In this paper, we present an algorithm for eigenvalue assignment of linear singularly perturbed systems in terms of reduced-order slow and fast subproblem matrices. No similar algorithm exists in the literature. First, we present an algorithm for the recursive solution of the singularly perturbed algebraic Sylvester equation used for eigenvalue assignment. Due to the presence of a small singular perturbation parameter that indicates separation of the system variables into slow and fast, the corresponding...
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Background. Luhong formula (LHF)—a traditional Chinese medicine containing Cervus nippon Temminck, Carthamus tinctorius L., Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, Codonopsis pilosula (Franch.) Nannf., Cinnamomum cassia Presl, and Lepidium apetalum Willd—is used in the treatment of heart failure, but little is known about its mechanism of action. We have investigated the effects of LHF on antifibrosis. Methods. Forty-eight SD male rats were randomly assigned into six...
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User interest mining is widely used in the fields of personalized search and personalized recommendation. Traditional methods ignore the formation of user interest which is a process that evolves over time. This leads to the inability to accurately describe the distribution of user interest. In this paper, we propose the interest tracking model (ITM). To add the timing, ITM uses Dirichlet distribution and multinomial distribution to describe the evolutional process of interest topics and frequent...
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Background. HeChan tablet (HCT) is a traditional Chinese medicine preparation extensively prescribed to treat lung cancer in China. However, the pharmacological mechanisms of HCT on lung cancer remain to be elucidated. Methods. A comprehensive network pharmacology-based strategy was conducted to explore underlying mechanisms of HCT on lung cancer. Putative targets and compounds of HCT were retrieved from TCMSP and BATMAN-TCM databases; related genes of lung cancer were retrieved from OMIM and DisGeNET...
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Background. The high prevalence of haemoglobin variants and glucose 6-phosphate dehydrogenase disorder (G6PDd) in sub-Saharan Africa means that substantial proportions of donor blood units carry these red cell abnormalities. Aim. This study investigated the impact that inherited haemoglobin variants and/or G6PD status have on whole blood banked at 4–6°C for 35 days. Method. This repeated-measure cohort study was undertaken on 103 donor blood units collected into blood bag containing CPDA-1 anticoagulant....
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Background. Uses of general anaesthesia in outpatient invasive procedures have increased, especially in dermatology. Being uncooperative, children often require general anaesthesia, since surgical skin operations are mostly painful. Aim. The purpose of this study is to evaluate the safety, significant adverse events, and the complication rates related to general anaesthesia, when used among pediatric population undergoing skin procedures. Methods. We conducted a first retrospective cohort study of...
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Introduction. Colonoscopy is considered as a gold standard investigation for screening of colorectal cancer and other lower gastrointestinal pathologies. Adequate bowel preparation is absolutely necessary for a fruitful colonoscopy. Various bowel cleansing agents are being used for his purpose. The aim of the present study was to compare the two bowel cleansing agents: a single dose of Polyethylene Glycol (PEG) solution and a split dose of Sodium Picosulfate (Na PICOSUL) tablet with regards to cleansing...
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This paper addresses a version of the linear quadratic control problem for mean-field stochastic differential equations with deterministic coefficients on time scales, which includes the discrete time and continuous time as special cases. Two coupled Riccati equations on time scales are given and the optimal control can be expressed as a linear state feedback. Furthermore, we give a numerical example.
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Background. Vitiligo is not a well-studied disease in Ethiopia. Therefore, this study assessed its clinico-epidemiological profile and treatment patterns. Methods. An institutional-based cross-sectional study was conducted in conveniently selected dermatologic clinics of Mekelle city, Ethiopia. A two-phased study was conducted, in which the first was to determine prevalence of vitiligo while the second phase was to describe the clinico-epidemiological profile and treatment pattern of vitiligo. Four-hundred...
