Abstract Objective When superficial tumors are treated with radiotherapy, bolus may be needed to ensure adequate dose delivery to target tissue. The bolus is typically fabricated at the time of computed tomography (CT) simulation, but in many cases, creating a bolus prior to simulation can be more efficient. Therefore, we devised a workflow that would allow for 3D patient scanning at the initial consultation so that bolus can be fabricated...
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Cancers, Vol. 12, Pages 1417: Fanconi Anemia Pathway Activation by FOXM1 Is Critical to Bladder Cancer Recurrence and Anticancer Drug Resistance Cancers doi: 10.3390/cancers12061417 Authors: Yun-Gil Roh Jeong-Yeon Mun Seon-Kyu Kim Wonyoung Park Mi-So Jeong Tae Nam Kim Won-Tae Kim Yung Hyun Choi In-Sun Chu Sun-Hee Leem Although the 5-year survival rate of patients diagnosed with nonmuscle invasive bladder cancer (NMIBC) has reached 85%, more than...
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Biosensors, Vol. 10, Pages 58: Application of Biosensors for Detection of Pathogenic Food Bacteria: A Review Biosensors doi: 10.3390/bios10060058 Authors: Athmar A. Ali Ammar B. Altemimi Nawfal Alhelfi Salam A. Ibrahim The use of biosensors is considered a novel approach for the rapid detection of foodborne pathogens in food products. Biosensors, which can convert biological, chemical, or biochemical signals into measurable electrical signals, are systems containing...
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Clinical decision support systems provide empirical guidance to improve the quality of nursing care. This study aimed to evaluate the outcomes of implementation of decision support functions into the preventive care system as regards nurses' acceptance of technology, documentation completeness, and incidence of hospital-acquired pressure injury. The researchers performed data collection in a regional hospital in northern Taiwan. The study used the Davis Science and Technology Acceptance Model scale...
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Information on HPV-associated sinonasal squamous cell carcinoma (SNSCC) is very limited in China. The aim of this study was to determine the prevalence of HPV in a large cohort of SNSCC patients in China.
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Abstract Changes in neurovascular coupling are associated with both Alzheimer’s disease and vascular dementia in later life, but this may be confounded by cerebrovascular risk. We hypothesized that hemodynamic latency would be associated with reduced cognitive functioning across the lifespan, holding constant demographic and cerebrovascular risk. In 387 adults aged 18–85 (mean = 48.82), dynamic causal modeling was used to estimate the hemodynamic response function in the left and...
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Abstract Innovative instructional technologies, especially virtual reality devices, are becoming more prominent and feasible in science education. Concerning science laboratories, activities enriched with virtual reality technology have the potential to make unobservable phenomena accessible in any school. This virtual reality technology has the potential to lead in a new milestone in terms of acquisition of the science process skills, not only in secondary school students but...
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To investigate the protective effects of Tualang honey against the toxicity effects induced by cadmium (Cd) on the ovary.
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Previous studies have acknowledged Tai Chi and Qigong exercise could be potential effective treatments for reducing depression and anxiety in both healthy and clinical populations. However, there is a scarcity...
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Related ArticlesDevelopment of an Outcome Measure of Observable Signs of Health and Well-Being in Infants With Orofacial Clefts. Cleft Palate Craniofac J. 2020 May 29;:1055665620922105 Authors: Heike CL, Albert M, Aspinall CL, Bautista S, Crilly Bellucci C, Kapp-Simon KA, Mecham S, Patrick DL, Rosenberg J, Siebold B, Stueckle LP, Edwards TC Abstract OBJECTIVE: To develop an outcomes instrument that assesses observations that can be reliably reported...
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Cancers, Vol. 12, Pages 1416: Efficacy and Safety of Oncolytic Viruses in Randomized Controlled Trials: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers12061416 Authors: Zengbin Li Zeju Jiang Yingxuan Zhang Xiaotian Huang Qiong Liu Oncolytic virotherapy is a promising antitumor therapeutic strategy. It is based on the ability of viruses to selectively kill cancer cells and induce host antitumor immune responses. However, the clinical outcomes of...
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Publication date: Available online 30 May 2020Source: Cell ReportsAuthor(s): Qi Peng, Ruchao Peng, Bin Yuan, Jingru Zhao, Min Wang, Xixi Wang, Qian Wang, Yan Sun, Zheng Fan, Jianxun Qi, George F. Gao, Yi Shi
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Cereal products are the most important dietary source for energy intake and several bioactive compounds with high concentrations in the bran and the germ. Different cereal products provide a rich source of bioactive phytochemicals, namely, phenolic acids, carotenoids, tocopherols, alkylresorcinols, benzoxazines, phytosterols, and lignans. The bioactive substance alkylresorcinols (ARs) present in the whole cereal can inhibit enzyme activity, prevent bacterial or fungal infection, reduce cholesterol...
