:00
Adipose Stem Cells and Platelet-Rich Plasma Induce Vascular-Like Structures in a Dermal Regeneration Template
Tissue Engineering Part A, Ahead of Print.
Tissue Engineering
Mon Oct 12, 2020 10:00
Molecular Beacon Imaging to Visualize Ki67 mRNA for Cell Proliferation Ability
Tissue Engineering Part A, Ahead of Print.
Tissue Engineering
Fri Sep 18, 2020 10:00
Call for TERMIS-AP 2020 Special Issue Papers: Revolutionizing Regenerative Research Strategies Towards Precision Medicine
Tissue Engineering Part A, Ahead of Print.
Tissue Engineering
Mon Oct 12, 2020 10:00
Call for Special Issue Papers: Tissue Engineering: Part A— Special Issue on Oncology and Tissue Engineering
Tissue Engineering Part A, Ahead of Print.
Tissue Engineering
Mon Oct 12, 2020 10:00
Call for Review Papers: Tissue Engineering, Part B
Tissue Engineering Part A, Ahead of Print.
Tissue Engineering
Mon Oct 12, 2020 10:00
Microarchitecture of cetacean vertebral trabecular bone among swimming modes and diving behaviors
Cetacean vertebral trabecular bone volume fraction was greatest in rigid‐torso shallow divers, smallest in flexible‐torso deep divers, and intermediate in rigid‐torso deep divers. Degree of anisotropy was greater in rigid‐torso swimmers compared to their flexible‐torso counterparts. Despite having osteoporotic skeletons overall, cetacean vertebrae show greater bone volume fraction, trabecular thickness, and degree of anisotropy than previously documented in terrestrial mammalian bone. Abstract...
Journal of Anatomy
Wed Oct 14, 2020 17:29
Altitudinal and Seasonal Variation in the Structure of Nocturnal Primate Assemblages on Mount Cameroon
Abstract Mountain ecosystems cover a large proportion of Earth and represent important environments for a range of different taxa, including nocturnal primates. This group of primates is generally understudied because of their small size and their cryptic and nocturnal nature. Thus, much of their ecology and distribution still remains unknown, especially in mountain ecosystems. We investigated the effects of altitude and seasonality (wet vs. dry season) on observed species richness...
International Journal of Primatology
03:00
The Impact of the Quantity and Quality of Social Support on Patients with Chronic Pain
Abstract Purpose of Review Social support is an important yet often overlooked aspect of chronic pain management. Understanding the impact of social support on patients with chronic pain and determining if a relationship exists between a patient’s perceived social support and their perceived quality of life is a crucial component to completely treating a pain patient. We sought to develop an intervention for patients with chronic...
Headache Reports
03:00
Prevalence of Cognitive Complaints and Impairment in Patients with Chronic Subdural Hematoma and Recovery after Treatment: A Systematic Review
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Tue Oct 13, 2020 10:00
Oral Immunotherapy for Food Allergy—a US Regulatory Perspective
Abstract The recent approval of Palforzia for treatment of peanut allergy by the US Food and Drug Administration (USFDA) predicts that additional products for oral immunotherapy (OIT) are on the horizon. In this article, the authors review the legal framework by which the USFDA regulates products for OIT of food allergy and the clinical data that demonstrated that the safety and effectiveness profile of Palforzia supported approval and conclude with a discussion of oral food...
Current Allergy and Asthma Reports
03:00
Frequency and Clinical Utility of Olfactory Dysfunction in COVID-19: a Systematic Review and Meta-analysis
Abstract Background Olfactory dysfunction (OD) has been gaining recognition as a symptom of COVID-19, but its clinical utility has not been well defined. Objectives To quantify the clinical utility of identifying OD in the diagnosis of COVID-19 and determine an estimate of the frequency of OD amongst these patients. ...
Current Allergy and Asthma Reports
Tue Oct 13, 2020 03:00
Improved cancer detection in Waldeyer’s tonsillar ring by 68 Ga-FAPI PET/CT imaging
Abstract Purpose In cancer of unknown primary (CUP), positron emission tomography/computed tomography (PET/CT) with the glucose analog [18F]FDG represents the standard imaging approach for localization of the malignant primary. Frequently, however, [18F]FDG PET/CT cannot precisely distinguish between small occult tumors and chronic inflammation, especially in Waldeyer’s tonsillar ring. To improve the accuracy for detecting primary tumors...
