Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Mohammad Akrami-Hasan-Kohal, Marjan Ghorbani, Farideh Mahmoodzadeh, Behzad Nikzad
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Yiping Zhang, Shaowen Zhong, Chengdeng Chi, Ying He, Xiaoxi Li, Ling Chen, Song Miao
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Murilo Álison Vigilato Rodrigues, Mirella Romanelli Vicente Bertolo, Crisiane Aparecida Marangon, Virginia Conceição Amaro Martins, Ana Maria de Guzzi Plepis
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Mohammed Auwal Ibrahim, June C. Serem, Megan J. Bester, Anabella R.M. Gaspar
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Dan Zheng, Bo Bai, Yunhua He, Na Hu, Honglun Wang
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Publication date: Available online 29 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Xiao Liu, Rui Wang, Jingjing Bi, Liqin Kang, Jiangsheng Zhou, Baiyun Duan, Zhonghua Liu, Sheng Yuan
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Studies examining the impact of injury on health-related quality of life (HRQL) over time are necessary to understand the short- and long-term consequences of injury for population health. The aim of this syst...
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Overweight and obesity are public concerns with risk of adverse health outcomes. Health-related quality of life (HRQoL) is lower in adolescents than children in general. An increase in body mass index (BMI) is...
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Abstract Purpose Several high-profile organizations have mandated the delivery of survivorship care plans (SCPs) despite mixed evidence regarding the effectiveness of SCPs on key survivor-level outcomes. There is a need to understand the types of survivor-level outcomes the SCPs are likely to change. Informed by existing frameworks and the literature, the objective of this study was to understand the pathways linking the receipt of a SCP...
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IntroductionLead exposure is toxic to all humans and is very harmful to young children, especially 5-year-olds. Elevated blood lead levels (BLLs) in children have been associated with their daily surrounding environment. This protocol seeks to evaluate the association between environmental lead exposure and BLLs among children in day-care centres, including household and other risk factors. Methods and analysisTo achieve the objectives of the study, we adopted a cross-sectional analytical design....
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ObjectiveTo explore the clinical pathways, including signs and symptoms, and symptom progression patterns preceding idiopathic pulmonary fibrosis (IPF) diagnosis. Design and settingA historical cohort study was conducted using primary care patient records from the Optimum Patient Care Research Database. ParticipantsPatients included were at least 30 years, had IPF diagnosis, identified via clinical-coding and free-text records and had a consultation with a chest specialist prior to IPF diagnosis....
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PurposeThe diabetic cohort (DC) was set up to study the determinants of complications in individuals with type 2 diabetes and examine the role of genetic, physiological and lifestyle factors in the development of complications in these individuals. ParticipantsA total of 14 033 adult participants with type 2 diabetes were recruited from multiple public sector polyclinics and hospital outpatient clinics in Singapore between November 2004 and November 2010. The first round of follow-up was conducted...
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BackgroundTarget-specific anticancer drugs are under rapid development. Little is known, however, about the risk of administering target-specific drugs to patients who have tumours with molecular alterations or other characteristics that can make the drug ineffective or even harmful. An increasing number of randomised clinical trials (RCTs) investigating target-specific anticancer drugs include subgroup analyses based on tumour characteristics. Such subgroup analyses have the potential to be more...
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Introduction and objectivesErrors are common within healthcare, especially those involving the prescribing of medications. Open disclosure is a policy stating doctors should apologise for such errors, discussing them with the harmed parties. Many junior doctors take part in open disclosure without any formal training or experience, which can lead to failure of the apology, and increased patient/family frustration. In this study, we explore the ways in which interns perceive the relationship between...
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IntroductionLow anterior resection syndrome (LARS) is described as disordered bowel function after rectal resection that leads to a detriment in quality of life, and affects the majority of individuals following restorative proctectomy for rectal cancer. The management of LARS includes personalised troubleshooting and effective self-management behaviours. Thus, affected individuals need to be well informed and appropriately engaged in their own LARS management. This manuscript describes the development...
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IntroductionOver 5 billion people in the world do not have access to safe, affordable surgical and anaesthesia care when needed. In order to improve health outcomes in patients with surgical conditions, both access to care and the quality of care need to be improved. A recent commission on high-quality health systems highlighted that poor-quality care is now a bigger barrier than non-utilisation of the health system for reducing mortality. AimTo carry out a systematic review to provide an evidence-based...