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Introduction. Interleukin 17A has been implicated in the pathophysiology of both human immune deficiency virus and preeclampsia. This study evaluated serum levels of IL-17A based on pregnancy type, gestational age, HIV status, and duration of HAART. Material and Methods. A sample size of 250 was analysed: normotensives (; N) and preeclamptics (; PE). Normotensives were further stratified into HIV negative (), HAART-acute (), and HAART-chronic (). The PE group was divided into early onset (; EOPE)...
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Oridonin (ORI), the major pharmacological component extracted from a traditional Chinese medicine, possesses a beneficial effect on myocardial ischemia/reperfusion (I/R) injury. However, the underlying molecular mechanism by which ORI effects take place is not completely known. Thus, whether ORI works via downregulating oxidative stress and nod-like receptor protein-3 (NLRP3) inflammasome pathway was investigated in this study. Mice underwent surgery to induce myocardial I/R injury, and some were...
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To predict the probability of roadside accidents for curved sections on highways, we chose eight risk factors that may contribute to the probability of roadside accidents to conduct simulation tests and collected a total of 12,800 data obtained from the PC-crash software. The chi-squared automatic interaction detection (CHAID) decision tree technique was employed to identify significant risk factors and explore the influence of different combinations of significant risk factors on roadside accidents...
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A healthy diet should nourish the brain with essential nutrients, including bioactive compounds, for normal brain functioning and to protect it from the negative effects of inflammation and oxidative stress. In this review, a concise summation of the protective effects of selected fruits, namely, berries, grapes, and citrus fruits, against neurological disorder is presented. The focus is on the neuroprotective potential of these fruits against neurodegenerative and mental disorders. The fruits selection...
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In the extrusion machine with double booster cylinder hydraulic system, the stability of the extrusion velocity is affected because of the switching process of the two booster cylinders in the hydraulic system. In this paper, the analytical solution of the extrusion velocity fluctuation caused by the double booster cylinder hydraulic system is derived. Firstly, the model of the double booster cylinder hydraulic system was established, and the switching process of the two booster cylinders was studied...
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In this paper, a nonsingular fast terminal adaptive neurosliding mode control for spacecraft formation flying systems is investigated. First, a supertwisting disturbance observer is employed to estimate external disturbances in the system. Second, a fast nonsingular terminal sliding mode control law is proposed to guarantee the tracking errors of the spacecraft formation converge to zero in finite time. Third, for the unknown parts in the spacecraft formation flying dynamics, we proposed an adaptive...
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The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane...
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In the actual traffic environment, the driver’s aggressive driving behaviors are closely related to the traffic conditions at the next-nearest grid point at next time step. The driver adjusts the acceleration of the driving vehicle by predicting the density of the front grid points. Considering the driver’s aggressive effect and the relative flow difference integral, a novel two-lane lattice hydrodynamic model is presented in this paper. The linear stability method is used to analyze the current...
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Objective. To compare the difference in clinical and radiographic outcomes between anterior transcorporeal and transdiscal percutaneous endoscopic cervical discectomy (ATc-PECD/ATd-PECD) approaches for treating patients with cervical intervertebral disc herniation (CIVDH). Method. We selected 77 patients with single-segment CIVDH and received ATc-PECD or ATd-PECD in the Second Affiliated Hospital of Chongqing Medical University between March 1, 2010, and July 1, 2015. 35 patients suffered from ATc-PECD,...
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Pernicious anemia (PA) is a rarely considered cause of anemia in HIV-infected population and is seldom on the list of differential diagnoses. However, PA can have serious consequences if misdiagnosed or left untreated. We present the case of a 38-year-old HIV-positive man who was diagnosed with PA, which was preceded by a one-year history of vitiligo. Our case is a reminder for clinicians to have a high index of suspicion for an autoimmune process as a potential cause of anemia in HIV-infected individuals.
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The primary objective of this study is to predict the short-term metro passenger flow using the proposed hybrid spatiotemporal deep learning neural network (HSTDL-net). The metro passenger flow data is collected from line 2 of Nanjing metro system to illustrate the study procedure. A hybrid spatiotemporal deep learning model is developed to predict both inbound and outbound passenger flows for every 10 minutes. The results suggest that the proposed HSTDL-net achieves better prediction performance...
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This study explored travelers’ behavioral intention to adopt ride-hailing services. With regard to perceived value, several factors related to perceived benefit and perceived sacrifice were considered. Moreover, subjective norm and perceived policy support were further introduced into the concept model. After the construction of the concept model, an empirical analysis was put forward to test the hypotheses proposed. In addition, the effect of sociodemographic factors and usage frequency was further...
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TRAF2 is a crucial adaptor protein involved in various signaling pathways. However, its biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we found that TRAF2 was overexpressed in nasopharyngeal carcinoma (NPC) cells. Knockdown of TRAF2 with shRNA significantly suppressed NPC cell proliferation and colony formation. The growth of xenograft tumor significantly reduced after TRAF2 was silenced. Conversely, the ectopic overexpression of TRAF2 significantly...
