Background:Several oncogenic signals are involved in the synthesis, metabolism, transportation, and modulation of cholesterol. However, the roles of genetic variants of the cholesterol pathway genes in cancer survival remain unclear. Methods:We investigated associations between 26,781 common SNPs in 209 genes of the cholesterol pathway and non–small cell lung cancer (NSCLC) survival by utilizing genotyping data from two published genome-wide association studies. We used multivariate Cox proportional...
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Background:Colorectal cancer incidence and mortality have declined with increased screening and scientific advances in treatment. However, improvement in colorectal cancer outcomes has not been equal for all groups and disparities have persisted over time. Methods:Data from the California Cancer Registry were used to estimate changes in 5-year colorectal cancer–specific survival over three diagnostic time periods: 1997–2002, 2003–2008, and 2009–2014. Analyses included all patients in California...
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Background:This study aimed to assess long-term trends in the incidence of prostate cancer by stage at diagnosis before and after the introduction of population-based PSA screening. Methods:We used data from three population-based cancer registries in Japan. A total of 29,458 malignant prostate cancer cases diagnosed between 1993 and 2014 were used for the analysis. Multiple imputation with chained equations was used to impute a specific stage at diagnosis for cases with "unknown" and missing status....
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Background:Synovial sarcoma is a rare cancer with peak incidence in the young adult period. Despite poor outcomes of this aggressive cancer, there is little epidemiologic research addressing its etiology. Methods:We collected birth characteristic data on synovial sarcoma cases born during 1978–2015 and diagnosed during 1988–2015 in California (n = 244), and 12,200 controls frequency-matched on year of birth. We also constructed a dataset of cancer cases in siblings of sarcoma subjects to assess...
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Background:The incidence of testicular germ cell tumors (TGCT) has been rising in the United States and is notably higher among white men. Previously, our group reported that rates were rising among Hispanic men in certain areas. This study sought to determine whether the patterns noted in our prior publication remained evident in more recent years and to determine whether any new patterns have emerged. Methods:Data from 51 U.S. cancer registries were examined. Racial/ethnic-specific incidence rates...
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Background:Familial aggregation of lymphoid cancers and immune-related disorders suggests a role for genetic susceptibility; however, few studies examine environmental factors. According to the hygiene hypothesis, adult-onset immune-related diseases may be a consequence of reduced childhood infectious exposures and aberrant immune development. In a cohort of 196 multiple-case lymphoid cancer families, we analyzed environmental factors related to the hygiene hypothesis. Methods:Family structure,...
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Background:Although vitamin D inhibits breast tumor growth in experimental settings, the findings from population-based studies remain inconclusive. Our goals were to investigate the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] concentration and breast cancer recurrence in prospective epidemiologic studies and to explore the molecular underpinnings linking 25(OH)D to slower progression of breast cancer in the Nurses' Health Studies (NHS, N = 659). Methods:Plasma 25(OH)D...
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Background:The 16.9 million cancer survivors in the United States are at increased risk for comorbidities and recurrence. However, this risk may be attenuated by a healthy lifestyle. This study describes health behaviors by cancer history to inform behavior change priorities. Methods:We analyzed 2013–2017 data from the National Health Interview Survey. There were 164,692 adults, of whom 12,648 reported a cancer history. We calculated prevalence of smoking, physical activity, alcohol consumption,...
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Background:Risk prediction models may be useful for precision breast cancer screening. We aimed to evaluate the performance of breast cancer risk models developed in European-ancestry studies in a Korean population. Methods:We compared discrimination and calibration of three multivariable risk models in a cohort of 77,457 women from the Korean Cancer Prevention Study (KCPS)-II. The first incorporated U.S. breast cancer incidence and mortality rates, U.S. risk factor distributions, and RR estimates...
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Background:Non-White cancer survivors often report poorer health compared with Non-Hispanic Whites. Whether those disparities are changing over time is unknown. We examined changes in health-related quality of life (HRQOL) by race/ethnicity from 1998 to 2012 among older adults with and without cancer. Methods:Data from Medicare Advantage beneficiaries were obtained from the linkage between the Medicare Health Outcomes Survey and Surveillance, Epidemiology, and End Results cancer registry data (SEER-MHOS)....
