Publication date: Available online 14 October 2020Source: Gene Expression PatternsAuthor(s): Satish Kumar Eeda, Wolfgang Werr
Wed Oct 14, 2020 18:31
Abstract Purpose In the phase III CLARINET study (NCT00353496), lanreotide autogel/depot (lanreotide) significantly improved progression-free survival (PFS) vs placebo in patients with non-functioning intestinal or pancreatic neuroendocrine tumours (NETs). The aim of CLARINET open-label extension (OLE) (NCT00842348) was to evaluate long-term safety and efficacy of lanreotide in these patients. ...
Wed Oct 14, 2020 03:00
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Tue Oct 13, 2020 03:00
Publication date: Available online 14 October 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): D. Beteramia, A. Sklavos, A. Saha, D. Hyam
Wed Oct 14, 2020 18:10
Publication date: Available online 14 October 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Vallen, T. Xi, M. Nienhuijs, W. Borstlap, T. Loonen, B. Hoogendoorn, L. van Vlimmeren, T. Maal
Wed Oct 14, 2020 18:10
Publication date: Available online 12 October 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): P. Tiwari, V. Pandey, R.N. Bera, S.P. Sharma, N. Chauhan
Tue Oct 13, 2020 16:59
Wed Oct 14, 2020 12:04
ABSTRACT Introduction There are several etiologic factors involved in the pathogenesis of acne vulgaris. Therefore, current treatment guidelines recommend applying different classes of medications for it. This makes medication adherence a challenging issue in acne patients. The current study was designed to assess medication adherence and its possible associated factors in patients with acne vulgaris. Methods This study was performed on patients with acne vulgaris in two dermatology clinics...
Wed Oct 14, 2020 12:02
Abstract Background Pemphigus vulgaris (PV), an autoimmune blistering disease is treated with immunosuppressive medications. As the immunosuppressive effect of rituximab, the first‐line therapy of PV, lasts more than six months, many concerns have raised due to the ongoing novel coronavirus disease (COVID‐19) pandemic. With this background, our objective was to review the currently available literature as well as important websites for the evidence related to rituximab, PV and COVID‐19, adverse...
Tue Oct 13, 2020 19:03
Abstract The efficacy of intravenous rituximab (RTX) in patients with pemphigus have been shown in the previous studies. The study aimed to investigate the effectiveness of intralesional injection of RTX in the healing of pemphigus lesions, with lower doses and probable better safety profile than intravenous RTX. Eleven Pemphigus patients with recalcitrant lesions received two intralesional injections of biosimilar RTX, 5mg / cm2. During six months follow‐up, Pemphigus Disease Area Index, the patients’...
Tue Oct 13, 2020 18:59
Abstract Background Keratinocyte carcinoma (KC) is the most common malignancy in white skinned populations. Metformin one of the most commonly prescribed drugs and has been reported to protect against solid cancers. The association between metformin and KC has not been studied in patients at high risk for a subsequent KC. Methods The purpose of this study is to evaluate the association between metformin and KC development in high risk patients. We performed a secondary analysis of patients...
Tue Oct 13, 2020 11:56
Abstract In early-stage sepsis, glucose metabolism is increased primarily through glycolysis in the inflammatory response of M1 macrophages. Heparin-binding protein (HBP) has been linked to sepsis, which can promote macrophage activation and inflammatory factor release. However, the mechanism by which glucose metabolism regulates the inflammatory response is unclear. We show that HBP contributes to sepsis by modulating the inflammatory response via lactate-dependent glycolysis...
Wed Oct 14, 2020 03:00
Publication date: Available online 14 October 2020Source: Journal of Neuroscience MethodsAuthor(s): Daria Genzel, Michael M. Yartsev
Wed Oct 14, 2020 17:58
Zusammenfassung Hintergrund und Fragestellung Eine Laryngektomie ist in der Regel mit einer Verminderung des Riechens für die Patienten verbunden. Wie erleben bzw. empfinden betroffene Patienten diese Umstellung? Material und Methoden In Kooperation mit dem Bundesverband der Kehlkopfoperierten entwickelten wir gemeinsam mit Betroffenen einen neuen Fragebogen,...
