Related ArticlesCYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens. Forensic Sci Int. 2020 Apr 28;312:110307 Authors: Skillman B, Kerrigan S Abstract Suvorexant (Belsomra®) is a sedative hypnotic that was approved for use in 2015. It has a novel mechanism of action and was the first dual orexin receptor antagonist (DORA) to be approved for the treatment of sleep disorders. Sedative hypnotics often feature...
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Related ArticlesCircadian distribution of autostimulations in rVNS therapy in patients with refractory focal epilepsy. Epilepsy Behav. 2020 May 27;110:107144 Authors: Kulju T, Verner R, Dibué-Adjei M, Eronen A, Rainesalo S, Lehtimäki K, Haapasalo J, Peltola J Abstract BACKGROUND: Responsive vagus nerve stimulation (rVNS) utilizes an electrocardiograph (ECG)-based algorithm to detect rapid sympathetic activations associated with the onset of a seizure....
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Related ArticlesAirway remodelling with spatial correlations: Implications for asthma pathogenesis. Respir Physiol Neurobiol. 2020 May 27;:103469 Authors: Pascoe CD, Green FHY, Elliot JG, James AL, Noble PB, Donovan GM Abstract Airway remodelling is a cardinal feature of asthma in which airways undergo structural changes - in particular, increased airway smooth muscle mass and total airway wall area. Remodelling has long been thought to have functional...
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Related ArticlesAssociation Between Breathing Route, Oxygen Desaturation, and Upper Airway Morphology. Laryngoscope. 2020 May 30;: Authors: Hsu YB, Lan MY, Huang YC, Kao MC, Lan MC Abstract OBJECTIVES/HYPOTHESIS: This study aimed to assess the role of capnography in objectively evaluating breathing routes during drug-induced sleep endoscopy (DISE) and further elucidate the relationship between breathing route, obstructive sleep apnea (OSA) severity,...
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Variation in Sleep Stability with Differences in Severity of Sleep-Disordered Breathing in Children.
Related ArticlesVariation in Sleep Stability with Differences in Severity of Sleep-Disordered Breathing in Children. Laryngoscope. 2020 May 30;: Authors: Seo MY, Han MS, Jeong YJ, Lee MK, Park S, Hwang SJ, Lee SH Abstract OBJECTIVES: The aim of this study was to analyze the association between obstructive sleep apnea (OSA) severity and various cardiopulmonary coupling (CPC) parameters in children with OSA. STUDY DESIGN: Retrospective cross-sectional...
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Related ArticlesEffect of an Innovative Mattress and Cryotherapy on Sleep after an Elite Rugby Match. Med Sci Sports Exerc. 2020 May 27;: Authors: Aloulou A, Luduc C, Duforez F, Piscione J, Cheradame J, Bieuzen F, Thomas C, Chennaoui M, Van Beers P, Nedelec M Abstract INTRODUCTION: This study aimed to explore the relationship between elite rugby union match and post-match sleep architecture and to investigate the effects of a high-heat capacity mattress...
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Related ArticlesDaily Morning Blue Light Therapy Improves Daytime Sleepiness, Sleep Quality, and Quality of Life Following a Mild Traumatic Brain Injury. J Head Trauma Rehabil. 2020 May 27;: Authors: Raikes AC, Dailey NS, Shane BR, Forbeck B, Alkozei A, Killgore WDS Abstract OBJECTIVE: Identify the treatment effects of 6 weeks of daily 30-minute sessions of morning blue light therapy compared with placebo amber light therapy in the treatment of sleep...
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Related ArticlesA COVID-19 Conundrum: Obstructive Sleep Apnea (OSA) and Non-Invasive Ventilation (NIV). Anesth Analg. 2020 May 27;: Authors: Abstract The challenges imposed by the COVID-19 pandemic become amplified in the setting of non-intubated patients with obstructive sleep apnea. Unlike the closed system that characterizes an intubated patient attached to a respiratory circuit, non-invasive ventilatory support threatens an increased risk of permeating...
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Related ArticlesAffective Recovery from Stress and its Associations with Sleep. Stress Health. 2020 May 30;: Authors: Leger KA, Charles ST Abstract Good sleep habits are important for emotional well-being. Studies have linked sleep with people's ability to regulate their emotions in response to stressful events, yet little is known specifically about how sleep is related to a person's ability to recover affectively from a stressful experience. The current...