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IntroductionThere is an unmet need to develop tailored therapeutic exercise protocols applying different treatment parameters and modalities for individuals with knee osteoarthritis (KOA). Cryotherapy is widely used in rehabilitation as an adjunct treatment due to its effects on pain and the inflammatory process. However, disagreement between KOA guidelines remains with respect to its recommendation status. The aim of this study is to verify the complementary effects of cryotherapy when associated...
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BackgroundPhysical exercise, a cornerstone of the conservative management of knee osteoarthritis (KOA), is exhaustively recommended by important clinical guidelines. A strength therapeutic exercise program (STEP) relieves pain, improves physical function and ultimately ameliorates quality of life (QoL). Furthermore, photobiomodulation (PBM) has been used as an adjunct treatment for people with KOA; however, there are still controversial recommendations regarding its use on this population. Thus,...
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Abstract Background While international agreement supports a causal relationship of benzene exposure with acute myeloid leukemia, there is debate about benzene and lymphoid neoplasm risks. Methods In a case‐cohort study with follow‐up of 110 631 Chinese workers during 1972‐1999, we evaluated benzene exposure‐response for non‐Hodgkin lymphoma (NHL), lymphoid leukemias (LL), acute lymphocytic leukemia (ALL), and total lymphoid neoplasms (LN). We estimated benzene exposures using state‐of‐the‐art...
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Main Points Beyond its neurogenic ability, zebrafish radial glia play homeostatic roles at the level of neural circuits and brain barriers. Thus, the zebrafish radial glia can be considered as the ancestral homolog of mammalian radial and astroglia combined. Abstract The neuroscience community has witnessed a tremendous expansion of glia research. Glial cells are now on center stage with leading roles in the development, maturation, and physiology of brain circuits. Over the course of evolution,...
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MRI scans of a 25-year-old Italian radiographer who contracted COVID-19 and...Read more on AuntMinnieEurope.comRelated Reading: Life in the time of COVID-19 What can ultrasound reveal about COVID-19 lung cases? Dutch radiologist talks about surviving COVID-19 Is COVID-19 nature's fight back against human hubris? How medical imaging can adapt to life after COVID-19
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FDG-PET/CT can be an effective tool when it comes to breast cancer staging...Read more on AuntMinnieEurope.comRelated Reading: U.K. study gives new data on long-term risks of DCIS Breast screening set to resume soon in Sweden and Hungary New Swedish study proves breast screening's value Scotland pauses breast cancer screenings amid COVID-19 Magnetized molecules monitor breast cancers
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A woman whose lawsuit claimed a breast cancer screening mobile unit was negligent...Read more on AuntMinnieEurope.comRelated Reading: Irish fears grow over litigation's impact on screening Could legal liability sink breast screening in Ireland? How not to get sued: A guide for radiologists Strickland spells out legal implications of missed cancer Patient access to imaging results brings awkward challenges
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BACKGROUND:Screening in pregnancy for subclinical hypothyroidism, often defined as thyroid-stimulating hormone (TSH) greater than 2.5 mIU/L or greater than 4.0 mIU/L, is controversial. We determined the frequency and distribution of TSH testing by gestational age, as well as TSH values associated with treatment during pregnancy and the frequency of postpartum continuation of thyroid hormone therapy. METHODS:We performed a retrospective cohort study of pregnancies in Alberta, Canada. We included...
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Activation of the immune costimulatory molecule cluster of differentiation 40 (CD40) in Müller glia has been implicated in the initiation of diabetes-induced retinal inflammation. Results from previous studies support that CD40 protein expression is elevated in Müller glia of diabetic mice; yet, the mechanisms responsible for this increase have not been explored. Here, we evaluated the hypothesis that diabetes augments translation of the Cd40 mRNA. Mice receiving thiamet G (TMG), an inhibitor of...
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Abstract Purpose of Review The field of acute myeloid leukemia (AML) has been revolutionized in recent years by the advent of high-throughput techniques, such as next-generation sequencing. In this review, we will discuss some of the recently identified mutations that have defined a new molecular landscape in this disease, as well as their prognostic, predictive, and therapeutic implications. ...
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Puberty is a transition period where a child transforms to an adult. Puberty can be affected by various genetic factors and environmental influences. In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis). A number of genes such as GnRH, Kiss1, and GPR54 have been reported as key regulators of puberty onset. In this study, we have conducted an association study of puberty-related candidate genes in Chinese female population. Gene variations reported...