European Journal of Nuclear Medicine and Molecular Imaging
03:00
18 F-FDG PET/CT versus anatomic imaging for evaluating disease extent and clinical trial eligibility in Erdheim-Chester disease: results from 50 patients in a registry study
Abstract Objectives The aim of this study was to [1] characterize distribution of Erdheim-Chester Disease (ECD) by 18F-FDG PET/CT and [2] determine the utility of metabolic (18F-FDG PET/CT) imaging versus anatomic imaging (CT or MRI) in evaluating ECD patients for clinical trial eligibility. Methods 18F-FDG PET/CT and corresponding CT or MRI studies...
European Journal of Nuclear Medicine and Molecular Imaging
03:00
Issue Information
Wiley: Pigment Cell & Melanoma Research: Table of Contents
Tue Oct 13, 2020 21:58
Cover Image
Endothelin signaling promotes melanoma in the mouse brain
Wiley: Pigment Cell & Melanoma Research: Table of Contents
Tue Oct 13, 2020 21:58
Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma
Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance a...
Journal of Experimental & Clinical Cancer Research - Latest Articles
Wed Oct 14, 2020 03:00
Venous thromboembolism and COVID-19: a case report and review of the literature
Currently, there is minimal data available highlighting the prevalence of venous thromboembolism in patients infected with coronavirus disease 2019 (COVID-19). This case report with a literature review emphasi...
Journal of Medical Case Reports - Latest Articles
03:00
Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case report
The understanding of coronavirus disease 2019 (COVID-19) is rapidly evolving. Although it is primarily a respiratory illness, other manifestations, such as Guillain-Barré syndrome, immune thrombocytopenia, and...
Journal of Medical Case Reports - Latest Articles
03:00
Ascites management by cell-free concentrated ascites reinfusion therapy during recovery from drug-induced acute liver injury: a case report
The symptoms of drug-induced hepatic injury are manifold; however, the presence of ascites indicates a severe disease condition. The rapid accumulation of ascites is distressing and requires palliative treatme...
Journal of Medical Case Reports - Latest Articles
Wed Oct 14, 2020 03:00
Chemotherapy combined with radiotherapy for successful treatment of angioimmunoblastic T-cell lymphoma: a case report
The incidence of angioimmunoblastic T-cell lymphoma is rare worldwide, and it has a poor prognosis. There is no proven or standard first-line therapy that works for the majority of patients with angioimmunobla...
Journal of Medical Case Reports - Latest Articles
Tue Oct 13, 2020 03:00
Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain
A recently deorphanized receptor, GPR18 showed to act with several endogenous cannaboinoid ligands. Among several potent functionalities the receptor activation also leads to the induction of anti‐infammatory and antinociceptive action. By using highly selective agonist of GPR18, PSB‐KK‐1415 we achieved an inflammation alleviation in two mouse models of colitis and a reduction in pain‐induced behaviors in mouse model of inflammatory pain. Abstract Background GPR18 is a recently deorphanized...
The European Gastrointestinal Motility Society
Wed Oct 14, 2020 15:59
Optical Coherence Tomography Angiography Features of Neovascularization in Proliferative Diabetic Retinopathy
Clinical Ophthalmology
05:10
Ocular Biometry and Their Correlations with Ocular and Anthropometric Measurements Among Ethiopian Adults
Clinical Ophthalmology
05:10
iStent Trabecular Micro-Bypass Stent Implantation with Cataract Surgery in a Japanese Glaucoma Population
Clinical Ophthalmology
05:05
The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea
Clinical Ophthalmology
05:03
Trends in Real-World Neovascular AMD Treatment Outcomes in the UK
Clinical Ophthalmology
Wed Oct 14, 2020 00:47
A Review on Different Tonometers for Intraocular Pressure Measurement After Photorefractive Keratectomy or Small Incision Lenticule Extraction
Clinical Ophthalmology
Wed Oct 14, 2020 00:47
Changes in Opacification of Hydrophobic Acrylic Intraocular Lenses According to Temperature and Hydration
Clinical Ophthalmology
Wed Oct 14, 2020 00:47
A Review of Advancements and Evidence Gaps in Diabetic Retinopathy Screening Models
Clinical Ophthalmology
Wed Oct 14, 2020 00:45
Contribution of Posterior Corneal Astigmatism to Total Corneal Astigmatism in a Sample of Egyptian Population
Clinical Ophthalmology
Wed Oct 14, 2020 00:44
Dexamethasone/Netilmicin Eye Drops and Eye Gel for the Treatment of Ocular Inflammation After Micro-Incisional Vitreoretinal Surgery
Clinical Ophthalmology
Wed Oct 14, 2020 00:43
Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway.
Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway. Cancer Biol Ther. 2020 Oct 13;:1-11 Authors: Huang XB, Song KJ, Chen GB, Liu R, Jiang ZF, He YL Abstract Cervical cancer (CC) is the second most common malignancy in women worldwide. The mechanism underlying CC development remains unclear. Recently, Circular RNAs (circRNAs)have attracted attention because of its role...
Cancer biology and therapy,http://www.tandfonline.com/toc/kcbt20/current
05:01
Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer.
Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 Oct 12;:1-8 Authors: Perez RE, Calhoun S, Shim D, Levenson VV, Duan L, Maki CG Abstract Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), is an enzyme that cleaves short peptides (<30 amino acids in length) on the C-terminal side of proline....
Cancer biology and therapy,http://www.tandfonline.com/toc/kcbt20/current
Tue Oct 13, 2020 23:24
Expression of STAT1 is positively correlated with PD-L1 in human ovarian cancer.
Expression of STAT1 is positively correlated with PD-L1 in human ovarian cancer. Cancer Biol Ther. 2020 Oct 12;:1-9 Authors: Liu F, Liu J, Zhang J, Shi J, Gui L, Xu G Abstract Signal transducer and activator of transcription 1 (STAT1) is related to the immune microenvironment of tumorigenesis. The programmed cell death 1 (PD-1) and its ligand (PD-L1) have been reported to be important in immunotherapy by mediating tumor immune evasion. Blocking...
Cancer biology and therapy,http://www.tandfonline.com/toc/kcbt20/current
Tue Oct 13, 2020 23:24
A systematic evaluation of bioinformatics tools for identification of long noncoding RNAs [Article]
High-throughput RNA sequencing unveiled the complexity of transcriptome and significantly increased the records of long noncoding RNAs (lncRNAs) which were reported to participate in a variety of biological processes. Identification of lncRNAs is a key step of lncRNA analysis, and a bunch of bioinformatics tools have been developed for this purpose in recent years. While these tools allow us to identify lncRNA more efficiently and accurately, they may produce inconsistent results, making selection...
RNA In Advance
Wed Oct 14, 2020 19:03
FDA Approval Summary: Tucatinib for the Treatment of Patients with Advanced or Metastatic HER2-Positive Breast Cancer
On April 17, 2020, the FDA approved tucatinib in combination with trastuzumab and capecitabine for the treatment of patients with advanced unresectable or metastatic HER2-positive breast cancer, including patients with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting. This was the first new molecular entity evaluated under Project Orbis, an FDA Oncology Center of Excellence initiative which supports concurrent review of oncology drugs by multiple...
Clinical Cancer Research Online First Articles
Wed Oct 14, 2020 16:21
Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma
Purpose:Preclinical and early clinical data suggested that combining histone deacetylase (HDAC) and mTOR inhibitors can synergistically inhibit Hodgkin lymphoma.Patients and Methods:During the dose-escalation study (ClinicalTrials.gov number: NCT01087554) with the HDAC inhibitor vorinostat and the mTOR inhibitor sirolimus (V+S), a patient with Hodgkin lymphoma refractory to nine prior therapies demonstrated a partial response (PR) lasting for 18.5 months, which promoted additional enrollment of patients...