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Background. The prognosis of patients with advanced gastric cancer remains unsatisfactory, highlighting the need for improved therapeutic strategies. We analyzed 23 resectable advanced gastric cancer patients who received FLOT followed by laparoscopic gastrectomy with D2 lymphadenectomy to evaluate the efficacy and safety. Methods. Patients aged 18–75 years with gastric adenocarcinoma (stage cT3–4 and/or N + M0) underwent neoadjuvant FLOT therapy (four preoperative and four postoperative 2-week cycles)...
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Volatile components of Haplophyllum canaliculatum Boiss. grown in Iran were extracted by hydrodistillation (HD), solvent-free microwave extraction (SFME), and headspace solid-phase microextraction (HS-SPME). The components were analyzed by means of GC and GC-MS. The extraction time and temperature for HS-SPME, microwave, power, and exposure time of extraction for SFME were optimized. Twenty-five compounds that represent 99.88% of total compounds in the oil were obtained by the HD method, and the...
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Pregnancy in women with complex congenital heart disease (CHD) can be poorly tolerated. Amongst pregnant women with CHD and pulmonary hypertension (PH), the mortality rate can be as high as 30%. Cardiac catheterization procedures for assessment of haemodynamics and pulmonary vascular resistance (PVR) are often required in this patient population for risk stratification. However, during the first few weeks of pregnancy, this should better be avoided due to the known adverse effects of the ionizing...
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The SEND uses CGA as its address configuration method. CGA binds the IPv6 address with multiple auxiliary parameters, thereby making the dependency relationship between IPv6 address and host provable, which prevents address embezzlement. Owing to the considerable overhead in CGA parameter verification, the malicious host can use this point to carry out DoS attacks. To prevent DoS, the paper proposes a new duplicate address detection method in an SDN environment called FDAD. Two additional mechanisms...
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Introduction. Lysosomal storage disorders (LSDs) are rare diseases with more than 50 different entities described today. The spectrum of phenotypes varies from severe to lethal and early-onset disease to mild and late onset. Recognition of the clinical signs and diagnostic workup is challenging and requires expertise. Diagnosis relies on finding abnormal metabolites in urine and serum followed by further enzymatic or molecular analysis. Routine histological examination of the foetal and placental...
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Lusutrombopag is a second oral thrombopoietin (TPO) receptor agonist that selectively acts on human TPO receptors. In the study, UPLC-MS/MS was used to establish a selective and sensitive method to determine lusutrombopag with poziotinib as IS (internal standard) in rat plasma. Samples were prepared by precipitating protein with acetonitrile as a precipitant. Separation of lusutrombopag and poziotinib was performed on a CORTECS UPLC C18 column (2.1 ∗ 50 mm, 1.6 μm). The mobile phase (acetonitrile...
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Objective. We recently reported on the expression and clinical role of molecules that mediate exosome secretion in high-grade serous carcinoma. In the present study, the biological role of these molecules was analyzed. Methods. OVCAR8 and ES-2 ovarian carcinoma cells were studied using a combination of CRISPR/Cas9 technology and two 3D in vitro models—spheroids emulating effusions and alginate scaffolds representing solid lesions. Isolation of exosomes was validated by electron microscopy. TSAP6,...
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Renal pelvis carcinoma associated with staghorn calculus is a clinically rare condition. A 66-year-old man presented with flank pain due to an 8 cm complete staghorn calculus. We performed three lithotomies using endoscopic combined intrarenal surgery and carried out intraoperative biopsy. Histopathological examinations revealed a keratinized lesion. One month later, contrast-enhanced computed tomography showed an advanced renal pelvis carcinoma. These findings demonstrate that even an intraoperative...
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Reducing the dimension of the hyperspectral image data can directly reduce the redundancy of the data, thus improving the accuracy of hyperspectral image classification. In this paper, the deep belief network algorithm in the theory of deep learning is introduced to extract the in-depth features of the imaging spectral image data. Firstly, the original data is mapped to feature space by unsupervised learning methods through the Restricted Boltzmann Machine (RBM). Then, a deep belief network will...