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Circular RNAs (circRNAs) are formed by joining the 3 and 5 ends of RNA molecules. Identification of circRNAs is an important part of circRNA research. The circRNA prediction methods can predict the circRNAs with start and end positions in the chromosome but cannot identify the full-length circRNA sequences. We present an R package FcircSEC (Full Length circRNA Sequence Extraction and Classification) to extract the full-length circRNA sequences based on gene annotation and the output of any circRNA...
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Veerendra K Shandilya, Lata D Parmar, Ashwinikumar V ShandilyaJournal of Family Medicine and Primary Care 2020 9(5):2492-2495 An adult male who never stood, ambulating on all four due to bilateral severe knee flexion contractures, since his childhood, was 21 years of age, and not deterred by his condition, was pursuing his higher education. He was coaxed by his friends to seek medical opinion and it was decided to give a trial and let the client have a feel of bipedal stance and ambulation. Although...
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Sudip Bhattacharya, Raman KumarJournal of Family Medicine and Primary Care 2020 9(5):2158-2160 Globally, the consumer food environment is often shaped by market interests rather than emphasizing nutritional quantity and quality. In low- income countries like India, such unhealthy food products are becoming increasingly available, accessible, and affordable to the common people, especially the school going children, which is a major concern to us. Despite huge amount of evidence, public health...
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Kamal Kant Sahu, Raman KumarJournal of Family Medicine and Primary Care 2020 9(5):2149-2157 The latest threat to global health is the form of the ongoing Coronavirus Disease 2019 (COVID-19) pandemic. This new coronavirus (SARS-COV-2) started as a local outbreak in Wuhan, China but soon tightened its grip on human lives around the globe. So far, we do not have a particularly effective anti-SARS-COV-2 vaccine or antiviral agent against COVID-19. Across the globe, many research organizations such...
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Sunil Kumar Raina, Raman Kumar, Sagar Galwankar, Suneela Garg, Ramesh Bhatt, Akshay C Dhariwal, DJ Christopher, Bakul J Parekh, S Vimal Krishnan, Praveen Aggarwal, Ishwar Gilada, Udhay BodhankarJournal of Family Medicine and Primary Care 2020 9(5):2161-2166 Covid-19 has once again brought into focus our limited preparedness to deal with epidemics. Most nations, across the globe, have responded with a resolve to come stronger out of this crisis and leaderships across the world have shown great...
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Shruthi K Patil, Neethu Telagi, Mukund R Nair, B R Ahmed MujibJournal of Family Medicine and Primary Care 2020 9(5):2544-2547 Desmoplastic ameloblastoma (DA) is a rare variant of ameloblastoma, accounting for approximately 4 to 13% of ameloblastomas. It is uncommon, aggressive in nature, and there are high chances of misdiagnosis. Clinical and radiographical features are similar to fibro-osseous lesions of jaw. We reported a case of 35-year-old male patient of DA.
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Satendra SinghJournal of Family Medicine and Primary Care 2020 9(5):2167-2171 The disability viewpoint is fundamental for understanding and advancing social justice for everyone in the population. Despite this fact, it is regularly dismissed by public health experts and policymakers. Understanding of disability rights is central in an all-inclusive COVID-19 preparedness. This paper attempts to explore disability ethics in understanding structural discrimination, equitable practices, respect for...
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Javed Iqbal, Ranjitkumar Patil, Vikram Khanna, Anurag Tripathi, Vandana Singh, M A I Munshi, Rahul TiwariJournal of Family Medicine and Primary Care 2020 9(5):2448-2453 Background: Fractal analysis is, a noninvasive method, used to determine the intricate characteristics of the matter. Oral leukoplakia (OL), a potential malignant disorder, has definite propensity to turn in to malignancy. In such lesions, fractal dimension analysis (FDA) could be helpful in the early detection of malignant transformation....
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Pugazhenthan Thangaraju, Meenalotchini P Gurunthalingam, Shobanbabu Varthya, Sajitha Venkatesan, Eswaran ThangarajuJournal of Family Medicine and Primary Care 2020 9(5):2172-2175 Currently no drug is approved for the prophylaxis and management of COVID 19. Lots of activities on vaccine and trials with drugs are underway. Some evidence have shown positive results using older established drug in the management of severe cases. We are also of same view and opinion to adopt some emergency measure...