Wed Oct 14, 2020 03:00
Deeskalationsstrategien für die Radiochemotherapie HPV-positiver Oropharynxkarzinome: Pro und Kontra
Zusammenfassung Hintergrund Die Inzidenz von humanen Papillomaviren (HPV)-assoziierten Oropharynxkarzinome nimmt stetig zu und betrifft im Gegensatz zu den durch Alkohol- und Nikotinkonsum induzierten Kopf-Hals-Tumoren vorwiegend jüngere Patienten. Aufgrund der deutlich besseren Prognose HPV-positiver Oropharynxkarzinome werden aktuell verschiedene Therapie-Deeskalationsstrategien in Studien mit dem Ziel untersucht, therapiebedingte Toxizitäten...
Tue Oct 13, 2020 03:00
The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China, introduced the third highly pathogenic coronavirus into humans in the 21st century. Scientific advance after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic and Middle East respiratory syndrome coronavirus (MERS-CoV) emergence enabled clinicians to understand the epidemiology and pathophysiology of SARS-CoV-2. In this review, we summarize and discuss the epidemiology, clinical features, and...
Wed Oct 14, 2020 15:30
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis populations that are temporarily able to survive antibiotic pressure in the absence of drug resistance-conferring mutations, a phenomenon termed drug tolerance. We summarize findings on M. tuberculosis tolerance published in the past 20 years. Key M. tuberculosis responses to drug pressure are reduced growth rates, metabolic shifting, and the promotion of efflux pump activity. Metabolic shifts upon drug pressure...
Wed Oct 14, 2020 15:30
Patients and physicians worldwide are facing tremendous health care hazards that are caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) pandemic. Remdesivir (GS-5734) is the first approved treatment for severe coronavirus disease 2019 (COVID-19). It is a novel nucleoside analog with a broad antiviral activity spectrum among RNA viruses, including ebolavirus (EBOV) and the respiratory pathogens Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV,...
Wed Oct 14, 2020 15:30
Publication date: Available online 14 October 2020Source: Auris Nasus LarynxAuthor(s): Hayato Yamaguchi, Hiroki Sato, Kiyoaki Tsukahara, Yasuyuki Kagawa, Isaku Okamoto, Akira Shimizu, Naoyoshi Nagata, Masakatsu Fukuzawa, Mitsushige Sugimoto, Takashi Kawai, Takao Itoi
Wed Oct 14, 2020 17:44
Publication date: Available online 13 October 2020Source: Auris Nasus LarynxAuthor(s): Ahmed Gamal Khafagy, Hany Kassamy, Ahmed A. Mohamed
Wed Oct 14, 2020 17:44
Publication date: Available online 13 October 2020Source: Auris Nasus LarynxAuthor(s): Manabu Mogitate, Yuko Sasaki, Ayako Komiyama
Wed Oct 14, 2020 17:44
Publication date: Available online 13 October 2020Source: Auris Nasus LarynxAuthor(s): Shinya Sugimoto, Tomohito Fuke, Daisuke Kobayashi, Kohki Ueda, Masahiro Sawa, Mamika Kaneko, Kohei Fukukita, Taishi Temma, Tatsuma Nomura, Nobukazu Fuwa, Hiroyuki Yamada
Tue Oct 13, 2020 17:32
Publication date: Available online 13 October 2020Source: Revue des Maladies RespiratoiresAuthor(s): P. Smondack, F.-É. Gravier, G. Prieur, A. Repel, J.-F. Muir, A. Cuvelier, Y. Combret, C. Medrinal, T. Bonnevie
Wed Oct 14, 2020 17:33
Publication date: Available online 13 October 2020Source: Revue des Maladies RespiratoiresAuthor(s): A. Slim, A. Hedhli, Y. Ouahchi, S. Toujani, S. Cheikh Rouhou, S. Hadj Taeib, M. Mjid, S. Merai, M. Feki
Wed Oct 14, 2020 17:33
Publication date: Available online 12 October 2020Source: Revue des Maladies RespiratoiresAuthor(s): C. Billiet, I. Chiairi, L. Berzenji, P.E. Van Schil
Tue Oct 13, 2020 16:26
Clinicians are facing important emotional stressors during the Covid-19 pandemic, including grief from seeing so many patients die, fears of contracting the virus and infecting their family members, and anger over health care disparities and other systems failures. For some, these stressors have…
Wed Oct 14, 2020 03:00
How are you holding up? This question has become my pandemic refrain, the way I begin all my virtual visits these days. I imagine Atlas, a Titan condemned to forever hold up the heavens after losing in battle to the invincible Greek god Zeus: knees bent, back hunched, arms raised above his head as…
Wed Oct 14, 2020 03:00
Publication date: 1 January 2021Source: NeuroImage, Volume 224Author(s): Cancan He, Ying Bai, Zan Wang, Dandan Fan, Qing Wang, Xinyi Liu, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Honghong Yao, Chunming Xie
Wed Oct 14, 2020 17:28
Publication date: 1 January 2021Source: NeuroImage, Volume 224Author(s): Anqi Qiu, Han Zhang, Brian K. Kennedy, Annie Lee
Wed Oct 14, 2020 17:28
Publication date: Available online 13 October 2020Source: Annals of Diagnostic PathologyAuthor(s): Cynthia M. Magro, Justin Mulvey, Jeffrey Kubiak, Sheridan Mikhail, David Suster, A. Neil Crowson, Jeffrey Laurence, Gerard Nuovo
Wed Oct 14, 2020 17:28
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Cholangiocarcinoma (CCA) is an extremely intractable malignancy since most patients are already in an advanced stage when firstly discovered. CCA needs more effective treatment, especially for advanced cases. Our study aimed to evaluate the effect of romidepsin on CCA cells in vitro and in vivo and explore the underlying mechanisms.Methods:The antitumor effect was determined by cell viability, cell...