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Related ArticlesAssociation between 24-hour movement guidelines and physical fitness in children. Pediatr Int. 2020 May 30;: Authors: Tanaka C, Tremblay MS, Okuda M, Tanaka S Abstract BACKGROUND: Physical fitness levels in Japanese children are lower than those in the 1980s. 24-h movement guidelines were recently developed to improve both present and future health of children. This study examined whether meeting the 24-hour movement guidelines was associated...
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Related ArticlesPrevalence of Alternative Diagnoses and Implications for Management in Idiopathic Normal Pressure Hydrocephalus Patients. Neurosurgery. 2020 May 30;: Authors: Macki M, Mahajan A, Shatz R, Air EL, Novikova M, Fakih M, Elmenini J, Kaur M, Bouchard KR, Funk BA, Schwalb JM Abstract BACKGROUND: Following Bayes theorem, ventriculomegaly and ataxia confer only a 30% chance of idiopathic Normal Pressure Hydrocephalus (NPH). When coupled with...
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Related ArticlesDiversity of simultaneous sleep in the motor cortex and hippocampus in rats. J Sleep Res. 2020 May 30;:e13090 Authors: Petrovic J, Radovanovic L, Saponjic J Abstract We investigated the homogeneity/heterogeneity of spontaneous sleep, simultaneously recorded in the motor cortex and the hippocampus of control rats, and particularly analysed simultaneous and non-simultaneous motor cortical and hippocampal non-rapid eye movement (NREM)/rapid...
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Related ArticlesCell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome. Stem Cells Transl Med. 2020 May 29;: Authors: Qu W, Wang Z, Hare JM, Bu G, Mallea JM, Pascual JM, Caplan AI, Kurtzberg J, Zubair AC, Kubrova E, Engelberg-Cook E, Nayfeh T, Shah VP, Hill JC, Wolf ME, Prokop LJ, Murad MH, Sanfilippo FP Abstract Severe cases of COVID-19 infection, often leading...
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Related ArticlesNo cognitive processing in the unconscious, Anesthetic-Like, state of sleep. J Comp Neurol. 2020 May 30;: Authors: Vertes RP, Linley SB Abstract We review evidence challenging the hypothesis that memories are processed or consolidated in sleep. We argue that the brain is in an unconscious state in sleep, akin to general anesthesia, and hence is incapable of meaningful cognitive processing - the sole purview of waking consciousness. At...
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Related ArticlesA Modified Cosmetic Genioplasty Can Affect Airway Space Positively in Skeletal Class II Patients: Studying Alterations of Hyoid Bone Position and Posterior Airway Space. Aesthetic Plast Surg. 2020 May 29;: Authors: Chen K, Sun X, Wang L, Ni S, Wu Z, Gao Y, Wang X, Xie K, Liu S, Wu G Abstract BACKGROUND: Improving the posterior airway space is one of the most important functions of genioplasty. Studies have shown that the posterior airway...
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Related ArticlesHeadache in the Older Population: Causes, Diagnoses, and Treatments. Curr Pain Headache Rep. 2020 May 29;24(7):34 Authors: Robblee J, Singh RH Abstract PURPOSE OF REVIEW: Primary headaches are less common and differ in presentation in older versus younger individuals. Secondary headaches become more common among older patients. RECENT FINDINGS: Diagnosis and management of headaches in those > 65 years are discussed. Migraine...
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Related ArticlesCPAP is associated with decreased risk of AF recurrence in patients with OSA, especially those younger and slimmer: a meta-analysis. J Interv Card Electrophysiol. 2020 May 29;: Authors: Yang Y, Ning Y, Wen W, Jia Y, Chen X, Huang M, Sara JD, Qin Y, Fang F, Zhang H, Du Y, Li L, Jiao X, Yang Y, Han X, Zhang M, Wei Y Abstract PURPOSE: Obstructive sleep apnea (OSA) is associated with the management of atrial fibrillation (AF). This manuscript...
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Related ArticlesPhenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 2020 May 29;: Authors: Cariou B, Hadjadj S, Wargny M, Pichelin M, Al-Salameh A, Allix I, Amadou C, Arnault G, Baudoux F, Bauduceau B, Borot S, Bourgeon-Ghittori M, Bourron O, Boutoille D, Cazenave-Roblot F, Chaumeil C, Cosson E, Coudol S, Darmon P, Disse E, Ducet-Boiffard A, Gaborit B, Joubert M, Kerlan V, Laviolle B, Marchand L, Meyer L,...
