Publication date: Available online 30 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): S.A.R. Nouraei, M. Girgis, J. Shorthouse, K. El-Boghdadly, I. Ahmad
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Abstract Parkinson’s disease (PD) was first formally described by James Parkinson in 1817, but the shaking of limbs was described in the literature of several ancient civilizations, such as ancient Chinese civilization and ancient Indian civilization. Historically, botanical drugs were used as the main source for the treatment of such kind of disorders. In Western countries, plant extracts also occupied an important place in the earlier medications of PD. With the adventure...
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Research Highlight (1) The interferometer resolution of 50 fs is obtained. (2) The 3D interferometer is novel. (3) The system used the practical device parameters, which can be fabricated and tested. (4) It can be applied for bio‐cells interferometer. (5) By using the plasmonic sensor, the wireless (remote sensor) is also possible. Abstract A 3D (three‐dimensional) quantum interferometer consisting of a silicon microring circuit proposed. The interferometer based on the electron spin cloud...
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Fusion of green fluorescent protein and phase contrast images in nonsubsampled shearlet transform domain. The high‐frequency coefficients are fused with a strategy based on phase congruency and parameter‐adaptive pulse coupled neural network, while the low frequency coefficients are merged by a local energy‐based rule. Abstract Image fusion technique is an effective way to merge the information contained in different imaging modalities by generating a more informative composite image. Fusion...
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Abstract In preclinical models of biliary tract cancer, NUC-1031 showed less potency than gemcitabine, no correlation with potential biomarkers and only moderate additive interaction in combination with cisplatin. These findings should prompt further careful pharmacological and translational studies to better define the purported therapeutic advantage of NUC-1031 over gemcitabine. That would be a more cautious approach than the phase III clinical trial which is planning to enrol...
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Abstract Failure of IT projects has risen to become an eyesore for most organisations. This is often attributed to the ‘mum effect’- an individual’s reluctance to report the exact position of troubled software projects. With the increasing digitalization of operations by most State Universities in Zimbabwe, the mum effect has the potential to rise to exponential proportions. Guided by the Design Science approach data was gathered from an intensity sample of 15 participants comprising...
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Background Subtyping chronic rhinosinusitis (CRS) by tissue eosinophilia has prognostic and therapeutic implications, and is difficult to predict using peripheral eosinophil counts or polyp status alone. The objective of this study was to test machine learning for prediction of eosinophilic CRS (eCRS). Methods Input variables were defined as peripheral eosinophil count, urinary leukotriene E4 (uLTE4) level, and polyp status. The output was diagnosis of eCRS, defined as tissue eosinophil count...
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Cancers, Vol. 12, Pages 1426: Retrospective Multicentric Study on Non-Optic CNS Tumors in Children and Adolescents with Neurofibromatosis Type 1 Cancers doi: 10.3390/cancers12061426 Authors: Santoro Picariello Palladino Spennato Melis Roth Cirillo Quaglietta D’Amico Gaudino Meucci Ferrara Constantini Perrotta Cinalli s: The natural history of non-optic central nervous system (CNS) tumors in neurofibromatosis...
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Cancers, Vol. 12, Pages 1425: A Phase 1 Study of mTORC1/2 Inhibitor BI 860585 as a Single Agent or with Exemestane or Paclitaxel in Patients with Advanced Solid Tumors Cancers doi: 10.3390/cancers12061425 Authors: Filippo de Braud Jean-Pascal H. Machiels Daniela Boggiani Sylvie W.H. Rottey Matteo Duca Marie Laruelle Stefania Salvagni Silvia Damian Lore D.F. Lapeire Marcello Tiseo Alexandre Dermine Mahmoud Ould-Kaci Juergen Braunger Juliane...
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NEPA is a novel fixed combination antiemetic comprised of the NK1RA, netupitant, and the 5‐HT3RA, palonosetron. The simultaneous targeting of two critical antiemetic pathways, in unison with single‐dose administration, offers a simplified and convenient antiemetic with 5‐day CINV prevention. The authors report significantly better protection from CINV during Days 3‐5 post‐chemotherapy for NEPA vs a 3‐day regimen of aprepitant/granisetron in Chinese patients, and in those receiving high‐dose cisplatin,...
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Despite the pivotal role that MDT TBs play in oncology care, the implementation of this science remains nebulous and has scope to improve. The need for standardising TB data reporting will enable to better understand HNC trends globally/regionally. Last but not the least, outcomes in HNC patients discussed at TBs and adherence of HNC patients to TB treatment plan is underreported, and analysis of this key area will be an essential cog in HNC patient management. Abstract Background Multidisciplinary...
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ABSTRACT Background Around 50% of PD patients experience motor fluctuations, which are often accompanied by mood fluctuations. The nature of the relationship between motor and mood fluctuations remains unknown. It is suggested that the experience sampling method can reveal such associations on both a group and individual level. Revealing group patterns may enhance our understanding of symptom interactions and lead to more general treatment recommendations, whereas analyses in individual patients...
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Abstract Background Juvenile forms of parkinsonism are rare conditions with onset of bradykinesia, tremor and rigidity before the age of 21 years. These atypical presentations commonly have a genetic aetiology, highlighting important insights into underlying pathophysiology. Genetic defects may affect key proteins of the endocytic pathway and clathrin‐mediated endocytosis (CME), as in DNAJC6‐related juvenile parkinsonism. Objective To report on a new patient cohort with juvenile‐onset DNAJC6...
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The MD Anderson Cancer Center expert spoke about the disconnect in women who are at risk for ovarian cancer to actually receive genetic counseling. (Source: CancerNetwork)
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A study presented at the 2020 ASCO Scientific Program combining mirvetuximab soravtansine with bevacizumab to treat platinum-agnostic ovarian cancer demonstrated an encouraging overall response rate and tolerability profile regardless of platinum status. (Source: CancerNetwork)
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The results suggested the potential for this agent to become a new standard for T-suppression in this patient population. (Source: CancerNetwork)
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Teclistamab appeared to be a safe and efficacious treatment for patients with relapsed/refractory multiple myeloma, according to a phase I study presented at the ASCO Virtual Scientific Program. (Source: CancerNetwork)
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Results of KEYNOTE-204 supports pembrolizumab as new standard of care for patients with classical Hodgkin Lymphoma who have relapsed after autologous stem cell transplant or are ineligible for autologous stem cell transplant. (Source: CancerNetwork)
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Baseline CTC counts were shown to be strong indicators for subsequent therapy response and 2-year progression-free survival. (Source: CancerNetwork)
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The allogeneic CAR-T cell therapy ALLO-501, paired with the monoclonal antibody ALLO-647, demonstrated clinical responses and manageable toxicity in patients with pretreated large B-cell and follicular lymphomas in the Phase I ALPHA trial. (Source: CancerNetwork)
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The FDA approved ramucirumab injection in combination with erlotinib for the first-line treatment of patients with metastatic non-small cell lung cancer with EGFR exon 19 deletions or exon 21 mutations. (Source: CancerNetwork)
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The HIF-2a Inhibitor, MK-6482, induced clinical responses among patients with von Hippel-Lindau disease –associated renal cell carcinoma. (Source: CancerNetwork)
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Frontline treatment with nivolumab plus ipilimumab induced durable and long-term efficacy, compared with chemotherapy, in patients with advanced non-small cell lung cancer, regardless of PD-L1 expression. (Source: CancerNetwork)
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Abstract Background Patients with high‐risk neuroblastoma (HR NBL) treated with myeloablative regimens are reported to be at risk for cardiovascular morbidity, and this risk may be increased by impaired renal function. Procedure Long‐term renal function was assessed in a national cohort of 18 (age 22.4 ± 4.9 years) HR NBL survivors by plasma creatinine (P‐Cr), urea, and cystatin C (P‐Cys C) concentrations, urine albumin/creatinine ratio (ACR), and estimated glomerular filtration rate (eGFR)....
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Abstract Opsoclonus myoclonus syndrome (OMS) is a rare neurological syndrome caused by a paraneoplastic autoimmune process that affects children with neuroblastic tumors. Treatment includes corticosteroids, intravenous gamma globulin (IVIG), rituximab, and other immunosuppressive therapies. Here, we describe a patient diagnosed with OMS associated with a localized inflammatory myofibroblastic tumor. The patient has no evidence of tumor recurrence following surgical resection with 8‐month follow‐up....
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Abstract Background Osteonecrosis is a debilitating complication in children and adolescents with acute lymphoblastic leukemia or acute lymphoblastic lymphoma (LLy). An objective screening test to identify patients at risk for symptomatic, extensive joint involvement will help manage osteonecrosis. Methods We performed a prospective, longitudinal pilot study with whole‐joint magnetic resonance imaging (MRI) of shoulders, elbows, hips, knees, ankles, and hindfeet to evaluate the incidence...
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Abstract Germline biallelic mutations in one of the mismatch repair genes, mutS homolog 2, mutS homolog 6, mutL homolog 1, or postmeiotic segregation increased 2, result in one of the most aggressive cancer syndromes in humans termed as constitutional mismatch repair deficiency (CMMRD). Individuals with CMMRD are affected with multiple tumors arising from multiple organs during childhood, and these individuals rarely reach adulthood without specific interventions. The most common tumors observed...
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Summary Rebound pain after brachial plexus block resolution and development of long‐lasting pain are problems associated with volar plate fixation for distal radius fractures. The aim of this double‐blind study was to evaluate the effect of a single prophylactic intravenous dose of dexamethasone in this setting. The primary endpoint was highest pain score during the first 24 hours after surgery. We included 51 adults of ASA physical status 1–2 due to undergo planned acute fixation of the radius....
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Abstract Background We evaluated the long‐term efficacy and safety of carbon‐ion radiotherapy (C‐ion RT) for skull base chordoma, a rare neoplasm. Methods Thirty‐four patients with skull base chordoma who were treated with C‐ion RT were prospectively enrolled and analyzed retrospectively. C‐ion RT was delivered with 60.8 Gy (relative biological effectiveness [RBE]) in 16 fractions at four fractions per week. Results The median follow‐up period was 108 months. The 5‐ and 9‐year local...
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Abstract Squamous cell carcinoma of the external auditory canal (SCC‐EAC) is rare and has a poor prognosis. SCC‐EAC cases with high‐grade tumor budding (TB) or poorly differentiated clusters (PDCs) are associated with shorter survival than those with low‐grade TB or PDCs. Emmprin is a protein expressed in tumor cells that stimulates the production of matrix metalloproteinase (MMP)‐2 by stromal fibroblasts to facilitate tumor invasion. Recently, we reported that emmprin forms a complex with CD73...
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Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis
Abstract Clear cell carcinoma of the ovary is thought to arise from endometriosis. Additionally, retrograde menstruation of shed endometrium is considered the origin of endometriosis. However, little evidence supports cellular continuity from uterine endometrium to clear cell carcinoma through endometriosis at the genomic level. Here, we performed multiregional whole‐exome sequencing to clarify clonal relationships among uterine endometrium, ovarian endometriosis, and ovarian clear cell carcinoma...
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Abstract The hepatocellular carcinoma (HCC) is a highly heterogenous liver cancer with significant male‐biases in incidence, disease progression and outcomes. Previous studies suggested that genes on the Y‐chromosome could be expressed and exert various male‐specific functions in the oncogenic processes. In particular, the RNA‐binding motif on the Y chromosome (RBMY ) gene is frequently activated in HCC and postulated to promote hepatic oncogenesis in patients and animal models. In the present study,...
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