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IntroductionReceiving a diagnosis of autism in adulthood is increasingly common for a subset of individuals who were either misdiagnosed in childhood or missed out on a diagnosis altogether. This qualitative study, coproduced with autistic people, invites late-diagnosed autistic adults to share their life histories to (1) understand better the consequences of living without a diagnosis, (2) elucidate what precipitates an autism diagnosis in mid-to-late adulthood and (3) identify the perceived impact...
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ObjectiveThere is concern about long-term safety of direct oral coagulants (DOACs) in clinical practice. Our aim was to investigate whether the introduction of DOACs compared with vitamin-K antagonists in England was associated with a change in admissions for bleeding or thromboembolic complications. Setting5508 General practitioner (GP) practices in England between 2011 and 2016. ParticipantsAll GP practices in England with a registered population size of greater than 1000 that had data for...
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ObjectiveTo explore the implementation of the International Committee of Medical Journal Editors (ICMJE) data-sharing policy which came into force on 1 July 2018 by ICMJE-member journals and by ICMJE-affiliated journals declaring they follow the ICMJE recommendations. DesignA cross-sectional survey of data-sharing policies in 2018 on journal websites and in data-sharing statements in randomised controlled trials (RCTs). SettingICMJE website; PubMed/Medline. Eligibility criteriaICMJE-member...
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ObjectivesClinical guidelines support evidence-informed quality patient care. Our study explored perspectives of South African subnational health managers regarding barriers to and enablers for implementation for all available primary care guidelines. DesignWe used qualitative research methods, including semistructured, individual interviews and an interpretative perspective. Thematic content analysis was used to develop data categories and themes. SettingWe conducted research in four of nine...
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IntroductionOesophagogastric cancers carry a high mortality, economic burden and rising incidence. There is a need to monitor and improve care for this disease. Pathologic information is a cornerstone of cancer diagnosis, treatment and prognosis. Few population-based studies combine pathology information and clinical outcomes. The objective of this study is to develop a clinical and pathological database of oesophagogastric cancers to study practice patterns, resource utilisation and clinical outcomes....
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Publication date: Available online 29 May 2020Source: GeneAuthor(s): Jürgen Klinner, Marcus Krüger, Theresa Brunet, Christine Makowski, Korbinian M. Riedhammer, Andreas Mollweide, Matias Wagner, Julia Hoefele
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Zusammenfassung Hintergrund Traumatische Schließmuskeldefekte treten häufig post partum oder postoperativ auf und können eine therapiebedürftige fäkale Inkontinenz zur Folge haben. Ziel der Arbeit Ziel dieser Arbeit ist die Darstellung der Ätiologie des traumatischen Schließmuskeldefekts, die Behandlungsmöglichkeiten bei konsekutiver fäkaler Inkontinenz und...
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Impact of heavy metals on pigment accumulation in macrophage aggregates in spleens of Vardar chub was assessed. Season‐dependent changes in melanin accumulation were observed. Heavy metals exposure results in increased hemosiderin accumulation. Abstract Pigmented macrophage aggregates (MAs) are known to change under influence of various factors, such as aging, season, starvation, and/or pollution. In this study, changes in the pigment content of the MAs in the spleen of Vardar chub...
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Related ArticlesHearing loss and employment: a systematic review of the association between hearing loss and employment among adults. J Laryngol Otol. 2020 May 29;:1-11 Authors: Shan A, Ting JS, Price C, Goman AM, Willink A, Reed NS, Nieman CL Abstract BACKGROUND: Hearing loss affects over 1.3 billion individuals worldwide, with the greatest burden among adults. Little is known regarding the association between adult-onset hearing loss and employment....
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Related ArticlesSemon Lecture: 'From the Felix to the helix, and from the cradle to the grave - Semon's contribution to thyroid surgery', Royal Society of Medicine, 1 November 2019, London, UK. J Laryngol Otol. 2020 May 29;:1-6 Authors: Watkinson JC Abstract Mr President, Mr President Elect, Fellows and Members, Ladies and Gentleman, it is a pleasure to address the Section of Laryngology this morning and deliver the 94th Semon Lecture. I would like to...
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Cancers, Vol. 12, Pages 1418: Pharmacogenomic Analysis Reveals CCNA2 as a Predictive Biomarker of Sensitivity to Polo-Like Kinase I Inhibitor in Gastric Cancer Cancers doi: 10.3390/cancers12061418 Authors: Yunji Lee Chae Eun Lee Sejin Oh Hakhyun Kim Jooyoung Lee Sang Bum Kim Hyun Seok Kim Despite recent innovations and advances in early diagnosis, the prognosis of advanced gastric cancer remains poor due to a limited number of available therapeutics. Here,...
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Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study we...
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The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among pat...
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Thousands of research articles on neuroblastoma have been published over the past few decades; however, the heterogeneity and variable quality of scholarly data may challenge scientists or clinicians to survey...
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Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle injury, while over-assist may result in muscle atrophy. This prov...
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Propofol provides a prominent sedation effect in colonoscopy. However, anesthesia and sedation induced with propofol in the elderly might result in cardiopulmonary complications, especially when it is combined...
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This retrospective study aimed to compare the clinical outcomes of parturients with placenta previa (PP) and placenta accreta (PA) according to their severity, when they were managed with intraoperative abdomi...
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GY Srinivasa, Manish Gupta, Rajeev K Seam, Sakshi Rana, Shalini Verma, Manoj GuptaClinical Cancer Investigation Journal 2020 9(2):27-33 Context: Several randomized trials have established that the best survival can be achieved in patients with locally advanced non-small cell lung cancer (NSCLC) with concurrent chemoradiation (CRT). In this study, we have compared different chemotherapy regime along with radiation in locally advanced NSCLC. Aims: Compare the disease response, toxicity, quality of...
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Renuka Verma, Sunita Singh, Rajnish Kalra, Vinay Kumar MalikClinical Cancer Investigation Journal 2020 9(2):54-57 Langerhans cell histiocytosis (LCH) is a rare cancer involving clonal proliferation of Langerhans cells (LCs) resembling epidermal dendritic cells. It can involve any organ or system. Temporal bone LCH is often confused with ear inflammatory lesions and malignant tumors. Diagnosis is based on clinical, radiological, and pathological findings. The definitive diagnosis is made on biopsy...
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Elham Homaei Hadad, Ali Ehsanpour, Tina Vosoughi, Najmaldin SakiClinical Cancer Investigation Journal 2020 9(2):34-41 Background: Human leukocyte antigen (HLA) phenotype is a prognostic marker of cancer immunotherapy, and the expression profile of its alleles is associated with therapeutic rate. Therefore, there is the likelihood of a relationship between HLA phenotype and minimal residual disease (MRD) in chronic myelogenous leukemia (CML) patients treated with imatinib. The goal of this study...
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Ramesh Omranipour, Bita Eslami, Mahtab Vasigh, Habibollah Mahmoodzadeh, Mohammad Shirkhoda, Mohammad Ali Mohagheghi, Amirmohsen JalaeefarClinical Cancer Investigation Journal 2020 9(2):49-53 Background: There is growing evidence that intranodal pressure (INP) can predict metastatic sentinel lymph nodes (SLNs). The objective of this study was to measure and utilize INP to evaluate the metastatic involvement of axillary SLNs in breast cancer patients. Materials and Methods: INP was measured in 73...
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Anvesh Rathore, Subhash Ranjan, Rajan Kapoor, Jasdeep Singh, Prince Arvind, Tejas Pandya, Neeraj KumarClinical Cancer Investigation Journal 2020 9(2):42-48 Introduction: Lymphoma is a neoplastic proliferation of lymphoid cells at various stages of differentiation and affects lymph nodes, with infiltration into the bone marrow, spleen, and thymus, which form the primary lymphatic organs. Extranodal lymphoma, by definition, involves sites other than lymph nodes, spleen, thymus, and the pharyngeal...
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Shagufta Qadri, Kiran Alam, Sayeedul Hasan Arif, Asfa ShamsClinical Cancer Investigation Journal 2020 9(2):58-60 Giant cell angiofibroma (GCA) is a rare, soft-tissue neoplasm that has a tendency to arise from the mesenchymal tissues of the head and neck, especially involving the orbital region. It is a benign neoplasm characterized by the presence of multinucleated stromal giant cells and angiectoid spaces. GCA belongs to the group of solitary fibrous tumor with histomorphological features intermediate...
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