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Related ArticlesAssociation between dopaminergic medications and REM sleep behavior disorder in Parkinson's disease: a preliminary cohort study. J Neurol. 2020 May 29;: Authors: Meloni M, Bortolato M, Cannas A, Laccu I, Figorilli M, Congiu P, Defazio G, Meloni F, Puligheddu M Abstract BACKGROUND: Rapid eye movement sleep behavior disorder (RBD) is highly comorbid with Parkinson's disease (PD). Emerging evidence suggests that dopamine-replacement therapies...
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Related ArticlesThe retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats. Psychopharmacology (Berl). 2020 May 30;: Authors: Murillo-Rodríguez E, Millán-Aldaco D, Arankowsky-Sandoval G, Yamamoto T, Cid L, Monteiro D, Rocha NB, Telles-Correia D, Teixeira DS, Veras AB, Budde H, Machado S, Imperatori C, Torterolo P Abstract RATIONALE: The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that...
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Related ArticlesA Prospective Cohort Study to Evaluate the Impact of Diet, Exercise, and Lifestyle on Fertility (IDEAL): Design and Baseline Characteristics. Am J Epidemiol. 2020 May 30;: Authors: Mumford SL, Johnstone E, Kim K, Ahmad M, Salmon S, Summers K, Chaney K, Ryan G, Hotaling JM, Purdue-Smithe AC, Chen Z, Clemons T Abstract Diet, lifestyle, and psychosocial factors may influence fertility for men and women, though evidence is mixed, and couple-based...
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Related ArticlesTwo nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation. Sci Rep. 2020 May 29;10(1):8774 Authors: Chai Y, Fang Z, Yang FN, Xu S, Deng Y, Raine A, Wang J, Yu M, Basner M, Goel N, Kim JJ, Wolk DA, Detre JA, Dinges DF, Rao H Abstract Sleep deprivation significantly impairs a range of cognitive and brain function, particularly episodic memory and the underlying hippocampal function....
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Related ArticlesENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing. Transl Psychiatry. 2020 May 29;10(1):172 Authors: Schmaal L, Pozzi E, C Ho T, van Velzen LS, Veer IM, Opel N, Van Someren EJW, Han LKM, Aftanas L, Aleman A, Baune BT, Berger K, Blanken TF, Capitão L, Couvy-Duchesne B, R Cullen K, Dannlowski U, Davey C, Erwin-Grabner T, Evans J, Frodl T, Fu CHY, Godlewska B, Gotlib IH, Goya-Maldonado R, Grabe HJ, Groenewold...
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Related ArticlesSleep disturbances in schizophrenia and psychosis. Schizophr Res. 2020 May 26;: Authors: Ferrarelli F PMID: 32471787 [PubMed - as supplied by publisher]
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Related ArticlesConcussion knowledge, attitudes and behaviour in equestrian athletes. J Sci Med Sport. 2020 May 17;: Authors: Theadom A, Reid D, Hardaker N, Lough J, Hume PA Abstract OBJECTIVE: To determine knowledge, attitudes and behaviour towards concussion in adult equestrian athletes. DESIGN: Nationwide, cross-sectional, questionnaire. METHODS: Participants were recruited via advertisements circulated through social media, community...
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Related ArticlesCognitive behavioural therapy for insomnia in patients with rheumatoid arthritis: protocol for the randomised, single-blinded, parallel-group Sleep-RA trial. Trials. 2020 May 29;21(1):440 Authors: Latocha KM, Løppenthin KB, Østergaard M, Jennum PJ, Christensen R, Hetland M, Røgind H, Lundbak T, Midtgaard J, Esbensen BA Abstract BACKGROUND: More than half of patients with rheumatoid arthritis complain of insomnia, which is predominantly...
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Related ArticlesBreastfeeding and caring for children: a qualitative exploration of the experiences of mothers with physical impairments in Ghana. BMC Pregnancy Childbirth. 2020 May 29;20(1):331 Authors: Acheampong AK, Aziato L, Marfo M, Amevor P Abstract BACKGROUND: Breastfeeding and caring for children demand time, energy and effort. Mothers with physical impairments in Ghana require special needs to be able to achieve optimal motherhood as society...
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Related ArticlesThe Neuropsychological Profile of Attention Deficits of Patients with Obstructive Sleep Apnea: An Update on the Daytime Attentional Impairment. Brain Sci. 2020 May 27;10(6): Authors: Angelelli P, Macchitella L, Toraldo DM, Abbate E, Marinelli CV, Arigliani M, De Benedetto M Abstract INTRODUCTION: Patients with obstructive sleep apnea (OSA) suffer from several neurocognitive disturbances. One of the neuropsychological processes most investigated...