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Eric C P. Chu, Fa Sain Lo, Amiya BhaumikJournal of Family Medicine and Primary Care 2020 9(5):2517-2520 The cervical spine is responsible for allowing mobility and stability to the head and neck. Any deviation to the center of gravity of the head results in an increase in cantilever loads, which can be particularly damaging to the upper cervical joints. Excessive neck bending also exaggerates stretching through the cervical spine and all of the spinal structures below. It has been reported that...
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Sudip Bhattacharya, Ruchi Juyal, Md Mahbub Hossain, Amarjeet SinghJournal of Family Medicine and Primary Care 2020 9(5):2176-2179 In the changing global socio-economic and epidemiological landscapes, non communicable diseases (NCDs) are affecting the health and wellbeing of populations. The burden is worse among people in low- and middle-income countries with more than 32 million deaths attributable to NCDs each year. This scenario can be explained through the concept of collateral damage, where...
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Shambhavi Singh, Sarika P Kombade, Salman Khan, Arghadip Sammadar, Jitu Mani Kalita, Vijay Lakshmi NagJournal of Family Medicine and Primary Care 2020 9(5):2573-2576 An iatrogenic injection abscess is usually easy to treat if caused by aerobic bacteria but some rapidly growing mycobacteria (RGM), namely, Mycobacterium fortuitum, M. chelonae, and M. abscessus are associated with postinjection abscess and may cause delayed wound healing. RGM can cause mild localized cellulitis or abscess to osteomyelitis...
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Binit Sureka, Arvind Sinha, Vibhor Tak, Mahendra Kumar Garg, Pradeep Kumar Bhatia, Pankaj Bhardwaj, Vijaya Lakshmi Nag, Naveen Dutt, Abhay Elhence, Suryanarayanan Bhaskar, Ashok Bishnoi, Nishant Chauhan, NR Bishnoi, Sanjeev MisraJournal of Family Medicine and Primary Care 2020 9(5):2180-2182 In the COVID-19 pandemic, global health care systems have become overwhelmed with potentially infectious patients seeking testing and care. Preventing spread of infection to and from health care workers (HCWs)...
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Afra Hassan Elrashid, Khalid Jamal Alderaa, Hamad Abdulaziz Alissa, Waad Hamad Almadhi, Hadeel Salem Bawazir, Sarah Saleh Alsougi, Sulaiman Ali AlraffaJournal of Family Medicine and Primary Care 2020 9(5):2426-2430 Background: Application of newer techniques in endodontics improves the prognosis and reduces the time to operate patients; hence, the present study was conducted to determine the characteristics of endodontic practice and to compare these characteristics between General Dental Practitioners...
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Reena Doomra, Anjana GoyalJournal of Family Medicine and Primary Care 2020 9(5):2183-2185 Nonsteroidal anti-inflammatory drugs (NSAIDs) are used by the patients frequently for pain which may be acute, acute-on-chronic, and chronic. For the relief of pain and inflammation, some patients may take the analgesics without consulting the family physician as they can procure the same easily, not realizing that there may be adverse effects associated with regular self-medication of NSAIDs. The NSAIDs...
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Parag Kisave, Vijay Shekhar, Prasoon S Babu, Syed W U. Hussaini, Rishabh Bhanot, Abhinav Kumar, Rahul V C. TiwariJournal of Family Medicine and Primary Care 2020 9(5):2469-2474 Background: Submucous fibrosis with a high incidence rate in the Indian subcontinent is a devastating disease affecting the oral cavity and oropharynx. Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning...
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Surender Deora, Pankaj Bhardwaj, Mahendra Kumar GargJournal of Family Medicine and Primary Care 2020 9(5):2186-2187 The world is facing the new pandemic COVID-19 caused by a novel coronavirus SARS-CoV-2. The demography and socio-economic condition are highly varied in different parts of the world. India also has braced itself to fight with this novel threat. Patients with COVID-19 may have primary cardiac involvement or may have associated cardiac disease. Therefore, the institution needs a protocol...
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Satya Ranjan Misra, Pavitra Baskaran, G MaragathavalliJournal of Family Medicine and Primary Care 2020 9(5):2505-2508 Dermatologic diseases are often associated with oral manifestations and sometimes the oral lesions are the sole presenting features of the disease. Diagnosing a dermatologic disease based on its oral manifestations is a challenge, especially in the absence of associated cutaneous lesions. Lichen planus is a common dermatologic disease that affects the oral mucosa in the adult...