Clinical Cancer Research Online First Articles
Wed Oct 14, 2020 10:05
TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas
Purpose.Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time and therapy. Detection of TERT promoter mutations (C228T, C250T) in cfDNA has been successful for some systemic cancers but has yet to be demonstrated in gliomas, despite the high prevalence of these mutations in glioma tissue (>60% of all tumors). Experimental Design. Here, we developed a novel digital droplet PCR (ddPCR) assay, that incorporates features to...
Clinical Cancer Research Online First Articles
Tue Oct 13, 2020 16:20
Subtype-discordant pancreatic ductal adenocarcinoma tumors show intermediate clinical and molecular characteristics
Background RNA-sequencing-based subtyping of pancreatic ductal adenocarcinoma (PDAC) has been reported by multiple research groups, each using different methodologies and patient cohorts. 'Classical' and 'basal-like' PDAC subtypes are associated with survival differences, with basal-like tumors associated with worse prognosis. We amalgamated various PDAC subtyping tools to evaluate the potential of such tools to be reliable in clinical practice. Methods Sequencing data for 574 PDAC tumors was...
Clinical Cancer Research Online First Articles
Tue Oct 13, 2020 16:20
B7-H3: an attractive target for antibody-based immunotherapy
The recent impressive clinical responses to antibody-based immunotherapy have prompted the identification of clinically relevant tumor antigens that can serve as targets in solid tumors. Among them, B7-H3, a member of the B7 ligand family, represents an attractive target for antibody-based immunotherapy: it is overexpressed on differentiated malignant cells and cancer initiating cells, with limited heterogeneity, and high frequency (60% of 25,000 tumor samples) in many different cancer types, but...
Clinical Cancer Research Online First Articles
Tue Oct 13, 2020 16:20
Exploiting B Cell Receptor Stereotypy to design Tailored Immunotherapy in Chronic Lymphocytic Leukemia
Purpose: Approximately 30% of patients with chronic lymphocytic leukemia (CLL) can be grouped into subsets with stereotyped B cell receptor immunoglobulin (BcR IG) displaying remarkable similarity in the heavy complementarity-determining region 3 (VH CDR3). Here, we investigated whether the consensus VH CDR3 sequences from CLL stereotyped subsets can be exploited for immunotherapy approaches. Experimental Design: Immunogenic epitopes from the consensus VH CDR3 sequence of the clinically aggressive...
Clinical Cancer Research Online First Articles
Tue Oct 13, 2020 16:20
Similarities in Risk for COVID-19 and Cancer Disparities
Coronavirus disease 2019 (COVID-19) is a novel infectious disease that has spread world-wide. In the United States, COVID-19 disproportionately affects racial and ethnic minorities, particularly African Americans, with an observed two-fold higher rate for hospitalization and greater than two-fold higher rate for death as compared to White Americans. The disparity seen with COVID-19 is consistent with patterns of disparities observed for cancer; it is well-documented that 5-year survival rates for...
Clinical Cancer Research Online First Articles
Tue Oct 13, 2020 16:20
How leaves reflect light reveals evolutionary history of seed plants
The way leaves reflect light, known as plant reflectance spectra, can illuminate the evolutionary history of seed plants, according to researchers. The researchers found that by measuring the light spectrum reflected by leaves, they can identify the plant and its chemistry, evolution and place in the tree of life.
Evolutionary Biology News -- ScienceDaily
00:13
Seeing evolution happening before your eyes
Researchers have established an automated pipeline to create mutations in genomic enhancers that let them watch evolution unfold before their eyes. Their findings on fruit flies may also be relevant to the understanding of human diseases, requiring researchers to reassess assumptions about how enhancers contribute to human health.
Evolutionary Biology News -- ScienceDaily
Wed Oct 14, 2020 18:46
Computer model uses virus 'appearance' to better predict winter flu strains
Combining genetic and experimental data into models about the influenza virus can help predict more accurately which strains will be most common during the next winter, says a study published recently in eLife.
