This interactive case features a 63-year-old woman with a history of multiple fractures who presents with progressively worsening pain in both ankles and difficulty walking. Test your diagnostic and therapeutic skills at NEJM.org.
Thu May 28, 2020 03:00
Abstract Objectives The purpose of this study was to assess the clinical and radiographic outcome of root-end microsurgery using a premixed fast-set calcium silicate putty as root-end filling material in human teeth. Materials and methods This study included 50 teeth in 35 patients, whose ages ranged from 16 to 69 years. After clinical and radiographic examination,...
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Abstract Aims The objective of this study is to compare size, enamel thickness and ion relative concentration in generalized megadontia (Ekman- Westborg and Julin trait) and a localized megadont upper third molar to normal teeth. Materials and methods The MD dimensions of permanent teeth were compared to controls. Tooth components of molars were measured...
Mon Jun 01, 2020 03:00
Oncogenesis, Published online: 01 June 2020; doi:10.1038/s41389-020-0239-7MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription
Mon Jun 01, 2020 03:00
Oncogenesis, Published online: 01 June 2020; doi:10.1038/s41389-020-0240-1GLIS2 promotes colorectal cancer through repressing enhancer activation
Mon Jun 01, 2020 03:00
Oncogenesis, Published online: 01 June 2020; doi:10.1038/s41389-020-0241-0PNO1, which is negatively regulated by miR-340-5p, promotes lung adenocarcinoma progression through Notch signaling pathway
Mon Jun 01, 2020 03:00
Mon Jun 01, 2020 03:00
Mon Jun 01, 2020 03:00
Objective: The purpose of this investigation was to review our experience with our "Comprehensive Gastrointestinal Transit Study" in the first 229 patients. This scintigraphic study analyzes motility of the entire gut, from esophagus through the rectosigmoid colon. Methods: Data were reviewed for our first two years of experience (184 females, 45 males), age 20-79 (mean 44±16) with this exam. Patients were referred with symptoms suggestive of a motility disorder. Patients first swallowed In-111...
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Transthyretin and light chain amyloidosis are the two main causes of cardiac amyloidosis. Recent developments in molecular imaging have transformed our ability to diagnose transthyretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease. This review summarizes the current and evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities that have arisen as a result of parallel developments in pharmacotherapy delivering...
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In this study we investigate the diagnostic performance of whole-body F18-FDG imaging using a simultaneous PET/MRI scanner with Time-of-Flight (TOF) capability for low-dose clinical imaging of pediatric patients. In addition to clinically acquired image data using a dosing regimen of 3.7 MBq/kg, images from simulated low-dose regimens (1.9 MBq/kg – 0.41 MBq/kg) were evaluated using several metrics: standardized uptake value (SUV) quantitation, qualitative image quality and lesion detectability. ...
01:39
Isothermal, cell-free, synthetic biology-based approaches to pathogen detection leverage the power of tools available in biological systems, such as highly active polymerases compatible with lyophilization, without the complexity inherent to live-cell systems, of which Nucleic Acid Sequence Based Amplification (NASBA) is well known. Despite the reduced complexity associated with cell-free systems, side reactions are a common characteristic of these systems. As a result, these systems often exhibit...
Mon Jun 01, 2020 18:50
Zinc (Zn) deficiency is a major risk factor for human health, affecting about 30% of the world's population. To study the potential of genomic selection (GS) for maize with increased Zn concentration, an association panel and two doubled haploid (DH) populations were evaluated in three environments. Three genomic prediction models, M (M1: Environment + Line, M2: Environment + Line + Genomic, and M3: Environment + Line + Genomic + Genomic x Environment) incorporating main effects (lines and genomic)...
Mon Jun 01, 2020 23:33
Next-generation sequencing (NGS)-based genotyping methods can generate numerous genetic markers in a single experiment and have contributed to plant genetic mapping. However, for high precision genetic analysis, the complicated genetic segregation mode in polyploid organisms requires high-coverage NGS data and elaborate analytical algorithms. In the present study, we propose a simple strategy for the genetic mapping of polyploids using low-coverage NGS data. The validity of the strategy was investigated...
Mon Jun 01, 2020 23:33
Microbial interactions contribute to shape ecosystems and their functions. The interplay between microorganisms also shapes the evolutionary trajectory of each species, by imposing metabolic and physiological selective pressures. The mechanisms underlying these interactions are thus of interest to improve our understanding of microbial evolution at the genetic level. Here we applied a functional genomics approach in the model yeast Saccharomyces cerevisiae to identify the fitness determinants of...
