The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and to achieve this function it must continually adapt to varying tissue demands. Newly formed vascular plexuses during development are immature and require dynamic remodeling to generate well-patterned functional networks. This is achieved by remodeling of the capillaries preserving those which are functional and eliminating other ones. A balanced and dynamically regulated capillary remodeling will therefore ensure optimal distribution of blood and nutrients to the tissues. This is particularly important in pathological contexts in which deficient or excessive vascular remodeling may worsen tissue perfusion and hamper tissue repair. Blood flow is a major determinant of microvascular reshaping since capillaries are pruned when relatively less perfused and they split when exposed to high flow in order to shape the microvascular network for optimal tissue perfusion and oxygenation. The molecular machinery underlying blood flow sensing by endothelial cells is being deciphered, but much less is known about how this translates into endothelial cell responses as alignment, polarization and directed migration to drive capillary remodeling, particularly in vivo. Part of this knowledge is theoretical from computational models since blood flow hemodynamics are not easily recapitulated by in vitro or ex vivo approaches. Moreover, these events are difficult to visualize in vivo due to their infrequency and briefness. Studies had been limited to postnatal mouse retina and vascular beds in zebrafish but new tools as advanced microscopy and image analysis are strengthening our understanding of capillary remodeling. In this review we introduce the concept of remodeling of the microvasculature and its relevance in physiology and pathology. We summarize the current knowledge on the mechanisms contributing to capillary regression and to capillary splitting highlighting the key role of blood flow to orchestrate these processes. Finally, we comment the potential and possibilities that microfluidics offers to this field. Since capillary remodeling mechanisms are often reactivated in prevalent pathologies as cancer and cardiovascular disease, all this knowledge could be eventually used to improve the functionality of capillary networks in diseased tissues and promote their repair.
Αρχειοθήκη ιστολογίου
-
►
2023
(256)
- ► Φεβρουαρίου (140)
- ► Ιανουαρίου (116)
-
►
2022
(1695)
- ► Δεκεμβρίου (78)
- ► Σεπτεμβρίου (142)
- ► Φεβρουαρίου (155)
-
►
2021
(5507)
- ► Δεκεμβρίου (139)
- ► Σεπτεμβρίου (333)
- ► Φεβρουαρίου (628)
-
▼
2020
(1810)
- ► Δεκεμβρίου (544)
-
▼
Οκτωβρίου
(204)
-
▼
Οκτ 14
(89)
- Medicine by Alexandros G. Sfakianakis
- Flow-Induced Transcriptomic Remodeling of Endothel...
- Two Undervalued Functions of the Golgi Apparatus: ...
- Physical Exercise and the Renin Angiotensin System...
- Functional Characterization of Facilitative Glucos...
- Palmitoyl Protein Thioesterase 1 Is Essential for ...
- Remodeling of the Microvasculature
- Effect of Hyperbilirubinemia on Medial Olivocochle...
- Preoperative assessment and optimization of cognit...
- High-risk surgical procedures and semi-emergent su...
- Spinal anesthesia for ambulatory surgery: current ...
- Peripheral nerve blockade and novel analgesic moda...
- Noninvasive, continuous monitoring modalities in p...
- The Bowtie diagram: a simple tool for analysis and...
- Maternal safety: recent advances and implications ...
- Nulla Per Os (NPO) guidelines
- Measuring and monitoring perioperative patient saf...
- Bacteria-derived long chain fatty acid exhibits an...
- Topic Application of the Probiotic Streptococcus d...
- Probiotic effects on sperm parameters, oxidative s...
- Effect of Limosilactobacillus reuteri LRE02-Lactic...
- Reduction of fatigue and anger-hostility by the or...
- Lactobacillus plantarum KSFY06 and geniposide coun...
- Impact of prebiotics on immune response: from the ...
- Weissella cibaria CMU exerts an anti‑inflammatory ...
- Lactiplantibacillus plantarum WJL administration d...
- Significant elevation of salivary human neutrophil...