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The vibration of grinding tools is very essential to the performance of parts and the safety of machine tools. However, the vibrationis rarely studied in the process of polishing aeroengine blade with abrasive cloth wheel. Polishing force is measured by dynamometer in the process of polishing aeroengine blade with abrasive cloth wheel, and the time-domain expressions of polishing force are obtained. Time-domain and frequency-domain vibration solutions of position at which the abrasive cloth wheel...
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Multiproject scheduling aims at the generation of the baseline schedules, which has been studied for several years with the goal of minimizing the total cost of the project. In this paper, we analyzed the impact of network structure disruption, activity disruption, and resource disruption on scheduling scheme, respectively; this problem is related to the disruptions in scheduling process, which leads to a deviation between actual scheduling and baseline scheduling. The mode of the related activities...
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Food supply chain plays a vital role in human health and food prices. Food supply chain inefficiencies in terms of unfair competition and lack of regulations directly affect the quality of human life and increase food safety risks. This work merges Hyperledger Fabric, an enterprise-ready blockchain platform with existing conventional infrastructure, to trace a food package from farm to fork using an identity unique for each food package while keeping it uncomplicated. It keeps the records of business...
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This paper recommends that Vietnam Airlines use a pro-offered model to both evaluate and improve its current service network being operated at international airports. The model includes cluster analysis, ANOVA, and Scheffé post hoc to provide service performance insights and to serve as a complementary corporate benchmark for evaluating service potential and for identifying deficient service areas. By means of this model, the managerial board can designate a potent strategy for ground handling service....
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The goal of this review was to summarize reported studies focusing on cellular reductive stress-induced mitochondrial dysfunction, cardiomyopathy, dithiothreitol- (DTT-) induced reductive stress, and reductive stress-related free radical reactions published in the past five years. Reductive stress is considered to be a double-edged sword in terms of antioxidation and disease induction. As many underlying mechanisms are still unclear, further investigations are obviously warranted. Nonetheless, reductive...
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Diabetic nephropathy (DN) is a chronic diabetic microvascular complication. Hyperactivity of the polyol pathway is involved in the pathogenesis of DN. Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, is expected to be an effective target in the treatment of DN. WJ-39 is a novel inhibitor of AR. The present study aimed at exploring the effects of WJ-39 in DN. DN was induced in rats by injecting 30 mg/kg streptozotocin (STZ). After 14 weeks, WJ-39 (10, 20, and 40 mg/kg) was intragastrically...
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Applying similar amount of fibre reinforced polymer (FRP) for all plastic hinge locations in a structure is not an ideal approach as damage occurring at these critical locations may vary considerably. Building owners also always want to keep FRP retrofitting cost and associated interruption to a minimum. In this context, the current paper proposes an FRP retrofitting approach, in which FRP is selectively distributed based on the distribution of seismic damage in structures. The proposed approach,...
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In this paper, we report a challenging case of a middle-age woman who developed antimelanoma differentiation-associated protein-5 dermatomyositis (anti-MDA5 DM) with interstitial lung disease (ILD) and was successfully treated with rituximab (RTX), after failure of a first-line therapy.
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Purpose. To optimize a rabbit dry eye model induced by topical instillation of benzalkonium chloride (BAC), reduce the days of instillation of the original model by increasing the concentration of BAC from 0.1% to 0.2%. Materials and Methods. An experimental, prospective, and randomized study was performed on 10 male New Zealand white rabbits, divided into two groups, considering both eyes: 5 rabbits as control (n = 10) and 5 rabbits with 0.2% BAC treatment (n = 10). Saline solution (control) and...
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The cumulative damage behavior of SRC columns under far-field long-period ground motions was simulated and studied by quasi-static tests with the same displacement for 10 times. Quasi-static tests of 8 SRC columns were conducted under the horizontal cyclic loading with the same displacement for 10 times or 3 times, and then the effects of steel ratio, stirrup ratio, axial compression ratio, and number of cyclic loading on the cumulative damage of SRC columns under the far-field long-period ground...
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In recent years, there has been a continuous increase in the intensity of natural disasters. Slope disasters such as rock falls occur along coastlines and in mountainous regions. Rock shed structures are implemented as measures to prevent rock fall damage; however, these structures deteriorate over time, and their impact resistance also decreases. As a supplementary measure, a method employing foam material as a cushioning material has been used in practical applications. However, the effect of the...
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In order to improve the robustness of the pipeline target detection algorithm against strong noises and occlusion, this paper presents an adaptive pipeline filtering algorithm (APFA). In APFA, the velocity and the center of the target are firstly predicted based on the smooth motion trajectory after background suppression. Then, time-domain energy enhancement of targets is adopted to improve the obscure target detection, and adaptively updating the center and radius of the pipeline filter are carried...
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