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Satish Bhat, Purvish M Parikh, Suresh Bada MathJournal of Family Medicine and Primary Care 2020 9(5):2188-2191 Historically India, that is Bharat, has shown its acceptance for refugees and the prosecuted minorities. As a civilization, India has given shelter, unbiased protection and habitation to the Christians from Syria, Zoroastrians (Parsis) from Iran, and Jews since ancient times from the Kingdom of Judah. More recently, Jews also arrived in India from Poland during the holocaust. The constitution...
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Prakarti Yadav, Deepak Kumar, Gopal K Bohra, Mahendra K GargJournal of Family Medicine and Primary Care 2020 9(5):2531-2534 Triple A syndrome (Allgrove syndrome) is characterized by a triad of specific features, namely, alacrimia, adrenal insufficiency, and achalasia cardia. It is a rare autosomal recessive disorder. In the present study, an 18-year-old boy was presented with complaints of decreased tears, darkening of the skin, difficulty in walking and standing up from sitting position, and...
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Shivani Chandra, P P R Prithvi, K Srija, Shalini Jauhari, Alka GroverJournal of Family Medicine and Primary Care 2020 9(5):2192-2199 It is a well-known fact that microorganisms are developing resistance to antimicrobial drugs present in the market that is known as antimicrobial resistance (AMR). This resistance in microbes is a great matter of concern among the scientific fraternity. This review article focuses on antibiotics and their respective resistant microbes, factors that cause resistance...
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Ali Zakaria, Fizan Khan, Shehbaz Ahmad, Issam Turk, Jay LevinsonJournal of Family Medicine and Primary Care 2020 9(5):2558-2561 Chronic massive gastric distention is a rare condition that can occur due to an underlying obstruction or dysmotility. Gastric outlet obstruction (GOO) is often the culprit that can manifest as the result of the luminal, mural, or extrinsic compression. Gastric adenocarcinoma can rarely manifest as massive gastric distention due to partially obstructing mass or peptic...
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Suraj Singh SenjamJournal of Family Medicine and Primary Care 2020 9(5):2200-2206 Glaucoma, a leading cause of irreversible blindness, can be prevented or stabilized the progression if identified early and managed it appropriately. In India, around 12 million people suffer from glaucoma, and 1.5 million are blind due to it, so making the third most common cause of blindness. More than 75% of glaucoma are undiagnosed, which perhaps represent the submerged portion of the iceberg phenomenon of the...
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Rachit Sharma, Md Mahbub Hossain, Priyanka PawarJournal of Family Medicine and Primary Care 2020 9(5):2585-2586
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Amit Dang, Dimple Arora, Pawan RaneJournal of Family Medicine and Primary Care 2020 9(5):2207-2213 With healthcare becoming digital, patients today are more empowered than ever before. As a result, digital health solutions have become the need of the hour to keep up with an increasing number of empowered patients participating in their own treatment decisions. Digital health encompasses various platforms and systems that apply technological solutions to enhance healthcare delivery. Digital therapeutics...
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Pramendra P Gupta, Pallawi Jyotsana, Chris Larrison, Shelly Rodrigues, Cindy Lam, Chris DowrickJournal of Family Medicine and Primary Care 2020 9(5):2416-2419 Background: Depression and anxiety is the leading cause of disease burden in low- and middle-income countries. It is associated with a worse clinical course over the lifespan. This study aims the post-effect on the approach of managing depression and anxiety after the training on diagnosis and management of depression and anxiety. Methods:...
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Dinesh Prasad Sahu, Sonu H Subba, Prajna Paramita GiriJournal of Family Medicine and Primary Care 2020 9(5):2214-2218 Cancer awareness is the key to early detection and better health-seeking behaviour. Cancer is quite common in both developing as well as developed countries, but awareness is yet poor among the general population. Poor awareness may lead to poor uptake of screening modalities and delay in diagnosis. One factor that has been consistently shown to be associated with late diagnosis...
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Puneeta Vohra, Vikram Belkhode, Sharayu Nimonkar, Suraj Potdar, Rishabh Bhanot, Izna , Rahul Vinay Chandra TiwariJournal of Family Medicine and Primary Care 2020 9(5):2437-2441 Background: Use of saliva as a specimen for detection of antibodies to infectious agents has generated particular interest in AIDS research community since 1980s. HIV specific antibodies of immunoglobulin isotypes IgA, IgG, and IgM are readily found in salivary secretions. Aim and Objectives: In the present study, HIV...
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