Wed Oct 14, 2020 14:02
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Purpose:Mutations of PIK3CA have recently been shown to play an important role in the pathogenesis and progression of breast neoplasms. The prevalence of PIK3CA in Chinese breast cancer patients may be underestimated. Therefore, we investigated the distribution of somatic PIK3CA mutation in Chinese breast cancer patients and explored their role in tumor phenotypes.Methods:Mutational analysis of PIK3CA was done...
Tue Oct 13, 2020 12:28
Publication date: Available online 13 October 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Laura Keogh, David Kilroy, Sourav Bhattacharjee
Wed Oct 14, 2020 17:13
AbstractGouty arthritis commonly occurs in peripheral synovial joints and involvement in the thoracic cage is extremely rare. We report a case of a 52-year-old presenting with a painful bony mass in her sternal notch. Imaging demonstrated a lobulated calcified and necrotic lesion causing mass effect on adjacent structures. Excision biopsy confirmed a benign cystic lesion with amorphous material containing needle-shaped refractile crystals suggestive of uric acid. Tophaceous gout was diagnosed. Presence...
Wed Oct 14, 2020 03:00
AbstractA literature search confirmed no previous cases of an arm amputation secondary to necrotizing fasciitis (NF) being successfully treated with a myoelectric prosthesis. This report explores a case of a 55-year-old right-handed male with flexor tenosynovitis infection of the hand after a small laceration. Following infectious disease consult of the infection, a diagnosis of NF was made. Broad-spectrum antibiotics were initiated but the infection worsened after 12 hours. Two debridements with...
Mon Oct 12, 2020 03:00
Publication date: 1 January 2021Source: Behavioural Brain Research, Volume 396Author(s):
Wed Oct 14, 2020 16:38
Publication date: Available online 14 October 2020Source: Behavioural Brain ResearchAuthor(s): Shane N. Glackin, Tom Roberts, Joel Krueger
Wed Oct 14, 2020 16:38
Publication date: Available online 13 October 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Frederico Bastos Gonçalves, Nabil Chakfé
Wed Oct 14, 2020 16:30
Publication date: Available online 13 October 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Rosa M. Smoor, Rogier H.J. Kropman, Suzette E.M. Brouwers, Jeroen L.A. van Vugt, Jan Wille, Wilton A. van Klei, Marielle H. Emmelot-Vonk, Eric P.A. van Dongen, Peter G. Noordzij
Wed Oct 14, 2020 16:30
Publication date: Available online 13 October 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Eric Allaire, Hélène Sussman, Ahmed S. Zugail, Pascal Hauet, Jean Floresco, Ronald Virag
Wed Oct 14, 2020 16:30
Publication date: Available online 13 October 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Lina F. Wübbeke, Bram Kremers, Jan-Willem H.C. Daemen, Maarten G.J. Snoeijs, Michael J. Jacobs, Barend M.E. Mees
Tue Oct 13, 2020 16:06
Publication date: Available online 13 October 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Taira Kobayashi, Masaki Hamamoto, Takanobu Okazaki, Misa Hasegawa, Shinya Takahashi
Tue Oct 13, 2020 16:06
Publication date: Available online 12 October 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): George A. Antoniou
Tue Oct 13, 2020 16:06
Publication date: Available online 12 October 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Gert J. de Borst
Tue Oct 13, 2020 16:06
New Findings What is the central question of this study? What ex‐vivo preparation of the rat's cavo‐atrial junction is efficient for characterising atrial mechanoreceptors? What is the main finding and its importance? Type A, B and intermediate atrial mechanoreceptors were studied using four different ex‐vivo preparations: static pressure, flow, open and euthermic. The optimal preparation (euthermic) involved direct recording from the right cardiac vagal branch with a Langendorff...
Wed Oct 14, 2020 12:44
Objectives Work-related lung diseases (WRLDs) are entirely preventable. To assess the impact of WRLDs on the US transplant system, we identified adult lung transplant recipients with a WRLD diagnosis specified at the time of transplant to describe demographic, payer and clinical characteristics of these patients and to assess post-transplant survival. Methods Using US registry data from 1991 to 2018, we identified lung transplant recipients with WRLDs including coal workers’ pneumoconiosis,...
Wed Oct 14, 2020 15:38
Objectives The natural history of coal workers’ pneumoconiosis (CWP) after cessation of exposure remains poorly understood. Methods We characterised the development of and progression to radiographic progressive massive fibrosis (PMF) among former US coal miners who applied for US federal benefits at least two times between 1 January 2000 and 31 December 2013. International Labour Office classifications of chest radiographs (CXRs) were used to determine initial and subsequent disease severity....
Wed Oct 14, 2020 15:38
We have read with interest various recent papers published on working from home and how productive one can try to be or how to preserve health.1 2 Although we very much appreciate how the healthcare service has embraced innovation to continue to deliver patient care throughout a pandemic, we wish to highlight some of the challenges faced by many working from home. As the COVID-19 pandemic took hold, we acquired laptops with access to laboratory results, electronic patient notes, radiology and various...
Wed Oct 14, 2020 15:38
Objectives We investigated the association between low-dose external occupational radiation exposure and circulatory disease morbidity among diagnostic medical radiation workers. Methods A cohort of 11 500 diagnostic medical radiation workers was linked with the National Dosimetry Registry data and the National Health Insurance Service data. Relative risks (RRs) were calculated to explore the association between occupational factors and circulatory disease morbidity, and excess relative...
Wed Oct 14, 2020 15:38
Objectives To examine the impact of COVID-19 lockdown restrictions in March/April 2020 on concentrations of nitrogen dioxide (NO2) and ambient fine particulate matter (PM2.5) air pollution measured at roadside monitors across Scotland by comparing data with previous years. Methods Publicly available data of PM2.5 concentrations from reference monitoring systems at sites across Scotland were extracted for the 31-day period immediately following the imposition of lockdown rules on 23 March...
Wed Oct 14, 2020 15:38
Objectives While life at sea traditionally has presented a variety of potential hazards, rigorous measures have been taken in the past decades to ensure the safety and health of all aboard merchant ships. The aim of this study was to examine overall and cause-specific mortality among Danish seafarers in light of these changes. Methods A cohort of 44 555 male (75%) and female (25%) seafarers employed on Danish ships during 1986–1999 was established through records from the Danish Seafarer...
Wed Oct 14, 2020 15:38
Police face an increased risk of developing mental health problems, yet reliable estimates of their psychological difficulties remain unknown. This systematic review and meta-analysis estimate the pooled prevalence and risk factors for mental health problems among police personnel worldwide. Three independent reviewers searched 16 databases and screened 11 506 articles published between January 1980 and October 2019. Eligible studies involved at least 100 active police professionals and used validated...
Wed Oct 14, 2020 15:38
Objectives The objective of this study was to assess the influence of antioxidant gene GSTM1 and GSTT1 on DNA damage in personnel occupationally exposed to volatile anaesthetics (VA). Methods The study groups were composed of 50 exposed subjects (anaesthesia workers) and 49 controls. Blood samples were collected from both subjects. DNA damage was analysed through the comet assay technique. Biomarker genes GSTM1 and GSTT1 were inspected through PCR technique for polymorphism. Results...
Wed Oct 14, 2020 15:38
Objectives Titanium dioxide (TiO2) is widely used in construction, food, cosmetic and medical industry. The current evidence on TiO2 carcinogenicity in humans is considered inadequate. As French participants of the European cohort of TiO2 workers exhibited an increase in mortality from lung cancer, we aimed at investigating whether TiO2 exposure, co-exposures or smoking can explain this increase. Methods We reanalysed the data of 833 French male workers (follow-up period 1968–1997) and used...
Wed Oct 14, 2020 15:38
Objectives To investigate temporal trends in the ‘healthy soldier effect’ (HSE) among 28 300 Royal Norwegian Navy servicemen who served during 1950–2004. Methods Standardised mortality ratios (SMRs) for all causes, diseases and external causes were calculated from national rates for the entire study period (1951–2017), and for seven successive follow-up periods after the first recorded day of Naval service, for the overall cohort and for two subgroups: land-based personnel and vessel crews....
Wed Oct 14, 2020 15:38
Objectives To identify the changes in serial 2-hourly forced expiratory volume in 1 s (FEV1) measurements required to identify occupational asthma (OA) using the Oasys Area Between Curves (ABC) score. Methods The ABC score from 2-hourly measurements of FEV1 was compared between workers with confirmed OA and asthmatics without occupational exposure to identify the optimum separation using receiver operator characteristic (ROC) analysis. Separate analyses were made for plots using clock time...
Wed Oct 14, 2020 15:38
Objectives Increasing sickness absence (SA) has been reported among healthcare workers in Sweden. Our aim was to analyse the impact of work environment factors on short-term and long-term SA based on musculoskeletal and psychiatric diagnoses among healthcare workers. Methods The study sample consisted of healthcare workers (n=12 452) drawn from representative samples of workers aged 16 to 64, who participated in the Swedish Work Environment Surveys (SWES) between 1993 and 2013. The outcomes...
Wed Oct 14, 2020 15:38
Dear Sir We read with interest the letter by Mégarbane and Tadayoni.1 Following reports of increasing eyelid cysts occurring in our local intensive care departments, we conducted a survey of clinical staff there. We aimed to establish the frequency and nature of eyelid cysts reported and to investigate possible associations. An online survey comprising 10 questions was distributed to all clinical staff working in intensive care. The respondents were asked if they had experienced any new eyelid cysts...
Wed Oct 14, 2020 15:38
Objectives Subglottic stenosis (SGS) is the most common type of laryngeal stenosis in neonates. SGS severity is currently graded based on percent area of obstruction (%AO) via the Myer‐Cotton grading scale. However, patients with similar %AO can have widely different clinical courses. Computational fluid dynamics (CFD) based on patient‐specific imaging can quantify the relationship between airway geometry and flow dynamics. We investigated the effect of %AO and axial position of SGS on work of breathing...
Wed Oct 14, 2020 15:36
Wed Oct 14, 2020 15:22
Publication date: Available online 14 October 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Nicola Marotta, Andrea Demeco, Cinzia Marinaro, Lucrezia Moggio, Ilaria Pino, Marianna Barletta, Annalisa Petraroli, Antonio Ammendolia
Wed Oct 14, 2020 15:45
Publication date: Available online 14 October 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Marc Possover
Wed Oct 14, 2020 15:45
Publication date: Available online 13 October 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Jarrad H. Van Stan, John Whyte, Joseph R. Duffy, Julie M. Barkmeier-Kraemer, Patricia B. Doyle, Shirley Gherson, Lisa Kelchner, Jason Muise, Brian Petty, Nelson Roy, Joseph Stemple, Susan Thibeault, Carol Jorgensen Tolejano
Tue Oct 13, 2020 20:39
Publication date: Available online 12 October 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Gabrielle Alvarez, Alyssa Krentzel, Joshua Vova, Laura Blackwell, Robyn Howarth
Tue Oct 13, 2020 20:39
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Nicolas H. Thurin, Magali Rouyer, Marine Gross-Goupil, Xavier Rebillard, Michel Soulié, Thibaud Haaser, Mathieu Roumiguié, Sylvestre Le Moulec, Camille Capone, Marie Pierrès, Stéphanie Lamarque, Jérémy Jové, Emmanuelle Bignon, Cécile Droz-Perroteau, Nicholas Moore, Patrick Blin
Wed Oct 14, 2020 15:18
Publication date: Available online 14 October 2020Source: Cancer EpidemiologyAuthor(s): Anne-Charlotte Le Floch, François Eisinger, Evelyne D’Incan, Jérôme Rey, Aude Charbonnier, Laurence Caymaris, Marion Stoler, Julien Mancini, Jean-Marie Boher, Patrick Sfumato, Norbert Vey
Wed Oct 14, 2020 15:18
Publication date: November 2020Source: Journal of Human Evolution, Volume 148Author(s): Mercedes Conde-Valverde, Ignacio Martínez, Rolf Quam, Juan-Luis Arsuaga, Joan Daura, Montserrat Sanz, João Zilhão
Wed Oct 14, 2020 15:05
Publication date: November 2020Source: Journal of Human Evolution, Volume 148Author(s): Anna M. Hardin
Tue Oct 13, 2020 14:49
Key points Age‐related hearing loss (ARHL) is a progressive hearing loss involving environmental and genetic factors, leading to a decrease in hearing sensitivity, threshold and speech discrimination. We compared age‐related changes in IHCs between four mouse strains with different levels of progressive hearing loss. The surface area of apical coil IHCs (9‐12 kHz cochlear region) decreases by about 30–40% with age. The number of BK channels progressively decreases with age in IHCs from most...