Evolutionary Biology News -- ScienceDaily
Tue Oct 13, 2020 19:40
Programmed Cell Death 2-like (Pdcd2l) Is Required for Mouse Embryonic Development
Globozoospermia is a rare form of male infertility where men produce round-headed sperm that are incapable of fertilizing an oocyte naturally. In a previous study where we undertook a whole exome screen to define novel genetic causes of globozoospermia, we identified homozygous mutations in the gene PDCD2L. Two brothers carried a p.(Leu225Val) variant predicted to introduce a novel splice donor site, thus presenting PDCD2L as a potential regulator of male fertility. In this study, we generated a...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
03:12
Dissecting the Genetic Architecture of Biofuel-Related Traits in a Sorghum Breeding Population
In sorghum [Sorghum bicolor (L.) Moench], hybrid cultivars for the biofuel industry are desired. Along with selection based on testcross performance, evaluation of the breeding population per se is also important for the success of hybrid breeding. In addition to additive genetic effects, non-additive (i.e., dominance and epistatic) effects are expected to contribute to the performance of early generations. Unfortunately, studies on early generations in sorghum breeding programs are limited. In this...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
Wed Oct 14, 2020 00:49
Gene Copy Number Variation Does Not Reflect Structure or Environmental Selection in Two Recently Diverged California Populations of Suillus brevipes
Gene copy number variation across individuals has been shown to track population structure and be a source of adaptive genetic variation with significant fitness impacts. In this study, we report opposite results for both predictions based on the analysis of gene copy number variants (CNVs) of Suillus brevipes, a mycorrhizal fungus adapted to coastal and montane habitats in California. In order to assess whether gene copy number variation mirrored population structure and selection in this species,...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
Wed Oct 14, 2020 00:49
Estimation of Molecular Pairwise Relatedness in Autopolyploid Crops
A suitable pairwise relatedness estimation is key to genetic studies. Several methods are proposed to compute relatedness in autopolyploids based on molecular data. However, unlike diploids, autopolyploids still need further studies considering scenarios with many linked molecular markers with known dosage. In this study, we provide guidelines for plant geneticists and breeders to access trustworthy pairwise relatedness estimates. To this end, we simulated populations considering different ploidy...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
Wed Oct 14, 2020 00:49
Maintenance of Cell Fate by the Polycomb Group Gene Sex Combs Extra Enables a Partial Epithelial Mesenchymal Transition in Drosophila
Epigenetic silencing by Polycomb group (PcG) complexes can promote epithelial-mesenchymal transition (EMT) and stemness and is associated with malignancy of solid cancers. Here we report a role for Drosophila PcG repression in a partial EMT event that occurs during wing disc eversion, an early event during metamorphosis. In a screen for genes required for eversion we identified the PcG genes Sex combs extra (Sce) and Sex combs midleg (Scm). Depletion of Sce or Scm resulted in internalised wings and...
G3: .Genes, Genomes, Genetics Mission - Online First Articles
Wed Oct 14, 2020 00:49
Apatinib and Camrelizumab in Recurrent or Metastatic Nasopharyngeal Carcinoma With First-line Treatment Failure
Conditions:   Nasopharyngeal Carcinoma;   Recurrent Nasopharyngeal Carcinoma;   Metastatic Nasopharyngeal Carcinoma;   Chemotherapy Effect;   Immunotherapy;   Molecular Targeted TherapyIntervention:   Drug: Apatinib plus CamrelizumabSponsor:   Sun Yat-sen UniversityRecruiting
ClinicalTrials
Wed Oct 14, 2020 19:00
Semi-sitting Versus Supine Position in Endoscopic Skull Base Surgery
Condition:   Pituitary AdenomaInterventions:   Procedure: Endonasal endoscopic pituitary surgery in semi-sitting position;   Procedure: Endonasal endoscopic pituitary surgery in supine positionSponsor:   University Hospital, Basel, SwitzerlandNot yet recruiting
ClinicalTrials
Tue Oct 13, 2020 16:04
Dysphagia and Dysphonia Outcomes in SARS CoV-2 (COVID-19) Infection (DYADS Study)
Conditions:   Dysphagia;   Dysphonia;   Subglottic Stenosis;   Voice Disorders;   Swallowing Disorder;   Covid19;   SARS (Severe Acute Respiratory Syndrome);   SARS Pneumonia;   Quality of Life;   SARS-CoV-2 InfectionInterventions:   Diagnostic Test: Fibreoptic Endoscopic Evaluation of Swallowing (FEES);   Diagnostic Test: Videofluoroscopy;   Other: Dysphagia Handicap Index (DHI);   Other: Voice Symptom Scale (VoiSS)Sponsor:   Cambridge University Hospitals NHS Foundation TrustRecruiting
ClinicalTrials
Tue Oct 13, 2020 16:04
The Cutoff Point and Diagnostic Accuracy of the Voice Handicap Index in Cantonese-Speaking Population.
The Cutoff Point and Diagnostic Accuracy of the Voice Handicap Index in Cantonese-Speaking Population. J Voice. 2020 Oct 09;: Authors: Ng E, Law T, Tang EC, Ho FN, Tong MC, Lee KY Abstract BACKGROUND: Voice Handicap Index (VHI) has been used extensively in research and clinical settings. It has been suggested to be used as a diagnostic tool in the literature. However, little is known if it could be applied as a diagnostic tool to the Cantonese-speaking...
Dysphonia
03:52
FDA Supplemental Approval Summary: Lenvatinib for the Treatment of Unresectable Hepatocellular Carcinoma.
FDA Supplemental Approval Summary: Lenvatinib for the Treatment of Unresectable Hepatocellular Carcinoma. Oncologist. 2020 Oct 12;: Authors: Nair A, Reece K, Donoghue MB, Yuan WV, Rodriguez L, Keegan P, Pazdur R Abstract On August 16, 2018, the Food and Drug Administration (FDA) approved lenvatinib (Lenvima®, Eisai Inc.) for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). Approval was based on an international,...
Dysphonia
Tue Oct 13, 2020 23:27
[ASAP] Enhancing the Gas Separation Selectivity of Mixed-Matrix Membranes Using a Dual-Interfacial Engineering Approach
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07378
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] A Neutral Heteroatomic Zintl Cluster for the Catalytic Hydrogenation of Cyclic Alkenes
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09742
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] In Situ Tracking of Colloidally Stable and Ordered Assemblies of Gold Nanorods
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06446
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] Cracking under Internal Pressure: Photodynamic Behavior of Vinyl Azide Crystals through N<sub>2</sub> Release
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07830
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] Palladium-Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4-Dipoles: Access to Chiral Cyclohexanes and Spiro [2.4] heptanes
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08348
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] Self-Powered Photodetector Using Two-Dimensional Ferroelectric Dion–Jacobson Hybrid Perovskites
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08189
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] Development of α,α-Disubstituted Crotylboronate Reagents and Stereoselective Crotylation via Brønsted or Lewis Acid Catalysis
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04107
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] Structural Contributions to Autocatalysis and Asymmetric Amplification in the Soai Reaction
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05994
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Wed Oct 14, 2020 07:00
[ASAP] Insights into the Enhanced Catalytic Activity of Cytochrome c When Encapsulated in a Metal–Organic Framework
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07870
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00
[ASAP] Spotlights on Recent <italic toggle="yes">JACS</italic> Publications
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c10801
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00
[ASAP] Transition-Metal-Free Cross-Coupling Reaction of Iodocarboranes with Terminal Alkynes Enabled by UV Light: Synthesis of 1-Alkynyl-<italic toggle="yes">o</italic>-Carboranes and Carborane-Fused Cyclics
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08652
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00
[ASAP] Fluorescence-Detected Circular Dichroism of a Chiral Molecular Monolayer with Dielectric Metasurfaces
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07140
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00
[ASAP] Theoretical Prediction and Synthesis of a Family of Atomic Laminate Metal Borides with In-Plane Chemical Ordering
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08113
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00
[ASAP] A New Strategy: Distinguishable Multi-substance Detection, Multiple Pathway Tracing Based on a New Site Constructed by the Reaction Process and Its Tumor Targeting
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c10210
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00
[ASAP] Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07490
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00
[ASAP] Inverted Region in Bimolecular Electron Transfer in Solution Enabled by Delocalization
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04780
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue Oct 13, 2020 07:00

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