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Abstract Parkinson’s disease (PD) was first formally described by James Parkinson in 1817, but the shaking of limbs was described in the literature of several ancient civilizations, such as ancient Chinese civilization and ancient Indian civilization. Historically, botanical drugs were used as the main source for the treatment of such kind of disorders. In Western countries, plant extracts also occupied an important place in the earlier medications of PD. With the adventure of...
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Related ArticlesGrade as prognostic variable in early tongue cancer patients: Are we getting off the track? Oral Oncol. 2020 May 26;:104812 Authors: Thaduri A, Sehrawat A, Poonia DR, Singh MP, Chowdhury N PMID: 32471802 [PubMed - as supplied by publisher]
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Related ArticlesDiagnostic Tests for SARS-CoV-2: Implications in Head and Neck Oncology. Oral Oncol. 2020 May 21;:104813 Authors: Kochhar AS, Bhasin R, Kochhar GK, Dadlani H PMID: 32471801 [PubMed - as supplied by publisher]
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Related ArticlesPsychosocial Reactions to Plagues in the Cultural History of Medicine: A Medical Humanities Approach. J Nerv Ment Dis. 2020 Jun;208(6):443-444 Authors: Wigand ME, Becker T, Steger F Abstract The aim of this work is to elucidate psychosocial reactions to plagues by analyzing three landmark descriptions from different eras: Thucydides' description of the plague of Athens (430 BC) in The History of the Peloponnesian War, Giovanni Boccaccio's...
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Related ArticlesCollege students responding to the Chinese version of Cardiff fertility knowledge scale show deficiencies in their awareness: a cross-sectional survey in Hunan, China. BMC Public Health. 2020 May 29;20(1):810 Authors: Zhou Y, Luo Y, Wang T, Cui Y, Chen M, Fu J Abstract BACKGROUND: Fertility knowledge is vital to the fertility health of young people and greatly impacts their fertility choices. Delayed childbearing has been increasing in...
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Cancers, Vol. 12, Pages 1431: Characterization of a Myeloid Activation Signature that Correlates with Survival in Melanoma Patients Cancers doi: 10.3390/cancers12061431 Authors: Kremenovic Rombini Chan Gruber Bäriswyl Lee Schenk Understanding the cellular interactions within the tumor microenvironment (TME) of melanoma paved the way for novel therapeutic modalities, such as T cell-targeted immune checkpoint inhibitors (ICI). However, only a limited...
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Cancers, Vol. 12, Pages 1432: Association of a CT-Based Clinical and Radiomics Score of Non-Small Cell Lung Cancer (NSCLC) with Lymph Node Status and Overall Survival Cancers doi: 10.3390/cancers12061432 Authors: Francesca Botta Sara Raimondi Lisa Rinaldi Federica Bellerba Federica Corso Vincenzo Bagnardi Daniela Origgi Rocco Minelli Giovanna Pitoni Francesco Petrella Lorenzo Spaggiari Alessio G. Morganti Filippo Del Del Grande Massimo...
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Despite advances in the treatment of schizophrenia spectrum disorders with atypical antipsychotics (AAPs), there is still need for compounds with improved efficacy/side-effect ratios. Evidence from challenge studies suggests that the assessment of gating functions in humans and rodents with naturally low-gating levels might be a useful model to screen for novel compounds with antipsychotic properties. To further evaluate and extend this translational approach, three AAPs were examined. Compounds...
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Publication date: Available online 30 May 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Luciano F. Huergo, Gillize A.T. Araújo, Adrian S.R. Santos, Edileusa C.M. Gerhardt, Fabio O. Pedrosa, Emanuel M. Souza, Karl Forchhammer
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Related ArticlesExecutive summary of EPOS 2020 including integrated care pathways. Rhinology. 2020 May 30;: Authors: Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitzma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J Abstract The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012(1-3). The core objective of the EPOS2020 guideline is to...
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Related ArticlesPausing cancer screening during the severe acute respiratory syndrome coronavirus 2pandemic: Should we revisit the recommendations? Eur J Cancer. 2020 May 20;134:86-89 Authors: Amit M, Tam S, Bader T, Sorkin A, Benov A PMID: 32473542 [PubMed - as supplied by publisher]
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