Mon Jun 01, 2020 03:00
Gibbons in the genus Hylobates, which live in Southeast Asia, show great diversity, comprising seven to nine species. Natural hybridisation has been observed in the species contact zones, although the roles played by hybridisation and introgression in the evolution of these species remain unclear. To uncover the divergence history and the contributions of hybridisation and introgression to the evolution of Hylobates, random amplicon sequencing-direct (GRAS-Di) analysis was employed to genotype 47...
Mon Jun 01, 2020 03:00
Sexual reproduction is a ubiquitous basic feature of life and genetic sex determination is thus widespread, at least among eukaryotes. Understanding the remarkable diversity of sex determination mechanisms, however, is limited by the paucity of empirical studies. Here, we traced back the evolution of sex determination in an entire clade of vertebrates and uncovered that the northern pike (Esox lucius) master sex-determining gene initiated from a 65 to 90 million-year-old gene duplication and remained...
Mon Jun 01, 2020 03:00
Gibbons in the genus Hylobates, which live in Southeast Asia, show great diversity, comprising seven to nine species. Natural hybridisation has been observed in the species contact zones, although the roles played by hybridisation and introgression in the evolution of these species remain unclear. To uncover the divergence history and the contributions of hybridisation and introgression to the evolution of Hylobates, random amplicon sequencing-direct (GRAS-Di) analysis was employed to genotype 47...
Mon Jun 01, 2020 03:00
Sperm, the male most fundamental reproductive feature allowing egg fertilization, evolves under sexual selection. Two components of sperm are mainly under selection, their number and their morphology (including the associated quality). Here we study the evolution of sperm morphology in the genus Daphnia. Based on microscopic observations of sperm morphologies mapped on a Daphnia phylogeny, we found that increase in sperm length evolved at least twice in Daphnia, once in the Daphnia sensus lato clade...
Mon Jun 01, 2020 03:00
There is increased awareness of the possibility of developmental memories resulting from evolutionary learning. Genetic regulatory and neural networks can be modelled by analogous formalism raising the important question of productive analogies in principles, processes and performance. We investigate the formation and persistence of various developmental memories of past phenotypes asking how the number of remembered past phenotypes scales with network size, to what extent memories stored form by...
Sun May 31, 2020 03:00
Cells consist of molecular modules which perform vital biological functions. Cellular modules are key units of adaptive evolution because organismal fitness depends on their performance. Theory shows that in rapidly evolving populations, such as those of many microbes, adaptation is driven primarily by common beneficial mutations with large effects, while other mutations behave as if they are effectively neutral. As a consequence, if a module can be improved only by rare and/or weak beneficial mutations,...
Sun May 31, 2020 03:00
Abstract A disrupted wound repair process often leads to the development of chronic wounds, and pose a major physical, social and economic inconvenience on patients and the public health sector. Chronic wounds are a common complication seen in diabetes mellitus (DM), and often the severity necessitates amputation of the lower limbs. Recently, there has been increasing evidence that photobiomodulation (PBM) initiates wound healing, including increased protein transcription for...
Mon Jun 01, 2020 03:00
Abstract A systematic study on the lack of dissimilatory nitrate reductase (NAR) properties in Halomonas strains had been reported so far. The effects of different factors on Halomonas sp. B01 NAR activity were investigated. The salt tolerance of NAR was characterized. The denitrification process under high salt conditions was reported. Halomonas sp. B01 expressed membrane-bound NAR under induced culture by nitrate. The optimum pH of the enzyme reaction system was 8, and the optimum...
Mon Jun 01, 2020 03:00
Abstract Copper deficiency can produce changes mimicking myelodysplasia, but its prevalence among haematology patients is unknown. This study evaluates the prevalence of deficiency in a population of patients with unexplained cytopenia(s) and dysplasia. Of 17 patients recruited, only one was found to have a low copper level. This is the first study evaluating hypocupremia in patients with isolated haematological manifestations. Our results suggest that copper deficiency is uncommon...
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Analytical ChemistryDOI: 10.1021/acs.analchem.0c01162
Mon Jun 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00970
Mon Jun 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01363
Mon Jun 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00929
Mon Jun 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00184
Sun May 31, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05608
Sat May 30, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00138
Mon Jun 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03349
Mon Jun 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03626
Mon Jun 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03097
Mon Jun 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04286
Mon Jun 01, 2020 07:00
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