Wed Oct 14, 2020 12:44
Publication date: Available online 13 October 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Kathleen M. Buchheit, Kathryn E. Hulse
Wed Oct 14, 2020 14:47
Publication date: Available online 12 October 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Jamie A. Rosenthal, Seemal F. Awan, Jonathan Fintzi, Anjeni Keswani, Daniel Ein
Tue Oct 13, 2020 18:48
Purpose: The aim of the study was to investigate whether diabetes mellitus (DM) is an independent risk factor in sight-threatening thyroid eye disease (ST-TED) and explore the interaction of DM with other known risk factors in TED. Methods: This was a retrospective cohort study and included 202 consecutive TED patients presenting between 2013 and 2019. Data collected included demography, history of smoking, thyroid dysmetabolism, and presence of DM, TED-duration, activity and severity,...
Thu Oct 08, 2020 03:00
Purpose: Deoxycholic acid (DCA) 1% is an injectable detergent indicated for submental fat reduction, although clinically it is being injected off-label for orbital fat prolapse. It is known to cause severe inflammation, local nerve dysfunction, and tissue necrosis, all of which could be catastrophic in the orbit and periocular region. This study evaluated the effects of periocular DCA on orbital and ocular adnexal tissues in a murine model. Methods: Mice were treated via split-face...
Thu Oct 08, 2020 03:00
Three patients (3 female patients; aged 7, 35, and 61 years) who had recalcitrant idiopathic sclerosing orbital inflammation were treated with rituximab. The disease was bilateral in 1 patient (4 orbits in total): diffuse in 2 and localized in 2 orbits. It caused optic neuropathy in 1 orbit of each patient. Conventional immunotherapy and tumor debulking surgery were unsuccessful in controlling the disease. After rituximab infusions (375 mg/m2/week for 4 weeks), all patients improved symptomatically....
Thu Oct 08, 2020 03:00
Purpose: To review the outcomes of orbital exenteration defect reconstruction using cheek or combined cheek-forehead advancement flap. Methods: Charts of 14 patients who underwent reconstruction of the exenterated orbit with cheek advancement flap were reviewed. In surgery, a cheek flap elevated via a nasofacial sulcus incision, and preperiosteal dissection was advanced over the defect. The upper orbital defect, if necessary, was covered with a forehead flap, which was dissected through...
Thu Oct 08, 2020 03:00
Herein, the authors report a case of relapsing polychondritis (RP) presenting as isolated bilateral nodular episcleritis. A 23-year-old male presented to us with bilateral large ocular surface masses for which he had received antitubercular medications. A workup was performed to rule out infective, neoplastic, and immune etiologies, after which the patient was then treated empirically with systemic steroids. No response to steroids was noted, so the lesions were removed surgically. On follow up,...
Thu Oct 08, 2020 03:00
No abstract available
Thu Oct 08, 2020 03:00
Publication date: Available online 14 October 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Renata Fofiu, Felix Bende, Alina Popescu, Roxana Şirli, Raluca Lupușoru, Ana-Maria Ghiuchici, Ioan Sporea
Wed Oct 14, 2020 14:15
Publication date: Available online 12 October 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Luo Yukun, Yuan Jianjun, Liu Minghui, Nie Fang, Bai Jiao, Fei Xiang, Deng Yujiao, Yu Tengfei, Mao Juan, Zhu Haohui, Li Chuang, Peng Qinghai, Zhang Ming, Zeng Shi, Xu Ganqiong, Niu Chengcheng, Dong Tiantian, He Wen, Tang Jie, Chinese Ultrasound Doctors AssociationChinese PLA Professional Committee of Ultrasound in MedicineBeijing Institute of Ultrasound in Medicine, Chinese Research Hospital Association...