- Periodontal pathogens promote cancer aggressivity ...
- Development of probiotic orodispersible tablets us...
- Development of probiotic orodispersible tablets us...
- Lactobacillus paracasei KBL382 administration atte...
- Synbiotic Effects of Enzyme and Probiotics on Inte...
- Efficacy of Spore Forming Bacilli Supplementation ...
- Isolation and Characterization of Nitrate-Reducing...
- Modulation of experimental autoimmune encephalomye...
- The potential of Streptococcus salivarius oral fil...
- MRI characterization of focal liver lesions in non...
- False-negative focused abdominal sonography for tr...
- Do we still need breast cancer screening in the er...
- Multimodality imaging features of desmoid tumors: ...
- Ultrasonography in the assessment of anterior knee...
- Sports-related lower limb muscle injuries
- Esophageal emergencies: another important cause of...
- Serum cystatin C: A potential predictor for hospit...
- Idiopathic Subglottic Stenosis
- Encorafenib-metastatic colorectal cancers with BRA...
- Breast Cancer Screening with Digital Breast Tomosy...
- MRI of Skeletal Muscles in Participants with Type ...
- Arterial Spin Labeling MRI in Carotid Stenosis: Ar...
- Nonablative Fractional Lasers (NAFL) on Hypertroph...
- Circular RNA hsa_circ_0003204 promotes cervical ca...
- Apatinib and Camrelizumab in Recurrent or Metastat...
- Programmed Cell Death 2-like (Pdcd2l) Is Required ...
- Vorinostat Plus Sirolimus or Everolimus in Patient...
- Tucatinib for the Treatment of Patients with Advan...
- Bioinformatics tools for identification of long no...
- Circular RNA hsa_circ_0003204 promotes cervical ca...
- Dry Eye Disease Among Patients Using Continuous Po...
- iStent Trabecular Micro-Bypass Stent Implantation ...
- Optical Coherence Tomography Angiography Features ...
- Novel selective agonist of GPR18, PSB‐KK‐1415 exer...
- Erdheim-Chester Disease (ECD) by 18F-FDG PET/CT
- Improved cancer detection in Waldeyer’s tonsillar ...
- Cetacean vertebral trabecular bone
- Loss of 5-Hydroxymethylcytosine is an Epigenetic H...
- pCLIF-SOFA is a reliable outcome prognostication s...
- High doses of tigecycline
- Tigecycline pharmacokinetics in critically ill pat...
- Persistent swallowing disorders after extubation
- Ancient DNA from Guam and the Peopling of the Pacific
- The American Journal of Surgical Pathology - Cur...
- BMC Research Notes
- Gene Expression Patterns<
- European Journal of Surgical Oncology (EJSO)
- bioRxiv Subject Collection: Evolutionary Biology
- American Goiter Association
- Biomedicine & Pharmacotherapy
- Multicentric endocrine mucin-producing sweat
- pubmed: epilepsy treatment
- Oncology
- American Journal of Cancer Research
- bioRxiv Subject Collection: Evolutionary Biology
- TCT Magazine | 3D Printer & 3D Printing News | A...
- Food and Drug Administration--Recalls/Safety Alerts
- Health sciences : nature.com subject feeds
- International Journal of Molecular Sciences
- International Journal of Environmental Research ...