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Aiming at the shortcomings of high feature reduction using traditional rough sets, such as insensitivity with noise data and easy loss of potentially useful information, combining with genetic algorithm, in this paper, a VPRS-GA (Variable Precision Rough Set--Genetic Algorithm) model for high-dimensional feature reduction of medical image is proposed. Firstly, rigid inclusion of the lower approximation is extended to partial inclusion by classification error rate β in the traditional rough set model,...
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Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a protein involved in the regulation of RNA processing, cell metabolism, migration, proliferation, and apoptosis. However, the effect of hnRNPA2/B1 on injured endothelial cells (ECs) remains unclear. We investigated the effect of hnRNPA2/B1 on lipopolysaccharide- (LPS-) induced vascular endothelial injury in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms. LPS was used to induce EC injury, and the roles of...
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Background. Meckel’s diverticulum is a vestigial remnant of the omphalomesenteric duct that in most cases (53%) is diagnosed in the first two years of life. Case report. A variety of complications are related to Meckel’s diverticulum including bleeding, intestinal obstruction, but in adults, the most important complication is intestinal obstruction. We reported Meckel’s diverticulum in a 92-year-old woman with symptoms of intestinal obstruction including abdominal pain, vomitus, and abdominal distention...
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The stabilization problem of the complex chaotic system is investigated in this paper. First, a systematic method is proposed, by which a given complex chaotic system can be transformed into its equivalent real chaotic system. Then, both simple and physical controller is designed for the corresponding real chaotic system by the dynamic feedback control method, thereby the controller for the original complex chaotic system is obtained. Especially, for some complex system, the controller is obtained...
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On 30 May, SpaceX and NASA pulled off a historic launch – the first private spacecraft to take astronauts into orbit, and the first crewed launch from US soil in 9 years
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Abstract Cell lines are powerful tools for research into liver function at the molecular level. However, they are generally unsuitable for rigorously assessing the effects of amino acid composition, because many lines require serum-containing medium for their maintenance. Here, we aimed to investigate the effects of ornithine and arginine, which are included in the characteristic metabolic process in hepatocyte, on a human hepatoma-derived cell line (FLC-4) that can be cultured...
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Abstract The new coronavirus disease outbreak in 2019 (COVID-19) represents a dramatic challenge for healthcare systems worldwide. As to viral tropism, lungs are not the only COVID-19 target but also the heart may be involved in a not negligible percentage of the infected patients. Myocarditis-related cardiac dysfunction and potentially life-threatening arrhythmias are the main aftermaths. A few studies showed that myocardial injury in adult patients is often linked with a fatal...
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Abstract Purpose Obstructive sleep apnoea (OSA) is a prevalent sleep disorder with significant health consequences. Sleep fragmentation is a feature of OSA and is often determined by the arousal index (ArI), a metric based on the electroencephalograph (EEG). The ArI has a weak correlation with neurocognitive outcomes in OSA patients. In this study, we examine whether changing from the current minimum EEG arousal duration of 3 s improves...
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Abstract Purpose Increased neck circumference is a major risk factor for obstructive sleep apnea (OSA). New data suggest that increased adipose tissue in the neck may be a contributory cause of OSA. The aim of this study was to investigate safety and efficacy of a recently developed injectable ice slurry in selective reduction of neck adipose tissue in a mouse model. Methods...
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The reflux symptom index (RSI) has been designed to raise the clinical suspicion of laryngopharyngeal reflux (LPR) in patients presenting with ear, nose, and throat symptoms.
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Spasmodic dysphonia is a chronic voice disorder that is characterized by involuntary spasms of the laryngeal muscles during speech production. Botulinum toxin injection into to the laryngeal muscles is the most common and effective treatment of choice for symptoms of spasmodic dysphonia. We present a 44-year-old man with adductor spasmodic dysphonia who was diagnosed as having upper airway obstruction in a polysomnographic examination during sleep after a botulinum toxin injection.
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Abstract Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disorder of the pilosebaceous units. To date, studies on the risk of keratinocyte carcinoma (KC), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), among HS patients have been limited. We performed a case‐control study comparing the incidence of BCC and SCC in HS patients (cases) to that in acne vulgaris patients (controls), which is also an inflammatory disorder of the pilosebaceous...
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Abstract Purpose Ivermectin is an antiparasitic drug that exhibits antitumor effects in preclinical studies, and as such is currently being repositioned for cancer treatment. However, divergences exist regarding its employed doses in preclinical works. Therefore, the aim of this study was to determine whether the antitumor effects of ivermectin are observable at clinically feasible drug concentrations. ...
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Abstract Purpose To evaluate the effectiveness of sonographic evaluation of the radial nerve at the first operation for closed humeral fracture cases. Methods Seventeen cases of closed humeral fractures were included in this study. These cases were categorized into two groups: Group P, consisting of seven cases with complete radial nerve palsy after the injuries;...
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Polling finds public trust in medical scientists has increased but only among Democrats—while optimism about a vaccine is broadly shared -- Read more on ScientificAmerican.com
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Abstract Caveolae are bulb-like invaginations made up of two essential structural proteins, caveolin-1 and cavins, which are abundantly present at the plasma membrane of vertebrate cells. Since their discovery more than 60 years ago, the function of caveolae has been mired in controversy. The last decade has seen the characterization of new caveolae components and regulators together with the discovery of additional cellular functions that have shed new light on these enigmatic...
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Human-animal interactions with mutual benefits in the wild are rare. Such positive interactions seem to require an intricate knowledge from the human side on the animals’ behavior and their habitat. In souther...
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Publication date: Available online 30 May 2020Source: CryobiologyAuthor(s): Kana Okuda, Aiko Kawauchi, Kentaro Yomogida
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Publication date: Available online 29 May 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): R. Samarei, S. Mabarian
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Publication date: Available online 29 May 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): C.-A. Righini, H. Gil, C. Colombé
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The pandemic is threatening the food supply chain, but automation can fill crucial gaps -- Read more on ScientificAmerican.com
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Publication date: August 2020Source: Microbiological Research, Volume 237Author(s):
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Acute appendicitis is a global disease and a very common indication for emergency surgery worldwide. The need for hospital resources is therefore constantly high. The administration in Kanta-Häme Central Hospi...
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Publication date: Available online 30 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Sahar Roozbehi, Simin Dadashzadeh, Manouchehr Mirshahi, Majid Sadeghizadeh, Reza H. Sajedi
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Publication date: Available online 30 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Iman Gholamali, Mehdi Yadollahi
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Publication date: Available online 30 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Ya-Ling Huang, Yung-Hsiang Tsai
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Publication date: Available online 30 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Vladimir I. Lozinsky, Anastasiya O. Shchekoltsova, Ekaterina S. Sinitskaya, Olga I. Vernaya, Anastasiya V. Nuzhdina, Irina V. Bakeeva, Mariam G. Ezernitskaya, Alexander M. Semenov, Tatyana I. Shabatina, Mikhail Ya. Melnikov
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Publication date: Available online 30 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Hanxiang Guo, Yang Peng, Yang Liu, Zhaofeng Wang, Jingwan Hu, Jinghao Liu, Qun Ding, Jiyou Gu
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Publication date: Available online 30 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Youwei Zhang, Li Wang, Tingting Li, Yingbin Shen, Jianguang Luo
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Publication date: Available online 30 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Dong-Hyun Jung, Dong-Ho Seo, Ye-Jin Kim, Won-Hyong Chung, Young-Do Nam, Cheon-Seok Park
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Yudi Deng, Xushan Yang, Xudong Zhang, Hehe Cao, Lianzhi Mao, Miaomaio Yuan, Wenzhen Liao
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Jun Wang, Lijun Wang, Shuhong Zhang, Junting Fan, Hui Yang, Qiqi Li, Chuanlong Guo
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Yongjie Wang, Na Liu, Xia Xue, Qiang Li, Deqing Sun, Zhongxi Zhao
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Heena Jariyal, Chanchal Gupta, Akshay Srivastava
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