Tue Oct 13, 2020 18:24
Publication date: Available online 14 October 2020Source: International Journal of PsychophysiologyAuthor(s): Kathryn Biernacki, Mei-Heng Lin, Travis E. Baker
Wed Oct 14, 2020 14:09
Publication date: Available online 13 October 2020Source: International Journal of PsychophysiologyAuthor(s): Xing-Jie Chen, Amanda Geagea, Jiyoung Park, Youngbin Kwak
Wed Oct 14, 2020 14:09
Publication date: January 2021Source: Clinical Imaging, Volume 69Author(s): Junzi Shi, Nityanand Miskin, Borna E. Dabiri, Ariadne K. DeSimone, Peter M. Schaefer, Shanna A. Matalon, Jennifer W. Uyeda, Jeffrey P. Guenette, Glenn C. Gaviola
Wed Oct 14, 2020 14:07
Publication date: January 2021Source: Clinical Imaging, Volume 69Author(s): Sadaf Alipour
Tue Oct 13, 2020 18:59
We here report on a 74-year-old man diagnosed with a pT3cN0 BRAF-mutated and mismatch repair-deficient adenocarcinoma in the colon ascendens and 3 liver metastases. After hemicolectomy, the patient received treatment with the PD-1 inhibitor pembrolizumab. Three weeks later (on day 22), laboratory tests showed leukocytosis and an increase in transaminases; immune checkpoint inhibitor (ICI)-induced hepatitis was suspected and prednisolone therapy was initiated. On day 29, the patient was acutely hospitalized...
Wed Oct 14, 2020 09:58
Temozolomide (TMZ) is an oral alkylating agent that is considered the standard therapy in primary intracranial malignancies. The medication is well tolerated with a most common side effect of bone marrow suppression that is encountered in a small proportion of patients, often reversible with medication discontinuation and supportive treatment. Rarely, aplastic anemia can develop during treatment with TMZ. Here, we present a case of a patient who developed aplastic anemia following treatment with...
Tue Oct 13, 2020 17:39
We report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiographically and biochemically (CA19-9). Her response has been more clinically relevant than responses in previous case reports of patients with BRAF-positive pancreatic cancer treated with targeted therapy....
Tue Oct 13, 2020 17:39
Publication date: Available online 14 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Shaqayeq Ramezanzade, Seied Omid Keyhan, Frank J. Tuminelli, Hamid Reza Fallahi, Parisa Yousefi, Jose Lopez-Lopez
Wed Oct 14, 2020 13:41
Publication date: Available online 13 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Sumun Khetpal, Joseph Lopez, Derek M. Steinbacher
Wed Oct 14, 2020 13:41
Publication date: Available online 13 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Peter Rekawek, Lindsay L. Graves, Neeraj Panchal, Thomas Schlieve
Wed Oct 14, 2020 13:41
Publication date: Available online 13 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Christoph Pautke, Alexander Wick, Sven Otto, Bettina Hohlweg-Majert, Jürgen Hoffmann, Oliver Ristow
Wed Oct 14, 2020 13:41
Publication date: Available online 13 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Yuncong Li, Lifeng Li, Jingyi Shi, Junbo Tu, Lin Niu, Xiaoyi Hu
Tue Oct 13, 2020 18:40
Publication date: Available online 13 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Shaoting Zhang, Hao Gu, Ying Yuan, Jiliang Ren, Zimin Zhang, Xiaofeng Tao
Tue Oct 13, 2020 18:40
Publication date: Available online 13 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Andrea Borgonovo, Tommaso Grandi, Sante Vassallo, Luca Signorini
Tue Oct 13, 2020 18:40
Publication date: Available online 12 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Alaettin Koç, Sema Kaya, Wisam Abdulrazzaq Abdulsalam
Tue Oct 13, 2020 18:40
Publication date: Available online 12 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Dr Jeetendra Mandal, Dr Ongkila Bhutia, Dr Ajoy Roychoudhury, Dr Rahul Yadav, Dr Manoj Adhikari, Dr Ganesh Chaudhary
Tue Oct 13, 2020 18:40
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