- Antibiotics
- Medicine by Alexandros G. Sfakianakis
-
▼
Οκτ 14
(89)
- ► Σεπτεμβρίου (32)
- ► Φεβρουαρίου (28)
-
►
2019
(7684)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (53)
- ► Φεβρουαρίου (2841)
- ► Ιανουαρίου (2803)
-
►
2018
(31838)
- ► Δεκεμβρίου (2810)
- ► Σεπτεμβρίου (2870)
- ► Φεβρουαρίου (2420)
- ► Ιανουαρίου (2395)
-
►
2017
(31987)
- ► Δεκεμβρίου (2460)
- ► Σεπτεμβρίου (2605)
- ► Φεβρουαρίου (2785)
- ► Ιανουαρίου (2830)
-
►
2016
(5308)
- ► Δεκεμβρίου (2118)
- ► Σεπτεμβρίου (877)
- ► Φεβρουαρίου (41)
- ► Ιανουαρίου (39)
Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174
Τετάρτη 14 Οκτωβρίου 2020
Remodeling of the Microvasculature
Remodeling of the Microvasculature: May the Blood Flow Be With You:
The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and to achieve this function it must continually adapt to varying tissue demands. Newly formed vascular plexuses during development are immature and require dynamic remodeling to generate well-patterned functional networks. This is achieved by remodeling of the capillaries preserving those which are functional and eliminating other ones. A balanced and dynamically regulated capillary remodeling will therefore ensure optimal distribution of blood and nutrients to the tissues. This is particularly important in pathological contexts in which deficient or excessive vascular remodeling may worsen tissue perfusion and hamper tissue repair. Blood flow is a major determinant of microvascular reshaping since capillaries are pruned when relatively less perfused and they split when exposed to high flow in order to shape the microvascular network for optimal tissue perfusion and oxygenation. The molecular machinery underlying blood flow sensing by endothelial cells is being deciphered, but much less is known about how this translates into endothelial cell responses as alignment, polarization and directed migration to drive capillary remodeling, particularly in vivo. Part of this knowledge is theoretical from computational models since blood flow hemodynamics are not easily recapitulated by in vitro or ex vivo approaches. Moreover, these events are difficult to visualize in vivo due to their infrequency and briefness. Studies had been limited to postnatal mouse retina and vascular beds in zebrafish but new tools as advanced microscopy and image analysis are strengthening our understanding of capillary remodeling. In this review we introduce the concept of remodeling of the microvasculature and its relevance in physiology and pathology. We summarize the current knowledge on the mechanisms contributing to capillary regression and to capillary splitting highlighting the key role of blood flow to orchestrate these processes. Finally, we comment the potential and possibilities that microfluidics offers to this field. Since capillary remodeling mechanisms are often reactivated in prevalent pathologies as cancer and cardiovascular disease, all this knowledge could be eventually used to improve the functionality of capillary networks in diseased tissues and promote their repair.
The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and to achieve this function it must continually adapt to varying tissue demands. Newly formed vascular plexuses during development are immature and require dynamic remodeling to generate well-patterned functional networks. This is achieved by remodeling of the capillaries preserving those which are functional and eliminating other ones. A balanced and dynamically regulated capillary remodeling will therefore ensure optimal distribution of blood and nutrients to the tissues. This is particularly important in pathological contexts in which deficient or excessive vascular remodeling may worsen tissue perfusion and hamper tissue repair. Blood flow is a major determinant of microvascular reshaping since capillaries are pruned when relatively less perfused and they split when exposed to high flow in order to shape the microvascular network for optimal tissue perfusion and oxygenation. The molecular machinery underlying blood flow sensing by endothelial cells is being deciphered, but much less is known about how this translates into endothelial cell responses as alignment, polarization and directed migration to drive capillary remodeling, particularly in vivo. Part of this knowledge is theoretical from computational models since blood flow hemodynamics are not easily recapitulated by in vitro or ex vivo approaches. Moreover, these events are difficult to visualize in vivo due to their infrequency and briefness. Studies had been limited to postnatal mouse retina and vascular beds in zebrafish but new tools as advanced microscopy and image analysis are strengthening our understanding of capillary remodeling. In this review we introduce the concept of remodeling of the microvasculature and its relevance in physiology and pathology. We summarize the current knowledge on the mechanisms contributing to capillary regression and to capillary splitting highlighting the key role of blood flow to orchestrate these processes. Finally, we comment the potential and possibilities that microfluidics offers to this field. Since capillary remodeling mechanisms are often reactivated in prevalent pathologies as cancer and cardiovascular disease, all this knowledge could be eventually used to improve the functionality of capillary networks in diseased tissues and promote their repair.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου